Details for: DSCAM

Gene ID: 1826

Symbol: DSCAM

Ensembl ID: ENSG00000171587

Description: DS cell adhesion molecule

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 207.8610
    Cell Significance Index: -84.4500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.4536
    Cell Significance Index: -20.6900
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 7.6050
    Cell Significance Index: 79.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 6.5682
    Cell Significance Index: 2355.9000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 4.2055
    Cell Significance Index: 2908.6700
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 3.7355
    Cell Significance Index: 49.8300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.5881
    Cell Significance Index: 719.7600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 3.5392
    Cell Significance Index: 134.0200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.1538
    Cell Significance Index: 47.1600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 1.4549
    Cell Significance Index: 18.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.7101
    Cell Significance Index: 31.4100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: 0.3557
    Cell Significance Index: 4.4900
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.3290
    Cell Significance Index: 3.6300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.1121
    Cell Significance Index: 3.6700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0846
    Cell Significance Index: 1.4500
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.0694
    Cell Significance Index: 0.6600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0606
    Cell Significance Index: 0.6600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0029
    Cell Significance Index: 5.5200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0109
    Cell Significance Index: -16.8500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0203
    Cell Significance Index: -37.3600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0329
    Cell Significance Index: -0.6600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0350
    Cell Significance Index: -47.6400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0633
    Cell Significance Index: -46.9200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0912
    Cell Significance Index: -57.9200
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1115
    Cell Significance Index: -0.9200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1185
    Cell Significance Index: -4.8600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1195
    Cell Significance Index: -67.3700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1244
    Cell Significance Index: -94.1600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1303
    Cell Significance Index: -81.3900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1339
    Cell Significance Index: -60.7700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.1349
    Cell Significance Index: -59.6500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.1407
    Cell Significance Index: -76.8200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1731
    Cell Significance Index: -8.7500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1925
    Cell Significance Index: -6.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1945
    Cell Significance Index: -38.5900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2224
    Cell Significance Index: -64.0000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3897
    Cell Significance Index: -82.0800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.4224
    Cell Significance Index: -76.1400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.4846
    Cell Significance Index: -82.7400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5182
    Cell Significance Index: -75.3200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.5447
    Cell Significance Index: -69.8300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.5595
    Cell Significance Index: -76.8300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5620
    Cell Significance Index: -14.0200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5639
    Cell Significance Index: -15.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.6549
    Cell Significance Index: -80.5200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6615
    Cell Significance Index: -68.8800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.8053
    Cell Significance Index: -35.0200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8137
    Cell Significance Index: -28.5100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.8271
    Cell Significance Index: -96.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.8364
    Cell Significance Index: -95.8200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.8376
    Cell Significance Index: -59.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.8870
    Cell Significance Index: -49.7800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.8896
    Cell Significance Index: -68.2700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.9262
    Cell Significance Index: -8.7800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.9472
    Cell Significance Index: -11.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.9763
    Cell Significance Index: -99.7300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.9907
    Cell Significance Index: -21.4100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.0088
    Cell Significance Index: -21.4100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.0515
    Cell Significance Index: -55.2100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -1.1578
    Cell Significance Index: -14.6100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -1.1640
    Cell Significance Index: -13.9200
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -1.2073
    Cell Significance Index: -9.2600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -1.2117
    Cell Significance Index: -29.3500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -1.2674
    Cell Significance Index: -15.7200
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -1.2750
    Cell Significance Index: -16.6400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.3351
    Cell Significance Index: -26.4000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -1.3684
    Cell Significance Index: -26.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.5618
    Cell Significance Index: -72.8200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.6242
    Cell Significance Index: -84.6000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.7536
    Cell Significance Index: -36.6000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.7730
    Cell Significance Index: -62.3000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.7879
    Cell Significance Index: -47.7400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.8707
    Cell Significance Index: -32.3500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -1.8735
    Cell Significance Index: -37.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -1.8973
    Cell Significance Index: -89.1700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.9086
    Cell Significance Index: -49.0600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.9426
    Cell Significance Index: -48.5600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -1.9630
    Cell Significance Index: -23.8000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -2.0648
    Cell Significance Index: -93.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -2.1536
    Cell Significance Index: -62.0500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -2.1747
    Cell Significance Index: -44.2500
  • Cell Name: diffuse bipolar 2 cell (CL4033028)
    Fold Change: -2.1859
    Cell Significance Index: -26.8500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -2.1891
    Cell Significance Index: -31.3500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -2.4411
    Cell Significance Index: -32.5400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -2.4603
    Cell Significance Index: -16.6700
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -2.6192
    Cell Significance Index: -20.8400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -2.7969
    Cell Significance Index: -58.0200
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -2.8128
    Cell Significance Index: -22.0600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -2.8691
    Cell Significance Index: -71.6600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -2.8749
    Cell Significance Index: -99.9000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -2.9790
    Cell Significance Index: -94.2200
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -2.9991
    Cell Significance Index: -30.2100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -3.0132
    Cell Significance Index: -65.2800
  • Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
    Fold Change: -3.0155
    Cell Significance Index: -30.4700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -3.0787
    Cell Significance Index: -83.8000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -3.0961
    Cell Significance Index: -71.5300
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron (CL4030065)
    Fold Change: -3.1371
    Cell Significance Index: -32.7800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -3.1718
    Cell Significance Index: -80.8100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -3.1751
    Cell Significance Index: -66.4600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -3.2189
    Cell Significance Index: -78.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DSCAM is a transmembrane protein consisting of an extracellular immunoglobulin-like domain and a cytoplasmic tail. Its unique structure allows it to engage in both homophilic and heterophilic interactions with other DSCAM molecules and other ligands, such as netrins and semaphorins. This versatility enables DSCAM to participate in various signaling pathways, including those involved in axon guidance, cell adhesion, and immune responses. **Pathways and Functions:** DSCAM's involvement in multiple signaling pathways underscores its multifunctional nature. Some of the key pathways and functions associated with DSCAM include: 1. **Axon guidance**: DSCAM's interaction with netrins and semaphorins regulates axon extension and guidance during neural development. 2. **Cell adhesion**: DSCAM's homophilic and heterophilic interactions facilitate cell-cell adhesion, modulating the behavior of neurons, glial cells, and immune cells. 3. **Immune responses**: DSCAM has been implicated in the regulation of immune responses, particularly in the context of autoimmune diseases and cancer. 4. **Neurodevelopment**: DSCAM's expression in the developing nervous system suggests its importance in neural patterning and organization. **Clinical Significance:** DSCAM's involvement in various biological processes has far-reaching implications for human health and disease. Some of the clinical significance of DSCAM includes: 1. **Autoimmune diseases**: DSCAM's role in immune responses makes it a potential target for the treatment of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer**: DSCAM's expression in cancer cells suggests its involvement in tumor progression and metastasis. 3. **Neurological disorders**: DSCAM's involvement in neural development and function implies its potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Neuropsychiatric disorders**: DSCAM's expression in the brain and its involvement in immune responses may also contribute to the pathogenesis of neuropsychiatric disorders, such as schizophrenia and autism. In conclusion, DSCAM is a complex and multifunctional protein that plays a critical role in various biological processes, including cell adhesion, axon guidance, and immune responses. Its clinical significance extends to autoimmune diseases, cancer, neurological disorders, and neuropsychiatric disorders, highlighting the need for further research into the mechanisms underlying DSCAM's functions and its potential therapeutic applications.

