Details for: CL0000970

Cell ID: CL0000970

Cell Name: unswitched memory B cell

Marker Score Threshold: 586
(Derived using integrated single-cell and genomic data)

Description: An unswitched memory B cell is a memory B cell that has the phenotype IgM-positive, IgD-positive, CD27-positive, CD138-negative, IgG-negative, IgE-negative, and IgA-negative.

Synonyms: IgD+ memory B cell, non-class-switched memory B cell, unswitched memory B lymphocyte, unswitched memory B-cell, unswitched memory B-lymphocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 4.4
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 4.21
    Ensembl ID: ENSG00000124172
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 4.09
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.82
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.76
    Ensembl ID: ENSG00000166710
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.75
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 3.55
    Ensembl ID: ENSG00000185883
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.37
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 3.37
    Ensembl ID: ENSG00000019582
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 3.33
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.2
    Ensembl ID: ENSG00000184009
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 3.11
    Ensembl ID: ENSG00000067560
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 3.05
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.77
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.68
    Ensembl ID: ENSG00000154518
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 2.65
    Ensembl ID: ENSG00000104894
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.56
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.53
    Ensembl ID: ENSG00000198668
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.52
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 2.51
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.49
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.39
    Ensembl ID: ENSG00000149925
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.39
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.37
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 2.27
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.27
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.26
    Ensembl ID: ENSG00000152234
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.25
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.2
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.16
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 2.15
    Ensembl ID: ENSG00000241837
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.05
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.98
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.93
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CD48 (ENSG00000117091)
    Fold Change: 1.9
    Ensembl ID: ENSG00000117091
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.88
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.85
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.85
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.84
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.81
    Ensembl ID: ENSG00000169020
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.77
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.77
    Ensembl ID: ENSG00000122359
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.76
    Ensembl ID: ENSG00000143878
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.76
    Ensembl ID: ENSG00000130303
  • Gene Symbol: CD69 (ENSG00000110848)
    Fold Change: 1.75
    Ensembl ID: ENSG00000110848
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.75
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.71
    Ensembl ID: ENSG00000197043
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.7
    Ensembl ID: ENSG00000112576
  • Gene Symbol: CD53 (ENSG00000143119)
    Fold Change: 1.69
    Ensembl ID: ENSG00000143119
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.66
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.66
    Ensembl ID: ENSG00000004059
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.64
    Ensembl ID: ENSG00000026508
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.64
    Ensembl ID: ENSG00000087088
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.64
    Ensembl ID: ENSG00000115307
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.62
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.61
    Ensembl ID: ENSG00000196776
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.5
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.46
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.45
    Ensembl ID: ENSG00000070961
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.44
    Ensembl ID: ENSG00000100823
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.43
    Ensembl ID: ENSG00000160014
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.43
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.42
    Ensembl ID: ENSG00000104763
  • Gene Symbol: CAPG (ENSG00000042493)
    Fold Change: 1.41
    Ensembl ID: ENSG00000042493
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.4
    Ensembl ID: ENSG00000165527
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.39
    Ensembl ID: ENSG00000136717
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.38
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.37
    Ensembl ID: ENSG00000160710
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.36
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.35
    Ensembl ID: ENSG00000146731
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.34
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.33
    Ensembl ID: ENSG00000035687
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.27
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.26
    Ensembl ID: ENSG00000143727
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.25
    Ensembl ID: ENSG00000198356
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.24
    Ensembl ID: ENSG00000140299
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 1.22
    Ensembl ID: ENSG00000132965
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.22
    Ensembl ID: ENSG00000156110
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.21
    Ensembl ID: ENSG00000196975
  • Gene Symbol: CD79A (ENSG00000105369)
    Fold Change: 1.2
    Ensembl ID: ENSG00000105369
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.19
    Ensembl ID: ENSG00000149311
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.19
    Ensembl ID: ENSG00000149823
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 1.19
    Ensembl ID: ENSG00000023445
  • Gene Symbol: CAT (ENSG00000121691)
    Fold Change: 1.15
    Ensembl ID: ENSG00000121691
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.14
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.14
    Ensembl ID: ENSG00000128272
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: 1.14
    Ensembl ID: ENSG00000168421
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.14
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.12
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.11
    Ensembl ID: ENSG00000138279
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.1
    Ensembl ID: ENSG00000104765
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 1.09
    Ensembl ID: ENSG00000196954
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.08
    Ensembl ID: ENSG00000072778
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.07
    Ensembl ID: ENSG00000164615
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.07
    Ensembl ID: ENSG00000107262
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 1.03
    Ensembl ID: ENSG00000145349
  • Gene Symbol: ACP5 (ENSG00000102575)
    Fold Change: 1.02
    Ensembl ID: ENSG00000102575
  • Gene Symbol: CD40 (ENSG00000101017)
    Fold Change: 1.01
    Ensembl ID: ENSG00000101017
  • Gene Symbol: ARHGAP4 (ENSG00000089820)
    Fold Change: N/A
    Ensembl ID: ENSG00000089820
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: N/A
    Ensembl ID: ENSG00000134480
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Immunoglobulin phenotype**: UMBCs express IgM and IgD surface immunoglobulins, similar to naive B cells. 2. **CD27 expression**: UMBCs express CD27, a marker commonly associated with memory B cells. 3. **Lack of CD138**: UMBCs do not express CD138, a marker typically seen in plasma cells. 4. **No class switching**: UMBCs do not undergo class switching to IgG, IgE, or IgA, which are characteristic of activated B cells. 5. **Memory B cell phenotype**: UMBCs retain many characteristics of memory B cells, including the ability to proliferate and differentiate into antibody-secreting plasma cells. **Clinical Significance** 1. **Long-term immunity**: UMBCs play a crucial role in the adaptive immune response, particularly in the defense against pathogens that induce long-term immunity. 2. **Antibody-mediated immunity**: UMBCs can differentiate into antibody-secreting plasma cells upon antigen re-exposure, providing a rapid and efficient response to infections. 3. **Autoimmune diseases**: UMBCs may contribute to the pathogenesis of autoimmune diseases, such as rheumatoid arthritis, where autoantibodies are produced by memory B cells. 4. **Cancer**: UMBCs may also play a role in cancer, where they can contribute to the development of tumor-associated antibodies. 5. **Immunotherapy**: UMBCs are a target for immunotherapies aimed at modulating the adaptive immune response, such as checkpoint inhibitors and CAR-T cell therapy. **Pathways and Ontology** UMBCs are involved in various cellular processes, including: 1. **Mitochondrial biogenesis and function**: UMBCs require mitochondrial biogenesis and function to maintain their energy metabolism. 2. **Cellular response to extracellular stimuli**: UMBCs respond to extracellular stimuli, such as antigens, through the activation of signaling pathways. 3. **Adaptive immune system**: UMBCs play a crucial role in the adaptive immune response, particularly in the defense against pathogens that induce long-term immunity. 4. **Gene expression regulation**: UMBCs regulate gene expression through various mechanisms, including transcriptional control and post-transcriptional regulation. Overall, UMBCs are an essential component of the adaptive immune response, and their unswitched phenotype is characterized by the retention of IgM and IgD surface immunoglobulins, CD27 expression, and the lack of CD138. Their clinical significance lies in their role in providing long-term immunity against pathogens and their potential contribution to autoimmune diseases and cancer.