DSCAM | ENSG00000171587 | NCBI 1826

Details for: DSCAM

Gene ID: 1826

Symbol: DSCAM

Ensembl ID: ENSG00000171587

Description: DS cell adhesion molecule

Associated with

Developmental biology
(R-HSA-1266738)
Dscam interactions
(R-HSA-376172)
Netrin-1 signaling
(R-HSA-373752)
Axon
(GO:0030424)
Axon guidance
(GO:0007411)
Camera-type eye photoreceptor cell differentiation
(GO:0060219)
Cell-cell adhesion mediator activity
(GO:0098632)
Cell adhesion
(GO:0007155)
Central nervous system development
(GO:0007417)
Dendrite
(GO:0030425)
Dendrite morphogenesis
(GO:0048813)
Dendrite self-avoidance
(GO:0070593)
Extracellular region
(GO:0005576)
Growth cone
(GO:0030426)
Homophilic cell adhesion via plasma membrane adhesion molecules
(GO:0007156)
Locomotory behavior
(GO:0007626)
Membrane
(GO:0016020)
Negative regulation of cell adhesion
(GO:0007162)
Nervous system development
(GO:0007399)
Netrin-activated signaling pathway
(GO:0038007)
Netrin receptor binding
(GO:1990890)
Neuronal cell body
(GO:0043025)
Plasma membrane
(GO:0005886)
Positive regulation of axon extension involved in axon guidance
(GO:0048842)
Positive regulation of phosphorylation
(GO:0042327)
Post-embryonic retina morphogenesis in camera-type eye
(GO:0060060)
Protein binding
(GO:0005515)
Protein tyrosine kinase binding
(GO:1990782)
Retina layer formation
(GO:0010842)
Synapse
(GO:0045202)
Synapse assembly
(GO:0007416)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: stellate neuron (CL0000122)
Fold Change: 8.65
Marker Score: 46,492
Cell Name: granule cell (CL0000120)
Fold Change: 7.99
Marker Score: 60,278
Cell Name: macroglial cell (CL0000126)
Fold Change: 7.55
Marker Score: 17,356
Cell Name: Purkinje cell (CL0000121)
Fold Change: 6.19
Marker Score: 209,023
Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 4.73
Marker Score: 24,789
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 4.45
Marker Score: 5,551
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 4.04
Marker Score: 1,811
Cell Name: neuronal brush cell (CL0000555)
Fold Change: 3.25
Marker Score: 10,909
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 3.07
Marker Score: 3,800
Cell Name: mature microglial cell (CL0002629)
Fold Change: 3
Marker Score: 1,086
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 2.99
Marker Score: 1,148
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 2.98
Marker Score: 5,007
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 2.97
Marker Score: 8,467
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 2.96
Marker Score: 1,471
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 2.88
Marker Score: 13,319
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 2.87
Marker Score: 22,007
Cell Name: retinal cone cell (CL0000573)
Fold Change: 2.87
Marker Score: 8,223
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 2.74
Marker Score: 104,094
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 2.73
Marker Score: 40,790
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 2.62
Marker Score: 1,097
Cell Name: bipolar neuron (CL0000103)
Fold Change: 2.51
Marker Score: 843
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 2.5
Marker Score: 4,744
Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 2.37
Marker Score: 1,374
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.36
Marker Score: 9,131
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 2.2
Marker Score: 20,661
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 2.09
Marker Score: 21,545
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.08
Marker Score: 127,941
Cell Name: neuron (CL0000540)
Fold Change: 2.05
Marker Score: 8,334
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 1.99
Marker Score: 1,115
Cell Name: ganglion interneuron (CL0000397)
Fold Change: 1.98
Marker Score: 602
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 1.97
Marker Score: 1,616
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 1.95
Marker Score: 534
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.93
Marker Score: 18,315
Cell Name: CNS interneuron (CL0000402)
Fold Change: 1.89
Marker Score: 910
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.88
Marker Score: 16,149
Cell Name: endocrine cell (CL0000163)
Fold Change: 1.84
Marker Score: 953
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.7
Marker Score: 3,465
Cell Name: monocyte (CL0000576)
Fold Change: 1.68
Marker Score: 2,179
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.65
Marker Score: 2,547
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.61
Marker Score: 503
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.6
Marker Score: 59,097
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.56
Marker Score: 31,124
Cell Name: mature astrocyte (CL0002627)
Fold Change: 1.54
Marker Score: 1,015
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.44
Marker Score: 1,659
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.37
Marker Score: 867
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.33
Marker Score: 798
Cell Name: macrophage (CL0000235)
Fold Change: 1.3
Marker Score: 1,450
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.29
Marker Score: 27,549
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 1.25
Marker Score: 749
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.25
Marker Score: 19,613
Cell Name: astrocyte (CL0000127)
Fold Change: 1.16
Marker Score: 1,004
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 1.1
Marker Score: 4,593
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.1
Marker Score: 4,549
Cell Name: dendritic cell (CL0000451)
Fold Change: 1.05
Marker Score: 717
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.04
Marker Score: 796
Cell Name: T cell (CL0000084)
Fold Change: 1.02
Marker Score: 1,765
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,758
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47,983
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,404
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.97
Marker Score: 2,294
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.97
Marker Score: 893
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.96
Marker Score: 210
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,413
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5,299
Cell Name: microglial cell (CL0000129)
Fold Change: 0.92
Marker Score: 1,673
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,740
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.91
Marker Score: 1,512
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.91
Marker Score: 2,595
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.9
Marker Score: 2,151
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,283
Cell Name: glial cell (CL0000125)
Fold Change: 0.85
Marker Score: 937
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.83
Marker Score: 394
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 0.8
Marker Score: 8,064
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.78
Marker Score: 202
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,263
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 400
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 703
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.76
Marker Score: 502
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.75
Marker Score: 1,646
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.72
Marker Score: 1,157
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.71
Marker Score: 182
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.7
Marker Score: 408
Cell Name: classical monocyte (CL0000860)
Fold Change: 0.67
Marker Score: 2,787
Cell Name: visceromotor neuron (CL0005025)
Fold Change: 0.66
Marker Score: 192
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.64
Marker Score: 438
Cell Name: meningeal macrophage (CL0000879)
Fold Change: 0.64
Marker Score: 179
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.64
Marker Score: 3,819
Cell Name: melanocyte (CL0000148)
Fold Change: 0.63
Marker Score: 254
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.61
Marker Score: 2,571
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.61
Marker Score: 485
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.59
Marker Score: 261
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.57
Marker Score: 151
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.57
Marker Score: 555
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.56
Marker Score: 230
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.56
Marker Score: 235
Cell Name: B cell (CL0000236)
Fold Change: 0.55
Marker Score: 521
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.54
Marker Score: 314
Cell Name: photoreceptor cell (CL0000210)
Fold Change: 0.53
Marker Score: 400
Cell Name: goblet cell (CL0000160)
Fold Change: 0.52
Marker Score: 3,461
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.51
Marker Score: 615

