Details for: CL0002048

Cell ID: CL0002048

Cell Name: late pro-B cell

Marker Score Threshold: 1180
(Derived using integrated single-cell and genomic data)

Description: A pre-B cell precursor is CD19-low, CD22-positive , CD34-positive, CD38-positive.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.69
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.66
    Ensembl ID: ENSG00000166710
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 3.53
    Ensembl ID: ENSG00000019582
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.51
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 3.41
    Ensembl ID: ENSG00000172757
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.39
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.39
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 3.37
    Ensembl ID: ENSG00000111348
  • Gene Symbol: CD79B (ENSG00000007312)
    Fold Change: 3.31
    Ensembl ID: ENSG00000007312
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 3.26
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 3.25
    Ensembl ID: ENSG00000104894
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.22
    Ensembl ID: ENSG00000169100
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 3.06
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CD79A (ENSG00000105369)
    Fold Change: 2.92
    Ensembl ID: ENSG00000105369
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 2.89
    Ensembl ID: ENSG00000010278
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.86
    Ensembl ID: ENSG00000110955
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.76
    Ensembl ID: ENSG00000143933
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.73
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CD52 (ENSG00000169442)
    Fold Change: 2.72
    Ensembl ID: ENSG00000169442
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.67
    Ensembl ID: ENSG00000154518
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.57
    Ensembl ID: ENSG00000133639
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2.52
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.51
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CD38 (ENSG00000004468)
    Fold Change: 2.5
    Ensembl ID: ENSG00000004468
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.48
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.46
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.45
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.39
    Ensembl ID: ENSG00000165629
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.39
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 2.27
    Ensembl ID: ENSG00000069849
  • Gene Symbol: AIF1 (ENSG00000204472)
    Fold Change: 2.19
    Ensembl ID: ENSG00000204472
  • Gene Symbol: CD53 (ENSG00000143119)
    Fold Change: 2.14
    Ensembl ID: ENSG00000143119
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.11
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.08
    Ensembl ID: ENSG00000077549
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 2.05
    Ensembl ID: ENSG00000143799
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 2.03
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ADA (ENSG00000196839)
    Fold Change: 2.03
    Ensembl ID: ENSG00000196839
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.02
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.97
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.95
    Ensembl ID: ENSG00000070831
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.92
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.85
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.83
    Ensembl ID: ENSG00000153922
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.8
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.8
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CDK6 (ENSG00000105810)
    Fold Change: 1.77
    Ensembl ID: ENSG00000105810
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.75
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.72
    Ensembl ID: ENSG00000160014
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.67
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.62
    Ensembl ID: ENSG00000099624
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.59
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CD27 (ENSG00000139193)
    Fold Change: 1.57
    Ensembl ID: ENSG00000139193
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.53
    Ensembl ID: ENSG00000146731
  • Gene Symbol: CD34 (ENSG00000174059)
    Fold Change: 1.52
    Ensembl ID: ENSG00000174059
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.5
    Ensembl ID: ENSG00000128272
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.49
    Ensembl ID: ENSG00000085662
  • Gene Symbol: BTK (ENSG00000010671)
    Fold Change: 1.49
    Ensembl ID: ENSG00000010671
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.48
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.47
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.44
    Ensembl ID: ENSG00000148700
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.44
    Ensembl ID: ENSG00000104765
  • Gene Symbol: BCL7A (ENSG00000110987)
    Fold Change: 1.43
    Ensembl ID: ENSG00000110987
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.43
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.42
    Ensembl ID: ENSG00000149311
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.41
    Ensembl ID: ENSG00000172270
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.41
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.39
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.39
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ALOX5 (ENSG00000012779)
    Fold Change: 1.38
    Ensembl ID: ENSG00000012779
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.35
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.34
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.32
    Ensembl ID: ENSG00000004059
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.32
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.31
    Ensembl ID: ENSG00000185883
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.27
    Ensembl ID: ENSG00000173575
  • Gene Symbol: CAT (ENSG00000121691)
    Fold Change: 1.27
    Ensembl ID: ENSG00000121691
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.25
    Ensembl ID: ENSG00000108561
  • Gene Symbol: CD72 (ENSG00000137101)
    Fold Change: 1.24
    Ensembl ID: ENSG00000137101
  • Gene Symbol: CD19 (ENSG00000177455)
    Fold Change: 1.24
    Ensembl ID: ENSG00000177455
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.24
    Ensembl ID: ENSG00000130303
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.24
    Ensembl ID: ENSG00000127022
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.23
    Ensembl ID: ENSG00000053254
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 1.22
    Ensembl ID: ENSG00000132965
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.2
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.2
    Ensembl ID: ENSG00000141522
  • Gene Symbol: CENPC (ENSG00000145241)
    Fold Change: 1.18
    Ensembl ID: ENSG00000145241
  • Gene Symbol: CDKN1B (ENSG00000111276)
    Fold Change: 1.17
    Ensembl ID: ENSG00000111276
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.17
    Ensembl ID: ENSG00000117054
  • Gene Symbol: ARRB2 (ENSG00000141480)
    Fold Change: 1.16
    Ensembl ID: ENSG00000141480
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.14
    Ensembl ID: ENSG00000110651
  • Gene Symbol: ARHGAP4 (ENSG00000089820)
    Fold Change: 1.12
    Ensembl ID: ENSG00000089820
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.08
    Ensembl ID: ENSG00000177105
  • Gene Symbol: BCL2L1 (ENSG00000171552)
    Fold Change: 1.08
    Ensembl ID: ENSG00000171552
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.08
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.06
    Ensembl ID: ENSG00000160710
  • Gene Symbol: AP1B1 (ENSG00000100280)
    Fold Change: 1.03
    Ensembl ID: ENSG00000100280
  • Gene Symbol: A1BG (ENSG00000121410)
    Fold Change: 1.02
    Ensembl ID: ENSG00000121410
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.02
    Ensembl ID: ENSG00000140299
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.02
    Ensembl ID: ENSG00000149823
  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 1.02
    Ensembl ID: ENSG00000168675
Hovered Details

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Hovered Details

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**Key Characteristics** Late pro-B cells are characterized by the following key features: * **Surface markers**: CD19-low, CD22-positive, and CD34-positive * **Gene expression**: ACTB and B2M genes are expressed * **Cellular processes**: Involved in antigen presentation, adaptive immune system, and cellular signaling pathways * **Morphology**: Typically small, round, and compact cells with a high nuclear-to-cytoplasmic ratio **Clinical Significance** Late pro-B cells play a critical role in the development of B lymphocytes, which are essential for the adaptive immune system. Abnormalities in the development of late pro-B cells can lead to immunodeficiency disorders, such as X-linked agammaglobulinemia (XLA) or Bruton's agammaglobulinemia (BA). These disorders are characterized by impaired antibody production and increased susceptibility to infections. Furthermore, late pro-B cells are also involved in the development of certain types of cancer, such as Burkitt lymphoma, which is characterized by the overexpression of the MYC gene. The MYC gene is involved in the regulation of cell proliferation and differentiation, and its dysregulation can lead to uncontrolled cell growth and tumor formation. In addition, late pro-B cells are also of interest in the study of autoimmune diseases, such as rheumatoid arthritis, which is characterized by the production of autoantibodies against self-antigens. The development of late pro-B cells and their interaction with antigen-presenting cells are thought to play a role in the initiation of autoimmune responses. Overall, late pro-B cells are a critical component of the adaptive immune system, and their dysregulation can lead to a range of immunological disorders.