GSTP1 | ENSG00000084207 | NCBI 2950

Details for: GSTP1

Gene ID: 2950

Symbol: GSTP1

Ensembl ID: ENSG00000084207

Description: glutathione S-transferase pi 1

Associated with

Biological oxidations
(R-HSA-211859)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Detoxification of reactive oxygen species
(R-HSA-3299685)
Drug adme
(R-HSA-9748784)
Glutathione conjugation
(R-HSA-156590)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Metabolism
(R-HSA-1430728)
Neutrophil degranulation
(R-HSA-6798695)
Paracetamol adme
(R-HSA-9753281)
Phase ii - conjugation of compounds
(R-HSA-156580)
Cellular oxidant detoxification
(GO:0098869)
Cellular response to lipopolysaccharide
(GO:0071222)
Central nervous system development
(GO:0007417)
Common myeloid progenitor cell proliferation
(GO:0035726)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dinitrosyl-iron complex binding
(GO:0035731)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fatty acid binding
(GO:0005504)
Ficolin-1-rich granule lumen
(GO:1904813)
Glutathione derivative biosynthetic process
(GO:1901687)
Glutathione metabolic process
(GO:0006749)
Glutathione peroxidase activity
(GO:0004602)
Glutathione transferase activity
(GO:0004364)
Hepoxilin biosynthetic process
(GO:0051122)
Jun kinase binding
(GO:0008432)
Kinase regulator activity
(GO:0019207)
Linoleic acid metabolic process
(GO:0043651)
Mitochondrion
(GO:0005739)
Negative regulation of acute inflammatory response
(GO:0002674)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of biosynthetic process
(GO:0009890)
Negative regulation of canonical nf-kappab signal transduction
(GO:0043124)
Negative regulation of erk1 and erk2 cascade
(GO:0070373)
Negative regulation of extrinsic apoptotic signaling pathway
(GO:2001237)
Negative regulation of fibroblast proliferation
(GO:0048147)
Negative regulation of interleukin-1 beta production
(GO:0032691)
Negative regulation of jun kinase activity
(GO:0043508)
Negative regulation of leukocyte proliferation
(GO:0070664)
Negative regulation of mapk cascade
(GO:0043409)
Negative regulation of map kinase activity
(GO:0043407)
Negative regulation of monocyte chemotactic protein-1 production
(GO:0071638)
Negative regulation of nitric-oxide synthase biosynthetic process
(GO:0051771)
Negative regulation of protein kinase activity
(GO:0006469)
Negative regulation of stress-activated mapk cascade
(GO:0032873)
Negative regulation of tumor necrosis factor-mediated signaling pathway
(GO:0010804)
Negative regulation of tumor necrosis factor production
(GO:0032720)
Nitric oxide binding
(GO:0070026)
Nitric oxide storage
(GO:0035732)
Nucleus
(GO:0005634)
Positive regulation of superoxide anion generation
(GO:0032930)
Prostaglandin metabolic process
(GO:0006693)
Protein binding
(GO:0005515)
Regulation of erk1 and erk2 cascade
(GO:0070372)
Regulation of stress-activated mapk cascade
(GO:0032872)
Response to reactive oxygen species
(GO:0000302)
S-nitrosoglutathione binding
(GO:0035730)
Secretory granule lumen
(GO:0034774)
Traf2-gstp1 complex
(GO:0097057)
Vesicle
(GO:0031982)
Xenobiotic metabolic process
(GO:0006805)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 904.6244
Cell Significance Index: -140.7100
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 418.5404
Cell Significance Index: -106.1600
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 387.5736
Cell Significance Index: -159.6600
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 336.7326
Cell Significance Index: -136.8000
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 323.5388
Cell Significance Index: -152.7500
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 293.2821
Cell Significance Index: -150.8600
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 228.7555
Cell Significance Index: -153.5000
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 146.2069
Cell Significance Index: -139.5900
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 121.2939
Cell Significance Index: -149.5500
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 39.4496
Cell Significance Index: -155.6700
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 37.4741
Cell Significance Index: -115.1000
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 32.4317
Cell Significance Index: -86.8800
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 29.4612
Cell Significance Index: 253.1600
Cell Name: peg cell (CL4033014)
Fold Change: 13.4935
Cell Significance Index: 311.7500
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 11.5920
Cell Significance Index: 310.0800
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 9.0080
Cell Significance Index: 245.1900
Cell Name: kidney cell (CL1000497)
Fold Change: 8.0421
Cell Significance Index: 64.2100
Cell Name: granulosa cell (CL0000501)
Fold Change: 7.4699
Cell Significance Index: 196.4200
Cell Name: cell in vitro (CL0001034)
Fold Change: 6.6631
Cell Significance Index: 3638.8700
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 5.8863
Cell Significance Index: 204.5500
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 5.5305
Cell Significance Index: 759.4900
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 5.3583
Cell Significance Index: 965.9300
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 5.2165
Cell Significance Index: 109.1900
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 4.9952
Cell Significance Index: 614.2100
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 4.9353
Cell Significance Index: 63.2100
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 4.8252
Cell Significance Index: 226.7800
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 4.4787
Cell Significance Index: 333.7900
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 4.0431
Cell Significance Index: 1787.5700
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 3.9572
Cell Significance Index: 466.6800
Cell Name: early pro-B cell (CL0002046)
Fold Change: 3.8574
Cell Significance Index: 248.8600
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.6910
Cell Significance Index: 68.2200
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 3.6031
Cell Significance Index: 33.1800
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 3.4353
Cell Significance Index: 178.9400
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 3.4182
Cell Significance Index: 241.7500
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 3.3696
Cell Significance Index: 38.2800
Cell Name: lactocyte (CL0002325)
Fold Change: 3.1721
Cell Significance Index: 409.8200
Cell Name: odontoblast (CL0000060)
Fold Change: 2.8580
Cell Significance Index: 366.3800
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.4823
Cell Significance Index: 66.2800
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.2539
Cell Significance Index: 64.6100
Cell Name: epidermal cell (CL0000362)
Fold Change: 2.2134
Cell Significance Index: 4.9900
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 2.2040
Cell Significance Index: 23.9600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.1451
Cell Significance Index: 111.4300
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 2.0445
Cell Significance Index: 1547.5000
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.0206
Cell Significance Index: 94.2100
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.4825
Cell Significance Index: 41.4300
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 1.1525
Cell Significance Index: 845.0200
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 1.0451
Cell Significance Index: 82.7800
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.9661
Cell Significance Index: 43.7900
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 0.9148
Cell Significance Index: 5.6300
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.7454
Cell Significance Index: 127.2800
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.7040
Cell Significance Index: 12.4400
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.6293
Cell Significance Index: 62.2500
