Details for: DNTT

Gene ID: 1791

Symbol: DNTT

Ensembl ID: ENSG00000107447

Description: DNA nucleotidylexotransferase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 5.51
    Marker Score: 7602
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 3.86
    Marker Score: 2927
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3176.5
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 2.89
    Marker Score: 3404
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 2.47
    Marker Score: 1371
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.38
    Marker Score: 9742
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 2.19
    Marker Score: 1492
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 2.1
    Marker Score: 1574
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.35
    Marker Score: 1431
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.26
    Marker Score: 12730
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.05
    Marker Score: 2182
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71831
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48056
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.98
    Marker Score: 2478
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5356
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.93
    Marker Score: 488
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.89
    Marker Score: 575
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.84
    Marker Score: 638
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.79
    Marker Score: 1120.5
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.79
    Marker Score: 633
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.78
    Marker Score: 450
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.75
    Marker Score: 369
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.75
    Marker Score: 237
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.74
    Marker Score: 417.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.64
    Marker Score: 481
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.61
    Marker Score: 9503
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 472
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.55
    Marker Score: 347
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.53
    Marker Score: 182.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.52
    Marker Score: 1066
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.52
    Marker Score: 990
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.49
    Marker Score: 240
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.44
    Marker Score: 215
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.43
    Marker Score: 282
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.4
    Marker Score: 382
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.38
    Marker Score: 100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.36
    Marker Score: 584
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.35
    Marker Score: 98
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.33
    Marker Score: 199
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.32
    Marker Score: 135
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.32
    Marker Score: 186
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.31
    Marker Score: 239
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.29
    Marker Score: 146
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.29
    Marker Score: 178
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.29
    Marker Score: 781
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.28
    Marker Score: 555
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.27
    Marker Score: 96
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.27
    Marker Score: 270
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.25
    Marker Score: 81
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.25
    Marker Score: 119
  • Cell Name: eosinophil (CL0000771)
    Fold Change: 0.23
    Marker Score: 76
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.22
    Marker Score: 221
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.2
    Marker Score: 478
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.2
    Marker Score: 72
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.2
    Marker Score: 486
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.19
    Marker Score: 347
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: 0.19
    Marker Score: 57
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.17
    Marker Score: 115
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.17
    Marker Score: 93
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.17
    Marker Score: 115
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.17
    Marker Score: 113
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.17
    Marker Score: 44
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.17
    Marker Score: 77
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.17
    Marker Score: 121
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.16
    Marker Score: 174
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.15
    Marker Score: 81
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.15
    Marker Score: 61
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.14
    Marker Score: 102
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.13
    Marker Score: 78
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.13
    Marker Score: 223
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.13
    Marker Score: 107
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.12
    Marker Score: 54
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.11
    Marker Score: 155
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.11
    Marker Score: 34
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.11
    Marker Score: 26
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.1
    Marker Score: 26
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.1
    Marker Score: 71
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.1
    Marker Score: 100
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.1
    Marker Score: 36
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.1
    Marker Score: 20
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.1
    Marker Score: 90
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.1
    Marker Score: 46
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.1
    Marker Score: 29
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.1
    Marker Score: 57
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.1
    Marker Score: 114.5
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.09
    Marker Score: 23
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.09
    Marker Score: 59
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.09
    Marker Score: 37
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.09
    Marker Score: 30
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.08
    Marker Score: 93
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.08
    Marker Score: 73

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Other Information

**Key characteristics:** * It is a protein of the ERAS (endoplasmic reticulum and splicing factor) family. * It is expressed in a variety of cell types, including immune cells, epithelial cells, and blood cells. * It is a highly conserved protein, with a similar sequence found in organisms from yeast to humans. **Pathways and functions:** * **Double-strand break repair via nonhomologous end joining:** DTT is essential for the repair of double-strand breaks in DNA. It is recruited to sites of DNA damage and catalyzes the repair of breaks by joining the broken ends together. * **DNA repair:** DTT is also involved in the repair of other types of DNA damage, such as single-strand breaks and insertions and deletions. * **DNA binding:** DTT can bind to DNA and facilitate the formation of DNA complexes. This allows it to interact with other proteins that are involved in DNA repair and transcription. * **DNA biosynthetic process:** DTT is involved in the biosynthesis of DNA. It is a key enzyme in the process of DNA replication, transcription, and translation. **Clinical significance:** DNTT has been linked to a number of human diseases, including cancer and autoimmune disorders. Mutations in DTT have been associated with an increased risk of cancer, particularly in individuals with chronic lymphocytic leukemia and acute myeloid leukemia. In addition, mutations in DTT have been linked to autoimmune disorders such as systemic sclerosis and rheumatoid arthritis. **Additional notes:** * DTT is a highly regulated protein. Its expression is typically low in healthy cells, but it is upregulated in cancer cells. * DTT is a multi-functional protein that can also be involved in other cellular processes, such as translation and mRNA splicing. * The crystal structure of DTT has been determined, which has helped to shed light on its molecular mechanisms and role in DNA repair.

