Gene KIF5C - ENSG00000168280 | NCBI Gene ID: 3800

Details for: KIF5C

Gene ID: 3800

Symbol: KIF5C

Ensembl ID: ENSG00000168280

Description: kinesin family member 5C

Associated with

Insulin processing
(R-HSA-264876)
Metabolism of proteins
(R-HSA-392499)
Peptide hormone metabolism
(R-HSA-2980736)
Anterograde axonal protein transport
(GO:0099641)
Anterograde dendritic transport of messenger ribonucleoprotein complex
(GO:0098964)
Anterograde dendritic transport of neurotransmitter receptor complex
(GO:0098971)
Apolipoprotein receptor binding
(GO:0034190)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Axonal growth cone
(GO:0044295)
Axon cytoplasm
(GO:1904115)
Axon guidance
(GO:0007411)
Ciliary rootlet
(GO:0035253)
Dendrite cytoplasm
(GO:0032839)
Distal axon
(GO:0150034)
Intracellular mrna localization
(GO:0008298)
Kinesin complex
(GO:0005871)
Microtubule
(GO:0005874)
Microtubule binding
(GO:0008017)
Microtubule motor activity
(GO:0003777)
Motor neuron axon guidance
(GO:0008045)
Mrna transport
(GO:0051028)
Neuronal cell body
(GO:0043025)
Organelle organization
(GO:0006996)
Plus-end-directed microtubule motor activity
(GO:0008574)
Postsynaptic cytosol
(GO:0099524)
Protein binding
(GO:0005515)
Synaptic vesicle transport
(GO:0048489)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 7.55
Marker Score: 39615
Cell Name: granule cell (CL0000120)
Fold Change: 5.9
Marker Score: 44472
Cell Name: macroglial cell (CL0000126)
Fold Change: 5.1
Marker Score: 11733.5
Cell Name: Purkinje cell (CL0000121)
Fold Change: 4.47
Marker Score: 151137.5
Cell Name: stellate neuron (CL0000122)
Fold Change: 4.32
Marker Score: 23181
Cell Name: neuronal brush cell (CL0000555)
Fold Change: 3.81
Marker Score: 12764
Cell Name: chromaffin cell (CL0000166)
Fold Change: 3.37
Marker Score: 4739
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 3.13
Marker Score: 14485
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 2.89
Marker Score: 5977
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 2.72
Marker Score: 1525
Cell Name: CNS interneuron (CL0000402)
Fold Change: 2.69
Marker Score: 1295
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 2.65
Marker Score: 52745
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 2.61
Marker Score: 98969.5
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 2.59
Marker Score: 38734
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 2.58
Marker Score: 19800
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 2.52
Marker Score: 10430
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 2.37
Marker Score: 994
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 2.36
Marker Score: 1380
Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 2.36
Marker Score: 1369
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 2.34
Marker Score: 86352
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 2.34
Marker Score: 3922
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 2.26
Marker Score: 761
Cell Name: rod bipolar cell (CL0000751)
Fold Change: 2.24
Marker Score: 1172.5
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.24
Marker Score: 8662
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 2.23
Marker Score: 6358
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 2.15
Marker Score: 828
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 2.15
Marker Score: 4362
Cell Name: endocrine cell (CL0000163)
Fold Change: 2.15
Marker Score: 1110
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 2.13
Marker Score: 20077
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 2.06
Marker Score: 4927
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 2.04
Marker Score: 2294
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.04
Marker Score: 125669
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.95
Marker Score: 8143
Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 1.93
Marker Score: 613
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 1.93
Marker Score: 2409
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.9
Marker Score: 18016
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.85
Marker Score: 15897
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 1.75
Marker Score: 477.5
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.64
Marker Score: 2535
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 1.53
Marker Score: 570
Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 169087.5
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1.47
Marker Score: 857.5
Cell Name: ganglion interneuron (CL0000397)
Fold Change: 1.45
Marker Score: 441
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 1.41
Marker Score: 568
Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 1.38
Marker Score: 650
Cell Name: motor neuron (CL0000100)
Fold Change: 1.28
Marker Score: 761
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.27
Marker Score: 1537
Cell Name: neuron (CL0000540)
Fold Change: 1.18
Marker Score: 4800
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 1.17
Marker Score: 1103.5
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 1.16
Marker Score: 4823
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.14
Marker Score: 4802
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.14
Marker Score: 831.5
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.13
Marker Score: 24145
Cell Name: sympathetic neuron (CL0011103)
Fold Change: 1.12
Marker Score: 370
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.11
Marker Score: 1279
Cell Name: Sertoli cell (CL0000216)
Fold Change: 1.06
Marker Score: 6262
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251788
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.03
Marker Score: 656
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 1.01
Marker Score: 321
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71807.5
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48033
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 500
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.96
Marker Score: 454
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: germ cell (CL0000586)
Fold Change: 0.93
Marker Score: 1620
Cell Name: PP cell (CL0000696)
Fold Change: 0.91
Marker Score: 206
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2736
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.91
Marker Score: 366
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.91
Marker Score: 5211
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.89
Marker Score: 319
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.88
Marker Score: 1295
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5282
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0.84
Marker Score: 3518
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.78
Marker Score: 597
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1265
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 702
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.75
Marker Score: 389
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.75
Marker Score: 242
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.74
Marker Score: 488
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.74
Marker Score: 917
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.73
Marker Score: 360
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 461
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 0.7
Marker Score: 363
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 175
Cell Name: T-helper 17 cell (CL0000899)
Fold Change: 0.68
Marker Score: 446
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.68
Marker Score: 311
Cell Name: neural crest cell (CL0011012)
Fold Change: 0.68
Marker Score: 722
Cell Name: visceromotor neuron (CL0005025)
Fold Change: 0.65
Marker Score: 190
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.65
Marker Score: 220
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 0.64
Marker Score: 603
Cell Name: goblet cell (CL0000160)
Fold Change: 0.63
Marker Score: 4209
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.62
Marker Score: 1470
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.62
Marker Score: 276
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.6
Marker Score: 724
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 0.59
Marker Score: 501
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.57
Marker Score: 360
Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.55
Marker Score: 363.5
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.55
Marker Score: 146
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 438

