Details for: GRIA4

Gene ID: 2893

Symbol: GRIA4

Ensembl ID: ENSG00000152578

Description: glutamate ionotropic receptor AMPA type subunit 4

Associated with

  • Activation of ampa receptors
    (R-HSA-399710)
  • Activation of nmda receptors and postsynaptic events
    (R-HSA-442755)
  • Glutamate binding, activation of ampa receptors and synaptic plasticity
    (R-HSA-399721)
  • Neuronal system
    (R-HSA-112316)
  • Neurotransmitter receptors and postsynaptic signal transmission
    (R-HSA-112314)
  • Protein-protein interactions at synapses
    (R-HSA-6794362)
  • Synaptic adhesion-like molecules
    (R-HSA-8849932)
  • Trafficking of ampa receptors
    (R-HSA-399719)
  • Trafficking of glur2-containing ampa receptors
    (R-HSA-416993)
  • Transmission across chemical synapses
    (R-HSA-112315)
  • Unblocking of nmda receptors, glutamate binding and activation
    (R-HSA-438066)
  • Ampa glutamate receptor activity
    (GO:0004971)
  • Ampa glutamate receptor complex
    (GO:0032281)
  • Amyloid-beta binding
    (GO:0001540)
  • Dendrite
    (GO:0030425)
  • Dendritic spine
    (GO:0043197)
  • Endocytic vesicle membrane
    (GO:0030666)
  • Extracellular vesicle
    (GO:1903561)
  • Glutamate-gated receptor activity
    (GO:0004970)
  • Glutamate receptor signaling pathway
    (GO:0007215)
  • Ionotropic glutamate receptor signaling pathway
    (GO:0035235)
  • Ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
    (GO:0099507)
  • Modulation of chemical synaptic transmission
    (GO:0050804)
  • Monoatomic ion transmembrane transport
    (GO:0034220)
  • Negative regulation of smooth muscle cell apoptotic process
    (GO:0034392)
  • Neuronal cell body
    (GO:0043025)
  • Plasma membrane
    (GO:0005886)
  • Postsynaptic density membrane
    (GO:0098839)
  • Protein binding
    (GO:0005515)
  • Regulation of postsynaptic membrane potential
    (GO:0060078)
  • Regulation of presynaptic membrane potential
    (GO:0099505)
  • Synaptic transmission, glutamatergic
    (GO:0035249)
  • Transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
    (GO:1904315)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 6.4676
    Cell Significance Index: 362.9300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 5.2530
    Cell Significance Index: 125.9800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 5.0306
    Cell Significance Index: 86.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 3.5494
    Cell Significance Index: 218.1700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 3.3557
    Cell Significance Index: 225.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.3056
    Cell Significance Index: 663.1100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.0903
    Cell Significance Index: 162.2600
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 2.8454
    Cell Significance Index: 29.6400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.7988
    Cell Significance Index: 1935.7800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.4755
    Cell Significance Index: 887.9400
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 2.0241
    Cell Significance Index: 26.2500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1953
    Cell Significance Index: 38.2900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.7555
    Cell Significance Index: 479.8000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.6493
    Cell Significance Index: 1222.5200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.6488
    Cell Significance Index: 8.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.6188
    Cell Significance Index: 1141.2900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6092
    Cell Significance Index: 550.0900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3489
    Cell Significance Index: 34.5100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2833
    Cell Significance Index: 53.9200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1485
    Cell Significance Index: 4.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0597
    Cell Significance Index: 9.7000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0265
    Cell Significance Index: 40.7400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0047
    Cell Significance Index: 6.3700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0627
    Cell Significance Index: -46.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0655
    Cell Significance Index: -36.9200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0811
    Cell Significance Index: -50.6500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1064
    Cell Significance Index: -3.7400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.1100
    Cell Significance Index: -48.6500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1201
    Cell Significance Index: -54.5300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1296
    Cell Significance Index: -98.0800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.1654
    Cell Significance Index: -90.3100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2060
    Cell Significance Index: -2.6000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.2441
    Cell Significance Index: -26.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2650
    Cell Significance Index: -76.2600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3333
    Cell Significance Index: -70.2000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3380
    Cell Significance Index: -15.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.3731
    Cell Significance Index: -63.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.3764
    Cell Significance Index: -74.6900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4076
    Cell Significance Index: -8.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4333
    Cell Significance Index: -62.9800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.4349
    Cell Significance Index: -3.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.4370
    Cell Significance Index: -78.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.6127
    Cell Significance Index: -84.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.6411
    Cell Significance Index: -78.8300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6569
    Cell Significance Index: -40.2800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.6644
    Cell Significance Index: -85.8400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.6811
    Cell Significance Index: -7.4200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7268
    Cell Significance Index: -75.6800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.7466
    Cell Significance Index: -9.2600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.7595
    Cell Significance Index: -52.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.8115
    Cell Significance Index: -92.9700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.8192
    Cell Significance Index: -93.5100
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: -0.8316
    Cell Significance Index: -6.7200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.8419
