Details for: DSCAM
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 207.8610
Cell Significance Index: -84.4500 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 9.4536
Cell Significance Index: -20.6900 - Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: 7.6050
Cell Significance Index: 79.2200 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 6.5682
Cell Significance Index: 2355.9000 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 4.2055
Cell Significance Index: 2908.6700 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: 3.7355
Cell Significance Index: 49.8300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 3.5881
Cell Significance Index: 719.7600 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 3.5392
Cell Significance Index: 134.0200 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 2.1538
Cell Significance Index: 47.1600 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: 1.4549
Cell Significance Index: 18.1400 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.7101
Cell Significance Index: 31.4100 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: 0.3557
Cell Significance Index: 4.4900 - Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
Fold Change: 0.3290
Cell Significance Index: 3.6300 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.1121
Cell Significance Index: 3.6700 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0846
Cell Significance Index: 1.4500 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.0694
Cell Significance Index: 0.6600 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 0.0606
Cell Significance Index: 0.6600 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0029
Cell Significance Index: 5.5200 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0109
Cell Significance Index: -16.8500 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0203
Cell Significance Index: -37.3600 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.0329
Cell Significance Index: -0.6600 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0350
Cell Significance Index: -47.6400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0633
Cell Significance Index: -46.9200 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0912
Cell Significance Index: -57.9200 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: -0.1115
Cell Significance Index: -0.9200 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.1185
Cell Significance Index: -4.8600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1195
Cell Significance Index: -67.3700 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.1244
Cell Significance Index: -94.1600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1303
Cell Significance Index: -81.3900 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1339
Cell Significance Index: -60.7700 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.1349
Cell Significance Index: -59.6500 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.1407
Cell Significance Index: -76.8200 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.1731
Cell Significance Index: -8.7500 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1925
Cell Significance Index: -6.1300 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.1945
Cell Significance Index: -38.5900 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2224
Cell Significance Index: -64.0000 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.3897
Cell Significance Index: -82.0800 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.4224
Cell Significance Index: -76.1400 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.4846
Cell Significance Index: -82.7400 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.5182
Cell Significance Index: -75.3200 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.5447
Cell Significance Index: -69.8300 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.5595
Cell Significance Index: -76.8300 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.5620
Cell Significance Index: -14.0200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.5639
Cell Significance Index: -15.7600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.6549
Cell Significance Index: -80.5200 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.6615
Cell Significance Index: -68.8800 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.8053
Cell Significance Index: -35.0200 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.8137
Cell Significance Index: -28.5100 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.8271
Cell Significance Index: -96.3900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.8364
Cell Significance Index: -95.8200 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.8376
Cell Significance Index: -59.2400 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.8870
Cell Significance Index: -49.7800 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.8896
Cell Significance Index: -68.2700 - Cell Name: neuron (CL0000540)
Fold Change: -0.9262
Cell Significance Index: -8.7800 - Cell Name: neural cell (CL0002319)
Fold Change: -0.9472
Cell Significance Index: -11.0500 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.9763
Cell Significance Index: -99.7300 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.9907
