Details for: DSCAM

Gene ID: 1826

Symbol: DSCAM

Ensembl ID: ENSG00000171587

Description: DS cell adhesion molecule

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 8.65
    Marker Score: 46,492
  • Cell Name: granule cell (CL0000120)
    Fold Change: 7.99
    Marker Score: 60,278
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 7.55
    Marker Score: 17,356
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 6.19
    Marker Score: 209,023
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 4.73
    Marker Score: 24,789
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 4.45
    Marker Score: 5,551
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 4.04
    Marker Score: 1,811
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 3.25
    Marker Score: 10,909
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 3.07
    Marker Score: 3,800
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 3
    Marker Score: 1,086
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.99
    Marker Score: 1,148
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.98
    Marker Score: 5,007
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.97
    Marker Score: 8,467
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.96
    Marker Score: 1,471
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.88
    Marker Score: 13,319
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.87
    Marker Score: 22,007
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.87
    Marker Score: 8,223
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.74
    Marker Score: 104,094
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.73
    Marker Score: 40,790
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.62
    Marker Score: 1,097
  • Cell Name: bipolar neuron (CL0000103)
    Fold Change: 2.51
    Marker Score: 843
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.5
    Marker Score: 4,744
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.37
    Marker Score: 1,374
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.36
    Marker Score: 9,131
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.2
    Marker Score: 20,661
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.09
    Marker Score: 21,545
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.08
    Marker Score: 127,941
  • Cell Name: neuron (CL0000540)
    Fold Change: 2.05
    Marker Score: 8,334
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.99
    Marker Score: 1,115
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 1.98
    Marker Score: 602
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.97
    Marker Score: 1,616
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.95
    Marker Score: 534
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.93
    Marker Score: 18,315
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.89
    Marker Score: 910
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.88
    Marker Score: 16,149
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.84
    Marker Score: 953
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.7
    Marker Score: 3,465
  • Cell Name: monocyte (CL0000576)
    Fold Change: 1.68
    Marker Score: 2,179
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.65
    Marker Score: 2,547
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.61
    Marker Score: 503
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.6
    Marker Score: 59,097
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.56
    Marker Score: 31,124
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.54
    Marker Score: 1,015
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.44
    Marker Score: 1,659
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 867
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.33
    Marker Score: 798
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.3
    Marker Score: 1,450
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.29
    Marker Score: 27,549
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.25
    Marker Score: 749
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.25
    Marker Score: 19,613
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.16
    Marker Score: 1,004
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.1
    Marker Score: 4,593
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.1
    Marker Score: 4,549
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.05
    Marker Score: 717
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 796
  • Cell Name: T cell (CL0000084)
    Fold Change: 1.02
    Marker Score: 1,765
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,758
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,983
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,404
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.97
    Marker Score: 2,294
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.97
    Marker Score: 893
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.96
    Marker Score: 210
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,299
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.92
    Marker Score: 1,673
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,740
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.91
    Marker Score: 1,512
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.91
    Marker Score: 2,595
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.9
    Marker Score: 2,151
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,283
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.85
    Marker Score: 937
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.83
    Marker Score: 394
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.8
    Marker Score: 8,064
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.78
    Marker Score: 202
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,263
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 703
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 502
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.75
    Marker Score: 1,646
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.72
    Marker Score: 1,157
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 182
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.7
    Marker Score: 408
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.67
    Marker Score: 2,787
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 0.66
    Marker Score: 192
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.64
    Marker Score: 438
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.64
    Marker Score: 179
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.64
    Marker Score: 3,819
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.63
    Marker Score: 254
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.61
    Marker Score: 2,571
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.61
    Marker Score: 485
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.59
    Marker Score: 261
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 151
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.57
    Marker Score: 555
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.56
    Marker Score: 230
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 235
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.55
    Marker Score: 521
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.54
    Marker Score: 314
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.53
    Marker Score: 400
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.52
    Marker Score: 3,461
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.51
    Marker Score: 615

