Details for: RBM39

Gene ID: 9584

Symbol: RBM39

Ensembl ID: ENSG00000131051

Description: RNA binding motif protein 39

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.42
    Marker Score: 150,244
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 4.13
    Marker Score: 3,128
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.83
    Marker Score: 4,087
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.73
    Marker Score: 890
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.71
    Marker Score: 10,399
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.7
    Marker Score: 7,800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 3.66
    Marker Score: 1,348
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.62
    Marker Score: 3,570
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.59
    Marker Score: 8,764
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 3.57
    Marker Score: 10,426
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 3.55
    Marker Score: 7,444
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.55
    Marker Score: 11,188
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.52
    Marker Score: 9,736
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 3.41
    Marker Score: 180,171
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 3.38
    Marker Score: 1,371
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.37
    Marker Score: 44,491
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 3.31
    Marker Score: 1,609
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.29
    Marker Score: 32,620
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 3.28
    Marker Score: 2,048
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.28
    Marker Score: 2,757
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.27
    Marker Score: 2,786
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 3.26
    Marker Score: 1,327
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 3.21
    Marker Score: 735
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 3.2
    Marker Score: 1,117
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 3.15
    Marker Score: 3,685
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 3.14
    Marker Score: 2,808
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.13
    Marker Score: 174,923
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.13
    Marker Score: 6,860
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 3.12
    Marker Score: 1,346
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 3.12
    Marker Score: 2,555
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 3.11
    Marker Score: 15,290
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.11
    Marker Score: 55,185
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.11
    Marker Score: 36,132
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 3.11
    Marker Score: 13,008
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 3.11
    Marker Score: 4,285
  • Cell Name: podocyte (CL0000653)
    Fold Change: 3.09
    Marker Score: 1,141
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3.07
    Marker Score: 2,412
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 3.07
    Marker Score: 1,065
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 3.07
    Marker Score: 3,337
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 3.06
    Marker Score: 68,488
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 3.06
    Marker Score: 2,220
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.04
    Marker Score: 867
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 3.03
    Marker Score: 40,770
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 3.01
    Marker Score: 660
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 3.01
    Marker Score: 748
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 3
    Marker Score: 2,896
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 3
    Marker Score: 1,931
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 2.99
    Marker Score: 650
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.99
    Marker Score: 7,289
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 2.98
    Marker Score: 602
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.98
    Marker Score: 1,992
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.98
    Marker Score: 30,157
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.97
    Marker Score: 1,732
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 2.97
    Marker Score: 1,526
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.97
    Marker Score: 2,339
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 2.96
    Marker Score: 872
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 2.96
    Marker Score: 1,346
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 2.96
    Marker Score: 834
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 2.96
    Marker Score: 688
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 2.95
    Marker Score: 781
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.94
    Marker Score: 3,797
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.94
    Marker Score: 2,225
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 2.94
    Marker Score: 730
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 2.93
    Marker Score: 1,359
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.92
    Marker Score: 1,310
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.91
    Marker Score: 1,455
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.91
    Marker Score: 3,624
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 2.91
    Marker Score: 715
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 2.91
    Marker Score: 3,135
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.9
    Marker Score: 2,717
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.9
    Marker Score: 2,601
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.9
    Marker Score: 3,899
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.88
    Marker Score: 1,735
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.87
    Marker Score: 2,699
  • Cell Name: parietal cell (CL0000162)
    Fold Change: 2.87
    Marker Score: 800
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.87
    Marker Score: 3,539
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 2.86
    Marker Score: 1,079
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.86
    Marker Score: 4,214
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.86
    Marker Score: 1,011
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 2.85
    Marker Score: 938
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 2.85
    Marker Score: 1,225
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.85
    Marker Score: 4,140
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.85
    Marker Score: 1,186
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 2.84
    Marker Score: 737
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.84
    Marker Score: 3,059
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.84
    Marker Score: 12,193
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 2.84
    Marker Score: 1,883
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 2.84
    Marker Score: 3,354
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 2.84
    Marker Score: 798
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 2.84
    Marker Score: 752
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 2.83
    Marker Score: 2,497
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 2.83
    Marker Score: 1,901
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 2.83
    Marker Score: 2,596
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.83
    Marker Score: 5,146
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.82
    Marker Score: 2,971
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.82
    Marker Score: 5,300
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 2.82
    Marker Score: 822
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.81
    Marker Score: 2,439
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.81
    Marker Score: 5,409
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 2.81
    Marker Score: 720

