Details for: KIF5C
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 404.8340
Cell Significance Index: -62.9700 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 250.1938
Cell Significance Index: -63.4600 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 171.6845
Cell Significance Index: -70.7300 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 44.2475
Cell Significance Index: -42.2500 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 22.9277
Cell Significance Index: -61.4200 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 3.7393
Cell Significance Index: 64.0800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.9518
Cell Significance Index: 1058.7600 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 2.9137
Cell Significance Index: 63.8000 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 2.8922
Cell Significance Index: 127.9300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.8864
Cell Significance Index: 579.0100 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 2.8175
Cell Significance Index: 106.6900 - Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: 2.1069
Cell Significance Index: 21.9500 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 2.0823
Cell Significance Index: 1440.1800 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.8851
Cell Significance Index: 40.8400 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 1.7644
Cell Significance Index: 13.6000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.3528
Cell Significance Index: 75.9100 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 1.3320
Cell Significance Index: 9.0300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.1543
Cell Significance Index: 59.9600 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.1423
Cell Significance Index: 59.9800 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 1.0309
Cell Significance Index: 149.8500 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.6469
Cell Significance Index: 584.1000 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5050
Cell Significance Index: 49.9600 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.4458
Cell Significance Index: 3.6800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4364
Cell Significance Index: 83.0500 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.3490
Cell Significance Index: 62.9200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.3109
Cell Significance Index: 585.3700 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: 0.2703
Cell Significance Index: 3.3700 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2333
Cell Significance Index: 37.9500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.1939
Cell Significance Index: 263.6500 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.1093
Cell Significance Index: 1.0400 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.0941
Cell Significance Index: 1.8600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0083
Cell Significance Index: 12.8300 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0016
Cell Significance Index: -0.1000 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0063
Cell Significance Index: -0.2200 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.0076
Cell Significance Index: -0.8300 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0116
Cell Significance Index: -7.2500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0200
Cell Significance Index: -14.8300 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0267
Cell Significance Index: -0.7700 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0329
Cell Significance Index: -1.6600 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0333
Cell Significance Index: -61.3700 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0474
Cell Significance Index: -30.1000 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0533
Cell Significance Index: -30.0500 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0630
Cell Significance Index: -7.7500 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0660
Cell Significance Index: -2.7000 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0677
Cell Significance Index: -49.6400 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0678
Cell Significance Index: -1.4400 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0809
Cell Significance Index: -44.1700 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0978
Cell Significance Index: -20.5900 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0989
Cell Significance Index: -74.8300 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0997
Cell Significance Index: -44.0600 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.1075
Cell Significance Index: -0.9900 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1164
Cell Significance Index: -52.8300 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.1176
Cell Significance Index: -5.3300 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1675
Cell Significance Index: -4.6800 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.2091
Cell Significance Index: -26.8000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2144
Cell Significance Index: -61.6900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.2178
Cell Significance Index: -37.1900 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2199
Cell Significance Index: -7.2000 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.2226
Cell Significance Index: -2.8100 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.2366
Cell Significance Index: -16.3700 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.2448
Cell Significance Index: -4.9200 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2882
Cell Significance Index: -9.1800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.3116
Cell Significance Index: -61.8400 - Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: -0.3325
Cell Significance Index: -4.0300 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.3396
Cell Significance Index: -46.6400 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -0.3801
Cell Significance Index: -5.0700 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.4382
Cell Significance Index: -26.3100 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.4479
Cell Significance Index: -4.8800 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.4563
Cell Significance Index: -58.9600 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.4597
Cell Significance Index: -14.7300 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.4752
Cell Significance Index: -56.0400 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.4844
Cell Significance Index: -49.4800 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.4942
Cell Significance Index: -6.1300 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.5097
Cell Significance Index: -58.4000 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.5220
Cell Significance Index: -60.8300 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.5266
Cell Significance Index: -10.9900 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.5370
Cell Significance Index: -40.0300 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.5431
Cell Significance Index: -13.5800 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.5899
Cell Significance Index: -61.4200 - Cell Name: fast muscle cell (CL0000190)
Fold Change: -0.6001
Cell Significance Index: -7.8600 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.6054
Cell Significance Index: -8.6700 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.6301
Cell Significance Index: -49.9000 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.6325
Cell Significance Index: -72.2000 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.6627
Cell Significance Index: -46.8700 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.7180
Cell Significance Index: -17.9100 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.7313
Cell Significance Index: -15.8000 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.7390
Cell Significance Index: -25.8900 - Cell Name: neuron (CL0000540)
Fold Change: -0.7606
Cell Significance Index: -7.2100 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.8099
Cell Significance Index: -42.1900 - Cell Name: neural cell (CL0002319)
Fold Change: -0.8889
Cell Significance Index: -10.3700 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.8928
Cell Significance Index: -57.6000 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.9323
Cell Significance Index: -14.0500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.9555
Cell Significance Index: -73.3200 - Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: -0.9772
Cell Significance Index: -6.3600 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -1.0447
Cell Significance Index: -65.8500 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: -1.0708
Cell Significance Index: -12.8100 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -1.1499
Cell Significance Index: -24.5800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -1.1573
Cell Significance Index: -54.3900 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -1.2773
Cell Significance Index: -25.1400 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -1.2929
Cell Significance Index: -22.3600
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3915941183
Symbol: KIF5C_HUMAN
Name: Kinesin heavy chain isoform 5C
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9628581
Title: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
PubMed ID: 9628581
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9361024
Title: Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin.
