Details for: ND5
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 478.3574
Cell Significance Index: -246.0600 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 478.3079
Cell Significance Index: -225.8200 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 337.9769
Cell Significance Index: -226.7900 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 65.3263
Cell Significance Index: -175.0000 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 52.5313
Cell Significance Index: 417.9700 - Cell Name: Sertoli cell (CL0000216)
Fold Change: 38.1037
Cell Significance Index: 534.4600 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 35.0961
Cell Significance Index: 1288.3500 - Cell Name: hepatic pit cell (CL2000054)
Fold Change: 15.8312
Cell Significance Index: 42.4100 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 13.9066
Cell Significance Index: 205.2600 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 12.9244
Cell Significance Index: 99.6200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 10.3239
Cell Significance Index: 467.9500 - Cell Name: abnormal cell (CL0001061)
Fold Change: 8.5842
Cell Significance Index: 876.8800 - Cell Name: pro-T cell (CL0000827)
Fold Change: 8.3003
Cell Significance Index: 212.0500 - Cell Name: cell in vitro (CL0001034)
Fold Change: 7.8232
Cell Significance Index: 4272.4500 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 7.5855
Cell Significance Index: 206.4700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 7.3378
Cell Significance Index: 1007.6900 - Cell Name: peg cell (CL4033014)
Fold Change: 7.2331
Cell Significance Index: 167.1100 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 6.9220
Cell Significance Index: 199.4400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 6.8516
Cell Significance Index: 5023.6000 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 6.6114
Cell Significance Index: 523.6200 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 6.3554
Cell Significance Index: 58.5300 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 6.1109
Cell Significance Index: 664.6900 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 5.7024
Cell Significance Index: 299.4000 - Cell Name: odontoblast (CL0000060)
Fold Change: 5.6696
Cell Significance Index: 726.8100 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 5.6155
Cell Significance Index: 103.7900 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 5.3571
Cell Significance Index: 249.7800 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 5.2595
Cell Significance Index: 59.7500 - Cell Name: granulosa cell (CL0000501)
Fold Change: 4.5298
Cell Significance Index: 119.1100 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 4.3087
Cell Significance Index: 277.9800 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 3.8755
Cell Significance Index: 201.3200 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.7996
Cell Significance Index: 48.6600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 3.6462
Cell Significance Index: 448.3300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 3.5500
Cell Significance Index: 264.5800 - Cell Name: lactocyte (CL0002325)
Fold Change: 3.3204
Cell Significance Index: 428.9700 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 2.5738
Cell Significance Index: 254.6100 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 2.4244
Cell Significance Index: 437.0500 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 2.2193
Cell Significance Index: 2003.8600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 2.1667
Cell Significance Index: 101.8400 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.9515
Cell Significance Index: 55.9400 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.9333
Cell Significance Index: 56.7800 - Cell Name: enterocyte (CL0000584)
Fold Change: 1.7054
Cell Significance Index: 10.5800 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.6974
Cell Significance Index: 30.0000 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.0494
Cell Significance Index: 208.2600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 1.0183
Cell Significance Index: 35.7800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.9691
Cell Significance Index: 347.6100 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.9180
Cell Significance Index: 31.9000 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.8504
Cell Significance Index: 643.7000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.3526
Cell Significance Index: 70.7300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2845
Cell Significance Index: 54.1500 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.1423
Cell Significance Index: 3.8000 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0468
Cell Significance Index: 7.6100 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.1099
Cell Significance Index: -206.9400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.1586
Cell Significance Index: -292.5600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.1901
Cell Significance Index: -292.7000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.2162
Cell Significance Index: -294.0000 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.2812
Cell Significance Index: -208.3000 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.2899
Cell Significance Index: -49.5000 - Cell Name: seromucus secreting cell (CL0000159)
Fold Change: -0.2978
Cell Significance Index: -6.2100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.3738
Cell Significance Index: -237.4100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.3825
