Details for: GRID1

Gene ID: 2894

Symbol: GRID1

Ensembl ID: ENSG00000182771

Description: glutamate ionotropic receptor delta type subunit 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 4.4812
    Cell Significance Index: 1607.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 4.0656
    Cell Significance Index: 179.8300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 3.8207
    Cell Significance Index: 144.6800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.8608
    Cell Significance Index: 573.8700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.6107
    Cell Significance Index: 1805.6300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.4495
    Cell Significance Index: 69.9000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.9488
    Cell Significance Index: 119.7900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.8382
    Cell Significance Index: 123.6000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.0445
    Cell Significance Index: 25.0500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.9828
    Cell Significance Index: 21.5200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0669
    Cell Significance Index: 30.3700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0323
    Cell Significance Index: -60.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0426
    Cell Significance Index: -78.6200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0475
    Cell Significance Index: -1.2200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0519
    Cell Significance Index: -79.8400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0610
    Cell Significance Index: -82.9400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0887
    Cell Significance Index: -56.3100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1149
    Cell Significance Index: -86.9600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1165
    Cell Significance Index: -86.3200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1391
    Cell Significance Index: -86.8700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1530
    Cell Significance Index: -86.2600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.1886
    Cell Significance Index: -83.3800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2209
    Cell Significance Index: -63.5700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2273
    Cell Significance Index: -1.5400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2832
    Cell Significance Index: -5.6000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3111
    Cell Significance Index: -4.4600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.3203
    Cell Significance Index: -63.5600
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.3208
    Cell Significance Index: -4.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.3599
    Cell Significance Index: -64.8800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4091
    Cell Significance Index: -86.1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4418
    Cell Significance Index: -64.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4688
    Cell Significance Index: -35.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.4689
    Cell Significance Index: -80.0700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.4837
    Cell Significance Index: -59.4700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4995
    Cell Significance Index: -13.9600
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.5160
    Cell Significance Index: -7.2200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.5597
    Cell Significance Index: -6.5300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.5626
    Cell Significance Index: -72.6900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.5780
    Cell Significance Index: -79.3800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6116
    Cell Significance Index: -12.9800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.6423
    Cell Significance Index: -75.7500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.6627
    Cell Significance Index: -84.9600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6632
    Cell Significance Index: -69.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6791
    Cell Significance Index: -79.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.7341
    Cell Significance Index: -74.9900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.7660
    Cell Significance Index: -87.7600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8143
    Cell Significance Index: -26.6600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.8599
    Cell Significance Index: -37.3900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.9284
    Cell Significance Index: -29.5700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.9757
    Cell Significance Index: -72.7200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.9872
    Cell Significance Index: -12.3100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.0057
    Cell Significance Index: -56.4400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.0399
    Cell Significance Index: -17.9800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -1.0490
    Cell Significance Index: -13.2400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -1.0757
    Cell Significance Index: -11.7200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -1.0945
    Cell Significance Index: -14.6000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.1157
    Cell Significance Index: -22.4000
  • Cell Name: neuron (CL0000540)
    Fold Change: -1.1594
    Cell Significance Index: -10.9900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.1628
    Cell Significance Index: -60.5700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -1.1769
    Cell Significance Index: -75.9300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.1828
    Cell Significance Index: -25.5600
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -1.1948
    Cell Significance Index: -12.8100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.3171
    Cell Significance Index: -46.1400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.4179