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

**Key Characteristics:** DSCAM is a transmembrane protein consisting of an extracellular immunoglobulin-like domain and a cytoplasmic tail. Its unique structure allows it to engage in both homophilic and heterophilic interactions with other DSCAM molecules and other ligands, such as netrins and semaphorins. This versatility enables DSCAM to participate in various signaling pathways, including those involved in axon guidance, cell adhesion, and immune responses. **Pathways and Functions:** DSCAM's involvement in multiple signaling pathways underscores its multifunctional nature. Some of the key pathways and functions associated with DSCAM include: 1. **Axon guidance**: DSCAM's interaction with netrins and semaphorins regulates axon extension and guidance during neural development. 2. **Cell adhesion**: DSCAM's homophilic and heterophilic interactions facilitate cell-cell adhesion, modulating the behavior of neurons, glial cells, and immune cells. 3. **Immune responses**: DSCAM has been implicated in the regulation of immune responses, particularly in the context of autoimmune diseases and cancer. 4. **Neurodevelopment**: DSCAM's expression in the developing nervous system suggests its importance in neural patterning and organization. **Clinical Significance:** DSCAM's involvement in various biological processes has far-reaching implications for human health and disease. Some of the clinical significance of DSCAM includes: 1. **Autoimmune diseases**: DSCAM's role in immune responses makes it a potential target for the treatment of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer**: DSCAM's expression in cancer cells suggests its involvement in tumor progression and metastasis. 3. **Neurological disorders**: DSCAM's involvement in neural development and function implies its potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Neuropsychiatric disorders**: DSCAM's expression in the brain and its involvement in immune responses may also contribute to the pathogenesis of neuropsychiatric disorders, such as schizophrenia and autism. In conclusion, DSCAM is a complex and multifunctional protein that plays a critical role in various biological processes, including cell adhesion, axon guidance, and immune responses. Its clinical significance extends to autoimmune diseases, cancer, neurological disorders, and neuropsychiatric disorders, highlighting the need for further research into the mechanisms underlying DSCAM's functions and its potential therapeutic applications.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

