Gene GSTP1 - ENSG00000084207 | NCBI Gene ID: 2950

Details for: GSTP1

Gene ID: 2950

Symbol: GSTP1

Ensembl ID: ENSG00000084207

Description: glutathione S-transferase pi 1

Associated with

Biological oxidations
(R-HSA-211859)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Detoxification of reactive oxygen species
(R-HSA-3299685)
Drug adme
(R-HSA-9748784)
Glutathione conjugation
(R-HSA-156590)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Metabolism
(R-HSA-1430728)
Neutrophil degranulation
(R-HSA-6798695)
Paracetamol adme
(R-HSA-9753281)
Phase ii - conjugation of compounds
(R-HSA-156580)
Cellular oxidant detoxification
(GO:0098869)
Cellular response to lipopolysaccharide
(GO:0071222)
Central nervous system development
(GO:0007417)
Common myeloid progenitor cell proliferation
(GO:0035726)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dinitrosyl-iron complex binding
(GO:0035731)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fatty acid binding
(GO:0005504)
Ficolin-1-rich granule lumen
(GO:1904813)
Glutathione derivative biosynthetic process
(GO:1901687)
Glutathione metabolic process
(GO:0006749)
Glutathione peroxidase activity
(GO:0004602)
Glutathione transferase activity
(GO:0004364)
Hepoxilin biosynthetic process
(GO:0051122)
Jun kinase binding
(GO:0008432)
Kinase regulator activity
(GO:0019207)
Linoleic acid metabolic process
(GO:0043651)
Mitochondrion
(GO:0005739)
Negative regulation of acute inflammatory response
(GO:0002674)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of biosynthetic process
(GO:0009890)
Negative regulation of canonical nf-kappab signal transduction
(GO:0043124)
Negative regulation of erk1 and erk2 cascade
(GO:0070373)
Negative regulation of extrinsic apoptotic signaling pathway
(GO:2001237)
Negative regulation of fibroblast proliferation
(GO:0048147)
Negative regulation of interleukin-1 beta production
(GO:0032691)
Negative regulation of jun kinase activity
(GO:0043508)
Negative regulation of leukocyte proliferation
(GO:0070664)
Negative regulation of mapk cascade
(GO:0043409)
Negative regulation of map kinase activity
(GO:0043407)
Negative regulation of monocyte chemotactic protein-1 production
(GO:0071638)
Negative regulation of nitric-oxide synthase biosynthetic process
(GO:0051771)
Negative regulation of protein kinase activity
(GO:0006469)
Negative regulation of stress-activated mapk cascade
(GO:0032873)
Negative regulation of tumor necrosis factor-mediated signaling pathway
(GO:0010804)
Negative regulation of tumor necrosis factor production
(GO:0032720)
Nitric oxide binding
(GO:0070026)
Nitric oxide storage
(GO:0035732)
Nucleus
(GO:0005634)
Positive regulation of superoxide anion generation
(GO:0032930)
Prostaglandin metabolic process
(GO:0006693)
Protein binding
(GO:0005515)
Regulation of erk1 and erk2 cascade
(GO:0070372)
Regulation of stress-activated mapk cascade
(GO:0032872)
Response to reactive oxygen species
(GO:0000302)
S-nitrosoglutathione binding
(GO:0035730)
Secretory granule lumen
(GO:0034774)
Traf2-gstp1 complex
(GO:0097057)
Vesicle
(GO:0031982)
Xenobiotic metabolic process
(GO:0006805)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 7.46
Marker Score: 2186
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 6.6
Marker Score: 4984.5
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 5.61
Marker Score: 4391
Cell Name: early promyelocyte (CL0002154)
Fold Change: 5.15
Marker Score: 4125
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 4.98
Marker Score: 3516.5
Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: 4.85
Marker Score: 2945
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 4.53
Marker Score: 6970
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 4.45
Marker Score: 28384
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 4.25
Marker Score: 11738
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 4.24
Marker Score: 5113.5
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 4.24
Marker Score: 22265
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 4.22
Marker Score: 11304.5
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 4.18
Marker Score: 31121
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 4.1
Marker Score: 10350
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.03
Marker Score: 225454
Cell Name: mesodermal cell (CL0000222)
Fold Change: 3.95
Marker Score: 52089
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.92
Marker Score: 9586
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 3.87
Marker Score: 33603
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 3.84
Marker Score: 25026
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 3.83
Marker Score: 4261
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 3.76
Marker Score: 4534
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 3.74
Marker Score: 2657
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 3.67
Marker Score: 4784
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 3.65
Marker Score: 3108.5
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 3.61
Marker Score: 1925.5
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.55
Marker Score: 3794
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 3.55
Marker Score: 120625.5
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 3.54
Marker Score: 10332
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 3.53
Marker Score: 3454.5
Cell Name: blood cell (CL0000081)