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.5818
Cell Significance Index: 115.4700
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.4988
Cell Significance Index: 26.1900
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3168
Cell Significance Index: 60.2800
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.1464
Cell Significance Index: 2.4500
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0481
Cell Significance Index: 90.5200
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0020
Cell Significance Index: -0.2000
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0319
Cell Significance Index: -0.9200
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0351
Cell Significance Index: -25.9900
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0807
Cell Significance Index: -148.8400
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0937
Cell Significance Index: -58.4900
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1011
Cell Significance Index: -6.3700
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.1021
Cell Significance Index: -157.1100
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.1320
Cell Significance Index: -179.4800
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.1443
Cell Significance Index: -91.6600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.2126
Cell Significance Index: -119.8900
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.2486
Cell Significance Index: -112.8200
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.2571
Cell Significance Index: -7.5500
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.2728
Cell Significance Index: -97.8600
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.3619
Cell Significance Index: -72.6100
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.4243
Cell Significance Index: -10.8400
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.4415
Cell Significance Index: -15.5200
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.4553
Cell Significance Index: -130.9900
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -0.4554
Cell Significance Index: -3.5100
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.5319
Cell Significance Index: -112.0400
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.5438
Cell Significance Index: -62.3000
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.6164
Cell Significance Index: -8.4100
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.6210
Cell Significance Index: -19.8900
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.6987
Cell Significance Index: -10.4700
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.7253
Cell Significance Index: -18.1300
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.7370
Cell Significance Index: -107.1300
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.7932
Cell Significance Index: -47.6200
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.9253
Cell Significance Index: -150.5000
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.9399
Cell Significance Index: -109.5300
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -1.0741
Cell Significance Index: -23.2700
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -1.0766
Cell Significance Index: -122.8900
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.4359
Cell Significance Index: -149.5100
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -1.4827
Cell Significance Index: -83.2000
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -1.5066
Cell Significance Index: -104.1900
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -1.5615
Cell Significance Index: -95.9800
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -1.8059
Cell Significance Index: -138.5900
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -1.8524
Cell Significance Index: -39.4500
Cell Name: retinal rod cell (CL0000604)
Fold Change: -2.1182
Cell Significance Index: -25.2500
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -2.2727
Cell Significance Index: -152.8200
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -2.4309
Cell Significance Index: -71.6000
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -2.5030
Cell Significance Index: -153.4600
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -2.9370
Cell Significance Index: -24.6700
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: -2.9967
Cell Significance Index: -18.6200
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -3.0852
Cell Significance Index: -18.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** GSTP1 exhibits several key characteristics that distinguish it from other GST isoforms: 1. **Cytosolic localization**: GSTP1 is primarily localized in the cytosol, where it can interact with glutathione and conjugate compounds. 2. **Glutathione conjugation**: GSTP1 catalyzes the conjugation of glutathione to electrophilic compounds, rendering them more soluble and facilitating their excretion. 3. **Induction by oxidative stress**: GSTP1 is induced by oxidative stress, which is a hallmark of various diseases, including cancer, neurodegenerative disorders, and metabolic disorders. 4. **Regulation of inflammation**: GSTP1 is involved in the regulation of inflammatory responses, including the negative regulation of pro-inflammatory cytokines and the promotion of anti-inflammatory responses. 5. **Expression in various tissues**: GSTP1 is expressed in various tissues, including the liver, lungs, immune cells, and cancer cells, where it plays a crucial role in detoxification and protection against oxidative damage. **Pathways and Functions** GSTP1 is involved in several key pathways and functions: 1. **Oxidative stress response**: GSTP1 plays a crucial role in protecting cells against oxidative stress by conjugating glutathione to electrophilic compounds and promoting the removal of reactive oxygen species (ROS). 2. **Detoxification**: GSTP1 is involved in the detoxification of various compounds, including environmental toxins, drugs, and carcinogens. 3. **Inflammation regulation**: GSTP1 regulates inflammatory responses by modulating the expression of pro-inflammatory and anti-inflammatory cytokines. 4. **Apoptosis regulation**: GSTP1 is involved in the regulation of apoptosis (programmed cell death) by modulating the expression of pro-apoptotic and anti-apoptotic genes. 5. **Cancer development**: GSTP1 is often overexpressed in cancer cells, where it may contribute to the development and progression of cancer by promoting detoxification and protecting against oxidative damage. **Clinical Significance** GSTP1 has significant clinical implications: 1. **Cancer risk**: GSTP1 is often overexpressed in cancer cells, where it may contribute to the development and progression of cancer. 2. **Oxidative stress disorders**: GSTP1 is involved in the regulation of oxidative stress responses, which are implicated in various diseases, including neurodegenerative disorders, metabolic disorders, and cardiovascular disease. 3. **Environmental toxins**: GSTP1 is involved in the detoxification of environmental toxins, which are a major public health concern. 4. **Pharmacokinetics**: GSTP1 is involved in the metabolism of various drugs, which can affect their efficacy and toxicity. 5. **Personalized medicine**: GSTP1 expression levels can be used as a biomarker to predict an individual's susceptibility to certain diseases and to tailor treatment strategies. In conclusion, GSTP1 is a crucial enzyme involved in the detoxification and conjugation of various compounds, including environmental toxins, drugs, and oxidative stress products. Its expression is widespread in various tissues, and its regulation is involved in the protection against oxidative damage, inflammation, and cancer development. Understanding the functions and clinical significance of GSTP1 can provide valuable insights into the development of novel therapeutic strategies and personalized medicine approaches.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

