Details for: KIF5C

Gene ID: 3800

Symbol: KIF5C

Ensembl ID: ENSG00000168280

Description: kinesin family member 5C

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 404.8340
    Cell Significance Index: -62.9700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 250.1938
    Cell Significance Index: -63.4600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 171.6845
    Cell Significance Index: -70.7300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 44.2475
    Cell Significance Index: -42.2500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.9277
    Cell Significance Index: -61.4200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 3.7393
    Cell Significance Index: 64.0800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.9518
    Cell Significance Index: 1058.7600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.9137
    Cell Significance Index: 63.8000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.8922
    Cell Significance Index: 127.9300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.8864
    Cell Significance Index: 579.0100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.8175
    Cell Significance Index: 106.6900
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 2.1069
    Cell Significance Index: 21.9500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.0823
    Cell Significance Index: 1440.1800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.8851
    Cell Significance Index: 40.8400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.7644
    Cell Significance Index: 13.6000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.3528
    Cell Significance Index: 75.9100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.3320
    Cell Significance Index: 9.0300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1543
    Cell Significance Index: 59.9600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.1423
    Cell Significance Index: 59.9800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.0309
    Cell Significance Index: 149.8500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6469
    Cell Significance Index: 584.1000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5050
    Cell Significance Index: 49.9600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.4458
    Cell Significance Index: 3.6800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4364
    Cell Significance Index: 83.0500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3490
    Cell Significance Index: 62.9200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3109
    Cell Significance Index: 585.3700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.2703
    Cell Significance Index: 3.3700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2333
    Cell Significance Index: 37.9500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1939
    Cell Significance Index: 263.6500
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.1093
    Cell Significance Index: 1.0400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.0941
    Cell Significance Index: 1.8600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0083
    Cell Significance Index: 12.8300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0016
    Cell Significance Index: -0.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0063
    Cell Significance Index: -0.2200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0076
    Cell Significance Index: -0.8300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0116
    Cell Significance Index: -7.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0200
    Cell Significance Index: -14.8300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0267
    Cell Significance Index: -0.7700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0329
    Cell Significance Index: -1.6600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0333
    Cell Significance Index: -61.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0474
    Cell Significance Index: -30.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0533
    Cell Significance Index: -30.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0630
    Cell Significance Index: -7.7500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0660
    Cell Significance Index: -2.7000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0677
    Cell Significance Index: -49.6400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0678
    Cell Significance Index: -1.4400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0809
    Cell Significance Index: -44.1700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0978
    Cell Significance Index: -20.5900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0989
    Cell Significance Index: -74.8300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0997
    Cell Significance Index: -44.0600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1075
    Cell Significance Index: -0.9900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1164
    Cell Significance Index: -52.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1176
    Cell Significance Index: -5.3300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1675
    Cell Significance Index: -4.6800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2091
    Cell Significance Index: -26.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2144
    Cell Significance Index: -61.6900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2178
    Cell Significance Index: -37.1900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2199
    Cell Significance Index: -7.2000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2226
    Cell Significance Index: -2.8100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2366
    Cell Significance Index: -16.3700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2448
    Cell Significance Index: -4.9200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2882
    Cell Significance Index: -9.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.3116
