Details for: MYL6

Gene ID: 4637

Symbol: MYL6

Ensembl ID: ENSG00000092841

Description: myosin light chain 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 1268.6342
    Cell Significance Index: -197.3300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 791.5444
    Cell Significance Index: -200.7700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 586.9193
    Cell Significance Index: -241.7800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 497.9850
    Cell Significance Index: -235.1100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 460.0151
    Cell Significance Index: -236.6300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 353.3713
    Cell Significance Index: -237.1200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 173.7207
    Cell Significance Index: -214.1900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 60.9851
    Cell Significance Index: -240.6500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 60.0628
    Cell Significance Index: -184.4800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 33.5650
    Cell Significance Index: -73.4600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 30.5839
    Cell Significance Index: -81.9300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 9.9585
    Cell Significance Index: 184.0600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 9.0021
    Cell Significance Index: 236.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 8.7824
    Cell Significance Index: 412.7700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 6.9667
    Cell Significance Index: 123.1100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 6.4997
    Cell Significance Index: 484.4200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 6.4470
    Cell Significance Index: 189.3400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 5.8378
    Cell Significance Index: 801.7000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 5.8150
    Cell Significance Index: 158.2800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 5.8062
    Cell Significance Index: 713.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 5.7271
    Cell Significance Index: 3127.6800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 5.6548
    Cell Significance Index: 1019.3900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 5.6507
    Cell Significance Index: 730.0300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 5.5244
    Cell Significance Index: 62.7600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 5.3134
    Cell Significance Index: 626.6100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 4.9236
    Cell Significance Index: 631.1800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 4.7717
    Cell Significance Index: 99.8800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.5547
    Cell Significance Index: 212.3600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 4.1960
    Cell Significance Index: 112.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 4.0826
    Cell Significance Index: 1805.0200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 4.0654
    Cell Significance Index: 287.5200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.9206
    Cell Significance Index: 90.5800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.8708
    Cell Significance Index: 35.6500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.5439
    Cell Significance Index: 228.6400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 3.0469
    Cell Significance Index: 301.4100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.8040
    Cell Significance Index: 80.3800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.7045
    Cell Significance Index: 93.9800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.3864
    Cell Significance Index: 63.7200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.9036
    Cell Significance Index: 11.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 1.3538
    Cell Significance Index: 1024.7200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.9910
    Cell Significance Index: 52.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.9562
    Cell Significance Index: 163.2700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9169
    Cell Significance Index: 47.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6750
    Cell Significance Index: 109.7800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.5849
    Cell Significance Index: 428.8400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4457
    Cell Significance Index: 88.4500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2959
    Cell Significance Index: 18.6500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2956
    Cell Significance Index: 13.4000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.1886
    Cell Significance Index: 2.4200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1649
    Cell Significance Index: 2.7600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0128
    Cell Significance Index: 24.0300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0407
    Cell Significance Index: -4.1600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0792
    Cell Significance Index: -35.9400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0805
    Cell Significance Index: -59.6400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1103
    Cell Significance Index: -203.4200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1344
    Cell Significance Index: -83.9400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1361
    Cell Significance Index: -209.4600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1394
    Cell Significance Index: -50.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1973
    Cell Significance Index: -268.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.2031
    Cell Significance Index: -128.9600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.2146
    Cell Significance Index: -40.8400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.2785
    Cell Significance Index: -55.8600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2871
    Cell Significance Index: -161.8900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.3645
    Cell Significance Index: -2.9100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3836
    Cell Significance Index: -4.1700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4973
    Cell Significance Index: -104.7400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.6694
    Cell Significance Index: -192.6000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7093
    Cell Significance Index: -56.1800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.8327
    Cell Significance Index: -23.2700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.8385
    Cell Significance Index: -64.3500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.8716
    Cell Significance Index: -13.0600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.0008
    Cell Significance Index: -114.2400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -1.0100
    Cell Significance Index: -109.8600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.0236
    Cell Significance Index: -117.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.1748
    Cell Significance Index: -170.7700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -1.3638
    Cell Significance Index: -158.9300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.4852
    Cell Significance Index: -91.2900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.5654
    Cell Significance Index: -39.9900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.7227
    Cell Significance Index: -14.4700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.8173
    Cell Significance Index: -10.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.9758
    Cell Significance Index: -110.8700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.9834
    Cell Significance Index: -42.9700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.0623
    Cell Significance Index: -214.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -2.2149
    Cell Significance Index: -70.9400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -2.3766
    Cell Significance Index: -32.4300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -3.1643
    Cell Significance Index: -37.7200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -3.5138
    Cell Significance Index: -236.2700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -3.6319
    Cell Significance Index: -62.6100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -3.8340
    Cell Significance Index: -235.0600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -4.0897
    Cell Significance Index: -79.8200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -4.5129
    Cell Significance Index: -132.9300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -4.6669
    Cell Significance Index: -125.0500
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -5.0262
    Cell Significance Index: -70.4500
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -5.6560
    Cell Significance Index: -26.1200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -5.6615
    Cell Significance Index: -207.8300
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -5.7487
    Cell Significance Index: -30.2500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -5.8874
    Cell Significance Index: -241.2400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -6.0285
    Cell Significance Index: -154.9600
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -6.0829
    Cell Significance Index: -52.2700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -6.0900
    Cell Significance Index: -269.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MYL6 is a small, acidic protein that belongs to the myosin light chain family. It is characterized by its ability to bind to actin filaments and regulate their dynamics, thereby influencing cell movement, morphology, and signaling. MYL6 is also known to interact with various proteins, including myosin heavy chains, tropomyosin, and actin-binding proteins, to modulate its activity. The protein is highly conserved across species, suggesting its essential role in fundamental cellular processes. **Pathways and Functions:** MYL6 is involved in multiple signaling pathways, including: 1. **Axon guidance**: MYL6 regulates axon guidance and growth cone collapse through its interaction with Eph receptors and ephrin ligands. 2. **Muscle contraction**: MYL6 is essential for smooth muscle contraction, as it regulates the dynamics of actin filaments and myosin II complexes. 3. **Cell migration**: MYL6 is involved in cell migration and invasion, particularly in the context of cancer and immune cell trafficking. 4. **Signaling by Rho GTPases**: MYL6 interacts with Rho GTPases, which regulate various cellular processes, including cytoskeletal dynamics, cell migration, and cell proliferation. **Clinical Significance:** MYL6 has been implicated in various disease contexts, including: 1. **Cancer**: MYL6 is overexpressed in several types of cancer, including breast, lung, and colon cancer, where it contributes to tumor progression and metastasis. 2. **Immune cell disorders**: MYL6 is expressed in immune cells, including T cells and natural killer cells, and its dysregulation has been linked to autoimmune diseases and immunodeficiency disorders. 3. **Muscular dystrophy**: MYL6 has been identified as a potential therapeutic target for muscular dystrophy, as it is involved in the regulation of muscle contraction and cell survival. 4. **Neurological disorders**: MYL6 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease, where it regulates axon guidance and neuronal survival. In conclusion, MYL6 is a multifaceted protein that plays a crucial role in various cellular processes, including muscle contraction, cell migration, and axon guidance. Its dysregulation has been linked to various disease contexts, including cancer, immune cell disorders, muscular dystrophy, and neurological disorders. Further research is needed to fully elucidate the role of MYL6 in these contexts and to explore its potential as a therapeutic target.