GST class-pi

Genular Protein ID: 2931175595

Symbol: GSTP1_HUMAN

Name: GST class-pi

UniProtKB Accession Codes:

P09211 O00460 Q15690 Q5TZY3

Database IDs:

Citations:

PubMed ID: 3664469

Title: Structure and expression of a human class pi glutathione S-transferase messenger RNA.

PubMed ID: 3664469

PubMed ID: 3196325

Title: The structure of the human glutathione S-transferase pi gene.

PubMed ID: 3196325

DOI: 10.1042/bj2550079

PubMed ID: 2542132

Title: Structure of the human genomic glutathione S-transferase-pi gene.

PubMed ID: 2542132

DOI: 10.1016/0378-1119(89)90377-6

PubMed ID: 2466554

Title: Expression of anionic glutathione-S-transferase and P-glycoprotein genes in human tissues and tumors.

PubMed ID: 2466554

PubMed ID: 9092542

Title: Molecular cloning, characterization, and expression in Escherichia coli of full-length cDNAs of three human glutathione S-transferase Pi gene variants. Evidence for differential catalytic activity of the encoded proteins.

PubMed ID: 9092542

DOI: 10.1074/jbc.272.15.10004

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3979555

Title: Structural evidence for three different types of glutathione transferase in human tissues.