    Cell Significance Index: -18.1900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.8442
    Cell Significance Index: -12.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.8497
    Cell Significance Index: -86.8000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.9000
    Cell Significance Index: -10.5000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.9141
    Cell Significance Index: -54.8800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.0144
    Cell Significance Index: -20.3700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.0198
    Cell Significance Index: -28.5000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.1327
    Cell Significance Index: -71.3900
  • Cell Name: neuron (CL0000540)
    Fold Change: -1.1372
    Cell Significance Index: -10.7800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -1.1515
    Cell Significance Index: -85.8200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.2268
    Cell Significance Index: -94.1400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -1.2406
    Cell Significance Index: -15.6600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -1.2642
    Cell Significance Index: -17.7200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -1.2710
    Cell Significance Index: -15.2000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.3589
    Cell Significance Index: -34.9300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.3628
    Cell Significance Index: -28.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.3847
    Cell Significance Index: -64.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.4623
    Cell Significance Index: -31.6800
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -1.4840
    Cell Significance Index: -14.1200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.5122
    Cell Significance Index: -29.9000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.5179
    Cell Significance Index: -67.1400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.5443
    Cell Significance Index: -80.4400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.5528
    Cell Significance Index: -50.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -1.6766
    Cell Significance Index: -78.8000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.6849
    Cell Significance Index: -42.0300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.7251
    Cell Significance Index: -49.2300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.7939
    Cell Significance Index: -37.4400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.9008
    Cell Significance Index: -66.5900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.9561
    Cell Significance Index: -62.3000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -2.0120
    Cell Significance Index: -76.1900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -2.2309
    Cell Significance Index: -70.5600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -2.3717
    Cell Significance Index: -35.7400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.4114
    Cell Significance Index: -88.5200
  • Cell Name: granule cell (CL0000120)
    Fold Change: -2.5315
    Cell Significance Index: -28.8200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -2.6144
    Cell Significance Index: -90.8500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -2.7633
    Cell Significance Index: -66.9400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -2.8005
    Cell Significance Index: -37.3300
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -2.8529
    Cell Significance Index: -30.6700
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -2.9022
    Cell Significance Index: -38.7200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -2.9167
    Cell Significance Index: -50.4300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -2.9917
    Cell Significance Index: -85.7600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -3.0060
    Cell Significance Index: -80.2700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -3.1248
    Cell Significance Index: -92.0400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -3.2045
    Cell Significance Index: -79.9100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -3.2110
    Cell Significance Index: -68.3900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -3.2224
    Cell Significance Index: -80.5500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -3.2250
    Cell Significance Index: -70.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The GRIA4 gene is a member of the GluR subfamily of AMPA receptor subunits, which are composed of four subunits (GluR1-4). Each subunit has distinct characteristics, including the presence of a glutamate-binding site and an ion channel pore. The GRIA4 subunit is specifically involved in the modulation of synaptic transmission, particularly at excitatory synapses. Its expression is tightly regulated, with a dynamic trafficking between the cell surface and endocytic vesicles. This dynamic regulation is crucial for the fine-tuning of synaptic strength and plasticity. **Pathways and Functions** GRIA4 is involved in several key pathways, including: 1. **Activation of AMPA receptors**: GRIA4 subunits assemble with other subunits to form functional AMPA receptors, which are activated by glutamate binding. This activation leads to the opening of the ion channel pore, allowing the influx of positively charged ions (Na+, K+) and the subsequent depolarization of the postsynaptic neuron. 2. **Postsynaptic events**: GRIA4-mediated AMPA receptor activation is critical for the regulation of postsynaptic events, including excitatory synaptic transmission and synaptic plasticity. 3. **Synaptic plasticity**: GRIA4 is involved in the regulation of synaptic strength and plasticity, particularly in the context of long-term potentiation (LTP) and long-term depression (LTD). 4. **Neurotransmitter receptors and postsynaptic signal transmission**: GRIA4 is also involved in the regulation of neurotransmitter receptors and postsynaptic signal transmission, particularly in the context of excitatory neurotransmission. **Clinical Significance** Dysregulation of GRIA4 has been implicated in various neurological and psychiatric disorders, including: 1. **Neurodegenerative diseases**: Altered GRIA4 expression has been observed in neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Mental health disorders**: Abnormal GRIA4 expression has been linked to mental health disorders, including depression, anxiety, and schizophrenia. 3. **Neuropsychiatric disorders**: GRIA4 has been implicated in the pathophysiology of neuropsychiatric disorders, such as attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). In summary, the GRIA4 gene plays a critical role in the regulation of synaptic transmission and plasticity, and its dysregulation has been implicated in various neurological and psychiatric disorders. Further research is needed to fully elucidate the functional roles of GRIA4 and its potential therapeutic targets for the treatment of these disorders.

