Details for: KLK1

Gene ID: 3816

Symbol: KLK1

Ensembl ID: ENSG00000167748

Description: kallikrein 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 3.33
    Marker Score: 1879
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 3.25
    Marker Score: 3116
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.53
    Marker Score: 5350
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.49
    Marker Score: 3541
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.14
    Marker Score: 7598
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.08
    Marker Score: 687
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 794
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 1.03
    Marker Score: 272
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71823
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48048
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.99
    Marker Score: 723
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5354
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.87
    Marker Score: 327
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.84
    Marker Score: 1362
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.8
    Marker Score: 782
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.8
    Marker Score: 1128
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.78
    Marker Score: 3741
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.76
    Marker Score: 2385
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.74
    Marker Score: 2027
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 670
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 465
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.71
    Marker Score: 284
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7
    Marker Score: 701.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2853.5
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.66
    Marker Score: 688
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.63
    Marker Score: 372
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.58
    Marker Score: 207
  • Cell Name: epithelial fate stem cell (CL0000036)
    Fold Change: 0.56
    Marker Score: 162
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 146
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.55
    Marker Score: 157
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.55
    Marker Score: 329
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.52
    Marker Score: 364
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.5
    Marker Score: 534
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.49
    Marker Score: 342
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 0.47
    Marker Score: 151
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.47
    Marker Score: 782
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 275
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.46
    Marker Score: 191
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.46
    Marker Score: 210
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.44
    Marker Score: 99
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.41
    Marker Score: 632
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.41
    Marker Score: 257
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.41
    Marker Score: 924
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.4
    Marker Score: 164
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.39
    Marker Score: 106
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.39
    Marker Score: 76
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.35
    Marker Score: 76
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.35
    Marker Score: 3507
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.34
    Marker Score: 85
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.33
    Marker Score: 156
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.33
    Marker Score: 313
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.33
    Marker Score: 193
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.32
    Marker Score: 166
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.31
    Marker Score: 3523
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.31
    Marker Score: 92
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.29
    Marker Score: 98
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.29
    Marker Score: 380
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.28
    Marker Score: 69
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.28
    Marker Score: 706
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.28
    Marker Score: 207
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.28
    Marker Score: 266
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.27
    Marker Score: 181
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.26
    Marker Score: 220
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 89
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.25
    Marker Score: 59
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.25
    Marker Score: 192
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.25
    Marker Score: 66
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.24
    Marker Score: 153
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.22
    Marker Score: 149
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.22
    Marker Score: 218
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.21
    Marker Score: 60
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.21
    Marker Score: 398
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.2
    Marker Score: 169
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.2
    Marker Score: 85
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.19
    Marker Score: 70
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.19
    Marker Score: 1675
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.19
    Marker Score: 90
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.19
    Marker Score: 309
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.19
    Marker Score: 307
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.19
    Marker Score: 115
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.18
    Marker Score: 91
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.18
    Marker Score: 213.5
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.17
    Marker Score: 1055
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.17
    Marker Score: 179
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.16
    Marker Score: 64
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.16
    Marker Score: 66
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.16
    Marker Score: 146
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.16
    Marker Score: 409
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.16
    Marker Score: 51

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Other Information

**Key characteristics:** - KLK1 is a transmembrane protein with a molecular weight of approximately 130 kDa. - It is a secreted protein that can be found in exosomes. - It is involved in the regulation of insulin-like growth factor (IGF) transport and uptake by insulin-like growth factor binding proteins (IGFBPs). **Pathways and functions:** - KLK1 is involved in the regulation of extracellular matrix remodeling. It acts as a proteolytic enzyme that cleaves a specific peptide sequence in extracellular matrix proteins, which facilitates their release into the extracellular environment. - It is involved in the metabolism of proteins. It is a substrate for the enzyme complement component C1r, which is involved in the complement cascade. - KLK1 is involved in the regulation of insulin-like growth factor (IGF) transport and uptake. It is a receptor for IGF, and its expression is regulated by IGF levels. - It is involved in the regulation of systemic arterial blood pressure. It acts as a negative regulator of blood pressure by inhibiting the production of vascular endothelial growth factor (VEGF), which is a key factor in the regulation of blood vessel growth and remodeling. **Clinical significance:** - Mutations in the KLK1 gene have been linked to a number of human diseases, including diabetes, cancer, and cardiovascular disease. - Overexpression of KLK1 has been linked to the development of these diseases. - Targeting KLK1 has been investigated as a potential therapeutic strategy for these diseases.