CHD2

Genular Protein ID: 1583329412

Symbol: DSCAM_HUMAN

Name: CHD2

UniProtKB Accession Codes:

O60469 O60468

Database IDs:

Citations:

PubMed ID: 9426258

Title: DSCAM: a novel member of the immunoglobulin superfamily maps in a Down syndrome region and is involved in the development of the nervous system.

PubMed ID: 9426258

DOI: 10.1093/hmg/7.2.227

PubMed ID: 10925149

Title: Down syndrome cell adhesion molecule DSCAM mediates homophilic intercellular adhesion.

PubMed ID: 10925149

DOI: 10.1016/s0169-328x(00)00108-x

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15169762

Title: The Down syndrome cell adhesion molecule (DSCAM) interacts with and activates Pak.

PubMed ID: 15169762

DOI: 10.1074/jbc.m401878200

PubMed ID: 26048998

Title: The Down syndrome cell adhesion molecule (DSCAM) interacts with and activates Pak.

PubMed ID: 26048998

DOI: 10.1074/jbc.a115.401878

PubMed ID: 18585357

Title: DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1.

PubMed ID: 18585357

DOI: 10.1016/j.cell.2008.05.030

PubMed ID: 19196994

Title: DSCAM functions as a netrin receptor in commissural axon pathfinding.

PubMed ID: 19196994

DOI: 10.1073/pnas.0811083106

PubMed ID: 22685302

Title: Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse.

PubMed ID: 22685302

DOI: 10.1074/jbc.m112.340174

Sequence Information:

Length: 2012
Mass: 222260
Checksum: 0E33CFB781A08334
Sequence:

