Gene IGLC3 - ENSG00000211679 | NCBI Gene ID: 3539

Details for: IGLC3

Gene ID: 3539

Symbol: IGLC3

Ensembl ID: ENSG00000211679

Description: immunoglobulin lambda constant 3 (Kern-Oz+ marker)

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Antigen binding
(GO:0003823)
B cell receptor signaling pathway
(GO:0050853)
Blood microparticle
(GO:0072562)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Iga immunoglobulin complex
(GO:0071745)
Igd immunoglobulin complex
(GO:0071738)
Ige immunoglobulin complex
(GO:0071742)
Igg immunoglobulin complex
(GO:0071735)
Igm immunoglobulin complex
(GO:0071753)
Immunoglobulin mediated immune response
(GO:0016064)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 15.98
Marker Score: 161993
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 3.68
Marker Score: 3132
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 2.38
Marker Score: 656
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 2.36
Marker Score: 620
Cell Name: germinal center B cell (CL0000844)
Fold Change: 2.1
Marker Score: 1276.5
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.95
Marker Score: 1943
Cell Name: naive B cell (CL0000788)
Fold Change: 1.7
Marker Score: 1521
Cell Name: respiratory basal cell (CL0002633)
Fold Change: 1.66
Marker Score: 2384
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 1.63
Marker Score: 1604
Cell Name: B-1 B cell (CL0000819)
Fold Change: 1.6
Marker Score: 2792
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.58
Marker Score: 4095
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 1.54
Marker Score: 1850.5
Cell Name: follicular B cell (CL0000843)
Fold Change: 1.47
Marker Score: 1597
Cell Name: immature B cell (CL0000816)
Fold Change: 1.44
Marker Score: 952
Cell Name: IgG plasma cell (CL0000985)
Fold Change: 1.37
Marker Score: 598
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 1.36
Marker Score: 480
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 1.34
Marker Score: 504
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.22
Marker Score: 823
Cell Name: mature B cell (CL0000785)
Fold Change: 1.19
Marker Score: 875
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 1.17
Marker Score: 402
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.16
Marker Score: 843
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.13
Marker Score: 4746
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 1.13
Marker Score: 679
Cell Name: goblet cell (CL0000160)
Fold Change: 1.11
Marker Score: 7409
Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
Fold Change: 1.08
Marker Score: 245
Cell Name: pre-B-I cell (CL0000956)
Fold Change: 1.07
Marker Score: 274
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 1.05
Marker Score: 6670
Cell Name: exhausted T cell (CL0011025)
Fold Change: 1.03
Marker Score: 591
Cell Name: mucous neck cell (CL0000651)
Fold Change: 1.01
Marker Score: 2287
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71741
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47967
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30402
Cell Name: plasmablast (CL0000980)
Fold Change: 0.97
Marker Score: 1288
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.95
Marker Score: 490
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2408
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 0.94
Marker Score: 487
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.94
Marker Score: 445
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.94
Marker Score: 438
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 0.92
Marker Score: 320
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2730
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 0.9
Marker Score: 377
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.9
Marker Score: 5160
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.9
Marker Score: 360
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.88
Marker Score: 315
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5272
Cell Name: B-1b B cell (CL0000821)
Fold Change: 0.87
Marker Score: 200
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 0.84
Marker Score: 1753
Cell Name: B cell (CL0000236)
Fold Change: 0.81
Marker Score: 774
Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: 0.81
Marker Score: 215
Cell Name: ionocyte (CL0005006)
Fold Change: 0.78
Marker Score: 237
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1263
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 0.75
Marker Score: 1033
Cell Name: classical monocyte (CL0000860)
Fold Change: 0.75
Marker Score: 3121
Cell Name: brush cell (CL0002204)
Fold Change: 0.75
Marker Score: 685
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.75
Marker Score: 373
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.75
Marker Score: 570
Cell Name: naive T cell (CL0000898)
Fold Change: 0.75
Marker Score: 480
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.74
Marker Score: 383
Cell Name: plasma cell (CL0000786)
Fold Change: 0.73
Marker Score: 815
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 0.72
Marker Score: 375
Cell Name: memory T cell (CL0000813)
Fold Change: 0.7
Marker Score: 303
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.7
Marker Score: 545.5
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.7
Marker Score: 409
Cell Name: fibroblast (CL0000057)
Fold Change: 0.7
Marker Score: 673
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 176
Cell Name: memory B cell (CL0000787)
Fold Change: 0.68
Marker Score: 514.5
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 0.67
Marker Score: 632
Cell Name: B-1a B cell (CL0000820)
Fold Change: 0.63
Marker Score: 151
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.62
Marker Score: 256
Cell Name: neutrophil (CL0000775)
Fold Change: 0.61
Marker Score: 373
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.61
Marker Score: 401
Cell Name: peptic cell (CL0000155)
Fold Change: 0.58
Marker Score: 241
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.58
Marker Score: 368
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.57
Marker Score: 2976
Cell Name: T cell (CL0000084)
Fold Change: 0.56
Marker Score: 969
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 443
Cell Name: colon macrophage (CL0009038)
Fold Change: 0.55
Marker Score: 151
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.55
Marker Score: 874.5
Cell Name: enterocyte (CL0000584)
Fold Change: 0.55
Marker Score: 2616
Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.54
Marker Score: 109
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 0.54
Marker Score: 391
Cell Name: mast cell (CL0000097)
Fold Change: 0.54
Marker Score: 311
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 0.53
Marker Score: 172
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 0.53
Marker Score: 1379
Cell Name: T-helper 1 cell (CL0000545)
Fold Change: 0.52
Marker Score: 204
Cell Name: microglial cell (CL0000129)
Fold Change: 0.51
Marker Score: 932
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.5
Marker Score: 181
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.5
Marker Score: 133
Cell Name: leukocyte (CL0000738)
Fold Change: 0.49
Marker Score: 280
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.49
Marker Score: 323
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 0.48
Marker Score: 150
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 0.48
Marker Score: 248
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 0.48
Marker Score: 108
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 0.48
Marker Score: 326
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.48
Marker Score: 257
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.47
Marker Score: 310
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.47
Marker Score: 1070
Cell Name: peritubular capillary endothelial cell (CL1001033)
Fold Change: 0.47
Marker Score: 109
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 0.46
Marker Score: 146
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.46
Marker Score: 391