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DSCAM is a transmembrane protein consisting of an extracellular immunoglobulin-like domain and a cytoplasmic tail. Its unique structure allows it to engage in both homophilic and heterophilic interactions with other DSCAM molecules and other ligands, such as netrins and semaphorins. This versatility enables DSCAM to participate in various signaling pathways, including those involved in axon guidance, cell adhesion, and immune responses. **Pathways and Functions:** DSCAM's involvement in multiple signaling pathways underscores its multifunctional nature. Some of the key pathways and functions associated with DSCAM include: 1. **Axon guidance**: DSCAM's interaction with netrins and semaphorins regulates axon extension and guidance during neural development. 2. **Cell adhesion**: DSCAM's homophilic and heterophilic interactions facilitate cell-cell adhesion, modulating the behavior of neurons, glial cells, and immune cells. 3. **Immune responses**: DSCAM has been implicated in the regulation of immune responses, particularly in the context of autoimmune diseases and cancer. 4. **Neurodevelopment**: DSCAM's expression in the developing nervous system suggests its importance in neural patterning and organization. **Clinical Significance:** DSCAM's involvement in various biological processes has far-reaching implications for human health and disease. Some of the clinical significance of DSCAM includes: 1. **Autoimmune diseases**: DSCAM's role in immune responses makes it a potential target for the treatment of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer**: DSCAM's expression in cancer cells suggests its involvement in tumor progression and metastasis. 3. **Neurological disorders**: DSCAM's involvement in neural development and function implies its potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Neuropsychiatric disorders**: DSCAM's expression in the brain and its involvement in immune responses may also contribute to the pathogenesis of neuropsychiatric disorders, such as schizophrenia and autism. In conclusion, DSCAM is a complex and multifunctional protein that plays a critical role in various biological processes, including cell adhesion, axon guidance, and immune responses. Its clinical significance extends to autoimmune diseases, cancer, neurological disorders, and neuropsychiatric disorders, highlighting the need for further research into the mechanisms underlying DSCAM's functions and its potential therapeutic applications.

Genular Protein ID: 1583329412

Symbol: DSCAM_HUMAN

Name: CHD2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9426258

Title: DSCAM: a novel member of the immunoglobulin superfamily maps in a Down syndrome region and is involved in the development of the nervous system.

PubMed ID: 9426258

DOI: 10.1093/hmg/7.2.227

PubMed ID: 10925149

Title: Down syndrome cell adhesion molecule DSCAM mediates homophilic intercellular adhesion.

PubMed ID: 10925149

DOI: 10.1016/s0169-328x(00)00108-x

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15169762

Title: The Down syndrome cell adhesion molecule (DSCAM) interacts with and activates Pak.

PubMed ID: 15169762

DOI: 10.1074/jbc.m401878200

PubMed ID: 26048998

Title: The Down syndrome cell adhesion molecule (DSCAM) interacts with and activates Pak.

PubMed ID: 26048998

DOI: 10.1074/jbc.a115.401878

PubMed ID: 18585357

Title: DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1.

PubMed ID: 18585357

DOI: 10.1016/j.cell.2008.05.030

PubMed ID: 19196994

Title: DSCAM functions as a netrin receptor in commissural axon pathfinding.

PubMed ID: 19196994

DOI: 10.1073/pnas.0811083106

PubMed ID: 22685302

Title: Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse.

PubMed ID: 22685302

DOI: 10.1074/jbc.m112.340174

Sequence Information:

