Details for: SARAF

Gene ID: 51669

Symbol: SARAF

Ensembl ID: ENSG00000133872

Description: store-operated calcium entry associated regulatory factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 342.9320
    Cell Significance Index: -141.2700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 332.0065
    Cell Significance Index: -134.8800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 309.7288
    Cell Significance Index: -146.2300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 286.9056
    Cell Significance Index: -147.5800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 218.4280
    Cell Significance Index: -146.5700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 141.5983
    Cell Significance Index: -135.1900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 32.1086
    Cell Significance Index: -98.6200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 28.9004
    Cell Significance Index: -77.4200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 16.1108
    Cell Significance Index: -35.2600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 5.8061
    Cell Significance Index: 304.8400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.5254
    Cell Significance Index: 92.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.3675
    Cell Significance Index: 250.9800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.7954
    Cell Significance Index: 180.3500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.7403
    Cell Significance Index: 80.4800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.4020
    Cell Significance Index: 329.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.3455
    Cell Significance Index: 470.5000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.3392
    Cell Significance Index: 1277.5100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.3241
    Cell Significance Index: 418.9700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.2918
    Cell Significance Index: 106.8500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.9769
    Cell Significance Index: 255.4100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.9320
    Cell Significance Index: 237.5600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.8630
    Cell Significance Index: 238.8300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.8078
    Cell Significance Index: 648.4300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.4942
    Cell Significance Index: 91.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.3846
    Cell Significance Index: 65.0800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.3603
    Cell Significance Index: 601.4300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9578
    Cell Significance Index: 662.4600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9312
    Cell Significance Index: 184.7900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8490
    Cell Significance Index: 23.1100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8162
    Cell Significance Index: 96.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.6988
    Cell Significance Index: 119.3300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6210
    Cell Significance Index: 43.9200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4584
    Cell Significance Index: 10.5900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1990
    Cell Significance Index: 37.8700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0910
    Cell Significance Index: 82.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0870
    Cell Significance Index: 63.8200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0526
    Cell Significance Index: 5.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0399
    Cell Significance Index: 75.1000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0314
    Cell Significance Index: 0.8400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0040
    Cell Significance Index: 0.2100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0020
    Cell Significance Index: -1.5400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0254
    Cell Significance Index: -2.5900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0622
    Cell Significance Index: -114.7800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0641
    Cell Significance Index: -98.6900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0745
    Cell Significance Index: -3.7700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0864
    Cell Significance Index: -5.8100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0926
    Cell Significance Index: -58.8100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0953
    Cell Significance Index: -129.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1097
    Cell Significance Index: -81.2800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1869
    Cell Significance Index: -4.9900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1981
    Cell Significance Index: -89.9000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2024
    Cell Significance Index: -114.1400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2619
    Cell Significance Index: -9.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2821
    Cell Significance Index: -176.1800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3314
    Cell Significance Index: -7.1800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3798
    Cell Significance Index: -23.9400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3963
    Cell Significance Index: -114.0400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4281
    Cell Significance Index: -7.1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4426
    Cell Significance Index: -64.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4949
    Cell Significance Index: -27.7700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.5173
    Cell Significance Index: -21.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5534
    Cell Significance Index: -63.4100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5854
    Cell Significance Index: -10.8200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.6480
    Cell Significance Index: -136.4800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6494
    Cell Significance Index: -16.5900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.6684
    Cell Significance Index: -46.2200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.7010
    Cell Significance Index: -76.2500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.7083
    Cell Significance Index: -12.2100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.8215
    Cell Significance Index: -7.5700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.8332
    Cell Significance Index: -63.9400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.9297
    Cell Significance Index: -32.6700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.9508
    Cell Significance Index: -110.8100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.0484
    Cell Significance Index: -29.3000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.0597
    Cell Significance Index: -18.1600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.0704
    Cell Significance Index: -25.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.0791
    Cell Significance Index: -48.9100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.0883
    Cell Significance Index: -22.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -1.0982
    Cell Significance Index: -31.6400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.2164
    Cell Significance Index: -126.6600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -1.3045
    Cell Significance Index: -14.8200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.3307
    Cell Significance Index: -38.1500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.3758
    Cell Significance Index: -39.2600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.6203
    Cell Significance Index: -128.3300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -1.6567
    Cell Significance Index: -12.7700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.7256
    Cell Significance Index: -36.7500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -1.7760
    Cell Significance Index: -22.7500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.7938
    Cell Significance Index: -79.3500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.8934
    Cell Significance Index: -22.5700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -2.2035
    Cell Significance Index: -83.4400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -2.2767
    Cell Significance Index: -118.5900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.3496
    Cell Significance Index: -144.0500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -2.5207
    Cell Significance Index: -37.7700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -2.5302
    Cell Significance Index: -81.0400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -2.7123
    Cell Significance Index: -59.3900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -2.7792
    Cell Significance Index: -90.9900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -2.8177
    Cell Significance Index: -89.7400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -2.9269
    Cell Significance Index: -15.9600
  • Cell Name: theca cell (CL0000503)
    Fold Change: -2.9532
    Cell Significance Index: -17.3500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.9646
    Cell Significance Index: -108.8300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -3.0141
    Cell Significance Index: -105.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SARAF is a transcription factor that regulates the expression of genes involved in store-operated calcium entry (SOCE), a process by which calcium ions are released from intracellular stores and enter the cytosol. SARAF is highly expressed in various cell types, including immune cells, muscle cells, and cells of the pancreas. Its expression is often associated with the presence of specific cell surface receptors, such as CD14 and CD16, which are involved in immune responses. **Pathways and Functions:** SARAF is integral to several key pathways, including calcium ion transport, endoplasmic reticulum-plasma membrane contact site, and protein binding. The SARAF gene is involved in the regulation of store-operated calcium entry, which is essential for various cellular processes, including: 1. **Immune responses**: SARAF regulates the expression of genes involved in immune responses, such as cytokine production and cell activation. 2. **Muscle contraction**: SARAF is involved in the regulation of calcium ion transport in skeletal muscle cells, which is essential for muscle contraction and relaxation. 3. **Cell signaling**: SARAF regulates the expression of genes involved in cell signaling pathways, including the PI3K/Akt and MAPK/ERK pathways. **Clinical Significance:** Dysregulation of SARAF has been implicated in various diseases, including: 1. **Immune disorders**: SARAF dysfunction has been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Muscle disorders**: SARAF mutations have been associated with muscle disorders, such as muscular dystrophy. 3. **Cancer**: SARAF has been implicated in cancer progression, particularly in immune-related cancers, such as melanoma and lymphoma. In conclusion, SARAF is a critical gene that regulates store-operated calcium entry and plays a pivotal role in various cellular processes, including immune responses, muscle contraction, and cell signaling. Its dysregulation has been implicated in various diseases, highlighting the importance of SARAF in maintaining cellular homeostasis and promoting overall health. **Recommendations:** 1. Further research is needed to elucidate the mechanisms by which SARAF regulates store-operated calcium entry and its role in various diseases. 2. SARAF should be considered as a potential therapeutic target for immune disorders, muscle disorders, and cancer. 3. The development of diagnostic biomarkers for SARAF-related diseases is crucial for early detection and treatment. **References:** [Insert references to relevant studies and articles] **Author's Note:** This article is intended for expert readers and provides a comprehensive review of the SARAF gene. Further research is needed to fully understand the mechanisms by which SARAF regulates store-operated calcium entry and its role in various diseases.

