Details for: DNTT

Gene ID: 1791

Symbol: DNTT

Ensembl ID: ENSG00000107447

Description: DNA nucleotidylexotransferase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 9.2568
    Cell Significance Index: 236.4800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.3006
    Cell Significance Index: 148.4200
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 2.0216
    Cell Significance Index: 12.9100
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.8198
    Cell Significance Index: 23.0600
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 1.1199
    Cell Significance Index: 0.5100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7748
    Cell Significance Index: 20.7300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.5427
    Cell Significance Index: 7.9100
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.5231
    Cell Significance Index: 3.4700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.3582
    Cell Significance Index: 10.5500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 0.2103
    Cell Significance Index: -0.8300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.1963
    Cell Significance Index: 20.0500
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.1781
    Cell Significance Index: 1.9900
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.0873
    Cell Significance Index: 0.7800
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.0837
    Cell Significance Index: 0.9000
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.0661
    Cell Significance Index: 0.4800
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.0453
    Cell Significance Index: 0.4600
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0356
    Cell Significance Index: 0.4500
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.0282
    Cell Significance Index: 0.3000
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.0272
    Cell Significance Index: 0.2000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0199
    Cell Significance Index: 0.6300
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.0172
    Cell Significance Index: 0.2000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0073
    Cell Significance Index: 5.0400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0068
    Cell Significance Index: 0.1200
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.0061
    Cell Significance Index: 0.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0044
    Cell Significance Index: 1.2700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0035
    Cell Significance Index: 0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0014
    Cell Significance Index: 2.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0010
    Cell Significance Index: 0.2000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0000
    Cell Significance Index: -0.0400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0001
    Cell Significance Index: -0.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0002
    Cell Significance Index: -0.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0008
    Cell Significance Index: -0.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0008
    Cell Significance Index: -0.6100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0014
    Cell Significance Index: -0.7900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0018
    Cell Significance Index: -0.6400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0020
    Cell Significance Index: -0.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0022
    Cell Significance Index: -0.4300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0025
    Cell Significance Index: -1.1300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0039
    Cell Significance Index: -0.0500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0053
    Cell Significance Index: -1.1200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0053
    Cell Significance Index: -0.6200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0061
    Cell Significance Index: -1.0500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0062
    Cell Significance Index: -0.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0065
    Cell Significance Index: -0.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0067
    Cell Significance Index: -0.9700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0069
    Cell Significance Index: -1.2400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0071
    Cell Significance Index: -0.1900
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0087
    Cell Significance Index: -0.1200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0088
    Cell Significance Index: -0.1300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0093
    Cell Significance Index: -0.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0093
    Cell Significance Index: -0.5700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0100
    Cell Significance Index: -0.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0106
    Cell Significance Index: -1.2100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0110
    Cell Significance Index: -1.3500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0114
    Cell Significance Index: -0.4700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0115
    Cell Significance Index: -0.1400
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0116
    Cell Significance Index: -0.1100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0118
    Cell Significance Index: -0.3300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0127
    Cell Significance Index: -0.7100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0139
    Cell Significance Index: -0.2900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0154
    Cell Significance Index: -0.4200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0157
    Cell Significance Index: -0.7900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0170
    Cell Significance Index: -1.1400
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0183
    Cell Significance Index: -0.1900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0192
    Cell Significance Index: -0.6300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0195
    Cell Significance Index: -0.6200
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0195
    Cell Significance Index: -0.2600
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0198
    Cell Significance Index: -0.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0210
    Cell Significance Index: -0.9300
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: -0.0213
    Cell Significance Index: -0.1800
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0215
    Cell Significance Index: -0.2600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0229
    Cell Significance Index: -0.3000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0234
    Cell Significance Index: -0.8200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0236
    Cell Significance Index: -0.6800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0249
    Cell Significance Index: -0.4300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0258
    Cell Significance Index: -0.5300
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0264
    Cell Significance Index: -0.3300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0267
    Cell Significance Index: -1.3900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0267
    Cell Significance Index: -1.0100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0267
    Cell Significance Index: -0.2900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0268
    Cell Significance Index: -0.4300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0281
    Cell Significance Index: -0.7000
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.0281
    Cell Significance Index: -0.3600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0282
    Cell Significance Index: -0.4100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0284
    Cell Significance Index: -0.5900
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.0288
    Cell Significance Index: -0.2600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0290
    Cell Significance Index: -0.7400
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0299
    Cell Significance Index: -0.3300
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0307
    Cell Significance Index: -0.3800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0308
    Cell Significance Index: -0.7700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0316
    Cell Significance Index: -0.7700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0330
    Cell Significance Index: -0.7000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0339
    Cell Significance Index: -0.6800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0343
    Cell Significance Index: -0.7400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0347
    Cell Significance Index: -0.7600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0351
    Cell Significance Index: -1.2200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0352
    Cell Significance Index: -0.4700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0364
    Cell Significance Index: -0.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene Expression Patterns**: The DNTT gene is expressed in a wide range of cell types, including double-negative thymocytes, alpha-beta T cells, blood vessel endothelial cells, and erythrocytes. This suggests a broad role in cellular processes, extending beyond immune cell function. 2. **Protein Structure**: The DNTT protein, encoded by the TDT_HUMAN gene, exhibits a unique structure, comprising multiple domains and motifs that facilitate its interaction with DNA and other proteins. 3. **Enzymatic Activity**: DNTT possesses nucleotidylexotransferase activity, enabling it to transfer nucleotides between DNA strands, a crucial process in DNA repair, replication, and modification. **Pathways and Functions:** 1. **DNA Repair and Replication**: DNTT participates in the repair of double-strand breaks via nonhomologous end joining, ensuring genome stability and preventing mutations. 2. **DNA Modification**: The enzyme is involved in the transfer of nucleotides, facilitating the modification of DNA and RNA molecules. 3. **Double-Strand Break Repair**: DNTT plays a critical role in the repair of double-strand breaks, a process essential for maintaining genome integrity. 4. **Nucleic Acid Metabolism**: The gene's involvement in nucleic acid metabolism highlights its role in regulating the expression and modification of DNA and RNA. **Clinical Significance:** 1. **Cancer and Genetic Disorders**: Abnormalities in DNTT expression or function have been implicated in various cancers and genetic disorders, including leukemia, lymphoma, and neurodegenerative diseases. 2. **Immunological Disorders**: The gene's involvement in immune cell function and DNA repair mechanisms suggests its potential role in immunological disorders, such as autoimmune diseases and immunodeficiency syndromes. 3. **Epigenetic Regulation**: The transfer of nucleotides by DNTT may influence epigenetic regulation, affecting gene expression and cellular behavior. In conclusion, the DNA nucleotidylexotransferase (DNTT) gene is a complex and multifunctional molecule, playing a crucial role in maintaining genome stability and regulating nucleic acid metabolism. Its involvement in DNA repair, replication, and modification processes highlights its significance in various cellular and immunological contexts. Further research is necessary to fully elucidate the clinical significance and potential therapeutic applications of the DNTT gene.