PubMed ID: 9361024
PubMed ID: 15644324
Title: GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin.
PubMed ID: 15644324
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24812067
Title: Involvement of the kinesin family members KIF4A and KIF5C in intellectual disability and synaptic function.
PubMed ID: 24812067
PubMed ID: 23033978
Title: Diagnostic exome sequencing in persons with severe intellectual disability.
PubMed ID: 23033978
PubMed ID: 23603762
Title: Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly.
PubMed ID: 23603762
DOI: 10.1038/ng.2613
PubMed ID: 29048727
Title: Mutations of KIF5C cause a neurodevelopmental disorder of infantile-onset epilepsy, absent language, and distinctive malformations of cortical development.
PubMed ID: 29048727
DOI: 10.1002/ajmg.a.38496
Sequence Information:
- Length: 957
- Mass: 109495
- Checksum: A9F25BB1C994322A
- Sequence:
MADPAECSIK VMCRFRPLNE AEILRGDKFI PKFKGDETVV IGQGKPYVFD RVLPPNTTQE QVYNACAKQI VKDVLEGYNG TIFAYGQTSS GKTHTMEGKL HDPQLMGIIP RIAHDIFDHI YSMDENLEFH IKVSYFEIYL DKIRDLLDVS KTNLAVHEDK NRVPYVKGCT ERFVSSPEEV MDVIDEGKAN RHVAVTNMNE HSSRSHSIFL INIKQENVET EKKLSGKLYL VDLAGSEKVS KTGAEGAVLD EAKNINKSLS ALGNVISALA EGTKTHVPYR DSKMTRILQD SLGGNCRTTI VICCSPSVFN EAETKSTLMF GQRAKTIKNT VSVNLELTAE EWKKKYEKEK EKNKTLKNVI QHLEMELNRW RNGEAVPEDE QISAKDQKNL EPCDNTPIID NIAPVVAGIS TEEKEKYDEE ISSLYRQLDD KDDEINQQSQ LAEKLKQQML DQDELLASTR RDYEKIQEEL TRLQIENEAA KDEVKEVLQA LEELAVNYDQ KSQEVEDKTR ANEQLTDELA QKTTTLTTTQ RELSQLQELS NHQKKRATEI LNLLLKDLGE IGGIIGTNDV KTLADVNGVI EEEFTMARLY ISKMKSEVKS LVNRSKQLES AQMDSNRKMN ASERELAACQ LLISQHEAKI KSLTDYMQNM EQKRRQLEES QDSLSEELAK LRAQEKMHEV SFQDKEKEHL TRLQDAEEMK KALEQQMESH REAHQKQLSR LRDEIEEKQK IIDEIRDLNQ KLQLEQEKLS SDYNKLKIED QEREMKLEKL LLLNDKREQA REDLKGLEET VSRELQTLHN LRKLFVQDLT TRVKKSVELD NDDGGGSAAQ KQKISFLENN LEQLTKVHKQ LVRDNADLRC ELPKLEKRLR ATAERVKALE SALKEAKENA MRDRKRYQQE VDRIKEAVRA KNMARRAHSA QIAKPIRPGH YPASSPTAVH AIRGGGGSSS NSTHYQK
Genular Protein ID: 963232121
Symbol: Q59GB8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 265
- Mass: 30578
- Checksum: 05A7B27788589930
- Sequence:
SLQILQNYCL YCTELIGLEQ NHGFSLMTQN FRLMWNILLF PLNFSLNQKL QLEQEKLSSD YNKLKIEDQE REMKLEKLLL LNDKREQARE DLKGLEETVS RELQTLHNLR KLFVQDLTTR VKKSVELDND DGGGSAAQKQ KISFLENNLE QLTKVHKQLV RDNADLRCEL PKLEKRLRAT AERVKALESA LKEAKENAMR DRKRYQQEVD RIKEAVRAKN MARRAHSAQI AKPIRPGHYP ASSPTAVHAI RGGGGSSSNS THYQK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.