Details for: UQCRB

Gene ID: 7381

Symbol: UQCRB

Ensembl ID: ENSG00000156467

Description: ubiquinol-cytochrome c reductase binding protein

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 4.91
    Marker Score: 3708.5
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 4.7
    Marker Score: 2505.5
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 4.67
    Marker Score: 46200.5
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 4.36
    Marker Score: 4269
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 4.23
    Marker Score: 3312
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 4.16
    Marker Score: 11146
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 4.15
    Marker Score: 6393
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.03
    Marker Score: 212865
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 4.02
    Marker Score: 7346
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4
    Marker Score: 4831
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 3.99
    Marker Score: 5195.5
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.91
    Marker Score: 12334
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.88
    Marker Score: 51169
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 3.85
    Marker Score: 2477
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.82
    Marker Score: 44371.5
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.8
    Marker Score: 3588.5
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.75
    Marker Score: 4010
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 3.71
    Marker Score: 1672
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.7
    Marker Score: 19455
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 3.69
    Marker Score: 2247
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.68
    Marker Score: 205658
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 3.66
    Marker Score: 1350
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.66
    Marker Score: 8338.5
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 3.65
    Marker Score: 4385
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.61
    Marker Score: 10113
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.59
    Marker Score: 1181.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.58
    Marker Score: 12706
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.53
    Marker Score: 6639
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 3.53
    Marker Score: 2360
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.52
    Marker Score: 10032
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 3.51
    Marker Score: 3137.5
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 3.51
    Marker Score: 2060
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 3.49
    Marker Score: 10194
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.48
    Marker Score: 8491
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.47
    Marker Score: 22619
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.47
    Marker Score: 14858
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.45
    Marker Score: 825
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.44
    Marker Score: 8664
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.43
    Marker Score: 3374
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.42
    Marker Score: 9449
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.41
    Marker Score: 115986
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.4
    Marker Score: 2436
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.39
    Marker Score: 2855
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 3.38
    Marker Score: 1738
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 3.37
    Marker Score: 1095.5
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.37
    Marker Score: 2871
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3.36
    Marker Score: 3246
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.35
    Marker Score: 21815.5
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.34
    Marker Score: 2977
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.34
    Marker Score: 5533
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.31
    Marker Score: 114757
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 3.31
    Marker Score: 2399
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 3.31
    Marker Score: 1706.5
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.3
    Marker Score: 25780
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.28
    Marker Score: 3747
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 3.27
    Marker Score: 3634
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 3.26
    Marker Score: 7860
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 3.25
    Marker Score: 2458
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.23
    Marker Score: 1614
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 3.22
    Marker Score: 5126
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 3.21
    Marker Score: 3959
  • Cell Name: basophil (CL0000767)
    Fold Change: 3.21
    Marker Score: 1523
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 3.2
    Marker Score: 2278
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 3.2
    Marker Score: 3203
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 3.19
    Marker Score: 1431
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.18
    Marker Score: 23692
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 3.17
    Marker Score: 3216
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 3.17
    Marker Score: 5196
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 3.17
    Marker Score: 839
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 3.16
    Marker Score: 1102
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.13
    Marker Score: 3269.5
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.12
    Marker Score: 6350
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 3.11
    Marker Score: 1415
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 3.11
    Marker Score: 2912
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 3.11
    Marker Score: 5329
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 3.09
    Marker Score: 3358
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 3.07
    Marker Score: 1274
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.07
    Marker Score: 11834
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3.07
    Marker Score: 2407
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 3.06
    Marker Score: 3615
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 3.06
    Marker Score: 806
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 3.06
    Marker Score: 1688
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 3.05
    Marker Score: 2008
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.04
    Marker Score: 2703
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 3.03
    Marker Score: 1900.5
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 3.03
    Marker Score: 3212
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.02
    Marker Score: 2382
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 3.02
    Marker Score: 5389.5
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 3.02
    Marker Score: 4269
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3.01
    Marker Score: 26185
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 3
    Marker Score: 1556
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 3
    Marker Score: 963
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 3
    Marker Score: 910
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.98
    Marker Score: 40086
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.98
    Marker Score: 1190
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.98
    Marker Score: 5046
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.97
    Marker Score: 6750
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 2.97
    Marker Score: 2622
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.97
    Marker Score: 5930
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.97
    Marker Score: 2661