Fold Change: 3.53
Marker Score: 40992
Cell Name: radial glial cell (CL0000681)
Fold Change: 3.51
Marker Score: 1295
Cell Name: supporting cell (CL0000630)
Fold Change: 3.51
Marker Score: 6596
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.49
Marker Score: 22692.5
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 3.4
Marker Score: 12058
Cell Name: malignant cell (CL0001064)
Fold Change: 3.39
Marker Score: 45580
Cell Name: cell in vitro (CL0001034)
Fold Change: 3.39
Marker Score: 117476
Cell Name: classical monocyte (CL0000860)
Fold Change: 3.39
Marker Score: 14078
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 3.39
Marker Score: 14125.5
Cell Name: mucous neck cell (CL0000651)
Fold Change: 3.37
Marker Score: 7656.5
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 3.37
Marker Score: 26319
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 3.36
Marker Score: 5573
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 3.35
Marker Score: 2854
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 3.28
Marker Score: 5372
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 3.27
Marker Score: 2579.5
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 3.27
Marker Score: 2153.5
Cell Name: lung macrophage (CL1001603)
Fold Change: 3.25
Marker Score: 3718
Cell Name: late promyelocyte (CL0002151)
Fold Change: 3.19
Marker Score: 801
Cell Name: retinal rod cell (CL0000604)
Fold Change: 3.19
Marker Score: 9114
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 3.17
Marker Score: 4482
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 3.17
Marker Score: 15555.5
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 3.16
Marker Score: 6159
Cell Name: myelocyte (CL0002193)
Fold Change: 3.16
Marker Score: 1364
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 3.15
Marker Score: 27172
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 3.14
Marker Score: 1008
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 3.14
Marker Score: 2662
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 3.12
Marker Score: 3168
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 3.12
Marker Score: 8174
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 3.11
Marker Score: 9827
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 3.1
Marker Score: 27247
Cell Name: chondrocyte (CL0000138)
Fold Change: 3.09
Marker Score: 1393
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 3.09
Marker Score: 4248
Cell Name: pneumocyte (CL0000322)
Fold Change: 3.08
Marker Score: 4950
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 3.08
Marker Score: 2056
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 3.07
Marker Score: 11849
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 3.04
Marker Score: 3202
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 3.04
Marker Score: 2900
Cell Name: enterocyte (CL0000584)
Fold Change: 3.04
Marker Score: 14588
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 3.02
Marker Score: 4377
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 3.02
Marker Score: 2896
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 3.01
Marker Score: 1253
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 3
Marker Score: 7634
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 2.97
Marker Score: 3152
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 2.97
Marker Score: 3189.5
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 2.96
Marker Score: 939
Cell Name: Kupffer cell (CL0000091)
Fold Change: 2.95
Marker Score: 2952
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 2.92
Marker Score: 961
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.91
Marker Score: 32726.5
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 2.9
Marker Score: 1431
Cell Name: granulocyte (CL0000094)
Fold Change: 2.9
Marker Score: 1300
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 2.88
Marker Score: 1811
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 2.87
Marker Score: 1476
Cell Name: reticular cell (CL0000432)
Fold Change: 2.86
Marker Score: 1045.5
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 2.86
Marker Score: 5709.5
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 2.85
Marker Score: 1944
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.85
Marker Score: 73073
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.85
Marker Score: 6490
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.84
Marker Score: 679.5
Cell Name: theca cell (CL0000503)
Fold Change: 2.84
Marker Score: 2032.5
Cell Name: pro-T cell (CL0000827)
Fold Change: 2.83
Marker Score: 11592
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 2.83
Marker Score: 7338
Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 2.81
Marker Score: 679
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 2.81
Marker Score: 969.5
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 2.79
Marker Score: 4108
Cell Name: decidual cell (CL2000002)
Fold Change: 2.79
Marker Score: 12027.5
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 2.78
Marker Score: 1586.5
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 2.78
Marker Score: 5804
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 2.78
Marker Score: 940
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.76
Marker Score: 8197
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 2.76
Marker Score: 1191
Cell Name: epithelial cell (CL0000066)
Fold Change: 2.76
Marker Score: 4385