Genular Protein ID: 874135712

Symbol: GRIA4_HUMAN

Name: AMPA-selective glutamate receptor 4

UniProtKB Accession Codes:

P48058 Q86XE8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 DrugCentral 1 EMBL 8 Ensembl 4 ExpressionAtlas 1 GO 17 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 5 RefSeq 5 Rhea 3 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8589990

Title: Cloning, expression and pharmacological characterization of a human glutamate receptor: hGluR4.

PubMed ID: 8589990

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21172611

Title: Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins.

PubMed ID: 21172611

DOI: 10.1016/j.neuron.2010.11.026

PubMed ID: 29220673

Title: De Novo Variants in GRIA4 Lead to Intellectual Disability with or without Seizures and Gait Abnormalities.

PubMed ID: 29220673

DOI: 10.1016/j.ajhg.2017.11.004

Sequence Information:

  • Length: 902
  • Mass: 100871
  • Checksum: 7793AEF0AB829FC5
  • Sequence:
    • MRIISRQIVL LFSGFWGLAM GAFPSSVQIG GLFIRNTDQE YTAFRLAIFL HNTSPNASEA 
PFNLVPHVDN IETANSFAVT NAFCSQYSRG VFAIFGLYDK RSVHTLTSFC SALHISLITP 
SFPTEGESQF VLQLRPSLRG ALLSLLDHYE WNCFVFLYDT DRGYSILQAI MEKAGQNGWH 
VSAICVENFN DVSYRQLLEE LDRRQEKKFV IDCEIERLQN ILEQIVSVGK HVKGYHYIIA 
NLGFKDISLE RFIHGGANVT GFQLVDFNTP MVIKLMDRWK KLDQREYPGS ETPPKYTSAL 
TYDGVLVMAE TFRSLRRQKI DISRRGNAGD CLANPAAPWG QGIDMERTLK QVRIQGLTGN 
VQFDHYGRRV NYTMDVFELK STGPRKVGYW NDMDKLVLIQ DVPTLGNDTA AIENRTVVVT 
TIMESPYVMY KKNHEMFEGN DKYEGYCVDL ASEIAKHIGI KYKIAIVPDG KYGARDADTK 
IWNGMVGELV YGKAEIAIAP LTITLVREEV IDFSKPFMSL GISIMIKKPQ KSKPGVFSFL 
DPLAYEIWMC IVFAYIGVSV VLFLVSRFSP YEWHTEEPED GKEGPSDQPP NEFGIFNSLW 
FSLGAFMQQG CDISPRSLSG RIVGGVWWFF TLIIISSYTA NLAAFLTVER MVSPIESAED 
LAKQTEIAYG TLDSGSTKEF FRRSKIAVYE KMWTYMRSAE PSVFTRTTAE GVARVRKSKG 
KFAFLLESTM NEYIEQRKPC DTMKVGGNLD SKGYGVATPK GSSLRTPVNL AVLKLSEAGV 
LDKLKNKWWY DKGECGPKDS GSKDKTSALS LSNVAGVFYI LVGGLGLAML VALIEFCYKS 
RAEAKRMKLT FSEAIRNKAR LSITGSVGEN GRVLTPDCPK AVHTGTAIRQ SSGLAVIASD 
LP

