Details for: MYL6
Gene ID: 4637
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: MYL6
Ensembl ID: ENSG00000092841
Description: myosin light chain 6
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 117.18rCSI 90.28%PRS 0.91
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CSI 116.43rCSI 97.6%PRS 1.22
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CSI 114.82rCSI 80.17%PRS 1.06
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CSI 113.33rCSI 75.53%PRS 2.87
-
CSI 107.04rCSI 88.74%PRS 0.94
-
CSI 106.97rCSI 71.1%PRS 1.2
-
CSI 104.35rCSI 91.76%PRS 0.74
-
CSI 103.33rCSI 89.47%PRS 1.13
-
CSI 103.31rCSI 94.86%PRS 1.14
-
CSI 101.84rCSI 98.04%PRS 1.05
-
CSI 101.25rCSI 75.93%PRS 3.05
-
CSI 100.92rCSI 79.39%PRS 1.2
-
CSI 99.29rCSI 100%PRS 1.03
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CSI 98.87rCSI 100%PRS 0.94
-
CSI 98.57rCSI 87.49%PRS 1.01
-
CSI 96.92rCSI 76.61%PRS 0.7
-
CSI 93.98rCSI 99.85%PRS 1.84
-
CSI 88.75rCSI 61.7%PRS 1.18
-
CSI 87.77rCSI 68.05%PRS 0.95
-
CSI 87.42rCSI 91.37%PRS 1.08
-
CSI 86.14rCSI 64.72%PRS 1.04
-
CSI 84.79rCSI 84.62%PRS 0.85
-
CSI 84.3rCSI 76.13%PRS 0.89
-
CSI 83.91rCSI 72.33%PRS 1.69
-
CSI 82.79rCSI 65.74%PRS 1.8
-
CSI 81.29rCSI 63.23%PRS 1.44
-
CSI 81.25rCSI 85.11%PRS 1.09
-
CSI 81.05rCSI 65.86%PRS 1.05
-
CSI 80.73rCSI 86.52%PRS 0.93
-
CSI 80.72rCSI 65.27%PRS 0.99
-
CSI 79.3rCSI 74.94%PRS 1.06
-
CSI 78.49rCSI 75.68%PRS 0.27
-
CSI 76.22rCSI 66.94%PRS 1.13
-
CSI 76.14rCSI 51.29%PRS 1.22
-
CSI 75.65rCSI 61.13%PRS 2.65
-
CSI 75.24rCSI 90.87%PRS 1.16
-
CSI 74.46rCSI 56.33%PRS 1.42
-
CSI 74.38rCSI 43.93%PRS 1.41
-
CSI 74.27rCSI 56.49%PRS 1.34
-
CSI 74.25rCSI 86.11%PRS 1.51
-
CSI 73.99rCSI 83.28%PRS 1.7
-
CSI 73.07rCSI 100%PRS 1.16
-
CSI 72.66rCSI 53.98%PRS 1.51
-
CSI 72.66rCSI 85.34%PRS 1.24
-
CSI 72.37rCSI 90.82%PRS 1.28
-
CSI 72.06rCSI 59.68%PRS 1.01
-
CSI 70.65rCSI 89.93%PRS 1.18
-
CSI 69.22rCSI 94.32%PRS 0.92
-
CSI 67.68rCSI 81.23%PRS 1.01
-
CSI 67.04rCSI 65.84%PRS 1.62
-
CSI 66.47rCSI 57.79%PRS 1.24
-
CSI 66.46rCSI 80.9%PRS 1.28
-
CSI 65.62rCSI 89.29%PRS 1.55
-
CSI 65.48rCSI 75.72%PRS 0.73
-
CSI 64.74rCSI 84.83%PRS 1.41
-
CSI 64.53rCSI 65.76%PRS 1.47
-
CSI 64.2rCSI 58.47%PRS 1.58
-
CSI 64.14rCSI 100%PRS 1.03
-
CSI 63.25rCSI 58.86%PRS 1.01
-
CSI 62.92rCSI 80.7%PRS 1.17
-
CSI 62.81rCSI 85.82%PRS 1.12
-
CSI 62.45rCSI 46.62%PRS 1.71
-
CSI 62.42rCSI 64.66%PRS 1.18
-
CSI 62.33rCSI 77.1%PRS 0.89
-
CSI 62.27rCSI 86.24%PRS 1.46
-
CSI 61.85rCSI 70.8%PRS 2.11
-
CSI 61.8rCSI 51.59%PRS 3.57
-
CSI 59.24rCSI 91.04%PRS 1.47
-
CSI 59rCSI 70.45%PRS 1.76
-
CSI 58.37rCSI 100%PRS 1.35
-
CSI 58.02rCSI 83.68%PRS 1.4
-