Hover over a box to see details here...

**Key characteristics:** * Gene name: GSTP1 * Ensembl ID: ENSG00000084207 * Protein name: GSTP1_HUMAN (GST class-pi) * Protein function: Detoxification of reactive oxygen species and other harmful substances **Pathways and functions:** * GSTP1 is involved in the detoxification of reactive oxygen species (ROS) and other harmful substances in the body. * It is a key enzyme in the glutathione (GSH) cycle, a pathway that helps to maintain the reduced form of glutathione, a key antioxidant. * GSH is produced by the liver and other cells in the body and is transported to other cells via the bloodstream. * GSTP1 catalyzes the transfer of glutathione from GSH to a variety of substrates, including drugs, toxins, and other harmful substances. * This process helps to protect cells from damage by these substances and can also help to regulate inflammation and immune responses. **Clinical significance:** * GSTP1 is a potential therapeutic target for a variety of diseases, including cancer, neurodegenerative diseases, and metabolic disorders. * Studies have shown that inhibitors of GSTP1 can reduce inflammation and cell damage in animal models of disease. * Therefore, GSTP1 inhibitors are being investigated as potential treatments for a variety of diseases. **Additional information:** * GSTP1 is a highly conserved protein that is found in all vertebrates. * It is expressed in high levels in the liver, kidney, and other organs. * GSTP1 is a member of the GST family of enzymes, which are involved in the metabolism of a variety of chemicals.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

GST class-pi

Genular Protein ID: 2931175595

Symbol: GSTP1_HUMAN

Name: GST class-pi

UniProtKB Accession Codes:

P09211 O00460 Q15690 Q5TZY3

Database IDs:

Citations:

PubMed ID: 3664469

Title: Structure and expression of a human class pi glutathione S-transferase messenger RNA.

PubMed ID: 3664469

PubMed ID: 3196325

Title: The structure of the human glutathione S-transferase pi gene.

PubMed ID: 3196325

DOI: 10.1042/bj2550079

PubMed ID: 2542132

Title: Structure of the human genomic glutathione S-transferase-pi gene.

PubMed ID: 2542132

DOI: 10.1016/0378-1119(89)90377-6

PubMed ID: 2466554

Title: Expression of anionic glutathione-S-transferase and P-glycoprotein genes in human tissues and tumors.

PubMed ID: 2466554

PubMed ID: 9092542

Title: Molecular cloning, characterization, and expression in Escherichia coli of full-length cDNAs of three human glutathione S-transferase Pi gene variants. Evidence for differential catalytic activity of the encoded proteins.

PubMed ID: 9092542

DOI: 10.1074/jbc.272.15.10004

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3979555

Title: Structural evidence for three different types of glutathione transferase in human tissues.

PubMed ID: 3979555

DOI: 10.1016/0014-5793(85)80324-0

PubMed ID: 3864155

Title: Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties.

PubMed ID: 3864155

DOI: 10.1073/pnas.82.21.7202

PubMed ID: 3395118

Title: Purification and characterization of unique glutathione S-transferases from human muscle.

PubMed ID: 3395118

DOI: 10.1016/0003-9861(88)90564-4

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 9150948

Title: A two-dimensional gel database of human colon carcinoma proteins.

PubMed ID: 9150948

DOI: 10.1002/elps.1150180344

PubMed ID: 2327795

Title: Primary and secondary structural analyses of glutathione S-transferase pi from human placenta.

