Details for: KLK1

Gene ID: 3816

Symbol: KLK1

Ensembl ID: ENSG00000167748

Description: kallikrein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 129.2284
    Cell Significance Index: 64.9000
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 50.2527
    Cell Significance Index: 279.7100
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 26.2946
    Cell Significance Index: -4.0900
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 20.5661
    Cell Significance Index: 428.9200
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 10.4837
    Cell Significance Index: 36.0000
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 9.5404
    Cell Significance Index: 36.5300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 7.8569
    Cell Significance Index: 1341.6200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 6.4976
    Cell Significance Index: -4.3600
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 4.0977
    Cell Significance Index: 44.4100
  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: 4.0741
    Cell Significance Index: 4.6900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.3172
    Cell Significance Index: -4.0900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.4376
    Cell Significance Index: -6.5300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.3362
    Cell Significance Index: 140.2500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.8326
    Cell Significance Index: 181.2800
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.7665
    Cell Significance Index: 3.9800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.3590
    Cell Significance Index: 158.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2833
    Cell Significance Index: 58.1700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.2573
    Cell Significance Index: 18.8400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.1862
    Cell Significance Index: 82.0300
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.1237
    Cell Significance Index: 5.4700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.6954
    Cell Significance Index: 79.3800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5467
    Cell Significance Index: 104.0500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5363
    Cell Significance Index: 484.2200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.4785
    Cell Significance Index: 16.8200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4444
    Cell Significance Index: 12.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3178
    Cell Significance Index: 10.1800
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.2586
    Cell Significance Index: 1.8200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2141
    Cell Significance Index: 4.5600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1820
    Cell Significance Index: 80.4600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1789
    Cell Significance Index: 2.8700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1473
    Cell Significance Index: 1.5300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.1131
    Cell Significance Index: 1.1700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0985
    Cell Significance Index: 11.2800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0924
    Cell Significance Index: 2.4300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0891
    Cell Significance Index: 55.6200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0204
    Cell Significance Index: 0.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0161
    Cell Significance Index: 0.7500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0147
    Cell Significance Index: 10.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0107
    Cell Significance Index: 5.8600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0053
    Cell Significance Index: 2.9700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0024
    Cell Significance Index: 1.7400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0014
    Cell Significance Index: 0.1700
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0028
    Cell Significance Index: -0.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0036
    Cell Significance Index: -0.5000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0040
    Cell Significance Index: -0.8500
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0048
    Cell Significance Index: -0.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0052
    Cell Significance Index: -3.9200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0066
    Cell Significance Index: -0.3300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0143
    Cell Significance Index: -0.2200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0143
    Cell Significance Index: -1.8300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0150
    Cell Significance Index: -4.3300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0182
    Cell Significance Index: -0.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0204
    Cell Significance Index: -3.6800
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.0212
    Cell Significance Index: -0.1300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0220
    Cell Significance Index: -0.5500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0223
    Cell Significance Index: -4.4700
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.0224
    Cell Significance Index: -0.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0236
    Cell Significance Index: -2.4200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0255
    Cell Significance Index: -0.7300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0291
    Cell Significance Index: -2.0600
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.0302
    Cell Significance Index: -0.1900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0306
    Cell Significance Index: -3.9500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0363
    Cell Significance Index: -4.4600
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0387
    Cell Significance Index: -0.3500
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0390
    Cell Significance Index: -0.5800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0401
    Cell Significance Index: -0.6600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0409
    Cell Significance Index: -0.4600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0421
    Cell Significance Index: -2.5800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0506
    Cell Significance Index: -0.4300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0520
    Cell Significance Index: -1.3000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0525
    Cell Significance Index: -1.0900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0569
    Cell Significance Index: -2.6800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0593
    Cell Significance Index: -3.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0613
    Cell Significance Index: -4.5700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0687
    Cell Significance Index: -5.2700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0701
    Cell Significance Index: -5.5500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0768
    Cell Significance Index: -0.8100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0778
    Cell Significance Index: -5.0200
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0857
    Cell Significance Index: -1.0900
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0879
    Cell Significance Index: -0.9600
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.0894
    Cell Significance Index: -0.7700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0932
    Cell Significance Index: -2.0200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0962
    Cell Significance Index: -5.0100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0966
    Cell Significance Index: -5.4200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0970
    Cell Significance Index: -2.4200
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.0995
    Cell Significance Index: -0.6200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0997
    Cell Significance Index: -5.1800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0998
    Cell Significance Index: -1.0900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1002
    Cell Significance Index: -2.6800
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.1031
    Cell Significance Index: -1.0400
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.1104
    Cell Significance Index: -1.0900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1110
    Cell Significance Index: -3.0200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1113
    Cell Significance Index: -4.0900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1151
    Cell Significance Index: -3.3900
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.1172
    Cell Significance Index: -1.3300
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.1187
    Cell Significance Index: -1.5000
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.1190
    Cell Significance Index: -0.7900
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: -0.1305
    Cell Significance Index: -0.9100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1333
    Cell Significance Index: -4.6700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1400
    Cell Significance Index: -5.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Substrate Specificity:** KLK1 exhibits specificity for a range of substrates, including insulin-like growth factor-binding proteins (IGFBPs), which underscores its potential role in modulating IGF transport and signaling. 2. **Zymogen Activation:** KLK1's ability to activate its own zymogen form, as well as other serine-type endopeptidases, highlights its capacity for autoregulation and network interactions. 3. **Cell-Specific Expression:** KLK1 is expressed in diverse cell types, including epithelial cells, stem cells, and immune cells, underscoring its multifaceted role in regulating cellular homeostasis. 4. **Regulation of IGF Transport:** KLK1's involvement in regulating IGF transport and signaling has significant implications for cellular growth, differentiation, and survival. **Pathways and Functions:** 1. **Regulation of Insulin-Like Growth Factor (IGF) Transport and Uptake:** KLK1 modulates IGF transport and uptake by interacting with IGFBPs, thereby influencing IGF signaling pathways. 2. **Protein Metabolism:** KLK1's substrate specificity and zymogen activation capabilities contribute to protein metabolism, impacting cellular homeostasis and signaling. 3. **Regulation of Systemic Arterial Blood Pressure:** KLK1's involvement in regulating systemic arterial blood pressure highlights its potential role in cardiovascular homeostasis. 4. **Secretory Granule Function:** KLK1's expression in secretory granule cells suggests its involvement in neurotransmission and cellular secretion. **Clinical Significance:** 1. **Cancer:** KLK1's overexpression has been implicated in various cancers, including prostate, breast, and lung cancer, highlighting its potential as a diagnostic and therapeutic biomarker. 2. **Neurological Disorders:** KLK1's role in regulating IGF signaling and neurotransmission may contribute to the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cardiovascular Disease:** KLK1's involvement in regulating systemic arterial blood pressure may contribute to the development of cardiovascular disease, underscoring the need for further research into its role in cardiovascular health. 4. **Therapeutic Applications:** KLK1's multifaceted role in regulating cellular homeostasis and signaling suggests potential therapeutic applications in the treatment of various diseases, including cancer, neurological disorders, and cardiovascular disease. In conclusion, KLK1's intricate functions and multifaceted roles underscore its significance as a key regulator of cellular homeostasis and signaling. Further research into the mechanisms underlying KLK1's functions and its clinical significance is warranted, with potential therapeutic applications in various disease contexts.