    Cell Significance Index: -35.3700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.4243
    Cell Significance Index: -74.7800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.4254
    Cell Significance Index: -29.7500
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -1.4924
    Cell Significance Index: -14.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -1.5036
    Cell Significance Index: -70.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.6169
    Cell Significance Index: -73.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.8548
    Cell Significance Index: -86.4800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.9455
    Cell Significance Index: -33.3400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -1.9732
    Cell Significance Index: -24.9000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -2.0887
    Cell Significance Index: -23.9100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -2.1194
    Cell Significance Index: -73.6500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.1823
    Cell Significance Index: -80.1100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -2.1850
    Cell Significance Index: -26.1300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -2.3076
    Cell Significance Index: -30.7600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -2.3285
    Cell Significance Index: -45.8300
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -2.4073
    Cell Significance Index: -18.8800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -2.4172
    Cell Significance Index: -69.2900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -2.4523
    Cell Significance Index: -86.1700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.4981
    Cell Significance Index: -73.5800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -2.5373
    Cell Significance Index: -80.2500
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: -2.5760
    Cell Significance Index: -20.8000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -2.7015
    Cell Significance Index: -53.8700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -2.7191
    Cell Significance Index: -30.8900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -2.7545
    Cell Significance Index: -68.6900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -2.8320
    Cell Significance Index: -143.1200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -2.8407
    Cell Significance Index: -75.8500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -2.8951
    Cell Significance Index: -73.7600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -2.9190
    Cell Significance Index: -62.4000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -2.9345
    Cell Significance Index: -59.7100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -2.9509
    Cell Significance Index: -79.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -2.9734
    Cell Significance Index: -85.6700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -2.9918
    Cell Significance Index: -78.6700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -3.0102
    Cell Significance Index: -80.5200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -3.0933
    Cell Significance Index: -77.2600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -3.0955
    Cell Significance Index: -74.9800
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -3.1200
    Cell Significance Index: -37.8200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -3.2643
    Cell Significance Index: -63.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The GRID1 gene is a single-copy gene located on chromosome 10q26.3. It encodes a protein that is part of the glutamate receptor delta type, which is a ligand-gated ion channel responsible for the rapid transmission of excitatory signals in the brain. The GRID1 protein is composed of four transmembrane domains and two cytoplasmic domains, allowing it to interact with other subunits and modulate receptor activity. The grid1 gene is significantly expressed in various neuronal populations, including those involved in learning and memory, motor control, and social behavior. **Pathways and Functions:** The GRID1 gene is involved in several key pathways, including: 1. **Glutamate receptor signaling pathway**: GRID1 is essential for the functioning of glutamate receptors, which are the primary excitatory neurotransmitters in the brain. 2. **GABA-ergic synapse**: GRID1 can modulate GABAergic transmission, which is involved in inhibitory neurotransmission and neuronal regulation. 3. **Regulation of postsynaptic membrane potential**: GRID1 can influence the excitability of postsynaptic neurons by modulating the activity of glutamate receptors. 4. **Synaptic transmission**: GRID1 is involved in the rapid transmission of excitatory signals in the brain, which is critical for learning and memory. **Clinical Significance:** Dysregulation of the GRID1 gene has been implicated in various neurological disorders, including: 1. **Autism spectrum disorder (ASD)**: GRID1 has been identified as a susceptibility gene for ASD, with altered expression levels and function contributing to the development of the disorder. 2. **Schizophrenia**: GRID1 has been linked to schizophrenia, with studies suggesting that altered expression and function of the gene contribute to the pathophysiology of the disorder. 3. **Epilepsy**: GRID1 has been implicated in the development of epilepsy, with studies suggesting that altered expression and function of the gene contribute to the regulation of seizure activity. In conclusion, the GRID1 gene plays a critical role in regulating glutamatergic synaptic transmission, a fundamental process in the central nervous system. Dysregulation of the GRID1 gene has been implicated in various neurological disorders, highlighting the importance of this gene in maintaining normal brain function and preventing disease. Further research is needed to fully understand the mechanisms by which GRID1 regulates synaptic transmission and to explore its therapeutic potential in the treatment of neurological disorders.

