IGLC3 | ENSG00000211679 | NCBI 3539

Details for: IGLC3

Gene ID: 3539

Symbol: IGLC3

Ensembl ID: ENSG00000211679

Description: immunoglobulin lambda constant 3 (Kern-Oz+ marker)

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Antigen binding
(GO:0003823)
B cell receptor signaling pathway
(GO:0050853)
Blood microparticle
(GO:0072562)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Iga immunoglobulin complex
(GO:0071745)
Igd immunoglobulin complex
(GO:0071738)
Ige immunoglobulin complex
(GO:0071742)
Igg immunoglobulin complex
(GO:0071735)
Igm immunoglobulin complex
(GO:0071753)
Immunoglobulin mediated immune response
(GO:0016064)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 41.9530
Cell Significance Index: -21.5800
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 34.8215
Cell Significance Index: -16.4400
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 6.9182
Cell Significance Index: 243.1000
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 4.3074
Cell Significance Index: -13.2300
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 3.7589
Cell Significance Index: 108.3000
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 3.3170
Cell Significance Index: 82.9200
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 2.0863
Cell Significance Index: 9.3300
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 1.2221
Cell Significance Index: 8.6000
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.0496
Cell Significance Index: 47.5800
Cell Name: follicular B cell (CL0000843)
Fold Change: 0.6177
Cell Significance Index: 3.0900
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5683
Cell Significance Index: 56.2200
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.5088
Cell Significance Index: 459.4400
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 0.3820
Cell Significance Index: 3.0700
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.3199
Cell Significance Index: 4.8200
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3061
Cell Significance Index: 49.7900
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.2185
Cell Significance Index: 3.3800
Cell Name: odontoblast (CL0000060)
Fold Change: 0.2076
Cell Significance Index: 26.6100
Cell Name: exhausted T cell (CL0011025)
Fold Change: 0.1945
Cell Significance Index: 1.5900
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1803
Cell Significance Index: 34.3100
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.1570
Cell Significance Index: 17.0800
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.1314
Cell Significance Index: 13.4200
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 0.1242
Cell Significance Index: 0.7500
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0387
Cell Significance Index: 2.6800
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.0053
Cell Significance Index: 0.0600
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0016
Cell Significance Index: -0.0800
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0018
Cell Significance Index: -0.0700
Cell Name: neural progenitor cell (CL0011020)
Fold Change: -0.0076
Cell Significance Index: -0.0700
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0084
Cell Significance Index: -15.8900
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0127
Cell Significance Index: -9.5800
Cell Name: duct epithelial cell (CL0000068)
Fold Change: -0.0210
Cell Significance Index: -0.2900
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.0254
Cell Significance Index: -0.3800
Cell Name: brain vascular cell (CL4023072)
Fold Change: -0.0282
Cell Significance Index: -0.3200
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0288
Cell Significance Index: -16.2600
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0293
Cell Significance Index: -0.9400
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0295
Cell Significance Index: -18.7600
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0356
Cell Significance Index: -2.3000
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0458
Cell Significance Index: -20.8000
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0745
Cell Significance Index: -14.7800
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0808
Cell Significance Index: -1.7200
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0856
Cell Significance Index: -3.9900
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.1023
Cell Significance Index: -20.5200
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.1034
Cell Significance Index: -18.6500
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.1126
Cell Significance Index: -2.4400
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1161
Cell Significance Index: -15.0100
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1284
Cell Significance Index: -18.6700
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.1292
Cell Significance Index: -7.7600
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1429
Cell Significance Index: -16.3700
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.1435
Cell Significance Index: -17.6500
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1603
Cell Significance Index: -9.8300
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1663
Cell Significance Index: -22.8400
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1873
Cell Significance Index: -13.9600
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.2323
Cell Significance Index: -10.1000
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2393
Cell Significance Index: -18.9500
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.2526
Cell Significance Index: -5.2400
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.2623
Cell Significance Index: -20.1300
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.3265
Cell Significance Index: -8.7400
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.3729
Cell Significance Index: -17.5300
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.3985
Cell Significance Index: -20.7000
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.4419
Cell Significance Index: -27.8500
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.4552
Cell Significance Index: -16.7100
Cell Name: plasma cell (CL0000786)
Fold Change: -0.4869
Cell Significance Index: -5.4400
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.4877
Cell Significance Index: -7.0800
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.5663
Cell Significance Index: -18.0400
Cell Name: IgG plasmablast (CL0000982)
Fold Change: -0.5815
Cell Significance Index: -4.8000
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.5991