Genular Protein ID: 3252335476

Symbol: TDT_HUMAN

Name: DNA nucleotidylexotransferase

UniProtKB Accession Codes:

P04053 Q53FH1 Q5W103 Q96E50

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChEBI 10 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 18 Ensembl 2 EvolutionaryTrace 1 GO 13 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 14 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PIRSF 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 Rhea 3 SABIO-RK 1 SMART 2 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2863268

Title: Expression of human terminal deoxynucleotidyl transferase in Escherichia coli.

PubMed ID: 2863268

DOI: 10.1016/s0021-9258(19)85111-6

PubMed ID: 2833741

Title: Human terminal deoxyribonucleotidyltransferase: molecular cloning and structural analysis of the gene and 5' flanking region.

PubMed ID: 2833741

DOI: 10.1073/pnas.85.8.2489

PubMed ID: 11554927

Title: Terminal deoxynucleotidyltransferase is negatively regulated by direct interaction with proliferating cell nuclear antigen.

PubMed ID: 11554927

DOI: 10.1046/j.1365-2443.2001.00460.x

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3395350

Title: Isolation of putative promoter region for human terminal deoxynucleotidyltransferase gene.

PubMed ID: 3395350

DOI: 10.1016/0006-291x(88)90654-7

PubMed ID: 6087320

Title: Molecular cloning of human terminal deoxynucleotidyltransferase.

PubMed ID: 6087320

DOI: 10.1073/pnas.81.14.4363

PubMed ID: 8163485

Title: Mutational analysis of residues in the nucleotide binding domain of human terminal deoxynucleotidyl transferase.

PubMed ID: 8163485

DOI: 10.1016/s0021-9258(17)32652-2

PubMed ID: 11473582

Title: Terminal deoxynucleotidyltransferase directly interacts with a novel nuclear protein that is homologous to p65.

PubMed ID: 11473582

DOI: 10.1046/j.1365-2443.2001.00449.x

PubMed ID: 12786946

Title: Terminal deoxynucleotidyltransferase forms a ternary complex with a novel chromatin remodeling protein with 82 kDa and core histone.

PubMed ID: 12786946

DOI: 10.1046/j.1365-2443.2003.00656.x

PubMed ID: 12960389

Title: Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase.

PubMed ID: 12960389

DOI: 10.1073/pnas.1631060100

PubMed ID: 16371131

Title: Direct binding of TReP-132 with TdT results in reduction of TdT activity.

PubMed ID: 16371131

DOI: 10.1111/j.1365-2443.2005.00916.x

Sequence Information:

  • Length: 509
  • Mass: 58536
  • Checksum: 0EC01E380FA7E5A2
  • Sequence:
    • MDPPRASHLS PRKKRPRQTG ALMASSPQDI KFQDLVVFIL EKKMGTTRRA FLMELARRKG 
FRVENELSDS VTHIVAENNS GSDVLEWLQA QKVQVSSQPE LLDVSWLIEC IRAGKPVEMT 
GKHQLVVRRD YSDSTNPGPP KTPPIAVQKI SQYACQRRTT LNNCNQIFTD AFDILAENCE 
FRENEDSCVT FMRAASVLKS LPFTIISMKD TEGIPCLGSK VKGIIEEIIE DGESSEVKAV 
LNDERYQSFK LFTSVFGVGL KTSEKWFRMG FRTLSKVRSD KSLKFTRMQK AGFLYYEDLV 
SCVTRAEAEA VSVLVKEAVW AFLPDAFVTM TGGFRRGKKM GHDVDFLITS PGSTEDEEQL 
LQKVMNLWEK KGLLLYYDLV ESTFEKLRLP SRKVDALDHF QKCFLIFKLP RQRVDSDQSS 
WQEGKTWKAI RVDLVLCPYE RRAFALLGWT GSRQFERDLR RYATHERKMI LDNHALYDKT 
KRIFLKAESE EEIFAHLGLD YIEPWERNA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.