Details for: CL0000236

Cell ID: CL0000236

Cell Name: B cell

Marker Score Threshold: 952
(Derived using integrated single-cell and genomic data)

Description: A lymphocyte of B lineage that is capable of B cell mediated immunity.

Synonyms: B lymphocyte, B-cell, B-lymphocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.82
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.8
    Ensembl ID: ENSG00000075624
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.39
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 2.33
    Ensembl ID: ENSG00000019582
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.23
    Ensembl ID: ENSG00000133639
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.09
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.07
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.04
    Ensembl ID: ENSG00000184009
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.85
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.81
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.79
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.73
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.72
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 1.71
    Ensembl ID: ENSG00000104894
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.7
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.69
    Ensembl ID: ENSG00000111348
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.68
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.5
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.49
    Ensembl ID: ENSG00000135404
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.48
    Ensembl ID: ENSG00000149925
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.47
    Ensembl ID: ENSG00000134825
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.42
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.36
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.36
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.36
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.35
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.32
    Ensembl ID: ENSG00000154723
  • Gene Symbol: MS4A1 (ENSG00000156738)
    Fold Change: 1.29
    Ensembl ID: ENSG00000156738
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.28
    Ensembl ID: ENSG00000110955
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.28
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CD69 (ENSG00000110848)
    Fold Change: 1.28
    Ensembl ID: ENSG00000110848
  • Gene Symbol: AMY1C (ENSG00000187733)
    Fold Change: 1.28
    Ensembl ID: ENSG00000187733
  • Gene Symbol: NR0B1 (ENSG00000169297)
    Fold Change: 1.28
    Ensembl ID: ENSG00000169297
  • Gene Symbol: BRS3 (ENSG00000102239)
    Fold Change: 1.27
    Ensembl ID: ENSG00000102239
  • Gene Symbol: CD48 (ENSG00000117091)
    Fold Change: 1.27
    Ensembl ID: ENSG00000117091
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.26
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CD53 (ENSG00000143119)
    Fold Change: 1.26
    Ensembl ID: ENSG00000143119
  • Gene Symbol: PHOX2A (ENSG00000165462)
    Fold Change: 1.26
    Ensembl ID: ENSG00000165462
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.26
    Ensembl ID: ENSG00000026508
  • Gene Symbol: CD79A (ENSG00000105369)
    Fold Change: 1.25
    Ensembl ID: ENSG00000105369
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.25
    Ensembl ID: ENSG00000198931
  • Gene Symbol: APOC4 (ENSG00000267467)
    Fold Change: 1.25
    Ensembl ID: ENSG00000267467
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.25
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.25
    Ensembl ID: ENSG00000116489
  • Gene Symbol: NKX3 2 (ENSG00000109705)
    Fold Change: 1.24
    Ensembl ID: ENSG00000109705
  • Gene Symbol: AVPR1B (ENSG00000198049)
    Fold Change: 1.23
    Ensembl ID: ENSG00000198049
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 1.23
    Ensembl ID: ENSG00000023445
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.23
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.2
    Ensembl ID: ENSG00000241837
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.2
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ALPG (ENSG00000163286)
    Fold Change: 1.2
    Ensembl ID: ENSG00000163286
  • Gene Symbol: CCKBR (ENSG00000110148)
    Fold Change: 1.2
    Ensembl ID: ENSG00000110148
  • Gene Symbol: CD79B (ENSG00000007312)
    Fold Change: 1.2
    Ensembl ID: ENSG00000007312
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.19
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ATOH1 (ENSG00000172238)
    Fold Change: 1.19
    Ensembl ID: ENSG00000172238
  • Gene Symbol: AMELY (ENSG00000099721)
    Fold Change: 1.19
    Ensembl ID: ENSG00000099721
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.19
    Ensembl ID: ENSG00000172270
  • Gene Symbol: AFM (ENSG00000079557)
    Fold Change: 1.18
    Ensembl ID: ENSG00000079557
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.18
    Ensembl ID: ENSG00000182718
  • Gene Symbol: CBLN1 (ENSG00000102924)
    Fold Change: 1.18
    Ensembl ID: ENSG00000102924
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.17
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.17
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.17
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.16
    Ensembl ID: ENSG00000165629