    Cell Significance Index: -61.8400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.3325
    Cell Significance Index: -4.0300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.3396
    Cell Significance Index: -46.6400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.3801
    Cell Significance Index: -5.0700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.4382
    Cell Significance Index: -26.3100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.4479
    Cell Significance Index: -4.8800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.4563
    Cell Significance Index: -58.9600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4597
    Cell Significance Index: -14.7300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4752
    Cell Significance Index: -56.0400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.4844
    Cell Significance Index: -49.4800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.4942
    Cell Significance Index: -6.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5097
    Cell Significance Index: -58.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5220
    Cell Significance Index: -60.8300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.5266
    Cell Significance Index: -10.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5370
    Cell Significance Index: -40.0300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5431
    Cell Significance Index: -13.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5899
    Cell Significance Index: -61.4200
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.6001
    Cell Significance Index: -7.8600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.6054
    Cell Significance Index: -8.6700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6301
    Cell Significance Index: -49.9000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6325
    Cell Significance Index: -72.2000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.6627
    Cell Significance Index: -46.8700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.7180
    Cell Significance Index: -17.9100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.7313
    Cell Significance Index: -15.8000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7390
    Cell Significance Index: -25.8900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.7606
    Cell Significance Index: -7.2100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.8099
    Cell Significance Index: -42.1900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.8889
    Cell Significance Index: -10.3700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.8928
    Cell Significance Index: -57.6000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.9323
    Cell Significance Index: -14.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.9555
    Cell Significance Index: -73.3200
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.9772
    Cell Significance Index: -6.3600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.0447
    Cell Significance Index: -65.8500
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -1.0708
    Cell Significance Index: -12.8100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.1499
    Cell Significance Index: -24.5800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -1.1573
    Cell Significance Index: -54.3900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -1.2773
    Cell Significance Index: -25.1400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.2929
    Cell Significance Index: -22.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** KIF5C is a plus-end-directed microtubule motor protein, which means it moves along the plus end of microtubules, a process that is essential for various cellular functions. The protein exhibits high processivity, allowing it to transport multiple cargoes along the microtubule filament. KIF5C is also highly specific, with a high affinity for certain cargoes, such as messenger ribonucleoprotein complexes and neurotransmitter receptor complexes. The protein's motor activity is driven by the hydrolysis of ATP, which provides the energy required for its movement along the microtubule. **Pathways and Functions** KIF5C is involved in various cellular pathways, including: 1. **Anterograde axonal protein transport**: KIF5C plays a crucial role in the transport of proteins and other cargoes from the axon hillock to the distal axon, where they are involved in neurotransmitter release and synaptic transmission. 2. **Anterograde dendritic transport of messenger ribonucleoprotein complex**: KIF5C is responsible for transporting messenger ribonucleoprotein complexes from the cell body to the dendrites, where they are involved in protein synthesis and neuronal signaling. 3. **Axonal growth cone formation**: KIF5C is involved in the formation and guidance of axonal growth cones, which are critical for axon outgrowth and neuronal migration. 4. **Intracellular mRNA localization**: KIF5C helps to localize mRNA to specific subcellular compartments, such as the nucleus and cytoplasm, where it can be translated into proteins. **Clinical Significance** Dysregulation of KIF5C has been implicated in various neurological disorders, including: 1. **Neurodevelopmental disorders**: Mutations in KIF5C have been associated with neurodevelopmental disorders, such as autism spectrum disorder and intellectual disability. 2. **Neuromuscular disorders**: KIF5C dysfunction has been linked to neuromuscular disorders, such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). 3. **Cerebellar disorders**: KIF5C has been implicated in cerebellar disorders, such as ataxia and cerebellar degeneration. In summary, KIF5C is a critical protein involved in various cellular processes, including anterograde axonal and dendritic transport, axonal growth cone formation, and neuronal cell body organization. Its dysregulation has been implicated in various neurological disorders, highlighting the importance of this protein in maintaining normal neuronal function and development.