PubMed ID: 2327795

DOI: 10.1016/0003-9861(90)90277-6

PubMed ID: 1567427

Title: Tyrosine-7 in human class Pi glutathione S-transferase is important for lowering the pKa of the thiol group of glutathione in the enzyme-glutathione complex.

PubMed ID: 1567427

DOI: 10.1016/0006-291x(92)91177-r

PubMed ID: 1540159

Title: Tyrosine-7 is an essential residue for the catalytic activity of human class PI glutathione S-transferase: chemical modification and site-directed mutagenesis studies.

PubMed ID: 1540159

DOI: 10.1016/0006-291x(92)91848-k

PubMed ID: 8433974

Title: Site-directed mutagenesis study on the roles of evolutionally conserved aspartic acid residues in human glutathione S-transferase P1-1.

PubMed ID: 8433974

DOI: 10.1093/protein/6.1.93

PubMed ID: 9084911

Title: Stereoselective conjugation of prostaglandin A2 and prostaglandin J2 with glutathione, catalyzed by the human glutathione S-transferases A1-1, A2-2, M1a-1a, and P1-1.

PubMed ID: 9084911

DOI: 10.1021/tx9601770

PubMed ID: 19269317

Title: Glutathione S-transferase pi localizes in mitochondria and protects against oxidative stress.

PubMed ID: 19269317

DOI: 10.1016/j.freeradbiomed.2009.02.025

PubMed ID: 19254954

Title: Tyrosine phosphorylation of the human glutathione S-transferase P1 by epidermal growth factor receptor.

PubMed ID: 19254954

DOI: 10.1074/jbc.m808153200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21046276

Title: Biosynthesis of 14,15-hepoxilins in human l1236 Hodgkin lymphoma cells and eosinophils.

PubMed ID: 21046276

DOI: 10.1007/s11745-010-3485-1

PubMed ID: 21668448

Title: Glutathione-S-transferase P1 is a critical regulator of Cdk5 kinase activity.

PubMed ID: 21668448

DOI: 10.1111/j.1471-4159.2011.07343.x

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 1522586

Title: Three-dimensional structure of class pi glutathione S-transferase from human placenta in complex with S-hexylglutathione at 2.8-A resolution.

PubMed ID: 1522586

DOI: 10.1016/0022-2836(92)90692-d

PubMed ID: 9012673

Title: The three-dimensional structure of the human Pi class glutathione transferase P1-1 in complex with the inhibitor ethacrynic acid and its glutathione conjugate.

PubMed ID: 9012673

DOI: 10.1021/bi962316i

PubMed ID: 9245401

Title: Structure and function of the xenobiotic substrate-binding site and location of a potential non-substrate-binding site in a class pi glutathione S-transferase.

PubMed ID: 9245401

DOI: 10.1021/bi970805s

PubMed ID: 9398518

Title: The structures of human glutathione transferase P1-1 in complex with glutathione and various inhibitors at high resolution.

PubMed ID: 9398518

DOI: 10.1006/jmbi.1997.1364

PubMed ID: 9351803

Title: Structures of class pi glutathione S-transferase from human placenta in complex with substrate, transition-state analogue and inhibitor.

PubMed ID: 9351803

DOI: 10.1016/s0969-2126(97)00281-5

PubMed ID: 10441116

Title: Structure and function of residue 104 and water molecules in the xenobiotic substrate-binding site in human glutathione S-transferase P1-1.

PubMed ID: 10441116

DOI: 10.1021/bi990668u

PubMed ID: 9485454

Title: Solution structure of glutathione bound to human glutathione transferase P1-1: comparison of NMR measurements with the crystal structure.

PubMed ID: 9485454

DOI: 10.1021/bi971902o

PubMed ID: 19396894

Title: Rational design of an organometallic glutathione transferase inhibitor.

PubMed ID: 19396894

DOI: 10.1002/anie.200900185

PubMed ID: 19808963

Title: Structural basis for the binding of the anticancer compound 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol to human glutathione s-transferases.

