Details for: CL0002048

Cell ID: CL0002048

Cell Name: late pro-B cell

Marker Score Threshold: 1,180
(Derived using integrated single-cell and genomic data)

Description: A pre-B cell precursor is CD19-low, CD22-positive , CD34-positive, CD38-positive.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: COX1 (ENSG00000198804)
    Fold Change: 4.91
    Ensembl ID: ENSG00000198804
  • Gene Symbol: COX2 (ENSG00000198712)
    Fold Change: 4.84
    Ensembl ID: ENSG00000198712
  • Gene Symbol: COX3 (ENSG00000198938)
    Fold Change: 4.84
    Ensembl ID: ENSG00000198938
  • Gene Symbol: ND4 (ENSG00000198886)
    Fold Change: 4.78
    Ensembl ID: ENSG00000198886
  • Gene Symbol: ND3 (ENSG00000198840)
    Fold Change: 4.71
    Ensembl ID: ENSG00000198840
  • Gene Symbol: ATP6 (ENSG00000198899)
    Fold Change: 4.7
    Ensembl ID: ENSG00000198899
  • Gene Symbol: CYTB (ENSG00000198727)
    Fold Change: 4.67
    Ensembl ID: ENSG00000198727
  • Gene Symbol: ND1 (ENSG00000198888)
    Fold Change: 4.2
    Ensembl ID: ENSG00000198888
  • Gene Symbol: ND4L (ENSG00000212907)
    Fold Change: 3.7
    Ensembl ID: ENSG00000212907
  • Gene Symbol: ND5 (ENSG00000198786)
    Fold Change: 3.7
    Ensembl ID: ENSG00000198786
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.69
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.66
    Ensembl ID: ENSG00000166710
  • Gene Symbol: PTMA (ENSG00000187514)
    Fold Change: 3.64
    Ensembl ID: ENSG00000187514
  • Gene Symbol: RPL15 (ENSG00000174748)
    Fold Change: 3.63
    Ensembl ID: ENSG00000174748
  • Gene Symbol: RPL13 (ENSG00000167526)
    Fold Change: 3.63
    Ensembl ID: ENSG00000167526
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 3.62
    Ensembl ID: ENSG00000156508
  • Gene Symbol: FTL (ENSG00000087086)
    Fold Change: 3.62
    Ensembl ID: ENSG00000087086
  • Gene Symbol: H3 3B (ENSG00000132475)
    Fold Change: 3.61
    Ensembl ID: ENSG00000132475
  • Gene Symbol: RPL19 (ENSG00000108298)
    Fold Change: 3.61
    Ensembl ID: ENSG00000108298
  • Gene Symbol: RPL5 (ENSG00000122406)
    Fold Change: 3.61
    Ensembl ID: ENSG00000122406
  • Gene Symbol: RPL11 (ENSG00000142676)
    Fold Change: 3.59
    Ensembl ID: ENSG00000142676
  • Gene Symbol: FTH1 (ENSG00000167996)
    Fold Change: 3.59
    Ensembl ID: ENSG00000167996
  • Gene Symbol: FAU (ENSG00000149806)
    Fold Change: 3.59
    Ensembl ID: ENSG00000149806
  • Gene Symbol: RPL18 (ENSG00000063177)
    Fold Change: 3.59
    Ensembl ID: ENSG00000063177
  • Gene Symbol: RPL3 (ENSG00000100316)
    Fold Change: 3.58
    Ensembl ID: ENSG00000100316
  • Gene Symbol: GAPDH (ENSG00000111640)
    Fold Change: 3.57
    Ensembl ID: ENSG00000111640
  • Gene Symbol: RPL8 (ENSG00000161016)
    Fold Change: 3.57
    Ensembl ID: ENSG00000161016
  • Gene Symbol: RPL23A (ENSG00000198242)
    Fold Change: 3.55
    Ensembl ID: ENSG00000198242
  • Gene Symbol: RPL21 (ENSG00000122026)
    Fold Change: 3.55
    Ensembl ID: ENSG00000122026
  • Gene Symbol: NACA (ENSG00000196531)
    Fold Change: 3.55
    Ensembl ID: ENSG00000196531
  • Gene Symbol: RPL10 (ENSG00000147403)
    Fold Change: 3.54
    Ensembl ID: ENSG00000147403
  • Gene Symbol: RPL9 (ENSG00000163682)
    Fold Change: 3.54
    Ensembl ID: ENSG00000163682
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 3.53
    Ensembl ID: ENSG00000019582
  • Gene Symbol: RPL18A (ENSG00000105640)
    Fold Change: 3.53
    Ensembl ID: ENSG00000105640
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.51
    Ensembl ID: ENSG00000145741
  • Gene Symbol: HLA DRA (ENSG00000204287)
    Fold Change: 3.51
    Ensembl ID: ENSG00000204287
  • Gene Symbol: RPL10A (ENSG00000198755)
    Fold Change: 3.51
    Ensembl ID: ENSG00000198755
  • Gene Symbol: RPL22 (ENSG00000116251)
    Fold Change: 3.5
    Ensembl ID: ENSG00000116251
  • Gene Symbol: RPL12 (ENSG00000197958)
    Fold Change: 3.5
    Ensembl ID: ENSG00000197958
  • Gene Symbol: RPL7A (ENSG00000148303)
    Fold Change: 3.5
    Ensembl ID: ENSG00000148303
  • Gene Symbol: H3 3A (ENSG00000163041)
    Fold Change: 3.49
    Ensembl ID: ENSG00000163041
  • Gene Symbol: RPL24 (ENSG00000114391)
    Fold Change: 3.48
    Ensembl ID: ENSG00000114391
  • Gene Symbol: RPL6 (ENSG00000089009)
    Fold Change: 3.48
    Ensembl ID: ENSG00000089009
  • Gene Symbol: RPL7 (ENSG00000147604)
    Fold Change: 3.47
    Ensembl ID: ENSG00000147604
  • Gene Symbol: HMGB1 (ENSG00000189403)
    Fold Change: 3.46
    Ensembl ID: ENSG00000189403
  • Gene Symbol: HNRNPA1 (ENSG00000135486)
    Fold Change: 3.44
    Ensembl ID: ENSG00000135486
  • Gene Symbol: EEF2 (ENSG00000167658)
    Fold Change: 3.44
    Ensembl ID: ENSG00000167658
  • Gene Symbol: RPSA (ENSG00000168028)
    Fold Change: 3.43
    Ensembl ID: ENSG00000168028
  • Gene Symbol: HSP90AA1 (ENSG00000080824)
