Details for: LUZP2

Gene ID: 338645

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: LUZP2

Ensembl ID: ENSG00000187398

Description: leucine zipper protein 2

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • pvalb GABAergic cortical interneuron CL4023018
    CSI 39.65
    rCSI 49.32%
    PRS 99.26
  • VIP GABAergic cortical interneuron CL4023016
    CSI 37.16
    rCSI 44.38%
    PRS 99.34
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 34.8
    rCSI 63.23%
    PRS 99.63
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 33.55
    rCSI 56.32%
    PRS 99.37
  • oligodendrocyte precursor cell CL0002453
    CSI 28.47
    rCSI 62.66%
    PRS 98.67
  • interneuron CL0000099
    CSI 27.69
    rCSI 55.6%
    PRS 99.67
  • sncg GABAergic cortical interneuron CL4023015
    CSI 26.2
    rCSI 42.13%
    PRS 99.23
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 22.56
    rCSI 39.84%
    PRS 99.27
  • cerebellar granule cell CL0001031
    CSI 22.31
    rCSI 32.79%
    PRS 99.53
  • macroglial cell CL0000126
    CSI 19.72
    rCSI 50.69%
    PRS 99.69
  • inhibitory interneuron CL0000498
    CSI 19.35
    rCSI 44.67%
    PRS 99.5
  • glycinergic amacrine cell CL4030028
    CSI 18.38
    rCSI 47.88%
    PRS 99.39
  • amacrine cell CL0000561
    CSI 18.18
    rCSI 52.69%
    PRS 99.5
  • glioblast CL0000030
    CSI 17.48
    rCSI 27.89%
    PRS 99.47
  • sst GABAergic cortical interneuron CL4023017
    CSI 17.1
    rCSI 22.04%
    PRS 99.54
  • retinal ganglion cell CL0000740
    CSI 15.58
    rCSI 34.41%
    PRS 99.31
  • neural cell CL0002319
    CSI 15.38
    rCSI 58.03%
    PRS 99.01
  • L6b glutamatergic cortical neuron CL4023038
    CSI 14.81
    rCSI 46.3%
    PRS 99.31
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 14.66
    rCSI 45.83%
    PRS 99.46
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 14.33
    rCSI 54.16%
    PRS 99.06
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 14.21
    rCSI 16.41%
    PRS 99.47
  • GABAergic amacrine cell CL4030027
    CSI 11.91
    rCSI 40.78%
    PRS 99.22
  • neural crest cell CL0011012
    CSI 11.87
    rCSI 9.38%
    PRS 99.76
  • GABAergic neuron CL0000617
    CSI 11.02
    rCSI 36.91%
    PRS 98.18
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 10.06
    rCSI 24.45%
    PRS 98.96
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 9.99
    rCSI 32.83%
    PRS 99.13
  • peripheral nervous system neuron CL2000032
    CSI 9.84
    rCSI 13.41%
    PRS 99.5
  • glutamatergic neuron CL0000679
    CSI 9.8
    rCSI 20.15%
    PRS 98.37
  • vascular leptomeningeal cell CL4023051
    CSI 9.68
    rCSI 16.97%
    PRS 99.7
  • Bergmann glial cell CL0000644
    CSI 9.34
    rCSI 12.78%
    PRS 99.43
  • basal cell of epidermis CL0002187
    CSI 9.11
    rCSI 16.15%
    PRS 94
  • stromal cell CL0000499
    CSI 8.9
    rCSI 25.04%
    PRS 99.78
  • dopaminergic neuron CL0000700
    CSI 8.53
    rCSI 48.2%
    PRS 99.12
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 8.24
    rCSI 48.51%
    PRS 99.23
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 8.13
    rCSI 29.25%
    PRS 99.13
  • serotonergic neuron CL0000850
    CSI 7.86
    rCSI 35.1%
    PRS 98.62
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 7.51
    rCSI 17.96%
    PRS 99.32
  • diffuse bipolar 6 cell CL4033032
    CSI 7.37
    rCSI 38.75%
    PRS 99.2
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 6.71
    rCSI 14.57%
    PRS 99.23
  • astrocyte of the cerebral cortex CL0002605
    CSI 5.6
    rCSI 12.56%
    PRS 99.32
  • central nervous system neuron CL2000029
    CSI 4.89
    rCSI 35.97%
    PRS 99.53
  • keratocyte CL0002363
    CSI 3.85
    rCSI 9.26%
    PRS 99.87
  • starburst amacrine cell CL0004232
    CSI 3.59
    rCSI 30.23%
    PRS 99.09
  • basal cell CL0000646
    CSI 3.51
    rCSI 4.69%
    PRS 99.8
  • midbrain dopaminergic neuron CL2000097
    CSI 3.49
    rCSI 22.35%
    PRS 99.57
  • ON parasol ganglion cell CL4033052
    CSI 2.87
    rCSI 40.71%
    PRS 99.4
  • OFF midget ganglion cell CL4033047
    CSI 1.93
    rCSI 39.23%
    PRS 99.46
  • indirect pathway medium spiny neuron CL4023029
    CSI 1.83
    rCSI 44.19%
    PRS 98.58
  • ON midget ganglion cell CL4033046
    CSI 1.77
    rCSI 36.07%
    PRS 99.41
  • direct pathway medium spiny neuron CL4023026
    CSI 1.67
    rCSI 39.93%
    PRS 98.65