  • Length: 2012
  • Mass: 222260
  • Checksum: 0E33CFB781A08334
  • Sequence:
  • MWILALSLFQ SFANVFSEDL HSSLYFVNAS LQEVVFASTT GTLVPCPAAG IPPVTLRWYL 
    ATGEEIYDVP GIRHVHPNGT LQIFPFPPSS FSTLIHDNTY YCTAENPSGK IRSQDVHIKA 
    VLREPYTVRV EDQKTMRGNV AVFKCIIPSS VEAYITVVSW EKDTVSLVSG SRFLITSTGA 
    LYIKDVQNED GLYNYRCITR HRYTGETRQS NSARLFVSDP ANSAPSILDG FDHRKAMAGQ 
    RVELPCKALG HPEPDYRWLK DNMPLELSGR FQKTVTGLLI ENIRPSDSGS YVCEVSNRYG 
    TAKVIGRLYV KQPLKATISP RKVKSSVGSQ VSLSCSVTGT EDQELSWYRN GEILNPGKNV 
    RITGINHENL IMDHMVKSDG GAYQCFVRKD KLSAQDYVQV VLEDGTPKII SAFSEKVVSP 
    AEPVSLMCNV KGTPLPTITW TLDDDPILKG GSHRISQMIT SEGNVVSYLN ISSSQVRDGG 
    VYRCTANNSA GVVLYQARIN VRGPASIRPM KNITAIAGRD TYIHCRVIGY PYYSIKWYKN 
    SNLLPFNHRQ VAFENNGTLK LSDVQKEVDE GEYTCNVLVQ PQLSTSQSVH VTVKVPPFIQ 
    PFEFPRFSIG QRVFIPCVVV SGDLPITITW QKDGRPIPGS LGVTIDNIDF TSSLRISNLS 
    LMHNGNYTCI ARNEAAAVEH QSQLIVRVPP KFVVQPRDQD GIYGKAVILN CSAEGYPVPT 
    IVWKFSKGAG VPQFQPIALN GRIQVLSNGS LLIKHVVEED SGYYLCKVSN DVGADVSKSM 
    YLTVKIPAMI TSYPNTTLAT QGQKKEMSCT AHGEKPIIVR WEKEDRIINP EMARYLVSTK 
    EVGEEVISTL QILPTVREDS GFFSCHAINS YGEDRGIIQL TVQEPPDPPE IEIKDVKART 
    ITLRWTMGFD GNSPITGYDI ECKNKSDSWD SAQRTKDVSP QLNSATIIDI HPSSTYSIRM 
    YAKNRIGKSE PSNELTITAD EAAPDGPPQE VHLEPISSQS IRVTWKAPKK HLQNGIIRGY 
    QIGYREYSTG GNFQFNIISV DTSGDSEVYT LDNLNKFTQY GLVVQACNRA GTGPSSQEII 
    TTTLEDVPSY PPENVQAIAT SPESISISWS TLSKEALNGI LQGFRVIYWA NLMDGELGEI 
    KNITTTQPSL ELDGLEKYTN YSIQVLAFTR AGDGVRSEQI FTRTKEDVPG PPAGVKAAAA 
    SASMVFVSWL PPLKLNGIIR KYTVFCSHPY PTVISEFEAS PDSFSYRIPN LSRNRQYSVW 
    VVAVTSAGRG NSSEIITVEP LAKAPARILT FSGTVTTPWM KDIVLPCKAV GDPSPAVKWM 
    KDSNGTPSLV TIDGRRSIFS NGSFIIRTVK AEDSGYYSCI ANNNWGSDEI ILNLQVQVPP 
    DQPRLTVSKT TSSSITLSWL PGDNGGSSIR GYILQYSEDN SEQWGSFPIS PSERSYRLEN 
    LKCGTWYKFT LTAQNGVGPG RISEIIEAKT LGKEPQFSKE QELFASINTT RVRLNLIGWN 
    DGGCPITSFT LEYRPFGTTV WTTAQRTSLS KSYILYDLQE ATWYELQMRV CNSAGCAEKQ 
    ANFATLNYDG STIPPLIKSV VQNEEGLTTN EGLKMLVTIS CILVGVLLLF VLLLVVRRRR 
    REQRLKRLRD AKSLAEMLMS KNTRTSDTLS KQQQTLRMHI DIPRAQLLIE ERDTMETIDD 
    RSTVLLTDAD FGEAAKQKSL TVTHTVHYQS VSQATGPLVD VSDARPGTNP TTRRNAKAGP 
    TARNRYASQW TLNRPHPTIS AHTLTTDWRL PTPRAAGSVD KESDSYSVSP SQDTDRARSS 
    MVSTESASST YEELARAYEH AKMEEQLRHA KFTITECFIS DTSSEQLTAG TNEYTDSLTS 
    STPSESGICR FTASPPKPQD GGRVMNMAVP KAHRPGDLIH LPPYLRMDFL LNRGGPGTSR 
    DLSLGQACLE PQKSRTLKRP TVLEPIPMEA ASSASSTREG QSWQPGAVAT LPQREGAELG 
    QAAKMSSSQE SLLDSRGHLK GNNPYAKSYT LV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.