Hover over a box to see details here...

**Key characteristics:** - KIF5C is a large protein (130 kDa) that is expressed in high levels in the brain. - It is a microtubule-associated protein (MAP) that is involved in the organization and dynamics of the neuronal cytoskeleton. - KIF5C is a key regulator of anterograde axonal and dendritic transport, where it facilitates the transport of proteins and RNA molecules from the cell body to the cell periphery. **Pathways and functions:** - KIF5C is involved in the anterograde transport of a variety of proteins and RNA molecules, including: - Proteins for neuronal function, such as neurotransmitters, growth factors, and cytoskeletal proteins - RNA molecules for neuronal development, plasticity, and disease - It is also involved in the regulation of insulin processing and secretion. - KIF5C is also involved in the organization of the neuronal cytoskeleton, where it interacts with other MAPs to form the axonal and dendritic transport machinery. **Clinical significance:** - Mutations in KIF5C have been linked to several neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). - These mutations can disrupt the normal function of KIF5C, leading to the accumulation of misfolded or truncated proteins that can be toxic to neurons. - Targeting KIF5C has been explored as a potential therapeutic strategy for neurodegenerative diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Kinesin heavy chain isoform 5C
Q59GB8_HUMAN

Genular Protein ID: 3915941183

Symbol: KIF5C_HUMAN

Name: Kinesin heavy chain isoform 5C

UniProtKB Accession Codes:

O60282 O95079 Q2YDC5

Database IDs:

Citations:

PubMed ID: 9628581

Title: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9628581

DOI: 10.1093/dnares/5.1.31

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9361024

Title: Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin.

PubMed ID: 9361024

DOI: 10.1093/hmg/6.13.2205

PubMed ID: 15644324

Title: GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin.

PubMed ID: 15644324

DOI: 10.1074/jbc.m409095200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24812067

Title: Involvement of the kinesin family members KIF4A and KIF5C in intellectual disability and synaptic function.

PubMed ID: 24812067

DOI: 10.1136/jmedgenet-2013-102182

PubMed ID: 23033978

Title: Diagnostic exome sequencing in persons with severe intellectual disability.

PubMed ID: 23033978

DOI: 10.1056/nejmoa1206524

PubMed ID: 23603762

Title: Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly.