Genular Protein ID: 3252335476

Symbol: TDT_HUMAN

Name: DNA nucleotidylexotransferase

UniProtKB Accession Codes:

P04053 Q53FH1 Q5W103 Q96E50

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChEBI 10 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 18 Ensembl 2 EvolutionaryTrace 1 GO 13 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 14 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PIR 1 PIRSF 2 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 Rhea 3 SABIO-RK 1 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2863268

Title: Expression of human terminal deoxynucleotidyl transferase in Escherichia coli.

PubMed ID: 2863268

DOI: 10.1016/s0021-9258(19)85111-6

PubMed ID: 2833741

Title: Human terminal deoxyribonucleotidyltransferase: molecular cloning and structural analysis of the gene and 5' flanking region.

PubMed ID: 2833741

DOI: 10.1073/pnas.85.8.2489

PubMed ID: 11554927

Title: Terminal deoxynucleotidyltransferase is negatively regulated by direct interaction with proliferating cell nuclear antigen.

PubMed ID: 11554927

DOI: 10.1046/j.1365-2443.2001.00460.x

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3395350

Title: Isolation of putative promoter region for human terminal deoxynucleotidyltransferase gene.

PubMed ID: 3395350

DOI: 10.1016/0006-291x(88)90654-7

PubMed ID: 6087320

Title: Molecular cloning of human terminal deoxynucleotidyltransferase.

PubMed ID: 6087320

DOI: 10.1073/pnas.81.14.4363

PubMed ID: 8163485

Title: Mutational analysis of residues in the nucleotide binding domain of human terminal deoxynucleotidyl transferase.

PubMed ID: 8163485

DOI: 10.1016/s0021-9258(17)32652-2

PubMed ID: 11473582

Title: Terminal deoxynucleotidyltransferase directly interacts with a novel nuclear protein that is homologous to p65.

PubMed ID: 11473582

DOI: 10.1046/j.1365-2443.2001.00449.x

PubMed ID: 12786946

Title: Terminal deoxynucleotidyltransferase forms a ternary complex with a novel chromatin remodeling protein with 82 kDa and core histone.

PubMed ID: 12786946

DOI: 10.1046/j.1365-2443.2003.00656.x

PubMed ID: 12960389

Title: Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase.

PubMed ID: 12960389

DOI: 10.1073/pnas.1631060100

PubMed ID: 16371131

Title: Direct binding of TReP-132 with TdT results in reduction of TdT activity.

PubMed ID: 16371131

DOI: 10.1111/j.1365-2443.2005.00916.x

Sequence Information:

  • Length: 509
  • Mass: 58536
  • Checksum: 0EC01E380FA7E5A2
  • Sequence:
    • MDPPRASHLS PRKKRPRQTG ALMASSPQDI KFQDLVVFIL EKKMGTTRRA FLMELARRKG 
FRVENELSDS VTHIVAENNS GSDVLEWLQA QKVQVSSQPE LLDVSWLIEC IRAGKPVEMT 
GKHQLVVRRD YSDSTNPGPP KTPPIAVQKI SQYACQRRTT LNNCNQIFTD AFDILAENCE 
FRENEDSCVT FMRAASVLKS LPFTIISMKD TEGIPCLGSK VKGIIEEIIE DGESSEVKAV 
LNDERYQSFK LFTSVFGVGL KTSEKWFRMG FRTLSKVRSD KSLKFTRMQK AGFLYYEDLV 
SCVTRAEAEA VSVLVKEAVW AFLPDAFVTM TGGFRRGKKM GHDVDFLITS PGSTEDEEQL 
LQKVMNLWEK KGLLLYYDLV ESTFEKLRLP SRKVDALDHF QKCFLIFKLP RQRVDSDQSS 
WQEGKTWKAI RVDLVLCPYE RRAFALLGWT GSRQFERDLR RYATHERKMI LDNHALYDKT 
KRIFLKAESE EEIFAHLGLD YIEPWERNA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.