Cell Significance Index: -21.4100 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -1.0088
Cell Significance Index: -21.4100 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -1.0515
Cell Significance Index: -55.2100 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: -1.1578
Cell Significance Index: -14.6100 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: -1.1640
Cell Significance Index: -13.9200 - Cell Name: pyramidal neuron (CL0000598)
Fold Change: -1.2073
Cell Significance Index: -9.2600 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -1.2117
Cell Significance Index: -29.3500 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -1.2674
Cell Significance Index: -15.7200 - Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: -1.2750
Cell Significance Index: -16.6400 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -1.3351
Cell Significance Index: -26.4000 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -1.3684
Cell Significance Index: -26.9300 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -1.5618
Cell Significance Index: -72.8200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -1.6242
Cell Significance Index: -84.6000 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -1.7536
Cell Significance Index: -36.6000 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -1.7730
Cell Significance Index: -62.3000 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -1.7879
Cell Significance Index: -47.7400 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -1.8707
Cell Significance Index: -32.3500 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -1.8735
Cell Significance Index: -37.3600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -1.8973
Cell Significance Index: -89.1700 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -1.9086
Cell Significance Index: -49.0600 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -1.9426
Cell Significance Index: -48.5600 - Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: -1.9630
Cell Significance Index: -23.8000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -2.0648
Cell Significance Index: -93.5900 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -2.1536
Cell Significance Index: -62.0500 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -2.1747
Cell Significance Index: -44.2500 - Cell Name: diffuse bipolar 2 cell (CL4033028)
Fold Change: -2.1859
Cell Significance Index: -26.8500 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -2.1891
Cell Significance Index: -31.3500 - Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -2.4411
Cell Significance Index: -32.5400 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -2.4603
Cell Significance Index: -16.6700 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: -2.6192
Cell Significance Index: -20.8400 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -2.7969
Cell Significance Index: -58.0200 - Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: -2.8128
Cell Significance Index: -22.0600 - Cell Name: keratinocyte (CL0000312)
Fold Change: -2.8691
Cell Significance Index: -71.6600 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -2.8749
Cell Significance Index: -99.9000 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -2.9790
Cell Significance Index: -94.2200 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: -2.9991
Cell Significance Index: -30.2100 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -3.0132
Cell Significance Index: -65.2800 - Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
Fold Change: -3.0155
Cell Significance Index: -30.4700 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -3.0787
Cell Significance Index: -83.8000 - Cell Name: peg cell (CL4033014)
Fold Change: -3.0961
Cell Significance Index: -71.5300 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron (CL4030065)
Fold Change: -3.1371
Cell Significance Index: -32.7800 - Cell Name: erythrocyte (CL0000232)
Fold Change: -3.1718
Cell Significance Index: -80.8100 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -3.1751
Cell Significance Index: -66.4600 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -3.2189
Cell Significance Index: -78.5400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1583329412
Symbol: DSCAM_HUMAN
Name: CHD2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9426258
Title: DSCAM: a novel member of the immunoglobulin superfamily maps in a Down syndrome region and is involved in the development of the nervous system.
PubMed ID: 9426258
DOI: 10.1093/hmg/7.2.227
PubMed ID: 10925149
Title: Down syndrome cell adhesion molecule DSCAM mediates homophilic intercellular adhesion.
PubMed ID: 10925149
PubMed ID: 10830953
PubMed ID: 15169762
Title: The Down syndrome cell adhesion molecule (DSCAM) interacts with and activates Pak.
PubMed ID: 15169762
PubMed ID: 26048998
Title: The Down syndrome cell adhesion molecule (DSCAM) interacts with and activates Pak.
PubMed ID: 26048998
PubMed ID: 18585357
Title: DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1.
PubMed ID: 18585357
PubMed ID: 19196994
Title: DSCAM functions as a netrin receptor in commissural axon pathfinding.
PubMed ID: 19196994
PubMed ID: 22685302
Title: Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse.