PubMed ID: 23603762

DOI: 10.1038/ng.2613

PubMed ID: 29048727

Title: Mutations of KIF5C cause a neurodevelopmental disorder of infantile-onset epilepsy, absent language, and distinctive malformations of cortical development.

PubMed ID: 29048727

DOI: 10.1002/ajmg.a.38496

Sequence Information:

Length: 957
Mass: 109495
Checksum: A9F25BB1C994322A
Sequence:

MADPAECSIK VMCRFRPLNE AEILRGDKFI PKFKGDETVV IGQGKPYVFD RVLPPNTTQE 
QVYNACAKQI VKDVLEGYNG TIFAYGQTSS GKTHTMEGKL HDPQLMGIIP RIAHDIFDHI 
YSMDENLEFH IKVSYFEIYL DKIRDLLDVS KTNLAVHEDK NRVPYVKGCT ERFVSSPEEV 
MDVIDEGKAN RHVAVTNMNE HSSRSHSIFL INIKQENVET EKKLSGKLYL VDLAGSEKVS 
KTGAEGAVLD EAKNINKSLS ALGNVISALA EGTKTHVPYR DSKMTRILQD SLGGNCRTTI 
VICCSPSVFN EAETKSTLMF GQRAKTIKNT VSVNLELTAE EWKKKYEKEK EKNKTLKNVI 
QHLEMELNRW RNGEAVPEDE QISAKDQKNL EPCDNTPIID NIAPVVAGIS TEEKEKYDEE 
ISSLYRQLDD KDDEINQQSQ LAEKLKQQML DQDELLASTR RDYEKIQEEL TRLQIENEAA 
KDEVKEVLQA LEELAVNYDQ KSQEVEDKTR ANEQLTDELA QKTTTLTTTQ RELSQLQELS 
NHQKKRATEI LNLLLKDLGE IGGIIGTNDV KTLADVNGVI EEEFTMARLY ISKMKSEVKS 
LVNRSKQLES AQMDSNRKMN ASERELAACQ LLISQHEAKI KSLTDYMQNM EQKRRQLEES 
QDSLSEELAK LRAQEKMHEV SFQDKEKEHL TRLQDAEEMK KALEQQMESH REAHQKQLSR 
LRDEIEEKQK IIDEIRDLNQ KLQLEQEKLS SDYNKLKIED QEREMKLEKL LLLNDKREQA 
REDLKGLEET VSRELQTLHN LRKLFVQDLT TRVKKSVELD NDDGGGSAAQ KQKISFLENN 
LEQLTKVHKQ LVRDNADLRC ELPKLEKRLR ATAERVKALE SALKEAKENA MRDRKRYQQE 
VDRIKEAVRA KNMARRAHSA QIAKPIRPGH YPASSPTAVH AIRGGGGSSS NSTHYQK

Genular Protein ID: 963232121

Symbol: Q59GB8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59GB8

Database IDs:

Sequence Information:

Length: 265
Mass: 30578
Checksum: 05A7B27788589930
Sequence:

SLQILQNYCL YCTELIGLEQ NHGFSLMTQN FRLMWNILLF PLNFSLNQKL QLEQEKLSSD 
YNKLKIEDQE REMKLEKLLL LNDKREQARE DLKGLEETVS RELQTLHNLR KLFVQDLTTR 
VKKSVELDND DGGGSAAQKQ KISFLENNLE QLTKVHKQLV RDNADLRCEL PKLEKRLRAT 
AERVKALESA LKEAKENAMR DRKRYQQEVD RIKEAVRAKN MARRAHSAQI AKPIRPGHYP 
ASSPTAVHAI RGGGGSSSNS THYQK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: KIF5C

Associated with

Cells (max top 100)

Other Information

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. PubMed ID: 9628581

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin. PubMed ID: 9361024

GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin. PubMed ID: 15644324

Initial characterization of the human central proteome. PubMed ID: 21269460

Involvement of the kinesin family members KIF4A and KIF5C in intellectual disability and synaptic function. PubMed ID: 24812067

Diagnostic exome sequencing in persons with severe intellectual disability. PubMed ID: 23033978

Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly. PubMed ID: 23603762

Mutations of KIF5C cause a neurodevelopmental disorder of infantile-onset epilepsy, absent language, and distinctive malformations of cortical development. PubMed ID: 29048727