PubMed ID: 3979555

DOI: 10.1016/0014-5793(85)80324-0

PubMed ID: 3864155

Title: Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties.

PubMed ID: 3864155

DOI: 10.1073/pnas.82.21.7202

PubMed ID: 3395118

Title: Purification and characterization of unique glutathione S-transferases from human muscle.

PubMed ID: 3395118

DOI: 10.1016/0003-9861(88)90564-4

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 9150948

Title: A two-dimensional gel database of human colon carcinoma proteins.

PubMed ID: 9150948

DOI: 10.1002/elps.1150180344

PubMed ID: 2327795

Title: Primary and secondary structural analyses of glutathione S-transferase pi from human placenta.

PubMed ID: 2327795

DOI: 10.1016/0003-9861(90)90277-6

PubMed ID: 1567427

Title: Tyrosine-7 in human class Pi glutathione S-transferase is important for lowering the pKa of the thiol group of glutathione in the enzyme-glutathione complex.

PubMed ID: 1567427

DOI: 10.1016/0006-291x(92)91177-r

PubMed ID: 1540159

Title: Tyrosine-7 is an essential residue for the catalytic activity of human class PI glutathione S-transferase: chemical modification and site-directed mutagenesis studies.

PubMed ID: 1540159

DOI: 10.1016/0006-291x(92)91848-k

PubMed ID: 8433974

Title: Site-directed mutagenesis study on the roles of evolutionally conserved aspartic acid residues in human glutathione S-transferase P1-1.

PubMed ID: 8433974

DOI: 10.1093/protein/6.1.93

PubMed ID: 9084911

Title: Stereoselective conjugation of prostaglandin A2 and prostaglandin J2 with glutathione, catalyzed by the human glutathione S-transferases A1-1, A2-2, M1a-1a, and P1-1.

PubMed ID: 9084911

DOI: 10.1021/tx9601770

PubMed ID: 19269317

Title: Glutathione S-transferase pi localizes in mitochondria and protects against oxidative stress.

PubMed ID: 19269317

DOI: 10.1016/j.freeradbiomed.2009.02.025

PubMed ID: 19254954

Title: Tyrosine phosphorylation of the human glutathione S-transferase P1 by epidermal growth factor receptor.

PubMed ID: 19254954

DOI: 10.1074/jbc.m808153200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21046276

Title: Biosynthesis of 14,15-hepoxilins in human l1236 Hodgkin lymphoma cells and eosinophils.

PubMed ID: 21046276

DOI: 10.1007/s11745-010-3485-1

PubMed ID: 21668448

Title: Glutathione-S-transferase P1 is a critical regulator of Cdk5 kinase activity.

PubMed ID: 21668448

DOI: 10.1111/j.1471-4159.2011.07343.x

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 1522586

Title: Three-dimensional structure of class pi glutathione S-transferase from human placenta in complex with S-hexylglutathione at 2.8-A resolution.

PubMed ID: 1522586

DOI: 10.1016/0022-2836(92)90692-d

PubMed ID: 9012673

Title: The three-dimensional structure of the human Pi class glutathione transferase P1-1 in complex with the inhibitor ethacrynic acid and its glutathione conjugate.

PubMed ID: 9012673

DOI: 10.1021/bi962316i

PubMed ID: 9245401

Title: Structure and function of the xenobiotic substrate-binding site and location of a potential non-substrate-binding site in a class pi glutathione S-transferase.

PubMed ID: 9245401

DOI: 10.1021/bi970805s

PubMed ID: 9398518

Title: The structures of human glutathione transferase P1-1 in complex with glutathione and various inhibitors at high resolution.

PubMed ID: 9398518

DOI: 10.1006/jmbi.1997.1364

PubMed ID: 9351803

Title: Structures of class pi glutathione S-transferase from human placenta in complex with substrate, transition-state analogue and inhibitor.

PubMed ID: 9351803

DOI: 10.1016/s0969-2126(97)00281-5

PubMed ID: 10441116

Title: Structure and function of residue 104 and water molecules in the xenobiotic substrate-binding site in human glutathione S-transferase P1-1.

PubMed ID: 10441116

DOI: 10.1021/bi990668u

PubMed ID: 9485454

Title: Solution structure of glutathione bound to human glutathione transferase P1-1: comparison of NMR measurements with the crystal structure.

PubMed ID: 9485454

DOI: 10.1021/bi971902o

PubMed ID: 19396894

Title: Rational design of an organometallic glutathione transferase inhibitor.