Genular Protein ID: 1583329412

Symbol: DSCAM_HUMAN

Name: CHD2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9426258

Title: DSCAM: a novel member of the immunoglobulin superfamily maps in a Down syndrome region and is involved in the development of the nervous system.

PubMed ID: 9426258

DOI: 10.1093/hmg/7.2.227

PubMed ID: 10925149

Title: Down syndrome cell adhesion molecule DSCAM mediates homophilic intercellular adhesion.

PubMed ID: 10925149

DOI: 10.1016/s0169-328x(00)00108-x

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15169762

Title: The Down syndrome cell adhesion molecule (DSCAM) interacts with and activates Pak.

PubMed ID: 15169762

DOI: 10.1074/jbc.m401878200

PubMed ID: 26048998

Title: The Down syndrome cell adhesion molecule (DSCAM) interacts with and activates Pak.

PubMed ID: 26048998

DOI: 10.1074/jbc.a115.401878

PubMed ID: 18585357

Title: DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1.

PubMed ID: 18585357

DOI: 10.1016/j.cell.2008.05.030

PubMed ID: 19196994

Title: DSCAM functions as a netrin receptor in commissural axon pathfinding.

PubMed ID: 19196994

DOI: 10.1073/pnas.0811083106

PubMed ID: 22685302

Title: Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse.