CSI 57.24rCSI 87.92%PRS 1.17
-
CSI 56.7rCSI 100%PRS 1.35
-
CSI 56.63rCSI 90.77%PRS 3.36
-
CSI 55.94rCSI 80.63%PRS 1.65
-
CSI 55.79rCSI 65.52%PRS 10.29
-
CSI 55.67rCSI 69.99%PRS 1.56
-
CSI 55rCSI 47.18%PRS 3.29
-
CSI 54.97rCSI 52.86%PRS 2.21
-
CSI 54.65rCSI 67.33%PRS 3.36
-
CSI 54.62rCSI 88.08%PRS 1.65
-
CSI 54.45rCSI 83.21%PRS 1.18
-
CSI 54.45rCSI 100%PRS 1.03
-
CSI 54.4rCSI 80.65%PRS 12.27
-
CSI 53.69rCSI 66.78%PRS 1.08
-
CSI 52.02rCSI 79.56%PRS 1.66
-
CSI 51.93rCSI 59.97%PRS 0.95
-
CSI 51.42rCSI 73.71%PRS 1.42
-
CSI 51.38rCSI 47.4%PRS 1.02
-
CSI 51.19rCSI 70.34%PRS 2.17
-
CSI 51.03rCSI 53.3%PRS 3.26
-
CSI 50.74rCSI 37.58%PRS 0.97
-
CSI 50.62rCSI 77.31%PRS 1.77
-
CSI 50.46rCSI 73.91%PRS 1.2
-
CSI 50.35rCSI 35.36%PRS 3.09
-
CSI 50.23rCSI 73.6%PRS 6.24
-
CSI 49.87rCSI 66.64%PRS 1.93
-
CSI 49.32rCSI 50.49%PRS 1.91
-
CSI 48.88rCSI 92.41%PRS 2.3
-
CSI 48.65rCSI 48.04%PRS 4.49
-
CSI -42.2rCSI -100.0%PRS 1.5%
-
CSI -40.2rCSI -70.4%PRS 0.9%
-
CSI -35.9rCSI -57.7%PRS 0.8%
-
CSI -34.7rCSI -40.7%PRS 1.7%
-
CSI -33.6rCSI -41.8%PRS 0.6%
-
CSI -32.8rCSI -75.6%PRS 1.0%
-
CSI -24.5rCSI -55.0%PRS 0.7%
-
CSI -24.3rCSI -100.0%PRS 0.7%
-
CSI -23.3rCSI -88.0%PRS 2.4%
-
CSI -23.1rCSI -29.7%PRS 1.4%
-
CSI -21.4rCSI -40.1%PRS 0.9%
-
CSI -20.1rCSI -100.0%PRS 2.9%
-
CSI -18.1rCSI -58.0%PRS 0.9%
-
CSI -16.8rCSI -49.8%PRS 1.8%
-
CSI -16.4rCSI -51.2%PRS 0.8%
-
CSI -16.2rCSI -54.1%PRS 1.1%
-
CSI -15.9rCSI -41.5%PRS 1.3%
-
CSI -15.6rCSI -36.7%PRS 1.8%
-
CSI -14.4rCSI -51.7%PRS 0.6%
-
CSI -13.3rCSI -56.6%PRS 2.9%
-
CSI -12.3rCSI -47.8%PRS 1.8%
-
CSI -11.6rCSI -15.8%PRS 1.2%
-
CSI -11.5rCSI -67.9%PRS 2.8%
-
CSI -10.6rCSI -19.2%PRS 1.2%
-
CSI -10.1rCSI -20.8%PRS 1.3%
-
CSI -9.9rCSI -46.8%PRS 3.3%
-
CSI -9.7rCSI -11.6%PRS 0.7%
-
CSI -9.5rCSI -50.3%PRS 9.8%
-
CSI -9.3rCSI -16.8%PRS 0.9%
-
CSI -9.3rCSI -16.0%PRS 0.8%
-
CSI -9.1rCSI -22.1%PRS 0.7%
-
CSI -9.0rCSI -97.7%PRS 6.7%
-
CSI -8.1rCSI -23.0%PRS 1.4%
-
CSI -8.0rCSI -53.3%PRS 2.8%
-
CSI -8.0rCSI -39.9%PRS 7.7%
-
CSI -7.1rCSI -55.3%PRS 3.1%
-
CSI -7.1rCSI -75.4%PRS 20.3%
-
CSI -7.0rCSI -35.5%PRS 5.3%
-
CSI -6.7rCSI -25.3%PRS 0.7%
-
CSI -5.9rCSI -14.1%PRS 0.8%
-
CSI -5.4rCSI -32.0%PRS 0.8%
-
CSI -5.2rCSI -35.3%PRS 2.7%
-
CSI -5.2rCSI -17.7%PRS 1.6%
-
CSI -5.1rCSI -8.5%PRS 0.7%
-
CSI -4.9rCSI -14.1%PRS 1.5%
-
CSI -4.9rCSI -25.2%PRS 4.5%
-
CSI -4.6rCSI -14.9%PRS 1.9%
-
CSI -3.7rCSI -18.4%PRS 2.2%
-
CSI -3.0rCSI -18.8%PRS 0.9%
-
CSI -2.9rCSI -41.4%PRS 15.1%
-
CSI -2.4rCSI -45.8%PRS 8.3%
-
CSI -2.3rCSI -15.9%PRS 3.9%
-
CSI -2.2rCSI -9.6%PRS 1.4%
-
CSI -1.9rCSI -4.8%PRS 1.6%
-
CSI -1.8rCSI -36.8%PRS 1.4%
-
CSI -1.7rCSI -27.9%PRS 6.0%