Cell Significance Index: -12.5400
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.6016
Cell Significance Index: -15.3700
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: -0.6269
Cell Significance Index: -8.1000
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.6380
Cell Significance Index: -17.0400
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.6626
Cell Significance Index: -16.0500
Cell Name: seromucus secreting cell (CL0000159)
Fold Change: -0.6684
Cell Significance Index: -13.9400
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.6741
Cell Significance Index: -19.8600
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.6881
Cell Significance Index: -17.1600
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.6923
Cell Significance Index: -4.6100
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.7098
Cell Significance Index: -19.3200
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.7232
Cell Significance Index: -18.0400
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.7300
Cell Significance Index: -20.9300
Cell Name: peg cell (CL4033014)
Fold Change: -0.7334
Cell Significance Index: -16.9500
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.7635
Cell Significance Index: -9.8800
Cell Name: keratocyte (CL0002363)
Fold Change: -0.8137
Cell Significance Index: -12.9100
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.8184
Cell Significance Index: -20.8500
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.8343
Cell Significance Index: -11.3500
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: -0.8377
Cell Significance Index: -8.4000
Cell Name: enterocyte (CL0000584)
Fold Change: -0.8398
Cell Significance Index: -5.2100
Cell Name: leukocyte (CL0000738)
Fold Change: -0.8532
Cell Significance Index: -14.4900
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.8694
Cell Significance Index: -17.4600
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.8834
Cell Significance Index: -23.2300
Cell Name: B cell (CL0000236)
Fold Change: -0.9385
Cell Significance Index: -11.0900
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: -0.9547
Cell Significance Index: -11.3600
Cell Name: stromal cell of endometrium (CL0002255)
Fold Change: -0.9596
Cell Significance Index: -13.6500
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.9702
Cell Significance Index: -18.9700
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.9713
Cell Significance Index: -24.2600
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.9722
Cell Significance Index: -23.7200
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.9886
Cell Significance Index: -21.3600
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -1.0015
Cell Significance Index: -18.5100
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -1.0106
Cell Significance Index: -21.4500
Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -1.0165
Cell Significance Index: -13.5500
Cell Name: hepatoblast (CL0005026)
Fold Change: -1.0226
Cell Significance Index: -17.2000
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -1.0259
Cell Significance Index: -17.1700
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -1.0335
Cell Significance Index: -17.4100
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -1.0457
Cell Significance Index: -11.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** IGLC3 is a member of the immunoglobulin lambda constant family, which is responsible for encoding the constant region of the lambda light chain of immunoglobulins. This gene is specifically expressed in B cells that express the Kern-Oz antigen, which is a marker for the B-1 cell subset. IGLC3 is also associated with the regulation of the BCR signaling pathway, which is essential for the activation of B cells in response to antigens. One of the key characteristics of IGLC3 is its involvement in the recognition and elimination of Leishmania parasites. The gene is specifically expressed in cells that are involved in the innate immune response, such as macrophages and dendritic cells, which are critical for the phagocytosis and killing of these pathogens. IGLC3 also plays a role in the regulation of the complement cascade, which is a key component of the innate immune response. **Pathways and Functions** IGLC3 is involved in several key pathways and functions, including: 1. **Adaptive immune response**: IGLC3 plays a crucial role in the adaptive immune response, particularly in the recognition and elimination of pathogens such as Leishmania parasites. 2. **B cell receptor signaling pathway**: IGLC3 is involved in the regulation of the BCR signaling pathway, which is essential for the activation of B cells in response to antigens. 3. **Complement cascade**: IGLC3 plays a role in the regulation of the complement cascade, which is a key component of the innate immune response. 4. **Phagocytosis**: IGLC3 is involved in the phagocytosis of pathogens, including Leishmania parasites, and is associated with the regulation of actin dynamics for phagocytic cup formation. 5. **Immune system regulation**: IGLC3 is also involved in the regulation of immune system function, including the regulation of cytokine production and the activation of immune cells. **Clinical Significance** IGLC3 has significant clinical implications, particularly in the context of Leishmania infections. The gene is often associated with the B-1 cell subset, which is critical for the innate immune response against Leishmania parasites. IGLC3 is also involved in the regulation of the complement cascade, which is essential for the elimination of pathogens. In addition to its role in Leishmania infections, IGLC3 has implications for the treatment of other diseases, including SARS-CoV infections. The gene is involved in the regulation of the BCR signaling pathway, which is essential for the activation of B cells in response to antigens. IGLC3 may also play a role in the regulation of immune system function, including the activation of immune cells and the production of cytokines. In conclusion, IGLC3 is a crucial gene that plays a pivotal role in the adaptive immune response, particularly in the recognition and elimination of pathogens such as Leishmania parasites. Its involvement in the regulation of the BCR signaling pathway, complement cascade, and phagocytosis highlights its importance in the development and function of B cells. The gene's clinical significance is particularly evident in the context of Leishmania infections and SARS-CoV infections, and further research is needed to fully understand its role in human disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.