Genular Protein ID: 1723662067

Symbol: SARAF_HUMAN

Name: Store-operated calcium entry-associated regulatory factor

UniProtKB Accession Codes:

Q96BY9 B3KQQ4 B7Z9J1 D3DSU7 H9MHJ8 H9MHJ9 Q53HE8 Q9UNZ3 Q9Y683

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 15 Ensembl 2 ExpressionAtlas 1 GO 5 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 22464749

Title: SARAF inactivates the store operated calcium entry machinery to prevent excess calcium refilling.

PubMed ID: 22464749

DOI: 10.1016/j.cell.2012.01.055

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 30481768

Title: EFHB is a Novel Cytosolic Ca2+ Sensor That Modulates STIM1-SARAF Interaction.

PubMed ID: 30481768

DOI: 10.1159/000495494

Sequence Information:

  • Length: 339
  • Mass: 36975
  • Checksum: 83CC0517AB635FE9
  • Sequence:
    • MAAACGPGAA GYCLLLGLHL FLLTAGPALG WNDPDRMLLR DVKALTLHYD RYTTSRRLDP 
IPQLKCVGGT AGCDSYTPKV IQCQNKGWDG YDVQWECKTD LDIAYKFGKT VVSCEGYESS 
EDQYVLRGSC GLEYNLDYTE LGLQKLKESG KQHGFASFSD YYYKWSSADS CNMSGLITIV 
VLLGIAFVVY KLFLSDGQYS PPPYSEYPPF SHRYQRFTNS AGPPPPGFKS EFTGPQNTGH 
GATSGFGSAF TGQQGYENSG PGFWTGLGTG GILGYLFGSN RAATPFSDSW YYPSYPPSYP 
GTWNRAYSPL HGGSGSYSVC SNSDTKTRTA SGYGGTRRR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.