Genular Protein ID: 3915941183

Symbol: KIF5C_HUMAN

Name: Kinesin heavy chain isoform 5C

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9628581

Title: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9628581

DOI: 10.1093/dnares/5.1.31

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9361024

Title: Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin.

PubMed ID: 9361024

DOI: 10.1093/hmg/6.13.2205

PubMed ID: 15644324

Title: GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin.

PubMed ID: 15644324

DOI: 10.1074/jbc.m409095200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24812067

Title: Involvement of the kinesin family members KIF4A and KIF5C in intellectual disability and synaptic function.

PubMed ID: 24812067

DOI: 10.1136/jmedgenet-2013-102182

PubMed ID: 23033978

Title: Diagnostic exome sequencing in persons with severe intellectual disability.

PubMed ID: 23033978

DOI: 10.1056/nejmoa1206524

PubMed ID: 23603762

Title: Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly.

PubMed ID: 23603762

DOI: 10.1038/ng.2613

PubMed ID: 29048727

Title: Mutations of KIF5C cause a neurodevelopmental disorder of infantile-onset epilepsy, absent language, and distinctive malformations of cortical development.

PubMed ID: 29048727

DOI: 10.1002/ajmg.a.38496

Sequence Information:

  • Length: 957
  • Mass: 109495
  • Checksum: A9F25BB1C994322A
  • Sequence:
  • MADPAECSIK VMCRFRPLNE AEILRGDKFI PKFKGDETVV IGQGKPYVFD RVLPPNTTQE 
    QVYNACAKQI VKDVLEGYNG TIFAYGQTSS GKTHTMEGKL HDPQLMGIIP RIAHDIFDHI 
    YSMDENLEFH IKVSYFEIYL DKIRDLLDVS KTNLAVHEDK NRVPYVKGCT ERFVSSPEEV 
    MDVIDEGKAN RHVAVTNMNE HSSRSHSIFL INIKQENVET EKKLSGKLYL VDLAGSEKVS 
    KTGAEGAVLD EAKNINKSLS ALGNVISALA EGTKTHVPYR DSKMTRILQD SLGGNCRTTI 
    VICCSPSVFN EAETKSTLMF GQRAKTIKNT VSVNLELTAE EWKKKYEKEK EKNKTLKNVI 
    QHLEMELNRW RNGEAVPEDE QISAKDQKNL EPCDNTPIID NIAPVVAGIS TEEKEKYDEE 
    ISSLYRQLDD KDDEINQQSQ LAEKLKQQML DQDELLASTR RDYEKIQEEL TRLQIENEAA 
    KDEVKEVLQA LEELAVNYDQ KSQEVEDKTR ANEQLTDELA QKTTTLTTTQ RELSQLQELS 
    NHQKKRATEI LNLLLKDLGE IGGIIGTNDV KTLADVNGVI EEEFTMARLY ISKMKSEVKS 
    LVNRSKQLES AQMDSNRKMN ASERELAACQ LLISQHEAKI KSLTDYMQNM EQKRRQLEES 
    QDSLSEELAK LRAQEKMHEV SFQDKEKEHL TRLQDAEEMK KALEQQMESH REAHQKQLSR 
    LRDEIEEKQK IIDEIRDLNQ KLQLEQEKLS SDYNKLKIED QEREMKLEKL LLLNDKREQA 
    REDLKGLEET VSRELQTLHN LRKLFVQDLT TRVKKSVELD NDDGGGSAAQ KQKISFLENN 
    LEQLTKVHKQ LVRDNADLRC ELPKLEKRLR ATAERVKALE SALKEAKENA MRDRKRYQQE 
    VDRIKEAVRA KNMARRAHSA QIAKPIRPGH YPASSPTAVH AIRGGGGSSS NSTHYQK

Genular Protein ID: 963232121

Symbol: Q59GB8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 265
  • Mass: 30578
  • Checksum: 05A7B27788589930
  • Sequence:
  • SLQILQNYCL YCTELIGLEQ NHGFSLMTQN FRLMWNILLF PLNFSLNQKL QLEQEKLSSD 
    YNKLKIEDQE REMKLEKLLL LNDKREQARE DLKGLEETVS RELQTLHNLR KLFVQDLTTR 
    VKKSVELDND DGGGSAAQKQ KISFLENNLE QLTKVHKQLV RDNADLRCEL PKLEKRLRAT 
    AERVKALESA LKEAKENAMR DRKRYQQEVD RIKEAVRAKN MARRAHSAQI AKPIRPGHYP 
    ASSPTAVHAI RGGGGSSSNS THYQK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.