Genular Protein ID: 3965741497

Symbol: MYL6_HUMAN

Name: Myosin light polypeptide 6

UniProtKB Accession Codes:

P60660 P16475 P24572 P24573 Q12790 Q561V9 Q6IAZ0 Q6IPY5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 3 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 3 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 7 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2722814

Title: The alkali light chains of human smooth and nonmuscle myosins are encoded by a single gene. Tissue-specific expression by alternative splicing pathways.

PubMed ID: 2722814

DOI: 10.1016/s0021-9258(18)81895-6

PubMed ID: 2304459

Title: Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function.

PubMed ID: 2304459

DOI: 10.1128/mcb.10.3.1095-1104.1990

PubMed ID: 8188229

Title: Molecular cloning, sequencing, and characterization of smooth muscle myosin alkali light chain from human eye cDNA: homology with myocardial fatty acid ethyl ester synthase-III cDNA.

PubMed ID: 8188229

DOI: 10.1006/geno.1994.1041

PubMed ID: 11436981

Title: Molecular cloning and sequencing of myosin light chains in human megakaryoblastic leukemia cells.

PubMed ID: 11436981

DOI: 10.1540/jsmr.37.25

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 151
  • Mass: 16930
  • Checksum: A2B7B4F41179523D
  • Sequence:
    • MCDFTEDQTA EFKEAFQLFD RTGDGKILYS QCGDVMRALG QNPTNAEVLK VLGNPKSDEM 
NVKVLDFEHF LPMLQTVAKN KDQGTYEDYV EGLRVFDKEG NGTVMGAEIR HVLVTLGEKM 
TEEEVEMLVA GHEDSNGCIN YEAFVRHILS G

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.