Details for: ADAM23

Gene ID: 8745

Symbol: ADAM23

Ensembl ID: ENSG00000114948

Description: ADAM metallopeptidase domain 23

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 5.2299
    Cell Significance Index: 231.3300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 5.0463
    Cell Significance Index: 191.0900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 4.3829
    Cell Significance Index: 95.9700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 3.3133
    Cell Significance Index: 56.7800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 3.1053
    Cell Significance Index: 88.6200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.0203
    Cell Significance Index: 605.8600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.8461
    Cell Significance Index: 218.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.6808
    Cell Significance Index: 180.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.3083
    Cell Significance Index: 827.9400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7853
    Cell Significance Index: 354.3100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 1.7107
    Cell Significance Index: 22.8200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.6347
    Cell Significance Index: 12.6000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.3211
    Cell Significance Index: 81.2000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.2851
    Cell Significance Index: 888.8400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.1342
    Cell Significance Index: 27.2000
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.9595
    Cell Significance Index: 7.9200
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.9122
    Cell Significance Index: 11.8300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.5712
    Cell Significance Index: 7.0900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.5052
    Cell Significance Index: 6.3000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4930
    Cell Significance Index: 27.6700
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.3648
    Cell Significance Index: 3.8000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2706
    Cell Significance Index: 6.9600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.2025
    Cell Significance Index: 2.9900
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.0862
    Cell Significance Index: 0.8200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0635
    Cell Significance Index: 86.3300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: 0.0586
    Cell Significance Index: 0.7400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0008
    Cell Significance Index: 1.2400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0080
    Cell Significance Index: -15.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0092
    Cell Significance Index: -16.9200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0211
    Cell Significance Index: -19.0900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0340
    Cell Significance Index: -0.9500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0367
    Cell Significance Index: -1.1700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0406
    Cell Significance Index: -1.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0435
    Cell Significance Index: -32.2000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0452
    Cell Significance Index: -8.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0463
    Cell Significance Index: -29.4000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0489
    Cell Significance Index: -35.8600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0547
    Cell Significance Index: -1.1600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0560
    Cell Significance Index: -0.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0561
    Cell Significance Index: -42.4800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0594
    Cell Significance Index: -26.9800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0667
    Cell Significance Index: -41.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0685
    Cell Significance Index: -38.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0700
    Cell Significance Index: -38.2100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0850
    Cell Significance Index: -37.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0986
    Cell Significance Index: -17.7800
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.1051
    Cell Significance Index: -1.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1158
    Cell Significance Index: -33.3100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1235
    Cell Significance Index: -2.4800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1299
    Cell Significance Index: -21.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1652
    Cell Significance Index: -24.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1715
    Cell Significance Index: -23.5500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1908
    Cell Significance Index: -40.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2259
    Cell Significance Index: -38.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2421
    Cell Significance Index: -29.7700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2579
    Cell Significance Index: -5.1000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.2612
    Cell Significance Index: -25.8400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.2642
    Cell Significance Index: -28.7400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2646
    Cell Significance Index: -12.0000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3042
    Cell Significance Index: -35.8800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3196
    Cell Significance Index: -37.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3671
    Cell Significance Index: -42.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3712
    Cell Significance Index: -37.9200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3793
    Cell Significance Index: -39.4900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3977
    Cell Significance Index: -24.3800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4001
    Cell Significance Index: -5.7300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.4449
    Cell Significance Index: -5.1900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4499
    Cell Significance Index: -15.8100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4546
    Cell Significance Index: -28.6500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4619
    Cell Significance Index: -9.9800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4622
    Cell Significance Index: -11.5300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4637
    Cell Significance Index: -9.6200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.4697
    Cell Significance Index: -28.2000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.4711
    Cell Significance Index: -32.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5076
    Cell Significance Index: -37.8300
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.5300
    Cell Significance Index: -6.4300
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.5326
    Cell Significance Index: -6.6200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.5582
    Cell Significance Index: -13.5200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5734
    Cell Significance Index: -30.1100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.5744
    Cell Significance Index: -7.3700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5980
    Cell Significance Index: -38.5800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6010
    Cell Significance Index: -19.2500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6061
    Cell Significance Index: -31.5700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.6077
    Cell Significance Index: -17.5100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6109
    Cell Significance Index: -21.4000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.6140
    Cell Significance Index: -5.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6156
    Cell Significance Index: -31.9800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.7192
    Cell Significance Index: -15.0100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.7796
    Cell Significance Index: -36.6400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.8004
    Cell Significance Index: -10.1000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.8036
    Cell Significance Index: -9.6100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8440
    Cell Significance Index: -22.6200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.8476
    Cell Significance Index: -12.1900
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.8569
    Cell Significance Index: -6.2300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.8605
    Cell Significance Index: -11.4700
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.8709
    Cell Significance Index: -6.6800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.8800
    Cell Significance Index: -41.0300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.9112
    Cell Significance Index: -33.4500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.9692
    Cell Significance Index: -19.0800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -1.0318
    Cell Significance Index: -25.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular localization:** ADAM23 is predominantly expressed in the CNS, with significant expression in Purkinje cells, regular ventricular cardiac myocytes, and various types of GABAergic interneurons. 2. **Protein structure:** ADAM23 contains a disintegrin and metalloproteinase (ADAM) domain, which is responsible for its proteolytic activity and cell adhesion functions. 3. **Functional diversity:** ADAM23 is involved in multiple cellular processes, including cell adhesion, proteolysis, signaling, and synaptic plasticity. 4. **Evolutionary conservation:** ADAM23 is highly conserved across species, suggesting its evolutionary importance. **Pathways and Functions:** 1. **Cell adhesion:** ADAM23 mediates cell adhesion through its disintegrin domain, which interacts with various ligands, including integrins and LGI-ADAM interactions. 2. **Proteolysis:** ADAM23's metalloendopeptidase activity enables it to cleave and regulate the activity of various proteins, including growth factors and adhesion molecules. 3. **Signaling:** ADAM23 modulates signaling pathways, including the glutamatergic synapse, which is crucial for learning and memory. 4. **Neurological functions:** ADAM23 plays a role in CNS development, synaptic plasticity, and the regulation of neuronal activity. **Clinical Significance:** 1. **Neurological disorders:** ADAM23's involvement in CNS development and function suggests its potential role in neurological disorders, such as autism spectrum disorder, schizophrenia, and Alzheimer's disease. 2. **Cardiac function:** ADAM23's expression in cardiac myocytes implies its potential role in cardiac function and disease, including heart failure and arrhythmias. 3. **Cancer:** ADAM23's proteolytic activity and involvement in cell adhesion suggest its potential role in cancer progression and metastasis. 4. **Therapeutic applications:** Understanding ADAM23's functional roles and cellular localization may lead to the development of novel therapeutic strategies for neurological and cardiac disorders. In conclusion, ADAM23 is a multifaceted gene that plays a critical role in various cellular processes, including cell adhesion, signaling, and neurological functions. Further research is necessary to fully elucidate ADAM23's functional roles and clinical significance, which may ultimately lead to the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 2967276130

