Details for: UQCRB

Gene ID: 7381

Symbol: UQCRB

Ensembl ID: ENSG00000156467

Description: ubiquinol-cytochrome c reductase binding protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 817.3186
    Cell Significance Index: -127.1300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 463.2094
    Cell Significance Index: -117.4900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 419.7864
    Cell Significance Index: -172.9300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 354.8019
    Cell Significance Index: -167.5100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 323.4055
    Cell Significance Index: -166.3600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 251.0051
    Cell Significance Index: -168.4300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 123.2810
    Cell Significance Index: -152.0000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 55.5330
    Cell Significance Index: -148.7700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 43.1976
    Cell Significance Index: -170.4600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 40.4727
    Cell Significance Index: -124.3100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 28.7217
    Cell Significance Index: -62.8600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 6.7497
    Cell Significance Index: 155.9400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 5.9738
    Cell Significance Index: 313.6500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 5.8214
    Cell Significance Index: 799.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 5.8080
    Cell Significance Index: 714.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 5.6586
    Cell Significance Index: 1020.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 5.6271
    Cell Significance Index: 262.3600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 4.7635
    Cell Significance Index: 54.1200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 4.7443
    Cell Significance Index: 2590.9800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 4.5752
    Cell Significance Index: 4131.0300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.3940
    Cell Significance Index: 119.6000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 4.0489
    Cell Significance Index: 37.2900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 4.0049
    Cell Significance Index: 517.4000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.9467
    Cell Significance Index: 185.4900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.8778
    Cell Significance Index: 289.0100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 3.8031
    Cell Significance Index: 268.9700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.6797
    Cell Significance Index: 65.0300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 3.5761
    Cell Significance Index: 1581.0800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.4801
    Cell Significance Index: 91.5100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.2938
    Cell Significance Index: 388.4400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.8995
    Cell Significance Index: 53.5900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.5770
    Cell Significance Index: 53.9400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.5586
    Cell Significance Index: 165.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.0491
    Cell Significance Index: 349.9000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 1.8753
    Cell Significance Index: 148.5200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.6874
    Cell Significance Index: 216.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.5614
    Cell Significance Index: 81.1100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.5452
    Cell Significance Index: 11.9100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 1.2104
    Cell Significance Index: 887.4900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.9854
    Cell Significance Index: 12.6200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9471
    Cell Significance Index: 42.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.8939
    Cell Significance Index: 56.3400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8900
    Cell Significance Index: 88.0400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7753
    Cell Significance Index: 22.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6828
    Cell Significance Index: 136.9700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.6400
    Cell Significance Index: 484.4500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5404
    Cell Significance Index: 107.2500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4600
    Cell Significance Index: 13.5100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2995
    Cell Significance Index: 107.4400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1371
    Cell Significance Index: 3.6600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1371
    Cell Significance Index: 1.4900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.1290
    Cell Significance Index: 1.0300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0705
    Cell Significance Index: 1.1800
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.0105
    Cell Significance Index: -0.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0319
    Cell Significance Index: -60.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0485
    Cell Significance Index: -35.9300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0570
    Cell Significance Index: -5.8200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0855
    Cell Significance Index: -157.7700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0874
    Cell Significance Index: -54.5700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1054
    Cell Significance Index: -162.2300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.1158
    Cell Significance Index: -22.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1354
    Cell Significance Index: -184.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1677
    Cell Significance Index: -106.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1784
    Cell Significance Index: -100.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2684
    Cell Significance Index: -121.8200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2895
    Cell Significance Index: -60.9800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2994
    Cell Significance Index: -18.4100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3612
    Cell Significance Index: -12.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.4674
    Cell Significance Index: -134.4900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.6770
    Cell Significance Index: -19.5100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.7081
    Cell Significance Index: -81.1300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7938
    Cell Significance Index: -20.2800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.8966
    Cell Significance Index: -130.3300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.9238
    Cell Significance Index: -107.6600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.9288
    Cell Significance Index: -32.6400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.0731
    Cell Significance Index: -16.0800
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -1.0836
    Cell Significance Index: -22.6000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.1655
    Cell Significance Index: -133.0400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.2238
    Cell Significance Index: -93.9100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.2460
    Cell Significance Index: -21.4800
  • Cell Name: theca cell (CL0000503)
    Fold Change: -1.4077
    Cell Significance Index: -8.2700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.4080
    Cell Significance Index: -39.3500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.5924
    Cell Significance Index: -34.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.5985
    Cell Significance Index: -166.4400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.6988
    Cell Significance Index: -54.4100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.7474
    Cell Significance Index: -20.8300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.8019
    Cell Significance Index: -121.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.8794
    Cell Significance Index: -105.4600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -2.1871
    Cell Significance Index: -29.8400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -2.2987
    Cell Significance Index: -57.4600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.4220
    Cell Significance Index: -148.4900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -2.6965
    Cell Significance Index: -22.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.8061
    Cell Significance Index: -124.1200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -2.8330
    Cell Significance Index: -48.5500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -3.0140
    Cell Significance Index: -18.2100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -3.0707
    Cell Significance Index: -82.1400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -3.1388
    Cell Significance Index: -92.4500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -3.6962
    Cell Significance Index: -139.9700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -3.8411
    Cell Significance Index: -141.0100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -4.1684
    Cell Significance Index: -99.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location:** UQCRB is encoded by the gene UQCRB, located on chromosome 6p21.3. 2. **Protein Structure:** The UQCRB protein is a subunit of the cytochrome b-c1 complex, specifically Cytochrome b-c1 complex subunit 7 (QCR7_HUMAN). 3. **Function:** UQCRB facilitates the transfer of electrons between ubiquinol and cytochrome c, enabling the production of ATP through oxidative phosphorylation. 4. **Expression:** UQCRB is highly expressed in various cell types, including hematopoietic stem cells, renal intercalated cells, and pancreatic A cells. 5. **Pathway Involvement:** UQCRB is involved in several key pathways, including aerobic respiration, cellular respiration, metabolism, mitochondrial electron transport, and oxidative phosphorylation. **Pathways and Functions:** 1. **Mitochondrial Electron Transport:** UQCRB plays a critical role in the mitochondrial electron transport chain, facilitating the transfer of electrons between ubiquinol and cytochrome c. 2. **Oxidative Phosphorylation:** UQCRB contributes to the production of ATP through oxidative phosphorylation, a crucial process for energy production in cells. 3. **Aerobic Respiration:** UQCRB is involved in aerobic respiration, a process that generates energy from the breakdown of glucose in the presence of oxygen. 4. **Cellular Respiration:** UQCRB participates in cellular respiration, a process that involves the breakdown of glucose to produce energy. 5. **Metabolism:** UQCRB is involved in various metabolic processes, including energy production, redox reactions, and biosynthesis. **Clinical Significance:** 1. **Mitochondrial Diseases:** Mutations in the UQCRB gene have been associated with mitochondrial diseases, such as Kearns-Sayre syndrome and MERRF syndrome. 2. **Cancer:** Alterations in UQCRB expression have been linked to cancer development and progression, highlighting its potential as a therapeutic target. 3. **Neurological Disorders:** UQCRB dysfunction has been implicated in neurological disorders, including Parkinson's disease, Alzheimer's disease, and Huntington's disease. 4. **Cardiovascular Disease:** UQCRB plays a critical role in cardiovascular health, and alterations in its expression have been linked to cardiovascular disease. In conclusion, UQCRB is a critical component of the mitochondrial respiratory chain, playing a pivotal role in energy production and cellular homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the molecular mechanisms underlying its function.