    Fold Change: 3.43
    Ensembl ID: ENSG00000080824
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 3.43
    Ensembl ID: ENSG00000127184
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 3.41
    Ensembl ID: ENSG00000172757
  • Gene Symbol: RPL4 (ENSG00000174444)
    Fold Change: 3.4
    Ensembl ID: ENSG00000174444
  • Gene Symbol: PPIA (ENSG00000196262)
    Fold Change: 3.4
    Ensembl ID: ENSG00000196262
  • Gene Symbol: HLA A (ENSG00000206503)
    Fold Change: 3.39
    Ensembl ID: ENSG00000206503
  • Gene Symbol: HLA B (ENSG00000234745)
    Fold Change: 3.39
    Ensembl ID: ENSG00000234745
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.39
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.39
    Ensembl ID: ENSG00000135390
  • Gene Symbol: NPM1 (ENSG00000181163)
    Fold Change: 3.38
    Ensembl ID: ENSG00000181163
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 3.37
    Ensembl ID: ENSG00000111348
  • Gene Symbol: OAZ1 (ENSG00000104904)
    Fold Change: 3.35
    Ensembl ID: ENSG00000104904
  • Gene Symbol: HNRNPA2B1 (ENSG00000122566)
    Fold Change: 3.32
    Ensembl ID: ENSG00000122566
  • Gene Symbol: CD79B (ENSG00000007312)
    Fold Change: 3.31
    Ensembl ID: ENSG00000007312
  • Gene Symbol: PCBP2 (ENSG00000197111)
    Fold Change: 3.3
    Ensembl ID: ENSG00000197111
  • Gene Symbol: MYL6 (ENSG00000092841)
    Fold Change: 3.3
    Ensembl ID: ENSG00000092841
  • Gene Symbol: EEF1D (ENSG00000104529)
    Fold Change: 3.29
    Ensembl ID: ENSG00000104529
  • Gene Symbol: RPL26 (ENSG00000161970)
    Fold Change: 3.28
    Ensembl ID: ENSG00000161970
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 3.26
    Ensembl ID: ENSG00000124172
  • Gene Symbol: HLA C (ENSG00000204525)
    Fold Change: 3.26
    Ensembl ID: ENSG00000204525
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 3.25
    Ensembl ID: ENSG00000104894
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 3.24
    Ensembl ID: ENSG00000131143
  • Gene Symbol: EIF3E (ENSG00000104408)
    Fold Change: 3.23
    Ensembl ID: ENSG00000104408
  • Gene Symbol: PFDN5 (ENSG00000123349)
    Fold Change: 3.23
    Ensembl ID: ENSG00000123349
  • Gene Symbol: CD99 (ENSG00000002586)
    Fold Change: 3.22
    Ensembl ID: ENSG00000002586
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.22
    Ensembl ID: ENSG00000169100
  • Gene Symbol: HNRNPK (ENSG00000165119)
    Fold Change: 3.16
    Ensembl ID: ENSG00000165119
  • Gene Symbol: HINT1 (ENSG00000169567)
    Fold Change: 3.15
    Ensembl ID: ENSG00000169567
  • Gene Symbol: HNRNPC (ENSG00000092199)
    Fold Change: 3.14
    Ensembl ID: ENSG00000092199
  • Gene Symbol: ND2 (ENSG00000198763)
    Fold Change: 3.11
    Ensembl ID: ENSG00000198763
  • Gene Symbol: HSP90AB1 (ENSG00000096384)
    Fold Change: 3.09
    Ensembl ID: ENSG00000096384
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 3.06
    Ensembl ID: ENSG00000067560
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 3.05
    Ensembl ID: ENSG00000108654
  • Gene Symbol: PFN1 (ENSG00000108518)
    Fold Change: 3.03
    Ensembl ID: ENSG00000108518
  • Gene Symbol: ATP8 (ENSG00000228253)
    Fold Change: 3.01
    Ensembl ID: ENSG00000228253
  • Gene Symbol: EIF4A2 (ENSG00000156976)
    Fold Change: 3
    Ensembl ID: ENSG00000156976
  • Gene Symbol: HLA E (ENSG00000204592)
    Fold Change: 3
    Ensembl ID: ENSG00000204592
  • Gene Symbol: STMN1 (ENSG00000117632)
    Fold Change: 2.97
    Ensembl ID: ENSG00000117632
  • Gene Symbol: HMGN1 (ENSG00000205581)
    Fold Change: 2.97
    Ensembl ID: ENSG00000205581
  • Gene Symbol: HLA DPB1 (ENSG00000223865)
    Fold Change: 2.96
    Ensembl ID: ENSG00000223865
  • Gene Symbol: CD79A (ENSG00000105369)
    Fold Change: 2.92
    Ensembl ID: ENSG00000105369
  • Gene Symbol: HLA DPA1 (ENSG00000231389)
    Fold Change: 2.9
    Ensembl ID: ENSG00000231389
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 2.89
    Ensembl ID: ENSG00000010278
  • Gene Symbol: DNTT (ENSG00000107447)
    Fold Change: 2.89
    Ensembl ID: ENSG00000107447
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.86
    Ensembl ID: ENSG00000110955
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 2.84
    Ensembl ID: ENSG00000126267
  • Gene Symbol: HSPA8 (ENSG00000109971)
    Fold Change: 2.84
    Ensembl ID: ENSG00000109971
  • Gene Symbol: PSME1 (ENSG00000092010)
    Fold Change: 2.84
    Ensembl ID: ENSG00000092010
  • Gene Symbol: LDHB (ENSG00000111716)
    Fold Change: 2.83
    Ensembl ID: ENSG00000111716
  • Gene Symbol: HMGB2 (ENSG00000164104)
    Fold Change: 2.82
    Ensembl ID: ENSG00000164104
  • Gene Symbol: FKBP1A (ENSG00000088832)
    Fold Change: 2.81
    Ensembl ID: ENSG00000088832
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.8
    Ensembl ID: ENSG00000099622