Symbol: ADA23_HUMAN

Name: Disintegrin and metalloproteinase domain-containing protein 23

UniProtKB Accession Codes:

O75077 A2RU59

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9693107

Title: Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain.

PubMed ID: 9693107

DOI: 10.1042/bj3340093

PubMed ID: 10749942

Title: ADAM 23/MDC3, a human disintegrin that promotes cell adhesion via interaction with the alpha v beta 3 integrin through an RGD-independent mechanism.

PubMed ID: 10749942

DOI: 10.1091/mbc.11.4.1457

PubMed ID: 14697522

Title: Two novel isoforms of Adam23 expressed in the developmental process of mouse and human brains.

PubMed ID: 14697522

DOI: 10.1016/j.gene.2003.10.012

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 832
  • Mass: 91926
  • Checksum: 7841A9670E1C24EF
  • Sequence:
    • MKPPGSSSRQ PPLAGCSLAG ASCGPQRGPA GSVPASAPAR TPPCRLLLVL LLLPPLAASS 
RPRAWGAAAP SAPHWNETAE KNLGVLADED NTLQQNSSSN ISYSNAMQKE ITLPSRLIYY 
INQDSESPYH VLDTKARHQQ KHNKAVHLAQ ASFQIEAFGS KFILDLILNN GLLSSDYVEI 
HYENGKPQYS KGGEHCYYHG SIRGVKDSKV ALSTCNGLHG MFEDDTFVYM IEPLELVHDE 
KSTGRPHIIQ KTLAGQYSKQ MKNLTMERGD QWPFLSELQW LKRRKRAVNP SRGIFEEMKY 
LELMIVNDHK TYKKHRSSHA HTNNFAKSVV NLVDSIYKEQ LNTRVVLVAV ETWTEKDQID 
ITTNPVQMLH EFSKYRQRIK QHADAVHLIS RVTFHYKRSS LSYFGGVCSR TRGVGVNEYG 
LPMAVAQVLS QSLAQNLGIQ WEPSSRKPKC DCTESWGGCI MEETGVSHSR KFSKCSILEY 
RDFLQRGGGA CLFNRPTKLF EPTECGNGYV EAGEECDCGF HVECYGLCCK KCSLSNGAHC 
SDGPCCNNTS CLFQPRGYEC RDAVNECDIT EYCTGDSGQC PPNLHKQDGY ACNQNQGRCY 
NGECKTRDNQ CQYIWGTKAA GSDKFCYEKL NTEGTEKGNC GKDGDRWIQC SKHDVFCGFL 
LCTNLTRAPR IGQLQGEIIP TSFYHQGRVI DCSGAHVVLD DDTDVGYVED GTPCGPSMMC 
LDRKCLQIQA LNMSSCPLDS KGKVCSGHGV CSNEATCICD FTWAGTDCSI RDPVRNLHPP 
KDEGPKGPSA TNLIIGSIAG AILVAAIVLG GTGWGFKNVK KRRFDPTQQG PI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.