-
CSI -1.4rCSI -5.7%PRS 1.2%
-
CSI -1.3rCSI -41.3%PRS 19.3%
-
CSI -1.3rCSI -18.1%PRS 1.1%
-
CSI -1.2rCSI -16.9%PRS 13.7%
-
CSI -0.8rCSI -17.1%PRS 1.5%
-
CSI -0.7rCSI -2.2%PRS 1.1%
-
CSI -0.7rCSI -14.4%PRS 26.9%
-
CSI -0.5rCSI -2.0%PRS 5.1%
-
CSI -0.4rCSI -1.2%PRS 0.7%
-
CSI -0.3rCSI -1.5%PRS 1.8%
-
CSI 0.1rCSI 0.1%PRS 0.9%
-
CSI 0.2rCSI 0.2%PRS 0.7%
-
CSI 0.3rCSI 0.6%PRS 0.8%
-
CSI 0.7rCSI 10.4%PRS 26.2%
-
CSI 1.0rCSI 20.6%PRS 19.8%
-
CSI 1.3rCSI 16.4%PRS 10.9%
-
CSI 1.3rCSI 2.3%PRS 0.6%
-
CSI 2.0rCSI 5.2%PRS 1.1%
-
CSI 2.1rCSI 7.1%PRS 4.4%
-
CSI 2.2rCSI 11.1%PRS 7.2%
-
CSI 2.2rCSI 69.2%PRS 14.9%
-
CSI 2.3rCSI 7.3%PRS 1.3%
-
CSI 2.5rCSI 35.7%PRS 16.7%
-
CSI 2.5rCSI 27.1%PRS 16.3%
-
CSI 2.7rCSI 19.5%PRS 16.6%
-
CSI 2.7rCSI 6.0%PRS 0.8%
-
CSI 2.8rCSI 35.9%PRS 7.3%
-
CSI 2.9rCSI 7.4%PRS 1.5%
-
CSI 3.0rCSI 69.6%PRS 0.8%
-
CSI 3.0rCSI 17.1%PRS 1.7%
-
CSI 3.1rCSI 56.6%PRS 1.3%
-
CSI 3.1rCSI 8.0%PRS 1.0%
-
CSI 3.1rCSI 78.1%PRS 10.1%
-
CSI 3.1rCSI 30.9%PRS 13.8%
-
CSI 3.2rCSI 83.6%PRS 5.9%
-
CSI 3.2rCSI 95.8%PRS 2.5%
-
CSI 3.3rCSI 77.0%PRS 7.3%
-
CSI 3.3rCSI 86.0%PRS 6.3%
-
CSI 3.4rCSI 18.7%PRS 4.0%
-
CSI 3.4rCSI 72.3%PRS 6.6%
-
CSI 3.5rCSI 78.1%PRS 6.2%
-
CSI 3.7rCSI 12.6%PRS 4.4%
-
CSI 3.7rCSI 86.0%PRS 3.8%
-
CSI 3.7rCSI 78.7%PRS 10.0%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3965741497
Symbol: MYL6_HUMAN
Name: Myosin light polypeptide 6
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2722814
Title: The alkali light chains of human smooth and nonmuscle myosins are encoded by a single gene. Tissue-specific expression by alternative splicing pathways.
PubMed ID: 2722814
PubMed ID: 2304459
Title: Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function.
PubMed ID: 2304459
PubMed ID: 8188229
Title: Molecular cloning, sequencing, and characterization of smooth muscle myosin alkali light chain from human eye cDNA: homology with myocardial fatty acid ethyl ester synthase-III cDNA.
PubMed ID: 8188229
PubMed ID: 11436981
Title: Molecular cloning and sequencing of myosin light chains in human megakaryoblastic leukemia cells.
PubMed ID: 11436981
DOI: 10.1540/jsmr.37.25
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 14654843
Title: Proteomic characterization of the human centrosome by protein correlation profiling.
PubMed ID: 14654843
DOI: 10.1038/nature02166
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 151
- Mass: 16930
- Checksum: A2B7B4F41179523D
- Sequence:
MCDFTEDQTA EFKEAFQLFD RTGDGKILYS QCGDVMRALG QNPTNAEVLK VLGNPKSDEM NVKVLDFEHF LPMLQTVAKN KDQGTYEDYV EGLRVFDKEG NGTVMGAEIR HVLVTLGEKM TEEEVEMLVA GHEDSNGCIN YEAFVRHILS G