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Other Information

**Key Characteristics:** 1. **Location:** UQCRB is encoded by the gene UQCRB, located on chromosome 6p21.3. 2. **Protein Structure:** The UQCRB protein is a subunit of the cytochrome b-c1 complex, specifically Cytochrome b-c1 complex subunit 7 (QCR7_HUMAN). 3. **Function:** UQCRB facilitates the transfer of electrons between ubiquinol and cytochrome c, enabling the production of ATP through oxidative phosphorylation. 4. **Expression:** UQCRB is highly expressed in various cell types, including hematopoietic stem cells, renal intercalated cells, and pancreatic A cells. 5. **Pathway Involvement:** UQCRB is involved in several key pathways, including aerobic respiration, cellular respiration, metabolism, mitochondrial electron transport, and oxidative phosphorylation. **Pathways and Functions:** 1. **Mitochondrial Electron Transport:** UQCRB plays a critical role in the mitochondrial electron transport chain, facilitating the transfer of electrons between ubiquinol and cytochrome c. 2. **Oxidative Phosphorylation:** UQCRB contributes to the production of ATP through oxidative phosphorylation, a crucial process for energy production in cells. 3. **Aerobic Respiration:** UQCRB is involved in aerobic respiration, a process that generates energy from the breakdown of glucose in the presence of oxygen. 4. **Cellular Respiration:** UQCRB participates in cellular respiration, a process that involves the breakdown of glucose to produce energy. 5. **Metabolism:** UQCRB is involved in various metabolic processes, including energy production, redox reactions, and biosynthesis. **Clinical Significance:** 1. **Mitochondrial Diseases:** Mutations in the UQCRB gene have been associated with mitochondrial diseases, such as Kearns-Sayre syndrome and MERRF syndrome. 2. **Cancer:** Alterations in UQCRB expression have been linked to cancer development and progression, highlighting its potential as a therapeutic target. 3. **Neurological Disorders:** UQCRB dysfunction has been implicated in neurological disorders, including Parkinson's disease, Alzheimer's disease, and Huntington's disease. 4. **Cardiovascular Disease:** UQCRB plays a critical role in cardiovascular health, and alterations in its expression have been linked to cardiovascular disease. In conclusion, UQCRB is a critical component of the mitochondrial respiratory chain, playing a pivotal role in energy production and cellular homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the molecular mechanisms underlying its function.

Genular Protein ID: 4143625772

Symbol: QCR7_HUMAN

Name: Cytochrome b-c1 complex subunit 7

UniProtKB Accession Codes:

P14927 E5RJU0 Q6FGD1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 CarbonylDB 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 9 EMBL 15 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 3 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3056408

Title: Cloning and sequencing of a cDNA for human mitochondrial ubiquinone-binding protein of complex III.

PubMed ID: 3056408

DOI: 10.1016/s0006-291x(88)80941-0

PubMed ID: 2543413

Title: Isolation of a single nuclear gene encoding human ubiquinone-binding protein in complex III of mitochondrial respiratory chain.

PubMed ID: 2543413

DOI: 10.1016/0006-291x(89)91607-0

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2159470

Title: Common protein-binding sites in the 5'-flanking regions of human genes for cytochrome c1 and ubiquinone-binding protein.

PubMed ID: 2159470

DOI: 10.1016/s0021-9258(19)39051-9

PubMed ID: 12709789

Title: A deletion in the human QP-C gene causes a complex III deficiency resulting in hypoglycaemia and lactic acidosis.

PubMed ID: 12709789

DOI: 10.1007/s00439-003-0946-0

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28844695

Title: Architecture of human mitochondrial respiratory megacomplex I2III2IV2.

PubMed ID: 28844695

DOI: 10.1016/j.cell.2017.07.050

Sequence Information:

  • Length: 111
  • Mass: 13530
  • Checksum: E61629D06DFA55B7
  • Sequence:
    • MAGKQAVSAS GKWLDGIRKW YYNAAGFNKL GLMRDDTIYE DEDVKEAIRR LPENLYNDRM 
FRIKRALDLN LKHQILPKEQ WTKYEEENFY LEPYLKEVIR ERKEREEWAK K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.