Details for: ND5

Gene ID: 4540

Symbol: ND5

Ensembl ID: ENSG00000198786

Description: NADH dehydrogenase subunit 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 6.09
    Cell Significance Index: 10
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.82
    Cell Significance Index: 2
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.77
    Cell Significance Index: 2
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.43
    Cell Significance Index: 2
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.35
    Cell Significance Index: 1
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.32
    Cell Significance Index: 1
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.25
    Cell Significance Index: 1
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.24
    Cell Significance Index: 1
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.24
    Cell Significance Index: 1
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.2
    Cell Significance Index: 1
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.19
    Cell Significance Index: 1
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.19
    Cell Significance Index: 1
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.19
    Cell Significance Index: 1
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.17
    Cell Significance Index: 1
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.17
    Cell Significance Index: 1
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.16
    Cell Significance Index: 1
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 1.16
    Cell Significance Index: 1
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.16
    Cell Significance Index: 1
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.15
    Cell Significance Index: 1
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.11
    Cell Significance Index: 1
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1
    Cell Significance Index: 1
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 1.07
    Cell Significance Index: 1
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.06
    Cell Significance Index: 1
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.06
    Cell Significance Index: 1
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.04
    Cell Significance Index: 1
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.04
    Cell Significance Index: 1
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.04
    Cell Significance Index: 1
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.03
    Cell Significance Index: 1
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.03
    Cell Significance Index: 1
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.03
    Cell Significance Index: 1
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.03
    Cell Significance Index: 1
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 1.02
    Cell Significance Index: 1
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.02
    Cell Significance Index: 1
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 1.02
    Cell Significance Index: 1
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.02
    Cell Significance Index: 1
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.01
    Cell Significance Index: 1
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: cell (CL0000000)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.97
    Cell Significance Index: 1
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.97
    Cell Significance Index: 1
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.97
    Cell Significance Index: 1
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.97
    Cell Significance Index: 1
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.97
    Cell Significance Index: 1
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.96
    Cell Significance Index: 1
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.96
    Cell Significance Index: 1
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.96
    Cell Significance Index: 1
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.96
    Cell Significance Index: 1
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.96
    Cell Significance Index: 1
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.96
    Cell Significance Index: 1
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.95
    Cell Significance Index: 1
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.95
    Cell Significance Index: 1
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.95
    Cell Significance Index: 1
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.95
    Cell Significance Index: 1
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.95
    Cell Significance Index: 1
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.95
    Cell Significance Index: 1
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.95
    Cell Significance Index: 1
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.95
    Cell Significance Index: 1
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.95
    Cell Significance Index: 1
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.95
    Cell Significance Index: 1
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.95
    Cell Significance Index: 1
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 0.95
    Cell Significance Index: 1
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.95
    Cell Significance Index: 1
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.95
    Cell Significance Index: 1
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: 0.95
    Cell Significance Index: 1
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.95
    Cell Significance Index: 1
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.94
    Cell Significance Index: 1
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.94
    Cell Significance Index: 1
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.94
    Cell Significance Index: 1
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.94
    Cell Significance Index: 1
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.94
    Cell Significance Index: 1
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.94
    Cell Significance Index: 1
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.94
    Cell Significance Index: 1
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.94
    Cell Significance Index: 1
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.94
    Cell Significance Index: 1
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.94
    Cell Significance Index: 1
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.94
    Cell Significance Index: 1
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: 0.93
    Cell Significance Index: 1
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.93
    Cell Significance Index: 1
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.93
    Cell Significance Index: 1
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.93
    Cell Significance Index: 1
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.93
    Cell Significance Index: 1
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.93
    Cell Significance Index: 1
  • Cell Name: Merkel cell (CL0000242)
    Fold Change: 0.93
    Cell Significance Index: 1
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.93
    Cell Significance Index: 1
  • Cell Name: glioblast (CL0000030)
    Fold Change: 0.93
    Cell Significance Index: 1
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.93
    Cell Significance Index: 1
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.93
    Cell Significance Index: 1
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.93
    Cell Significance Index: 1
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.93
    Cell Significance Index: 1
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.93
    Cell Significance Index: 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ND5 is a subunit of the mitochondrial respiratory chain complex I, comprising 32 kDa protein. It is encoded by the NDUFA5 gene and is predominantly expressed in tissues with high energy demands, such as skeletal muscle, brain, and heart. ND5 is a crucial component of the electron transport chain, facilitating the transfer of electrons from NADH to ubiquinone. The protein is highly conserved across species, suggesting its essential role in mitochondrial function. **Pathways and Functions:** ND5 is involved in several critical pathways, including: 1. **Aerobic Respiration:** ND5 plays a central role in the electron transport chain, generating a proton motive force that drives ATP synthesis. 2. **Mitochondrial Electron Transport:** ND5 facilitates the transfer of electrons from NADH to ubiquinone, contributing to the production of ATP. 3. **Proton Motive Force-Driven ATP Synthesis:** ND5 is essential for the generation of ATP through chemiosmotic coupling. 4. **Metabolism of Proteins:** ND5 is involved in the regulation of protein degradation and synthesis in mitochondria. 5. **Response to Hypoxia and Hydrogen Peroxide:** ND5 has been shown to be sensitive to changes in oxygen levels and oxidative stress, highlighting its role in maintaining mitochondrial homeostasis. **Clinical Significance:** Alterations in ND5 expression or function have been implicated in various diseases, including: 1. **Neurodegenerative Disorders:** Mutations in the NDUFA5 gene have been associated with neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease. 2. **Cardiovascular Diseases:** ND5 dysfunction has been linked to cardiovascular diseases, including heart failure and arrhythmias. 3. **Metabolic Disorders:** ND5 alterations have been implicated in metabolic disorders, such as diabetes and obesity. 4. **Cancer:** ND5 has been shown to be overexpressed in certain types of cancer, suggesting its potential as a therapeutic target. In conclusion, ND5 is a crucial component of the mitochondrial respiratory chain complex I, playing a vital role in energy production and mitochondrial function. Alterations in ND5 expression or function have significant implications for various diseases, highlighting the need for further research into the molecular mechanisms underlying ND5-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.