Details for: GRID1

Gene ID: 2894

Symbol: GRID1

Ensembl ID: ENSG00000182771

Description: glutamate ionotropic receptor delta type subunit 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 3.93
    Marker Score: 9408
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.17
    Marker Score: 107190
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.85
    Marker Score: 60787
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.81
    Marker Score: 12991
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.77
    Marker Score: 41388.5
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.77
    Marker Score: 7939
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.76
    Marker Score: 54916
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.72
    Marker Score: 20876
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.72
    Marker Score: 14616
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.69
    Marker Score: 3331
  • Cell Name: granule cell (CL0000120)
    Fold Change: 2.64
    Marker Score: 19904
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.61
    Marker Score: 13706
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.61
    Marker Score: 10823
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.59
    Marker Score: 4343
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.46
    Marker Score: 4481
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.44
    Marker Score: 3426.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.39
    Marker Score: 88083
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.37
    Marker Score: 89964
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.32
    Marker Score: 8979
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.19
    Marker Score: 20566
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 2.16
    Marker Score: 4976
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.09
    Marker Score: 5966
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.02
    Marker Score: 124459
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.99
    Marker Score: 8101
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.99
    Marker Score: 20522
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.95
    Marker Score: 819
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.92
    Marker Score: 18214.5
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.87
    Marker Score: 719
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.87
    Marker Score: 16038
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.82
    Marker Score: 1195
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.79
    Marker Score: 3930
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.78
    Marker Score: 1544
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.78
    Marker Score: 3617
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.73
    Marker Score: 972
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.65
    Marker Score: 2546
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.61
    Marker Score: 934
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.6
    Marker Score: 1842
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.58
    Marker Score: 432
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.49
    Marker Score: 3510
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167296
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.42
    Marker Score: 853
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 868
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.31
    Marker Score: 20525
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.19
    Marker Score: 392
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 1.12
    Marker Score: 9487
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.08
    Marker Score: 493
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 795
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.01
    Marker Score: 963
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.01
    Marker Score: 315
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71799
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48024
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.97
    Marker Score: 2471
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5325
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.93
    Marker Score: 443
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.87
    Marker Score: 471
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.87
    Marker Score: 570
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.86
    Marker Score: 477
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.81
    Marker Score: 3375
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.79
    Marker Score: 988.5
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.78
    Marker Score: 5213
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.78
    Marker Score: 236
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.73
    Marker Score: 189
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.69
    Marker Score: 251
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.66
    Marker Score: 269
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.65
    Marker Score: 433
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.62
    Marker Score: 253
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.58
    Marker Score: 150
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.58
    Marker Score: 256
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 457
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.56
    Marker Score: 295
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.56
    Marker Score: 1080
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.56
    Marker Score: 332
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.54
    Marker Score: 1027
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.54
    Marker Score: 861
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.52
    Marker Score: 147
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.5
    Marker Score: 126
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.48
    Marker Score: 629
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.46
    Marker Score: 223
  • Cell Name: bipolar neuron (CL0000103)
    Fold Change: 0.46
    Marker Score: 154
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.44
    Marker Score: 255
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.43
    Marker Score: 411
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.41
    Marker Score: 130
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.41
    Marker Score: 9126
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.4
    Marker Score: 480
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.4
    Marker Score: 232
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.39
    Marker Score: 436
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.39
    Marker Score: 3972
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.39
    Marker Score: 122
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.38
    Marker Score: 2261
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 372
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.37
    Marker Score: 406
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.35
    Marker Score: 392

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Other Information

**Key characteristics:** * The GRID1 gene is over 1300 nucleotides long and encodes a protein that is predicted to be a transmembrane protein. * The protein is a member of the Glutamate receptor ion channel family. * GRID1 is expressed in a variety of cell types, including oligodendrocytes, Purkinje cells, astrocytes, inhibitory interneurons, and retinal cone cells. * The protein is a ligand for the GABA-ergic synapse. * GRID1 is involved in the regulation of synaptic transmission. **Pathways and functions:** * GRID1 is involved in the regulation of synaptic transmission. * It is a ligand for the Gaba-ergic synapse, which is a type of inhibitory synapse that is involved in the regulation of neuronal excitability. * GRID1 is also involved in the modulation of chemical synaptic transmission. **Clinical significance:** * Mutations in the GRID1 gene have been linked to a number of neurological disorders, including autism spectrum disorder, schizophrenia, and epilepsy. * These disorders are characterized by abnormal synaptic transmission, which is the process by which neurotransmitters are released from one neuron to another. * GRID1 is a promising target for the treatment of these disorders. **Additional information:** * The GRID1 gene is located on chromosome 15q21.1. * The protein is expressed in high levels in the central nervous system. * GRID1 is a highly conserved protein, with a similar protein found in other vertebrates.