Cell Significance Index: -215.6900 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.3945
Cell Significance Index: -7.7000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.4338
Cell Significance Index: -270.8800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.5043
Cell Significance Index: -228.9000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.6390
Cell Significance Index: -183.8500 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.8023
Cell Significance Index: -12.0900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.8199
Cell Significance Index: -93.9300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -1.2014
Cell Significance Index: -253.0400 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -1.2181
Cell Significance Index: -81.9100 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -1.3430
Cell Significance Index: -67.8700 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -1.4136
Cell Significance Index: -35.3400 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -1.4259
Cell Significance Index: -24.0200 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -1.5387
Cell Significance Index: -33.3400 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -1.5754
Cell Significance Index: -64.5500 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -1.7536
Cell Significance Index: -254.9000 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -1.8075
Cell Significance Index: -30.2500 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -1.8521
Cell Significance Index: -128.0900 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -1.9002
Cell Significance Index: -114.0800 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -2.0546
Cell Significance Index: -213.9300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -2.0602
Cell Significance Index: -65.9900 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -2.3863
Cell Significance Index: -150.4000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -2.8161
Cell Significance Index: -216.1100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -2.8783
Cell Significance Index: -161.5200 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -2.9020
Cell Significance Index: -178.3700 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -2.9158
Cell Significance Index: -43.6900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -3.1173
Cell Significance Index: -191.1200 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -3.5445
Cell Significance Index: -101.1500 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -3.6289
Cell Significance Index: -97.0700 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -3.7728
Cell Significance Index: -78.9700 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -3.8949
Cell Significance Index: -40.3200 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -4.0942
Cell Significance Index: -87.2000 - Cell Name: late promyelocyte (CL0002151)
Fold Change: -4.1543
Cell Significance Index: -27.5600 - Cell Name: early promyelocyte (CL0002154)
Fold Change: -4.4238
Cell Significance Index: -28.2400 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -4.7770
Cell Significance Index: -211.3000 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -5.6796
Cell Significance Index: -167.2900 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -5.7153
Cell Significance Index: -98.5300 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -5.9022
Cell Significance Index: -223.5000 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -5.9352
Cell Significance Index: -123.1200 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -6.1076
Cell Significance Index: -213.9600 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -6.4407
Cell Significance Index: -210.8700 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -6.5728
Cell Significance Index: -209.3400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 757629391
Symbol: NU5M_HUMAN
Name: NADH-ubiquinone oxidoreductase chain 5
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7219534
Title: Sequence and organization of the human mitochondrial genome.
PubMed ID: 7219534
DOI: 10.1038/290457a0
PubMed ID: 7530363
Title: Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs.
PubMed ID: 7530363
PubMed ID: 11553319
Title: Major genomic mitochondrial lineages delineate early human expansions.
PubMed ID: 11553319
PubMed ID: 12949126
Title: Lineage-specific selection in human mtDNA: lack of polymorphisms in a segment of MTND5 gene in haplogroup J.
PubMed ID: 12949126
PubMed ID: 11130070
Title: Mitochondrial genome variation and the origin of modern humans.
PubMed ID: 11130070
DOI: 10.1038/35047064
PubMed ID: 12840039
Title: Mitochondrial genome variation and evolutionary history of Australian and New Guinean aborigines.
PubMed ID: 12840039
DOI: 10.1101/gr.686603
PubMed ID: 14760490
Title: Single nucleotide polymorphisms over the entire mtDNA genome that increase the power of forensic testing in Caucasians.
PubMed ID: 14760490
PubMed ID: 6284948
Title: Mitochondrial DNA sequences of primates: tempo and mode of evolution.
PubMed ID: 6284948
DOI: 10.1007/bf01734101
PubMed ID: 3921850
Title: Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase.
PubMed ID: 3921850
DOI: 10.1038/314592a0
PubMed ID: 12611891
Title: The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification.
PubMed ID: 12611891
PubMed ID: 15250827
Title: Structural organization of mitochondrial human complex I: role of the ND4 and ND5 mitochondria-encoded subunits and interaction with prohibitin.