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in late pro-B cell cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in late pro-B cell cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** 1. **Surface Markers**: The late pro-B cell expresses CD22, CD34, and CD38, while having low expression of CD19. 2. **Gene Expression Profile**: The late pro-B cell exhibits a unique gene expression profile, which includes the expression of COX1, COX2, and COX3 genes. 3. **Mitochondrial Function**: The late pro-B cell has a functional mitochondria, which is essential for its survival and development. 4. **Response to Stimuli**: The late pro-B cell is responsive to various stimuli, including copper ions, hypoxia, and oxidative stress. **Clinical Significance** 1. **Immune System Development**: The late pro-B cell plays a crucial role in the development of the immune system, particularly in the adaptive response. 2. **Cancer Research**: The late pro-B cell has been implicated in the development of certain types of cancer, including B-cell lymphoma. 3. **Immunodeficiency Disorders**: Abnormalities in the late pro-B cell can lead to immunodeficiency disorders, such as X-linked agammaglobulinemia. **Gene Expression Profile** The late pro-B cell exhibits a unique gene expression profile, which includes the expression of COX1, COX2, and COX3 genes. These genes are involved in mitochondrial function and are essential for the survival and development of the late pro-B cell. **COX1 Gene** The COX1 gene is involved in the production of cytochrome c oxidase, an enzyme that plays a crucial role in mitochondrial function. The COX1 gene is expressed in the late pro-B cell and is essential for its survival and development. **COX2 Gene** The COX2 gene is involved in the production of cytochrome c oxidase and is also expressed in the late pro-B cell. The COX2 gene is essential for the regulation of mitochondrial function and is involved in the response to various stimuli. **COX3 Gene** The COX3 gene is involved in the production of cytochrome c oxidase and is also expressed in the late pro-B cell. The COX3 gene is essential for the regulation of mitochondrial function and is involved in the response to various stimuli. **Mitochondrial Function** The late pro-B cell has a functional mitochondria, which is essential for its survival and development. The mitochondria play a crucial role in the production of ATP, which is necessary for the cell's survival. **Response to Stimuli** The late pro-B cell is responsive to various stimuli, including copper ions, hypoxia, and oxidative stress. The cell's response to these stimuli is mediated by the expression of specific genes, including COX1, COX2, and COX3. In conclusion, the late pro-B cell is a unique cell type that plays a crucial role in the development and function of the immune system. Its expression of specific surface markers and its ability to respond to various stimuli make it an essential component of the adaptive response. The gene expression profile of the late pro-B cell, including the expression of COX1, COX2, and COX3 genes, is essential for its survival and development.