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.16
    Ensembl ID: ENSG00000196776
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: 1.15
    Ensembl ID: ENSG00000168421
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.15
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CCIN (ENSG00000185972)
    Fold Change: 1.14
    Ensembl ID: ENSG00000185972
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.13
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.12
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.11
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.11
    Ensembl ID: ENSG00000122359
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.11
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.1
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.1
    Ensembl ID: ENSG00000070961
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.09
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ATP4B (ENSG00000186009)
    Fold Change: 1.09
    Ensembl ID: ENSG00000186009
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.09
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.09
    Ensembl ID: ENSG00000104763
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.09
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.09
    Ensembl ID: ENSG00000146731
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.08
    Ensembl ID: ENSG00000087088
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.07
    Ensembl ID: ENSG00000127022
  • Gene Symbol: AGTR2 (ENSG00000180772)
    Fold Change: 1.06
    Ensembl ID: ENSG00000180772
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.05
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.05
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ATP2B3 (ENSG00000067842)
    Fold Change: 1.05
    Ensembl ID: ENSG00000067842
  • Gene Symbol: C4B (ENSG00000224389)
    Fold Change: 1.05
    Ensembl ID: ENSG00000224389
  • Gene Symbol: NAT2 (ENSG00000156006)
    Fold Change: 1.05
    Ensembl ID: ENSG00000156006
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.05
    Ensembl ID: ENSG00000163399
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.04
    Ensembl ID: ENSG00000177105
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.04
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.04
    Ensembl ID: ENSG00000143727
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.03
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.02
    Ensembl ID: ENSG00000159199
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.02
    Ensembl ID: ENSG00000100823
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.01
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 1.01
    Ensembl ID: ENSG00000132965
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.01
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: N/A
    Ensembl ID: ENSG00000197043
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **B cell lineage**: B cells are a type of lymphocyte that originates from the bone marrow and matures in the spleen and lymph nodes. 2. **Antigen recognition**: B cells recognize antigens through their surface-bound antibodies, which are generated through a process called clonal selection. 3. **Antibody production**: B cells produce antibodies, also known as immunoglobulins, which are proteins that can bind to specific antigens. 4. **Antigen presentation**: B cells can present antigens to T cells through major histocompatibility complex (MHC) class II molecules, which helps activate T cells and initiate an immune response. 5. **Cytokine production**: B cells produce cytokines, such as IL-6 and IL-10, which are essential for coordinating the immune response and promoting inflammation. 6. **Cell surface receptors**: B cells express various cell surface receptors, including CD19, CD20, and CD21, which are involved in antigen recognition and signaling. 7. **Antigen processing and presentation**: B cells can process and present antigens to T cells through MHC class II molecules, which helps activate T cells and initiate an immune response. **Clinical Significance** 1. **Immunodeficiency disorders**: B cell deficiencies or dysfunction can lead to immunodeficiency disorders, such as X-linked agammaglobulinemia (XLA) or common variable immunodeficiency (CVID). 2. **Autoimmune diseases**: B cells can contribute to autoimmune diseases, such as rheumatoid arthritis or lupus, by producing autoantibodies that target self-antigens. 3. **Cancer**: B cells can play a role in cancer development and progression, particularly in lymphomas and leukemias. 4. **Vaccine development**: B cells are essential for the development of vaccines, which rely on the ability of B cells to produce antibodies against specific antigens. 5. **Immunotherapy**: B cells can be targeted for immunotherapy, such as checkpoint inhibitors or antibody-based therapies, to enhance the immune response against cancer or viral infections. 6. **Infectious diseases**: B cells play a critical role in fighting infectious diseases, such as tuberculosis or malaria, by producing antibodies that neutralize or remove pathogens from the body. In summary, B cells are essential for the adaptive immune system, and their dysfunction or deficiency can lead to various clinical manifestations. Understanding the biology of B cells is crucial for developing effective treatments for immune-related disorders and infectious diseases.