PubMed ID: 22685302

DOI: 10.1074/jbc.m112.340174

Sequence Information:

  • Length: 2012
  • Mass: 222260
  • Checksum: 0E33CFB781A08334
  • Sequence:
  • MWILALSLFQ SFANVFSEDL HSSLYFVNAS LQEVVFASTT GTLVPCPAAG IPPVTLRWYL 
    ATGEEIYDVP GIRHVHPNGT LQIFPFPPSS FSTLIHDNTY YCTAENPSGK IRSQDVHIKA 
    VLREPYTVRV EDQKTMRGNV AVFKCIIPSS VEAYITVVSW EKDTVSLVSG SRFLITSTGA 
    LYIKDVQNED GLYNYRCITR HRYTGETRQS NSARLFVSDP ANSAPSILDG FDHRKAMAGQ 
    RVELPCKALG HPEPDYRWLK DNMPLELSGR FQKTVTGLLI ENIRPSDSGS YVCEVSNRYG 
    TAKVIGRLYV KQPLKATISP RKVKSSVGSQ VSLSCSVTGT EDQELSWYRN GEILNPGKNV 
    RITGINHENL IMDHMVKSDG GAYQCFVRKD KLSAQDYVQV VLEDGTPKII SAFSEKVVSP 
    AEPVSLMCNV KGTPLPTITW TLDDDPILKG GSHRISQMIT SEGNVVSYLN ISSSQVRDGG 
    VYRCTANNSA GVVLYQARIN VRGPASIRPM KNITAIAGRD TYIHCRVIGY PYYSIKWYKN 
    SNLLPFNHRQ VAFENNGTLK LSDVQKEVDE GEYTCNVLVQ PQLSTSQSVH VTVKVPPFIQ 
    PFEFPRFSIG QRVFIPCVVV SGDLPITITW QKDGRPIPGS LGVTIDNIDF TSSLRISNLS 
    LMHNGNYTCI ARNEAAAVEH QSQLIVRVPP KFVVQPRDQD GIYGKAVILN CSAEGYPVPT 
    IVWKFSKGAG VPQFQPIALN GRIQVLSNGS LLIKHVVEED SGYYLCKVSN DVGADVSKSM 
    YLTVKIPAMI TSYPNTTLAT QGQKKEMSCT AHGEKPIIVR WEKEDRIINP EMARYLVSTK 
    EVGEEVISTL QILPTVREDS GFFSCHAINS YGEDRGIIQL TVQEPPDPPE IEIKDVKART 
    ITLRWTMGFD GNSPITGYDI ECKNKSDSWD SAQRTKDVSP QLNSATIIDI HPSSTYSIRM 
    YAKNRIGKSE PSNELTITAD EAAPDGPPQE VHLEPISSQS IRVTWKAPKK HLQNGIIRGY 
    QIGYREYSTG GNFQFNIISV DTSGDSEVYT LDNLNKFTQY GLVVQACNRA GTGPSSQEII 
    TTTLEDVPSY PPENVQAIAT SPESISISWS TLSKEALNGI LQGFRVIYWA NLMDGELGEI 
    KNITTTQPSL ELDGLEKYTN YSIQVLAFTR AGDGVRSEQI FTRTKEDVPG PPAGVKAAAA 
    SASMVFVSWL PPLKLNGIIR KYTVFCSHPY PTVISEFEAS PDSFSYRIPN LSRNRQYSVW 
    VVAVTSAGRG NSSEIITVEP LAKAPARILT FSGTVTTPWM KDIVLPCKAV GDPSPAVKWM 
    KDSNGTPSLV TIDGRRSIFS NGSFIIRTVK AEDSGYYSCI ANNNWGSDEI ILNLQVQVPP 
    DQPRLTVSKT TSSSITLSWL PGDNGGSSIR GYILQYSEDN SEQWGSFPIS PSERSYRLEN 
    LKCGTWYKFT LTAQNGVGPG RISEIIEAKT LGKEPQFSKE QELFASINTT RVRLNLIGWN 
    DGGCPITSFT LEYRPFGTTV WTTAQRTSLS KSYILYDLQE ATWYELQMRV CNSAGCAEKQ 
    ANFATLNYDG STIPPLIKSV VQNEEGLTTN EGLKMLVTIS CILVGVLLLF VLLLVVRRRR 
    REQRLKRLRD AKSLAEMLMS KNTRTSDTLS KQQQTLRMHI DIPRAQLLIE ERDTMETIDD 
    RSTVLLTDAD FGEAAKQKSL TVTHTVHYQS VSQATGPLVD VSDARPGTNP TTRRNAKAGP 
    TARNRYASQW TLNRPHPTIS AHTLTTDWRL PTPRAAGSVD KESDSYSVSP SQDTDRARSS 
    MVSTESASST YEELARAYEH AKMEEQLRHA KFTITECFIS DTSSEQLTAG TNEYTDSLTS 
    STPSESGICR FTASPPKPQD GGRVMNMAVP KAHRPGDLIH LPPYLRMDFL LNRGGPGTSR 
    DLSLGQACLE PQKSRTLKRP TVLEPIPMEA ASSASSTREG QSWQPGAVAT LPQREGAELG 
    QAAKMSSSQE SLLDSRGHLK GNNPYAKSYT LV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.