Genular Protein ID: 1110834664

Symbol: A0A994J6J2_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A994J6J2

Database IDs:

ARBA 12 CDD 2 CTD 1 EMBL 6 Ensembl 2 GO 4 Gene3D 3 GeneTree 1 HGNC 1 InterPro 6 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 3 Proteomes 2 RefSeq 1 RuleBase 1 SMART 2 SMR 1 SUPFAM 3

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 814
  • Mass: 91762
  • Checksum: F90A6A2A719BB1AF
  • Sequence:
    • MRIISRQIVL LFSGFWGLAM GAFPSSVQIG GLFIRNTDQE YTAFRLAIFL HNTSPNASEA 
PFNLVPHVDN IETANSFAVT NAFCSQYSRG VFAIFGLYDK RSVHTLTSFC SALHISLITP 
SFPTEGESQF VLQLRPSLRG ALLSLLDHYE WNCFVFLYDT DRGYSILQAI MEKAGQNGWH 
VSAICVENFN DVSYRQLLEE LDRRQEKKFV IDCEIERLQN ILEQIVSVGK HVKGYHYIIA 
NLGFKDISLE RFIHGGANVT GFQLVDFNTP MVIKLMDRWK KLDQREYPGS ETPPKYTSAL 
TYDGVLVMAE TFRSLRRQKI DISRRGNAGD CLANPAAPWG QGIDMERTLK QVRIQGLTGN 
VQFDHYGRRV NYTMDVFELK STGPRKVGYW NDMDKLVLIQ DVPTLGNDTA AIENRTVVVT 
TIMESPYVMY KKNHEMFEGN DKYEGYCVDL ASEIAKHIGI KYKIAIVPDG KYGARDADTK 
IWNGMVGELV YGKAEIAIAP LTITLVREEV IDFSKPFMSL GISIMIKKPQ KSKPGVFSFL 
DPLAYEIWMC IVFAYIGVSV VLFLVSRFSP YEWHTEEPED GKEGPSDQPP NEFGIFNSLW 
FSLGAFMQQG CDISPRSLSG RIVGGVWWFF TLIIISSYTA NLAAFLTVER MVSPIESAED 
LAKQTEIAYG TLDSGSTKEF FRRSKIAVYE KMWTYMRSAE PSVFTRTTAE GVARVRKSKG 
KFAFLLESTM NEYIEQRKPC DTMKVGGNLD SKGYGVATPK GSSLRNAVNL AVLKLNEQGL 
LDKLKNKWWY DKGECGSGGG DSKNSCKPCR FETQ

Genular Protein ID: 2478379641

Symbol: A0A8D9PH77_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8D9PH77

Database IDs:

ARBA 4 CDD 1 CTD 1 DisGeNET 1 EMBL 2 GO 7 Gene3D 1 InterPro 3 NCBI Taxonomy 1 PANTHER 2 Pfam 2 RefSeq 2 SAM 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 34100982

Title: Splicing and editing of ionotropic glutamate receptors: a comprehensive analysis based on human RNA-Seq data.