Genular Protein ID: 4143625772

Symbol: QCR7_HUMAN

Name: Cytochrome b-c1 complex subunit 7

UniProtKB Accession Codes:

P14927 E5RJU0 Q6FGD1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 CarbonylDB 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 9 EMBL 15 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3056408

Title: Cloning and sequencing of a cDNA for human mitochondrial ubiquinone-binding protein of complex III.

PubMed ID: 3056408

DOI: 10.1016/s0006-291x(88)80941-0

PubMed ID: 2543413

Title: Isolation of a single nuclear gene encoding human ubiquinone-binding protein in complex III of mitochondrial respiratory chain.

PubMed ID: 2543413

DOI: 10.1016/0006-291x(89)91607-0

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2159470

Title: Common protein-binding sites in the 5'-flanking regions of human genes for cytochrome c1 and ubiquinone-binding protein.

PubMed ID: 2159470

DOI: 10.1016/s0021-9258(19)39051-9

PubMed ID: 12709789

Title: A deletion in the human QP-C gene causes a complex III deficiency resulting in hypoglycaemia and lactic acidosis.

PubMed ID: 12709789

DOI: 10.1007/s00439-003-0946-0

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28844695

Title: Architecture of human mitochondrial respiratory megacomplex I2III2IV2.

PubMed ID: 28844695

DOI: 10.1016/j.cell.2017.07.050

Sequence Information:

  • Length: 111
  • Mass: 13530
  • Checksum: E61629D06DFA55B7
  • Sequence:
    • MAGKQAVSAS GKWLDGIRKW YYNAAGFNKL GLMRDDTIYE DEDVKEAIRR LPENLYNDRM 
FRIKRALDLN LKHQILPKEQ WTKYEEENFY LEPYLKEVIR ERKEREEWAK K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.