PubMed ID: 19396894

DOI: 10.1002/anie.200900185

PubMed ID: 19808963

Title: Structural basis for the binding of the anticancer compound 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol to human glutathione s-transferases.

PubMed ID: 19808963

DOI: 10.1158/0008-5472.can-09-1314

Sequence Information:

Length: 210
Mass: 23356
Checksum: 409E33FFAA338396
Sequence:

MPPYTVVYFP VRGRCAALRM LLADQGQSWK EEVVTVETWQ EGSLKASCLY GQLPKFQDGD 
LTLYQSNTIL RHLGRTLGLY GKDQQEAALV DMVNDGVEDL RCKYISLIYT NYEAGKDDYV 
KALPGQLKPF ETLLSQNQGG KTFIVGDQIS FADYNLLDLL LIHEVLAPGC LDAFPLLSAY 
VGRLSARPKL KAFLASPEYV NLPINGNGKQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: GSTP1

Associated with

Cells (max top 100)

Other Information

Structure and expression of a human class pi glutathione S-transferase messenger RNA. PubMed ID: 3664469

The structure of the human glutathione S-transferase pi gene. PubMed ID: 3196325

Structure of the human genomic glutathione S-transferase-pi gene. PubMed ID: 2542132

Expression of anionic glutathione-S-transferase and P-glycoprotein genes in human tissues and tumors. PubMed ID: 2466554

Molecular cloning, characterization, and expression in Escherichia coli of full-length cDNAs of three human glutathione S-transferase Pi gene variants. Evidence for differential catalytic activity of the encoded proteins. PubMed ID: 9092542

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Structural evidence for three different types of glutathione transferase in human tissues. PubMed ID: 3979555

Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties. PubMed ID: 3864155

Purification and characterization of unique glutathione S-transferases from human muscle. PubMed ID: 3395118

Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. PubMed ID: 12665801

A two-dimensional gel database of human colon carcinoma proteins. PubMed ID: 9150948

Primary and secondary structural analyses of glutathione S-transferase pi from human placenta. PubMed ID: 2327795

Tyrosine-7 in human class Pi glutathione S-transferase is important for lowering the pKa of the thiol group of glutathione in the enzyme-glutathione complex. PubMed ID: 1567427

Tyrosine-7 is an essential residue for the catalytic activity of human class PI glutathione S-transferase: chemical modification and site-directed mutagenesis studies. PubMed ID: 1540159

Site-directed mutagenesis study on the roles of evolutionally conserved aspartic acid residues in human glutathione S-transferase P1-1. PubMed ID: 8433974

Stereoselective conjugation of prostaglandin A2 and prostaglandin J2 with glutathione, catalyzed by the human glutathione S-transferases A1-1, A2-2, M1a-1a, and P1-1. PubMed ID: 9084911

Glutathione S-transferase pi localizes in mitochondria and protects against oxidative stress. PubMed ID: 19269317

Tyrosine phosphorylation of the human glutathione S-transferase P1 by epidermal growth factor receptor. PubMed ID: 19254954

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

Biosynthesis of 14,15-hepoxilins in human l1236 Hodgkin lymphoma cells and eosinophils. PubMed ID: 21046276

Glutathione-S-transferase P1 is a critical regulator of Cdk5 kinase activity. PubMed ID: 21668448

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Three-dimensional structure of class pi glutathione S-transferase from human placenta in complex with S-hexylglutathione at 2.8-A resolution. PubMed ID: 1522586

The three-dimensional structure of the human Pi class glutathione transferase P1-1 in complex with the inhibitor ethacrynic acid and its glutathione conjugate. PubMed ID: 9012673

Structure and function of the xenobiotic substrate-binding site and location of a potential non-substrate-binding site in a class pi glutathione S-transferase. PubMed ID: 9245401

The structures of human glutathione transferase P1-1 in complex with glutathione and various inhibitors at high resolution. PubMed ID: 9398518

Structures of class pi glutathione S-transferase from human placenta in complex with substrate, transition-state analogue and inhibitor. PubMed ID: 9351803

Structure and function of residue 104 and water molecules in the xenobiotic substrate-binding site in human glutathione S-transferase P1-1. PubMed ID: 10441116

Solution structure of glutathione bound to human glutathione transferase P1-1: comparison of NMR measurements with the crystal structure. PubMed ID: 9485454

Rational design of an organometallic glutathione transferase inhibitor. PubMed ID: 19396894

Structural basis for the binding of the anticancer compound 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol to human glutathione s-transferases. PubMed ID: 19808963