Genular Protein ID: 2349279308

Symbol: KLK1_HUMAN

Name: Kallikrein-1

UniProtKB Accession Codes:

P06870 Q66US9 Q86U61 Q8TCV8 Q9BS53 Q9NQU4 Q9UD19 Q9UMJ1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 8 DrugCentral 1 EC 2 EMBL 15 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 2 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 2 PRIDE 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3004571

Title: Nucleotide sequence of cloned cDNA for human pancreatic kallikrein.

PubMed ID: 3004571

DOI: 10.1021/bi00348a030

PubMed ID: 2898948

Title: Structure and chromosomal localization of the human renal kallikrein gene.

PubMed ID: 2898948

DOI: 10.1021/bi00409a003

PubMed ID: 2686621

Title: Cloning and expression of human salivary-gland kallikrein in Escherichia coli.

PubMed ID: 2686621

DOI: 10.1042/bj2620787

PubMed ID: 7749372

Title: Molecular cloning and characterization of a novel kallikrein transcript in colon and its distribution in human tissues.

PubMed ID: 7749372

PubMed ID: 11006094

Title: Genomic organization of the human kallikrein gene family on chromosome 19q13.3-q13.4.

PubMed ID: 11006094

DOI: 10.1006/bbrc.2000.3448

PubMed ID: 11054574

Title: Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region.

PubMed ID: 11054574

DOI: 10.1016/s0378-1119(00)00382-6

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3853975

Title: Human kidney kallikrein: cDNA cloning and sequence analysis.

PubMed ID: 3853975

DOI: 10.1089/dna.1985.4.445

PubMed ID: 3163150

Title: Human urinary kallikrein -- amino acid sequence and carbohydrate attachment sites.

PubMed ID: 3163150

PubMed ID: 2666327

Title: Human urinary kallikrein. Complete amino acid sequence and sites of glycosylation.

PubMed ID: 2666327

DOI: 10.1111/j.1399-3011.1989.tb01277.x

PubMed ID: 393608

Title: N-terminal amino acid sequence of human urinary kallikrein homology with other serine proteases.

PubMed ID: 393608

PubMed ID: 3635530

Title: N-terminal amino acid sequence of human urinary prokallikrein.

PubMed ID: 3635530

DOI: 10.1093/oxfordjournals.jbchem.a135563

PubMed ID: 31369555

Title: NHBA is processed by kallikrein from human saliva.

PubMed ID: 31369555

DOI: 10.1371/journal.pone.0203234

PubMed ID: 15651049

Title: 1.70 A X-ray structure of human apo kallikrein 1: structural changes upon peptide inhibitor/substrate binding.

PubMed ID: 15651049

DOI: 10.1002/prot.20368

PubMed ID: 11912256

Title: Loss-of-function polymorphism of the human kallikrein gene with reduced urinary kallikrein activity.

PubMed ID: 11912256

DOI: 10.1681/asn.v134968

PubMed ID: 15765151

Title: Arterial and renal consequences of partial genetic deficiency in tissue kallikrein activity in humans.

PubMed ID: 15765151

DOI: 10.1172/jci23669

Sequence Information:

  • Length: 262
  • Mass: 28890
  • Checksum: 7D8A715E9E104D60
  • Sequence:
    • MWFLVLCLAL SLGGTGAAPP IQSRIVGGWE CEQHSQPWQA ALYHFSTFQC GGILVHRQWV 
LTAAHCISDN YQLWLGRHNL FDDENTAQFV HVSESFPHPG FNMSLLENHT RQADEDYSHD 
LMLLRLTEPA DTITDAVKVV ELPTEEPEVG STCLASGWGS IEPENFSFPD DLQCVDLKIL 
PNDECKKAHV QKVTDFMLCV GHLEGGKDTC VGDSGGPLMC DGVLQGVTSW GYVPCGTPNK 
PSVAVRVLSY VKWIEDTIAE NS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.