PubMed ID: 22685302
Sequence Information:
- Length: 2012
- Mass: 222260
- Checksum: 0E33CFB781A08334
- Sequence:
MWILALSLFQ SFANVFSEDL HSSLYFVNAS LQEVVFASTT GTLVPCPAAG IPPVTLRWYL ATGEEIYDVP GIRHVHPNGT LQIFPFPPSS FSTLIHDNTY YCTAENPSGK IRSQDVHIKA VLREPYTVRV EDQKTMRGNV AVFKCIIPSS VEAYITVVSW EKDTVSLVSG SRFLITSTGA LYIKDVQNED GLYNYRCITR HRYTGETRQS NSARLFVSDP ANSAPSILDG FDHRKAMAGQ RVELPCKALG HPEPDYRWLK DNMPLELSGR FQKTVTGLLI ENIRPSDSGS YVCEVSNRYG TAKVIGRLYV KQPLKATISP RKVKSSVGSQ VSLSCSVTGT EDQELSWYRN GEILNPGKNV RITGINHENL IMDHMVKSDG GAYQCFVRKD KLSAQDYVQV VLEDGTPKII SAFSEKVVSP AEPVSLMCNV KGTPLPTITW TLDDDPILKG GSHRISQMIT SEGNVVSYLN ISSSQVRDGG VYRCTANNSA GVVLYQARIN VRGPASIRPM KNITAIAGRD TYIHCRVIGY PYYSIKWYKN SNLLPFNHRQ VAFENNGTLK LSDVQKEVDE GEYTCNVLVQ PQLSTSQSVH VTVKVPPFIQ PFEFPRFSIG QRVFIPCVVV SGDLPITITW QKDGRPIPGS LGVTIDNIDF TSSLRISNLS LMHNGNYTCI ARNEAAAVEH QSQLIVRVPP KFVVQPRDQD GIYGKAVILN CSAEGYPVPT IVWKFSKGAG VPQFQPIALN GRIQVLSNGS LLIKHVVEED SGYYLCKVSN DVGADVSKSM YLTVKIPAMI TSYPNTTLAT QGQKKEMSCT AHGEKPIIVR WEKEDRIINP EMARYLVSTK EVGEEVISTL QILPTVREDS GFFSCHAINS YGEDRGIIQL TVQEPPDPPE IEIKDVKART ITLRWTMGFD GNSPITGYDI ECKNKSDSWD SAQRTKDVSP QLNSATIIDI HPSSTYSIRM YAKNRIGKSE PSNELTITAD EAAPDGPPQE VHLEPISSQS IRVTWKAPKK HLQNGIIRGY QIGYREYSTG GNFQFNIISV DTSGDSEVYT LDNLNKFTQY GLVVQACNRA GTGPSSQEII TTTLEDVPSY PPENVQAIAT SPESISISWS TLSKEALNGI LQGFRVIYWA NLMDGELGEI KNITTTQPSL ELDGLEKYTN YSIQVLAFTR AGDGVRSEQI FTRTKEDVPG PPAGVKAAAA SASMVFVSWL PPLKLNGIIR KYTVFCSHPY PTVISEFEAS PDSFSYRIPN LSRNRQYSVW VVAVTSAGRG NSSEIITVEP LAKAPARILT FSGTVTTPWM KDIVLPCKAV GDPSPAVKWM KDSNGTPSLV TIDGRRSIFS NGSFIIRTVK AEDSGYYSCI ANNNWGSDEI ILNLQVQVPP DQPRLTVSKT TSSSITLSWL PGDNGGSSIR GYILQYSEDN SEQWGSFPIS PSERSYRLEN LKCGTWYKFT LTAQNGVGPG RISEIIEAKT LGKEPQFSKE QELFASINTT RVRLNLIGWN DGGCPITSFT LEYRPFGTTV WTTAQRTSLS KSYILYDLQE ATWYELQMRV CNSAGCAEKQ ANFATLNYDG STIPPLIKSV VQNEEGLTTN EGLKMLVTIS CILVGVLLLF VLLLVVRRRR REQRLKRLRD AKSLAEMLMS KNTRTSDTLS KQQQTLRMHI DIPRAQLLIE ERDTMETIDD RSTVLLTDAD FGEAAKQKSL TVTHTVHYQS VSQATGPLVD VSDARPGTNP TTRRNAKAGP TARNRYASQW TLNRPHPTIS AHTLTTDWRL PTPRAAGSVD KESDSYSVSP SQDTDRARSS MVSTESASST YEELARAYEH AKMEEQLRHA KFTITECFIS DTSSEQLTAG TNEYTDSLTS STPSESGICR FTASPPKPQD GGRVMNMAVP KAHRPGDLIH LPPYLRMDFL LNRGGPGTSR DLSLGQACLE PQKSRTLKRP TVLEPIPMEA ASSASSTREG QSWQPGAVAT LPQREGAELG QAAKMSSSQE SLLDSRGHLK GNNPYAKSYT LV
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.