Genular Protein ID: 2349279308

Symbol: KLK1_HUMAN

Name: Kallikrein-1

UniProtKB Accession Codes:

P06870 Q66US9 Q86U61 Q8TCV8 Q9BS53 Q9NQU4 Q9UD19 Q9UMJ1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 8 DrugCentral 1 EC 2 EMBL 15 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 2 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 2 PRIDE 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3004571

Title: Nucleotide sequence of cloned cDNA for human pancreatic kallikrein.

PubMed ID: 3004571

DOI: 10.1021/bi00348a030

PubMed ID: 2898948

Title: Structure and chromosomal localization of the human renal kallikrein gene.

PubMed ID: 2898948

DOI: 10.1021/bi00409a003

PubMed ID: 2686621

Title: Cloning and expression of human salivary-gland kallikrein in Escherichia coli.

PubMed ID: 2686621

DOI: 10.1042/bj2620787

PubMed ID: 7749372

Title: Molecular cloning and characterization of a novel kallikrein transcript in colon and its distribution in human tissues.

PubMed ID: 7749372

PubMed ID: 11006094

Title: Genomic organization of the human kallikrein gene family on chromosome 19q13.3-q13.4.

PubMed ID: 11006094

DOI: 10.1006/bbrc.2000.3448

PubMed ID: 11054574

Title: Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region.

PubMed ID: 11054574

DOI: 10.1016/s0378-1119(00)00382-6

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3853975

Title: Human kidney kallikrein: cDNA cloning and sequence analysis.

PubMed ID: 3853975

DOI: 10.1089/dna.1985.4.445

PubMed ID: 3163150

Title: Human urinary kallikrein -- amino acid sequence and carbohydrate attachment sites.

PubMed ID: 3163150

PubMed ID: 2666327

Title: Human urinary kallikrein. Complete amino acid sequence and sites of glycosylation.

PubMed ID: 2666327

DOI: 10.1111/j.1399-3011.1989.tb01277.x

PubMed ID: 393608

Title: N-terminal amino acid sequence of human urinary kallikrein homology with other serine proteases.

PubMed ID: 393608

PubMed ID: 3635530

Title: N-terminal amino acid sequence of human urinary prokallikrein.

PubMed ID: 3635530

DOI: 10.1093/oxfordjournals.jbchem.a135563

PubMed ID: 31369555

Title: NHBA is processed by kallikrein from human saliva.

PubMed ID: 31369555

DOI: 10.1371/journal.pone.0203234

PubMed ID: 15651049

Title: 1.70 A X-ray structure of human apo kallikrein 1: structural changes upon peptide inhibitor/substrate binding.

PubMed ID: 15651049

DOI: 10.1002/prot.20368

PubMed ID: 11912256

Title: Loss-of-function polymorphism of the human kallikrein gene with reduced urinary kallikrein activity.

PubMed ID: 11912256

DOI: 10.1681/asn.v134968

PubMed ID: 15765151

Title: Arterial and renal consequences of partial genetic deficiency in tissue kallikrein activity in humans.

PubMed ID: 15765151

DOI: 10.1172/jci23669

Sequence Information:

  • Length: 262
  • Mass: 28890
  • Checksum: 7D8A715E9E104D60
  • Sequence:
    • MWFLVLCLAL SLGGTGAAPP IQSRIVGGWE CEQHSQPWQA ALYHFSTFQC GGILVHRQWV 
LTAAHCISDN YQLWLGRHNL FDDENTAQFV HVSESFPHPG FNMSLLENHT RQADEDYSHD 
LMLLRLTEPA DTITDAVKVV ELPTEEPEVG STCLASGWGS IEPENFSFPD DLQCVDLKIL 
PNDECKKAHV QKVTDFMLCV GHLEGGKDTC VGDSGGPLMC DGVLQGVTSW GYVPCGTPNK 
PSVAVRVLSY VKWIEDTIAE NS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.