PubMed ID: 34100982

DOI: 10.1007/s00018-021-03865-z

Sequence Information:

  • Length: 433
  • Mass: 49146
  • Checksum: 0013C833D25B75CE
  • Sequence:
    • MRIISRQIVL LFSGFWGLAM GAFPSSVQIG GLFIRNTDQE YTAFRLAIFL HNTSPNASEA 
PFNLVPHVDN IETANSFAVT NAFCSQYSRG VFAIFGLYDK RSVHTLTSFC SALHISLITP 
SFPTEGESQF VLQLRPSLRG ALLSLLDHYE WNCFVFLYDT DRGYSILQAI MEKAGQNGWH 
VSAICVENFN DVSYRQLLEE LDRRQEKKFV IDCEIERLQN ILEQIVSVGK HVKGYHYIIA 
NLGFKDISLE RFIHGGANVT GFQLVDFNTP MVIKLMDRWK KLDQREYPGS ETPPKYTSAL 
TYDGVLVMAE TFRSLRRQKI DISRRGNAGD CLANPAAPWG QGIDMERTLK QVRIQGLTGN 
VQFDHYGRRV NYTMDVFELK STGPRKVGYW NDMDKLVLIQ DVPTLGNDTA AIENRTVVVT 
TIMPLMKNPI LRN

Genular Protein ID: 250173704

Symbol: Q1WWK6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q1WWK6

Database IDs:

ARBA 12 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 8 Gene3D 3 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 2 RuleBase 1 SMART 4 SUPFAM 3

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 883
  • Mass: 99019
  • Checksum: A5EB35FFD97A2126
  • Sequence:
    • RIISRQIVLL FSGFWGLAMG AFPSSVQIGG LFIRNTDQEY TAFRLAIFLH NTSPNASEAP 
FNLVPHVDNI ETANSFAVTN AFCSQYSRGV FAIFGLYDKR SVHTLTSFCS ALHISLITPS 
FPTEGESQFV LQLRPSLRGA LLSLLDHYEW NCFVFLYDTD RGYSILQAIM EKAGQNGWHV 
SAICVENFND VSYRQLLEEL DRRQEKKFVI DCEIERLQNI LEQIVSVGKH VKGYHYIIAN 
LGFKDISLER FIHGGANVTG FQLVDFNTPM VIKLMDRWKK LDQREYPGSE TPPKYTSALT 
YDGVLVMAET FRSLRRQKID ISRRGNAGDC LANPAAPWGQ GIDMERTLKQ VRIQGLTGNV 
QFDHYGRRVN YTMDVFELKS TGPRKVGYWN DMDKLVLIQD VPTLGNDTAA IENRTVVVTT 
IMESPYVMYK KNHEMFEGND KYEGYCVDLA SEIAKHIGIK YKIAIVPDGK YGARDADTKI 
WNGMVGELVY GKAEIAIAPL TITLVREEVI DFSKPFMSLG ISIMIKKPQK SKPGVFSFLD 
PLAYEIWMCI VFAYIGVSVV LFLVSRFSPY EWHTEEPEDG KEGPSDQPPN EFGIFNSLWF 
SLGAFMQQGC DISPRSLSGR IVGGVWWFFT LIIISSYTAN LAAFLTVERM VSPIESAEDL 
AKQTEIAYGT LDSGSTKEFF RRSKIAVYEK MWTYMRSAEP SVFTRTTAEG VARVRKSKGK 
FAFLLESTMN EYIEQRKPCD TMKVGGNLDS KGYGVATPKG SSLGNAVNLA VLKLNEQGLL 
DKLKNKWWYD KGECGSGGGD SKDKTSALSL SNVAGVFYIL VGGLGLAMLV ALIEFCYKSR 
AEAKRMKVAK SAQTFNPTSS QNTQNLATYR EGYNVYGTES IKI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.