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **RNA binding domain:** RBM39 contains a conserved RNA binding domain (RBD), which is essential for its ability to interact with RNA molecules. 2. **Splicing regulator:** RBM39 is a spliceosome-associated factor, which means it regulates the splicing of pre-mRNA by interacting with spliceosomal components. 3. **Multifunctional protein:** RBM39 has been implicated in various cellular processes, including RNA metabolism, microtubule organization, and regulation of gene expression. 4. **Cell type specificity:** RBM39 expression is tissue-specific, with significant levels detected in immune cells, epithelial cells, and stem cells. **Pathways and Functions:** 1. **RNA splicing:** RBM39 regulates the splicing of pre-mRNA by interacting with spliceosomal components, such as U1 snRNP and U2AF65. 2. **mRNA processing:** RBM39 is involved in the processing of capped intron-containing pre-mRNA, which is essential for the production of mature mRNA. 3. **Microtubule organization:** RBM39 interacts with microtubule-associated proteins, such as MAPs, to regulate microtubule dynamics and cell morphology. 4. **Regulation of gene expression:** RBM39 modulates gene expression by regulating the splicing of pre-mRNA and interacting with transcription factors. **Clinical Significance:** 1. **Cancer association:** RBM39 has been implicated in various cancers, including breast, lung, and colon cancer, where it is often overexpressed. 2. **Immune system disorders:** RBM39 has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus, where it is involved in regulating immune cell function. 3. **Neurological disorders:** RBM39 has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's, where it is involved in regulating RNA metabolism and gene expression. 4. **Stem cell biology:** RBM39 plays a crucial role in the regulation of stem cell fate and function, particularly in the context of hematopoiesis and epithelial homeostasis. In conclusion, RBM39 is a multifaceted RNA binding protein that plays a crucial role in regulating RNA metabolism, splicing, and gene expression. Its involvement in various cellular processes and its association with various diseases highlight its importance in understanding human biology and disease. Further research is needed to fully elucidate the functions of RBM39 and its role in human health and disease.

Genular Protein ID: 795432031

Symbol: RBM39_HUMAN

Name: RNA-binding motif protein 39

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8227358

Title: Novel nuclear autoantigen with splicing factor motifs identified with antibody from hepatocellular carcinoma.

PubMed ID: 8227358

DOI: 10.1172/jci116848

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15694343

Title: Steroid hormone receptor coactivation and alternative RNA splicing by U2AF65-related proteins CAPERalpha and CAPERbeta.

PubMed ID: 15694343

DOI: 10.1016/j.molcel.2004.12.025

PubMed ID: 15798186

Title: A novel SR-related protein is required for the second step of pre-mRNA splicing.

PubMed ID: 15798186

DOI: 10.1128/mcb.25.8.2969-2980.2005

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28437394

Title: Selective degradation of splicing factor CAPERalpha by anticancer sulfonamides.

PubMed ID: 28437394

DOI: 10.1038/nchembio.2363

PubMed ID: 28302793

Title: Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.

PubMed ID: 28302793

DOI: 10.1126/science.aal3755

PubMed ID: 28546157

Title:

PubMed ID: 28546157

DOI: 10.1126/science.aan7977

PubMed ID: 31693891

Title: Aryl sulfonamides degrade RBM39 and RBM23 by recruitment to CRL4-DCAF15.