Genular Protein ID: 2780408391

Symbol: GRID1_HUMAN

Name: Glutamate receptor ionotropic, delta-1

UniProtKB Accession Codes:

Q9ULK0 B3KXD5 B7Z7L0 Q8IXT3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 1 ExpressionAtlas 1 GO 13 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10574462

Title: Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10574462

DOI: 10.1093/dnares/6.5.337

Sequence Information:

  • Length: 1009
  • Mass: 112131
  • Checksum: 201DA12ECC8E1F1A
  • Sequence:
    • MEALTLWLLP WICQCVSVRA DSIIHIGAIF EENAAKDDRV FQLAVSDLSL NDDILQSEKI 
TYSIKVIEAN NPFQAVQEAC DLMTQGILAL VTSTGCASAN ALQSLTDAMH IPHLFVQRNP 
GGSPRTACHL NPSPDGEAYT LASRPPVRLN DVMLRLVTEL RWQKFVMFYD SEYDIRGLQS 
FLDQASRLGL DVSLQKVDKN ISHVFTSLFT TMKTEELNRY RDTLRRAILL LSPQGAHSFI 
NEAVETNLAS KDSHWVFVNE EISDPEILDL VHSALGRMTV VRQIFPSAKD NQKCTRNNHR 
ISSLLCDPQE GYLQMLQISN LYLYDSVLML ANAFHRKLED RKWHSMASLN CIRKSTKPWN 
GGRSMLDTIK KGHITGLTGV MEFREDSSNP YVQFEILGTT YSETFGKDMR KLATWDSEKG 
LNGSLQERPM GSRLQGLTLK VVTVLEEPFV MVAENILGQP KRYKGFSIDV LDALAKALGF 
KYEIYQAPDG RYGHQLHNTS WNGMIGELIS KRADLAISAI TITPERESVV DFSKRYMDYS 
VGILIKKPEE KISIFSLFAP FDFAVWACIA AAIPVVGVLI FVLNRIQAVR AQSAAQPRPS 
ASATLHSAIW IVYGAFVQQG GESSVNSMAM RIVMGSWWLF TLIVCSSYTA NLAAFLTVSR 
MDNPIRTFQD LSKQVEMSYG TVRDSAVYEY FRAKGTNPLE QDSTFAELWR TISKNGGADN 
CVSSPSEGIR KAKKGNYAFL WDVAVVEYAA LTDDDCSVTV IGNSISSKGY GIALQHGSPY 
RDLFSQRILE LQDTGDLDVL KQKWWPHMGR CDLTSHASAQ ADGKSLKLHS FAGVFCILAI 
GLLLACLVAA LELWWNSNRC HQETPKEDKE VNLEQVHRRM NSLMDEDIAH KQISPASIEL 
SALEMGGLAP TQTLEPTREY QNTQLSVSTF LPEQSSHGTS RTLSSGPSSN LPLPLSSSAT 
MPSMQCKHRS PNGGLFRQSP VKTPIPMSFQ PVPGGVLPEA LDTSHGTSI

Genular Protein ID: 163883865

Symbol: A8KAN9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8KAN9

Database IDs:

ARBA 12 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 3 Genevisible 1 GenomeRNAi 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 4 SUPFAM 2

Sequence Information:

  • Length: 1009
  • Mass: 112104
  • Checksum: 201DA133D18E0207
  • Sequence:
    • MEALTLWLLP WICQCVSVRA DSIIHIGAIF EENAAKDDRV FQLAVSDLSL NDDILQSEKI 
TYSIKVIEAN NPFQAVQEAC DLMTQGILAL VTSTGCASAN ALQSLTDAMH IPHLFVQRNP 
GGSPRTACHL NPSPDGEAYT LASRPPVRLN DVMLRLVTEL RWQKFVMFYD SEYDIRGLQS 
FLDQASRLGL DVSLQKVDKN ISHVFTSLFT TMKTEELNRY RDTLRRAILL LSPQGAHSFI 
NEAVETNLAS KDSHWVFVNE EISDPEILDL VHSALGRMTV VRQIFPSAKD NQKCTRNNHR 
ISSLLCDPQE GYLQMLQISN LYLYDSVLML ANAFHRKLED RKWHSMASLN CIRKSTKPWN 
GGRSMLDTIK KGHITGLTGV MEFREDSSNP YVQFEILGTT YSETFGKDMR KLATWDSEKG 
LNGSLQERPM GSRLQGLTLK VVTVLEEPFV MVAENILGQP KRYKGFSIDV LDALAKALGF 
KYEIYQAPDG RYGHQLHNTS WNGMIGELIS KRADLAISAI TITPERESVV DFSKRYMDYS 
VGILIKKPEE KISIFSLFAP FDFAVWACIA AAIPVVGVLI FVLNRIQAVR AQSAAQPRPS 
ASATLHSAIW IVYGAFVQQG GESSVNSMAM RIVMGSWWLF TLIVCSSYTA NLAAFLTVSR 
MDNPIRTFQD LSKQVEMSYG TVRDSAVYEY FRAKGTNPLE QDSTFAELWR TISKNGGADN 
CVSSPSEGIR KAKKGNYAFL WDVAVVEYAA LTDDDCSVTV IGNSISSKGY GIALQHGSPY 
RDLFSQRILE LQDTGDLDVL KQKWWPHMGR CDLTSHASAQ ADGKSLKLHS FAGVFCILAI 
GLLLACLVAA LELWWNSNRC HQETPKEDKE VNLEQVHRRM NSLMDEDIAH KQISPASIEL 
SALEMGGLAP TQTLEPTREY QNTQLSVSTF LPEQSSHGTS RTLSSGPSSS LPLPLSSSAT 
MPSMQCKHRS PNGGLFRQSP VKTPIPMSFQ PVPGGVLPEA LDTSHGTSI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.