MWILALSLFQ SFANVFSEDL HSSLYFVNAS LQEVVFASTT GTLVPCPAAG IPPVTLRWYL 
ATGEEIYDVP GIRHVHPNGT LQIFPFPPSS FSTLIHDNTY YCTAENPSGK IRSQDVHIKA 
VLREPYTVRV EDQKTMRGNV AVFKCIIPSS VEAYITVVSW EKDTVSLVSG SRFLITSTGA 
LYIKDVQNED GLYNYRCITR HRYTGETRQS NSARLFVSDP ANSAPSILDG FDHRKAMAGQ 
RVELPCKALG HPEPDYRWLK DNMPLELSGR FQKTVTGLLI ENIRPSDSGS YVCEVSNRYG 
TAKVIGRLYV KQPLKATISP RKVKSSVGSQ VSLSCSVTGT EDQELSWYRN GEILNPGKNV 
RITGINHENL IMDHMVKSDG GAYQCFVRKD KLSAQDYVQV VLEDGTPKII SAFSEKVVSP 
AEPVSLMCNV KGTPLPTITW TLDDDPILKG GSHRISQMIT SEGNVVSYLN ISSSQVRDGG 
VYRCTANNSA GVVLYQARIN VRGPASIRPM KNITAIAGRD TYIHCRVIGY PYYSIKWYKN 
SNLLPFNHRQ VAFENNGTLK LSDVQKEVDE GEYTCNVLVQ PQLSTSQSVH VTVKVPPFIQ 
PFEFPRFSIG QRVFIPCVVV SGDLPITITW QKDGRPIPGS LGVTIDNIDF TSSLRISNLS 
LMHNGNYTCI ARNEAAAVEH QSQLIVRVPP KFVVQPRDQD GIYGKAVILN CSAEGYPVPT 
IVWKFSKGAG VPQFQPIALN GRIQVLSNGS LLIKHVVEED SGYYLCKVSN DVGADVSKSM 
YLTVKIPAMI TSYPNTTLAT QGQKKEMSCT AHGEKPIIVR WEKEDRIINP EMARYLVSTK 
EVGEEVISTL QILPTVREDS GFFSCHAINS YGEDRGIIQL TVQEPPDPPE IEIKDVKART 
ITLRWTMGFD GNSPITGYDI ECKNKSDSWD SAQRTKDVSP QLNSATIIDI HPSSTYSIRM 
YAKNRIGKSE PSNELTITAD EAAPDGPPQE VHLEPISSQS IRVTWKAPKK HLQNGIIRGY 
QIGYREYSTG GNFQFNIISV DTSGDSEVYT LDNLNKFTQY GLVVQACNRA GTGPSSQEII 
TTTLEDVPSY PPENVQAIAT SPESISISWS TLSKEALNGI LQGFRVIYWA NLMDGELGEI 
KNITTTQPSL ELDGLEKYTN YSIQVLAFTR AGDGVRSEQI FTRTKEDVPG PPAGVKAAAA 
SASMVFVSWL PPLKLNGIIR KYTVFCSHPY PTVISEFEAS PDSFSYRIPN LSRNRQYSVW 
VVAVTSAGRG NSSEIITVEP LAKAPARILT FSGTVTTPWM KDIVLPCKAV GDPSPAVKWM 
KDSNGTPSLV TIDGRRSIFS NGSFIIRTVK AEDSGYYSCI ANNNWGSDEI ILNLQVQVPP 
DQPRLTVSKT TSSSITLSWL PGDNGGSSIR GYILQYSEDN SEQWGSFPIS PSERSYRLEN 
LKCGTWYKFT LTAQNGVGPG RISEIIEAKT LGKEPQFSKE QELFASINTT RVRLNLIGWN 
DGGCPITSFT LEYRPFGTTV WTTAQRTSLS KSYILYDLQE ATWYELQMRV CNSAGCAEKQ 
ANFATLNYDG STIPPLIKSV VQNEEGLTTN EGLKMLVTIS CILVGVLLLF VLLLVVRRRR 
REQRLKRLRD AKSLAEMLMS KNTRTSDTLS KQQQTLRMHI DIPRAQLLIE ERDTMETIDD 
RSTVLLTDAD FGEAAKQKSL TVTHTVHYQS VSQATGPLVD VSDARPGTNP TTRRNAKAGP 
TARNRYASQW TLNRPHPTIS AHTLTTDWRL PTPRAAGSVD KESDSYSVSP SQDTDRARSS 
MVSTESASST YEELARAYEH AKMEEQLRHA KFTITECFIS DTSSEQLTAG TNEYTDSLTS 
STPSESGICR FTASPPKPQD GGRVMNMAVP KAHRPGDLIH LPPYLRMDFL LNRGGPGTSR 
DLSLGQACLE PQKSRTLKRP TVLEPIPMEA ASSASSTREG QSWQPGAVAT LPQREGAELG 
QAAKMSSSQE SLLDSRGHLK GNNPYAKSYT LV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: DSCAM

Associated with

Cells (max top 100)

Other Information

DSCAM: a novel member of the immunoglobulin superfamily maps in a Down syndrome region and is involved in the development of the nervous system. PubMed ID: 9426258

Down syndrome cell adhesion molecule DSCAM mediates homophilic intercellular adhesion. PubMed ID: 10925149

The DNA sequence of human chromosome 21. PubMed ID: 10830953

The Down syndrome cell adhesion molecule (DSCAM) interacts with and activates Pak. PubMed ID: 15169762

The Down syndrome cell adhesion molecule (DSCAM) interacts with and activates Pak. PubMed ID: 26048998

DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1. PubMed ID: 18585357

DSCAM functions as a netrin receptor in commissural axon pathfinding. PubMed ID: 19196994

Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse. PubMed ID: 22685302