Details for: GABRG3

Gene ID: 2567

Symbol: GABRG3

Ensembl ID: ENSG00000182256

Description: gamma-aminobutyric acid type A receptor subunit gamma3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: interneuron (CL0000099)
    Fold Change: 6.15
    Marker Score: 2808.5
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 3.86
    Marker Score: 17841
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.71
    Marker Score: 40576
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.64
    Marker Score: 20241.5
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.62
    Marker Score: 10867
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.54
    Marker Score: 96544
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.43
    Marker Score: 89564
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.36
    Marker Score: 9108
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.25
    Marker Score: 4269
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.19
    Marker Score: 20560.5
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.11
    Marker Score: 41947
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.07
    Marker Score: 127430
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.97
    Marker Score: 5608
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.92
    Marker Score: 18237.5
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.88
    Marker Score: 16129
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.87
    Marker Score: 3144
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.77
    Marker Score: 7189
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.74
    Marker Score: 2409
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.72
    Marker Score: 3954
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.59
    Marker Score: 2458
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.59
    Marker Score: 712
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.49
    Marker Score: 3510
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.43
    Marker Score: 1144
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.37
    Marker Score: 2786
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 863.5
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.36
    Marker Score: 14006.5
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.2
    Marker Score: 2311.5
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.17
    Marker Score: 4889
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.12
    Marker Score: 673
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.05
    Marker Score: 229
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.04
    Marker Score: 326
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 790
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.03
    Marker Score: 16120
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.02
    Marker Score: 1378
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71795
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48020
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2426
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5317
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.84
    Marker Score: 631
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.78
    Marker Score: 455
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1258
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 706
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.77
    Marker Score: 447
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.75
    Marker Score: 497
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.73
    Marker Score: 190
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.71
    Marker Score: 4713
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.69
    Marker Score: 1254.5
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.67
    Marker Score: 829
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.64
    Marker Score: 307.5
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.59
    Marker Score: 195
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.59
    Marker Score: 649
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.59
    Marker Score: 237
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.57
    Marker Score: 654
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.57
    Marker Score: 172
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 445
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 232
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.55
    Marker Score: 660
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.55
    Marker Score: 894.5
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.53
    Marker Score: 168
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.52
    Marker Score: 2817
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.52
    Marker Score: 5312
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.5
    Marker Score: 300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.49
    Marker Score: 10472
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.48
    Marker Score: 213
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.46
    Marker Score: 552
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.45
    Marker Score: 261
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.43
    Marker Score: 148.5
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.43
    Marker Score: 410.5
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.42
    Marker Score: 368
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.42
    Marker Score: 163
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.42
    Marker Score: 236
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.42
    Marker Score: 5567
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.42
    Marker Score: 275
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.4
    Marker Score: 504
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4
    Marker Score: 1683
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.4
    Marker Score: 449
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.4
    Marker Score: 690
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.4
    Marker Score: 162
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.38
    Marker Score: 354
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.37
    Marker Score: 443
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.37
    Marker Score: 429
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.37
    Marker Score: 251
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 368
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.35
    Marker Score: 394
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.35
    Marker Score: 99
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.34
    Marker Score: 444
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.32
    Marker Score: 1186
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.32
    Marker Score: 114
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.31
    Marker Score: 181
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.31
    Marker Score: 530
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.31
    Marker Score: 1042
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.31
    Marker Score: 149
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.3
    Marker Score: 271
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.3
    Marker Score: 87

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Other Information

**Key characteristics:** - GBRG3 is a type I transmembrane receptor, meaning it has a single extracellular domain and a single transmembrane domain. - It is expressed in a variety of cell types, including interneurons, cardiac endothelial cells, and sympathetic neurons. - GBRG3 is a ligand for the Gaba-a receptor, which is a G protein-coupled receptor. - When GBRG3 binds to the Gaba-a receptor, it activates the receptor and initiates a cascade of intracellular events that lead to the inhibition of postsynaptic membrane potential. **Pathways and functions:** - GBRG3 is involved in the regulation of synaptic transmission by influencing the assembly and function of inhibitory synapses. - It is expressed in the somatostatin-secreting cells of the hypothalamus, where it is thought to regulate the release of neurotransmitters such as somatostatin. - In the central nervous system, GBRG3 is expressed in interneurons and other neuronal cells. - It is thought to play a role in the regulation of inhibitory synaptic transmission, as well as in the regulation of other processes such as learning and memory. **Clinical significance:** - Mutations in the GABRG3 gene have been linked to several neurological disorders, including schizophrenia, autism, and epilepsy. - Drugs that target GBRG3 have been investigated as potential treatments for these disorders. - However, clinical trials of these drugs have been unsuccessful so far.

Genular Protein ID: 2250889328

Symbol: GBRG3_HUMAN

Name: Gamma-aminobutyric acid receptor subunit gamma-3

UniProtKB Accession Codes:

Q99928 G3V594 Q9HD46 Q9NYT2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEMBL 2 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 78 DrugCentral 1 EMBL 21 Ensembl 2 ExpressionAtlas 1 GO 20 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 4 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8719414

Title: Expression and pharmacology of human GABAA receptors containing gamma 3 subunits.

PubMed ID: 8719414

DOI: 10.1016/0922-4106(95)90070-5

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 26566883

Title: Homozygous missense mutation in the LMAN2L gene segregates with intellectual disability in a large consanguineous Pakistani family.

PubMed ID: 26566883

DOI: 10.1136/jmedgenet-2015-103179

Sequence Information:

  • Length: 467
  • Mass: 54289
  • Checksum: 1B22D145166438D6
  • Sequence:
    • MAPKLLLLLC LFSGLHARSR KVEEDEYEDS SSNQKWVLAP KSQDTDVTLI LNKLLREYDK 
KLRPDIGIKP TVIDVDIYVN SIGPVSSINM EYQIDIFFAQ TWTDSRLRFN STMKILTLNS 
NMVGLIWIPD TIFRNSKTAE AHWITTPNQL LRIWNDGKIL YTLRLTINAE CQLQLHNFPM 
DEHSCPLIFS SYGYPKEEMI YRWRKNSVEA ADQKSWRLYQ FDFMGLRNTT EIVTTSAGDY 
VVMTIYFELS RRMGYFTIQT YIPCILTVVL SWVSFWIKKD ATPARTALGI TTVLTMTTLS 
TIARKSLPRV SYVTAMDLFV TVCFLFVFAA LMEYATLNYY SSCRKPTTTK KTTSLLHPDS 
SRWIPERISL QAPSNYSLLD MRPPPTAMIT LNNSVYWQEF EDTCVYECLD GKDCQSFFCC 
YEECKSGSWR KGRIHIDILE LDSYSRVFFP TSFLLFNLVY WVGYLYL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.