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Other Information

Description

**Key characteristics**: * IGLC3 is a type of immunoglobulin that is expressed in the plasma membrane of cells. * It is a member of the immunoglobulin lambda family, which are involved in the regulation of inflammation and immune responses. * IGLC3 is expressed in high levels on the surface of activated T cells, B cells, and dendritic cells. * It is also expressed in lower levels on the surface of resting cells, such as macrophages and endothelial cells. **Pathways and functions**: * IGLC3 is involved in the regulation of inflammation and immune responses. * It is expressed in high levels on the surface of activated T cells and B cells, which are the cells that are responsible for initiating and responding to immune responses. * IGLC3 binds to a variety of ligands, including lipopolysaccharide (LPS), zymosin, and zymosin-related proteins. * When IGLC3 binds to its ligands, it recruits the immune complex to the cell surface, which leads to the activation of the immune response. * IGLC3 also plays a role in the regulation of inflammation. * It can inhibit the inflammatory response by binding to LPS and preventing it from interacting with its receptor, CD11b. * IGLC3 can also promote the resolution of inflammation by promoting the migration of inflammatory cells to sites of injury. **Clinical significance**: * Mutations in the IGLC3 gene have been linked to a number of autoimmune diseases, including rheumatoid arthritis, Crohn's disease, and lupus. * IGLC3 is a promising target for the treatment of autoimmune diseases. * Antibodies that block IGLC3 have been shown to be effective in suppressing autoimmune responses in animal models.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.