PubMed ID: 31693891

DOI: 10.1016/j.celrep.2019.09.079

PubMed ID: 31271494

Title: U2AF65 assemblies drive sequence-specific splice site recognition.

PubMed ID: 31271494

DOI: 10.15252/embr.201847604

PubMed ID: 24795046

Title: Cancer-relevant splicing factor CAPERalpha engages the essential splicing factor SF3b155 in a specific ternary complex.

PubMed ID: 24795046

DOI: 10.1074/jbc.m114.558825

PubMed ID: 31686031

Title: Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15.

PubMed ID: 31686031

DOI: 10.1038/s41589-019-0378-3

PubMed ID: 31819272

Title: Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex.

PubMed ID: 31819272

DOI: 10.1038/s41589-019-0411-6

PubMed ID: 31693911

Title: Structural basis and kinetic pathway of RBM39 recruitment to DCAF15 by a sulfonamide molecular glue E7820.

PubMed ID: 31693911

DOI: 10.1016/j.str.2019.10.005

Sequence Information:

  • Length: 530
  • Mass: 59380
  • Checksum: 0CC610356D4AA040
  • Sequence:
  • MADDIDIEAM LEAPYKKDEN KLSSANGHEE RSKKRKKSKS RSRSHERKRS KSKERKRSRD 
    RERKKSKSRE RKRSRSKERR RSRSRSRDRR FRGRYRSPYS GPKFNSAIRG KIGLPHSIKL 
    SRRRSRSKSP FRKDKSPVRE PIDNLTPEER DARTVFCMQL AARIRPRDLE EFFSTVGKVR 
    DVRMISDRNS RRSKGIAYVE FVDVSSVPLA IGLTGQRVLG VPIIVQASQA EKNRAAAMAN 
    NLQKGSAGPM RLYVGSLHFN ITEDMLRGIF EPFGRIESIQ LMMDSETGRS KGYGFITFSD 
    SECAKKALEQ LNGFELAGRP MKVGHVTERT DASSASSFLD SDELERTGID LGTTGRLQLM 
    ARLAEGTGLQ IPPAAQQALQ MSGSLAFGAV AEFSFVIDLQ TRLSQQTEAS ALAAAASVQP 
    LATQCFQLSN MFNPQTEEEV GWDTEIKDDV IEECNKHGGV IHIYVDKNSA QGNVYVKCPS 
    IAAAIAAVNA LHGRWFAGKM ITAAYVPLPT YHNLFPDSMT ATQLLVPSRR

Genular Protein ID: 4245750920

Symbol: B4DRA0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 502
  • Mass: 56411
  • Checksum: 140FAB1725010D75
  • Sequence:
  • MADDIDIEAM LEAPYKKDEN KLSSANGHEE RSKKRKKSKS RSRCHERKRS KSKERKRSRD 
    RERKKSKSRE RKRSRSRERR RSRSRSRDRR FRGRYRSPYR RRSRSKSPFR KDKSPVREPI 
    DNLTPEERDA RTVFCMQLAA RIRPRDLEEF FSTVGKVRDV RMISDRNSRR SKGIAYVEFV 
    DVSSVPLAIG LTGQRVLGVP IIVQASQAEK NRAAAMANNL QKGSAGPMRL YVGSLHFNIT 
    EDMLRGIFEP FGRIESIQLM MDSETGRSKG YGFITFSDSE CAKKALEQLN GFELAGRPMK 
    VGHVTERTDA SSASSFLDSD ELERTGIDLG TTGRLQLMAR LAEGTGLQIP PAAQQALQMS 
    GSLAFGAVAD LQTRLSQQTE ASALAAAASV QPLATQCFQL SNMFNPQTEE EVGWDTEIKD 
    DVIEECNKHG GVIHIYVDKN SAQGNVYVKC PSIAAAIAAV NALHGRWFAG KMITAAYVPL 
    PTYHNLFPDS MTATQLLVPS RR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.