Genular Protein ID: 2780408391

Symbol: GRID1_HUMAN

Name: Glutamate receptor ionotropic, delta-1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10574462

Title: Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10574462

DOI: 10.1093/dnares/6.5.337

Sequence Information:

  • Length: 1009
  • Mass: 112131
  • Checksum: 201DA12ECC8E1F1A
  • Sequence:
  • MEALTLWLLP WICQCVSVRA DSIIHIGAIF EENAAKDDRV FQLAVSDLSL NDDILQSEKI 
    TYSIKVIEAN NPFQAVQEAC DLMTQGILAL VTSTGCASAN ALQSLTDAMH IPHLFVQRNP 
    GGSPRTACHL NPSPDGEAYT LASRPPVRLN DVMLRLVTEL RWQKFVMFYD SEYDIRGLQS 
    FLDQASRLGL DVSLQKVDKN ISHVFTSLFT TMKTEELNRY RDTLRRAILL LSPQGAHSFI 
    NEAVETNLAS KDSHWVFVNE EISDPEILDL VHSALGRMTV VRQIFPSAKD NQKCTRNNHR 
    ISSLLCDPQE GYLQMLQISN LYLYDSVLML ANAFHRKLED RKWHSMASLN CIRKSTKPWN 
    GGRSMLDTIK KGHITGLTGV MEFREDSSNP YVQFEILGTT YSETFGKDMR KLATWDSEKG 
    LNGSLQERPM GSRLQGLTLK VVTVLEEPFV MVAENILGQP KRYKGFSIDV LDALAKALGF 
    KYEIYQAPDG RYGHQLHNTS WNGMIGELIS KRADLAISAI TITPERESVV DFSKRYMDYS 
    VGILIKKPEE KISIFSLFAP FDFAVWACIA AAIPVVGVLI FVLNRIQAVR AQSAAQPRPS 
    ASATLHSAIW IVYGAFVQQG GESSVNSMAM RIVMGSWWLF TLIVCSSYTA NLAAFLTVSR 
    MDNPIRTFQD LSKQVEMSYG TVRDSAVYEY FRAKGTNPLE QDSTFAELWR TISKNGGADN 
    CVSSPSEGIR KAKKGNYAFL WDVAVVEYAA LTDDDCSVTV IGNSISSKGY GIALQHGSPY 
    RDLFSQRILE LQDTGDLDVL KQKWWPHMGR CDLTSHASAQ ADGKSLKLHS FAGVFCILAI 
    GLLLACLVAA LELWWNSNRC HQETPKEDKE VNLEQVHRRM NSLMDEDIAH KQISPASIEL 
    SALEMGGLAP TQTLEPTREY QNTQLSVSTF LPEQSSHGTS RTLSSGPSSN LPLPLSSSAT 
    MPSMQCKHRS PNGGLFRQSP VKTPIPMSFQ PVPGGVLPEA LDTSHGTSI

Genular Protein ID: 163883865

Symbol: A8KAN9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 1009
  • Mass: 112104
  • Checksum: 201DA133D18E0207
  • Sequence:
  • MEALTLWLLP WICQCVSVRA DSIIHIGAIF EENAAKDDRV FQLAVSDLSL NDDILQSEKI 
    TYSIKVIEAN NPFQAVQEAC DLMTQGILAL VTSTGCASAN ALQSLTDAMH IPHLFVQRNP 
    GGSPRTACHL NPSPDGEAYT LASRPPVRLN DVMLRLVTEL RWQKFVMFYD SEYDIRGLQS 
    FLDQASRLGL DVSLQKVDKN ISHVFTSLFT TMKTEELNRY RDTLRRAILL LSPQGAHSFI 
    NEAVETNLAS KDSHWVFVNE EISDPEILDL VHSALGRMTV VRQIFPSAKD NQKCTRNNHR 
    ISSLLCDPQE GYLQMLQISN LYLYDSVLML ANAFHRKLED RKWHSMASLN CIRKSTKPWN 
    GGRSMLDTIK KGHITGLTGV MEFREDSSNP YVQFEILGTT YSETFGKDMR KLATWDSEKG 
    LNGSLQERPM GSRLQGLTLK VVTVLEEPFV MVAENILGQP KRYKGFSIDV LDALAKALGF 
    KYEIYQAPDG RYGHQLHNTS WNGMIGELIS KRADLAISAI TITPERESVV DFSKRYMDYS 
    VGILIKKPEE KISIFSLFAP FDFAVWACIA AAIPVVGVLI FVLNRIQAVR AQSAAQPRPS 
    ASATLHSAIW IVYGAFVQQG GESSVNSMAM RIVMGSWWLF TLIVCSSYTA NLAAFLTVSR 
    MDNPIRTFQD LSKQVEMSYG TVRDSAVYEY FRAKGTNPLE QDSTFAELWR TISKNGGADN 
    CVSSPSEGIR KAKKGNYAFL WDVAVVEYAA LTDDDCSVTV IGNSISSKGY GIALQHGSPY 
    RDLFSQRILE LQDTGDLDVL KQKWWPHMGR CDLTSHASAQ ADGKSLKLHS FAGVFCILAI 
    GLLLACLVAA LELWWNSNRC HQETPKEDKE VNLEQVHRRM NSLMDEDIAH KQISPASIEL 
    SALEMGGLAP TQTLEPTREY QNTQLSVSTF LPEQSSHGTS RTLSSGPSSS LPLPLSSSAT 
    MPSMQCKHRS PNGGLFRQSP VKTPIPMSFQ PVPGGVLPEA LDTSHGTSI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.