PubMed ID: 15250827
DOI: 10.1042/bj20040256
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 1757091
Title: Normal variants of human mitochondrial DNA and translation products: the building of a reference data base.
PubMed ID: 1757091
DOI: 10.1007/bf00206061
PubMed ID: 1732158
Title: Mitochondrial DNA complex I and III mutations associated with Leber's hereditary optic neuropathy.
PubMed ID: 1732158
PubMed ID: 1900003
Title: Alternative, simultaneous complex I mitochondrial DNA mutations in Leber's hereditary optic neuropathy.
PubMed ID: 1900003
PubMed ID: 8213825
Title: When does bilateral optic atrophy become Leber hereditary optic neuropathy?
PubMed ID: 8213825
PubMed ID: 9299505
Title: Identification of a novel mutation in the mtDNA ND5 gene associated with MELAS.
PubMed ID: 9299505
PubMed ID: 9461455
Title: Automating the identification of DNA variations using quality-based fluorescence re-sequencing: analysis of the human mitochondrial genome.
PubMed ID: 9461455
DOI: 10.1093/nar/26.4.967
PubMed ID: 11938446
Title: Leigh disease associated with a novel mitochondrial DNA ND5 mutation.
PubMed ID: 11938446
PubMed ID: 12509858
Title: Is the mitochondrial complex I ND5 gene a hot-spot for MELAS causing mutations?
PubMed ID: 12509858
DOI: 10.1002/ana.10435
PubMed ID: 12796552
Title: A missense mutation in the mitochondrial ND5 gene associated with a Leigh-MELAS overlap syndrome.
PubMed ID: 12796552
PubMed ID: 16240359
Title: The role of the ND5 gene in LHON: characterization of a new, heteroplasmic LHON mutation.
PubMed ID: 16240359
DOI: 10.1002/ana.20669
PubMed ID: 15767514
Title: Novel mitochondrial DNA ND5 mutation in a patient with clinical features of MELAS and MERRF.
PubMed ID: 15767514
PubMed ID: 17400793
Title: Mutations in the ND5 subunit of complex I of the mitochondrial DNA are a frequent cause of oxidative phosphorylation disease.
PubMed ID: 17400793
PubMed ID: 20818383
Title: High-throughput, pooled sequencing identifies mutations in NUBPL and FOXRED1 in human complex I deficiency.
PubMed ID: 20818383
DOI: 10.1038/ng.659
Sequence Information:
- Length: 603
- Mass: 67027
- Checksum: 18A06227ABC9162A
- Sequence:
MTMHTTMTTL TLTSLIPPIL TTLVNPNKKN SYPHYVKSIV ASTFIISLFP TTMFMCLDQE VIISNWHWAT TQTTQLSLSF KLDYFSMMFI PVALFVTWSI MEFSLWYMNS DPNINQFFKY LLIFLITMLI LVTANNLFQL FIGWEGVGIM SFLLISWWYA RADANTAAIQ AILYNRIGDI GFILALAWFI LHSNSWDPQQ MALLNANPSL TPLLGLLLAA AGKSAQLGLH PWLPSAMEGP TPVSALLHSS TMVVAGIFLL IRFHPLAENS PLIQTLTLCL GAITTLFAAV CALTQNDIKK IVAFSTSSQL GLMMVTIGIN QPHLAFLHIC THAFFKAMLF MCSGSIIHNL NNEQDIRKMG GLLKTMPLTS TSLTIGSLAL AGMPFLTGFY SKDHIIETAN MSYTNAWALS ITLIATSLTS AYSTRMILLT LTGQPRFPTL TNINENNPTL LNPIKRLAAG SLFAGFLITN NISPASPFQT TIPLYLKLTA LAVTFLGLLT ALDLNYLTNK LKMKSPLCTF YFSNMLGFYP SITHRTIPYL GLLTSQNLPL LLLDLTWLEK LLPKTISQHQ ISTSIITSTQ KGMIKLYFLS FFFPLILTLL LIT
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.