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary Leucine zipper protein 2, encoded by the gene [LUZP2](/details-gene/338645), is a protein-coding gene located on chromosome 11. Despite its name suggesting an intracellular role, functional annotation identifies it as a component of the extracellular region ([GO:0005576](https://www.ebi.ac.uk/QuickGO/term/GO:0005576)), a finding supported by large-scale screens for secreted proteins [[Link](https://doi.org/10.1101/gr.1293003)]. **Overall**, expression data reveals that [LUZP2](/details-gene/338645) is a highly significant marker for various cell types within the central nervous system, particularly inhibitory interneurons and glial lineage cells, suggesting a specialized function in neural development, communication, or maintenance. ## Cellular Roles and Expression Landscape The expression profile of [LUZP2](/details-gene/338645) indicates a highly specific role within the nervous system. The gene shows the most significant expression in multiple subtypes of inhibitory neurons, including [pvalb GABAergic cortical interneuron](/details-cell/CL4023018) (CSI: 39.65), [VIP GABAergic cortical interneuron](/details-cell/CL4023016) (CSI: 37.16), and [lamp5 GABAergic cortical interneuron](/details-cell/CL4023011) (CSI: 33.55). This strong and consistent signal across different classes of [interneuron](/details-cell/CL0000099)s suggests a fundamental role in the regulation of inhibitory circuits in the cortex. In addition to its neuronal expression, [LUZP2](/details-gene/338645) is also a prominent marker in glial cells. It is highly significant in [differentiation-committed oligodendrocyte precursor](/details-cell/CL4023059) (CSI: 34.80) and [oligodendrocyte precursor cell](/details-cell/CL0002453) (CSI: 28.47), pointing towards a potential involvement in the processes of oligodendrocyte development and myelination. Its notable expression in [glioblast](/details-cell/CL0000030)s (CSI: 17.48) also suggests a possible role in the pathology of glial tumors. The collective data portrays [LUZP2](/details-gene/338645) as a key molecular player at the interface of neuronal and glial cell biology in the CNS. ## Pathways and Molecular Function The primary functional annotation available for [LUZP2](/details-gene/338645) indicates it is a component of the extracellular region ([GO:0005576](https://www.ebi.ac.uk/QuickGO/term/GO:0005576)). This is consistent with its identification in a large-scale bioinformatics screen for novel human secreted and transmembrane proteins [[Link](https://doi.org/10.1101/gr.1293003)]. While the leucine zipper motif is often associated with DNA-binding and transcription factors, its presence in a secreted protein suggests it may mediate protein-protein interactions in the extracellular space. Combined with its specific expression in neurons and glia, this suggests [LUZP2](/details-gene/338645) may function as a signaling ligand, a component of the extracellular matrix, or a cell adhesion molecule involved in mediating communication and structural organization between these cell types. Further research is required to elucidate the specific molecular pathways it participates in. ## Research Directions The highly specific expression of [LUZP2](/details-gene/338645) in distinct CNS cell populations, coupled with its putative extracellular function, opens several avenues for future investigation. Based on the available data, several testable hypotheses can be proposed: 1. Given its high expression in various [interneuron](/details-cell/CL0000099) subtypes, [LUZP2](/details-gene/338645) may act as a secreted factor that modulates the formation, maturation, or plasticity of inhibitory synapses. 2. The strong signal in [oligodendrocyte precursor cell](/details-cell/CL0002453)s suggests that [LUZP2](/details-gene/338645) is a key regulator of oligodendrocyte differentiation and myelination, potentially acting as a signaling cue in the glial niche. 3. Its expression in [glioblast](/details-cell/CL0000030)s indicates that [LUZP2](/details-gene/338645) could contribute to glioblastoma pathogenesis by promoting tumor cell proliferation, invasion, or communication within the tumor microenvironment. A key experiment to test the second hypothesis regarding its role in oligodendrocytes would be to utilize a conditional knockout approach. By deleting [LUZP2](/details-gene/338645) specifically in the oligodendrocyte lineage in mice (e.g., using an Olig2-Cre driver), one could assess the impact on the number of precursor cells, the rate of differentiation into mature oligodendrocytes, and the integrity of myelination in the brain and spinal cord using techniques like immunohistochemistry, electron microscopy, and functional assays for nerve conduction. From a therapeutic standpoint, [LUZP2](/details-gene/338645) presents a dual potential. If it is shown to promote glioblastoma progression, its extracellular location would make it an accessible target for **inhibition** via monoclonal antibodies or antibody-drug conjugates. Conversely, if its role in promoting oligodendrocyte differentiation is confirmed, [LUZP2](/details-gene/338645) or a molecule that mimics its function could be explored as a therapeutic agent for **activation** to promote remyelination in diseases such as multiple sclerosis.

Genular Protein ID: 3854078812

Symbol: LUZP2_HUMAN

Name: Leucine zipper protein 2

UniProtKB Accession Codes:

Q86TE4 A2RUB8 E9PN53 Q6UXE7 Q6ZS65

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 3 ExpressionAtlas 1 GO 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 RefSeq 4 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 346
  • Mass: 38958
  • Checksum: AC29F2D885EC3278
  • Sequence:
    • MKFSPAHYLL PLLPALVLST RQDYEELEKQ LKEVFKERST ILRQLTKTSR ELDGIKVNLQ 
SLKNDEQSAK TDVQKLLELG QKQREEMKSL QEALQNQLKE TSEKAEKHQA TINFLKTEVE 
RKSKMIRDLQ NENKSLKNKL LSGNKLCGIH AEESKKIQAQ LKELRYGKKD LLFKAQQLTD 
LEQKLAVAKN ELEKAALDRE SQMKAMKETV QLCLTSVFRD QPPPPLSLIT SNPTRMLLPP 
RNIASKLPDA AAKSKPQQSA SGNNESSQVE STKEGNPSTT ACDSQDEGRP CSMKHKESPP 
SNATAETEPI PQKLQMPPCS ECEVKKAPEK PLTSFEGMAA REEKIL