PubMed ID: 19808963

DOI: 10.1158/0008-5472.can-09-1314

Sequence Information:

Length: 210
Mass: 23356
Checksum: 409E33FFAA338396
Sequence:

MPPYTVVYFP VRGRCAALRM LLADQGQSWK EEVVTVETWQ EGSLKASCLY GQLPKFQDGD 
LTLYQSNTIL RHLGRTLGLY GKDQQEAALV DMVNDGVEDL RCKYISLIYT NYEAGKDDYV 
KALPGQLKPF ETLLSQNQGG KTFIVGDQIS FADYNLLDLL LIHEVLAPGC LDAFPLLSAY 
VGRLSARPKL KAFLASPEYV NLPINGNGKQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: GSTP1

Associated with

Cells (max top 100)

Other Information

Structure and expression of a human class pi glutathione S-transferase messenger RNA. PubMed ID: 3664469

The structure of the human glutathione S-transferase pi gene. PubMed ID: 3196325

Structure of the human genomic glutathione S-transferase-pi gene. PubMed ID: 2542132

Expression of anionic glutathione-S-transferase and P-glycoprotein genes in human tissues and tumors. PubMed ID: 2466554

Molecular cloning, characterization, and expression in Escherichia coli of full-length cDNAs of three human glutathione S-transferase Pi gene variants. Evidence for differential catalytic activity of the encoded proteins. PubMed ID: 9092542

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Structural evidence for three different types of glutathione transferase in human tissues. PubMed ID: 3979555

Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties. PubMed ID: 3864155

Purification and characterization of unique glutathione S-transferases from human muscle. PubMed ID: 3395118

Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. PubMed ID: 12665801

A two-dimensional gel database of human colon carcinoma proteins. PubMed ID: 9150948

Primary and secondary structural analyses of glutathione S-transferase pi from human placenta. PubMed ID: 2327795

Tyrosine-7 in human class Pi glutathione S-transferase is important for lowering the pKa of the thiol group of glutathione in the enzyme-glutathione complex. PubMed ID: 1567427

Tyrosine-7 is an essential residue for the catalytic activity of human class PI glutathione S-transferase: chemical modification and site-directed mutagenesis studies. PubMed ID: 1540159

Site-directed mutagenesis study on the roles of evolutionally conserved aspartic acid residues in human glutathione S-transferase P1-1. PubMed ID: 8433974

Stereoselective conjugation of prostaglandin A2 and prostaglandin J2 with glutathione, catalyzed by the human glutathione S-transferases A1-1, A2-2, M1a-1a, and P1-1. PubMed ID: 9084911

Glutathione S-transferase pi localizes in mitochondria and protects against oxidative stress. PubMed ID: 19269317

Tyrosine phosphorylation of the human glutathione S-transferase P1 by epidermal growth factor receptor. PubMed ID: 19254954

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

Biosynthesis of 14,15-hepoxilins in human l1236 Hodgkin lymphoma cells and eosinophils. PubMed ID: 21046276

Glutathione-S-transferase P1 is a critical regulator of Cdk5 kinase activity. PubMed ID: 21668448

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Three-dimensional structure of class pi glutathione S-transferase from human placenta in complex with S-hexylglutathione at 2.8-A resolution. PubMed ID: 1522586

The three-dimensional structure of the human Pi class glutathione transferase P1-1 in complex with the inhibitor ethacrynic acid and its glutathione conjugate. PubMed ID: 9012673

Structure and function of the xenobiotic substrate-binding site and location of a potential non-substrate-binding site in a class pi glutathione S-transferase. PubMed ID: 9245401

The structures of human glutathione transferase P1-1 in complex with glutathione and various inhibitors at high resolution. PubMed ID: 9398518

Structures of class pi glutathione S-transferase from human placenta in complex with substrate, transition-state analogue and inhibitor. PubMed ID: 9351803

Structure and function of residue 104 and water molecules in the xenobiotic substrate-binding site in human glutathione S-transferase P1-1. PubMed ID: 10441116

Solution structure of glutathione bound to human glutathione transferase P1-1: comparison of NMR measurements with the crystal structure. PubMed ID: 9485454

Rational design of an organometallic glutathione transferase inhibitor. PubMed ID: 19396894

Structural basis for the binding of the anticancer compound 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol to human glutathione s-transferases. PubMed ID: 19808963