IGKV3 20 | ENSG00000239951 | NCBI 28912

Details for: IGKV3 20

Gene ID: 28912

Symbol: IGKV3 20

Ensembl ID: ENSG00000239951

Description: immunoglobulin kappa variable 3-20

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Antibacterial humoral response
(GO:0019731)
Antigen binding
(GO:0003823)
Blood microparticle
(GO:0072562)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Glomerular filtration
(GO:0003094)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Monomeric iga immunoglobulin complex
(GO:0071748)
Pentameric igm immunoglobulin complex
(GO:0071756)
Plasma membrane
(GO:0005886)
Secretory iga immunoglobulin complex
(GO:0071751)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 4.8473
Cell Significance Index: 121.1700
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 4.6027
Cell Significance Index: -12.3300
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 3.0572
Cell Significance Index: 46.0700
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.1549
Cell Significance Index: 219.7800
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.7118
Cell Significance Index: 15.1600
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.6546
Cell Significance Index: 39.3000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4890
Cell Significance Index: 48.3700
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.4883
Cell Significance Index: 53.1200
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4304
Cell Significance Index: 388.6500
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3013
Cell Significance Index: 49.0000
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2441
Cell Significance Index: 16.8800
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0140
Cell Significance Index: 1.7900
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0076
Cell Significance Index: 0.2200
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0003
Cell Significance Index: -0.0200
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0028
Cell Significance Index: -0.1000
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.0052
Cell Significance Index: -0.0800
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0100
Cell Significance Index: -7.6000
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0120
Cell Significance Index: -0.2600
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0199
Cell Significance Index: -2.0300
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0610
Cell Significance Index: -10.4100
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0624
Cell Significance Index: -2.0000
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0663
Cell Significance Index: -1.6600
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0672
Cell Significance Index: -8.6800
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0892
Cell Significance Index: -1.8500
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1052
Cell Significance Index: -6.4500
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1095
Cell Significance Index: -12.5500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1165
Cell Significance Index: -8.6800
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.1265
Cell Significance Index: -3.3900
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.1280
Cell Significance Index: -1.4500
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.1285
Cell Significance Index: -2.5800
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1308
Cell Significance Index: -6.1000
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1624
Cell Significance Index: -12.4600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1665
Cell Significance Index: -8.6500
Cell Name: collagen secreting cell (CL0000667)
Fold Change: -0.1922
Cell Significance Index: -1.0700
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2381
Cell Significance Index: -8.7400
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: -0.2810
Cell Significance Index: -3.1400
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.2988
Cell Significance Index: -2.5100
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.3058
Cell Significance Index: -4.4400
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.3168
Cell Significance Index: -7.9000
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.3169
Cell Significance Index: -9.3400
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3251
Cell Significance Index: -9.3200
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.3394
Cell Significance Index: -8.6700
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.3619
Cell Significance Index: -8.8300
Cell Name: plasma cell (CL0000786)
Fold Change: -0.3724
Cell Significance Index: -4.1600
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.3808
Cell Significance Index: -5.1800
Cell Name: peg cell (CL4033014)
Fold Change: -0.3878
Cell Significance Index: -8.9600
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.4125
Cell Significance Index: -10.5100
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.4232
Cell Significance Index: -10.2500
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.4341
Cell Significance Index: -5.3700
Cell Name: helper T cell (CL0000912)
Fold Change: -0.4680
Cell Significance Index: -6.6500
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.4756
Cell Significance Index: -7.9600
Cell Name: duct epithelial cell (CL0000068)
Fold Change: -0.4773
Cell Significance Index: -6.6000
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.4782
Cell Significance Index: -9.3500
Cell Name: memory B cell (CL0000787)
Fold Change: -0.4822
Cell Significance Index: -5.1300
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.4841
Cell Significance Index: -22.7500
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.4878
Cell Significance Index: -5.7700
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.4910
Cell Significance Index: -3.2700
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.4932
Cell Significance Index: -9.1200
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.5082
Cell Significance Index: -8.9800
Cell Name: naive B cell (CL0000788)
Fold Change: -0.5428
Cell Significance Index: -5.7200
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.5436
Cell Significance Index: -8.8100
Cell Name: B cell (CL0000236)
Fold Change: -0.5708
Cell Significance Index: -6.7500
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.5727
Cell Significance Index: -9.7900
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.5788
Cell Significance Index: -8.4700
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.5825
Cell Significance Index: -7.4600
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.6010
Cell Significance Index: -7.8600
Cell Name: fibroblast of breast (CL4006000)
Fold Change: -0.6011
Cell Significance Index: -3.7800
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.6069
Cell Significance Index: -7.1400
Cell Name: B-2 B cell (CL0000822)
Fold Change: -0.6126
Cell Significance Index: -5.4300
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.6159
Cell Significance Index: -9.0900
Cell Name: leukocyte (CL0000738)
Fold Change: -0.6201
Cell Significance Index: -10.5300
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.6322
Cell Significance Index: -8.1800
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.6405
Cell Significance Index: -10.7900
Cell Name: suprabasal keratinocyte (CL4033013)
Fold Change: -0.6511
Cell Significance Index: -10.4700
Cell Name: keratocyte (CL0002363)
Fold Change: -0.6587
Cell Significance Index: -10.4500
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: -0.6615
Cell Significance Index: -7.9900
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.6628
Cell Significance Index: -9.6600
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: -0.6692
Cell Significance Index: -7.3200
Cell Name: germinal center B cell (CL0000844)
Fold Change: -0.6729
Cell Significance Index: -4.7600
Cell Name: IgG plasma cell (CL0000985)
Fold Change: -0.6758
Cell Significance Index: -6.1800
Cell Name: thymocyte (CL0000893)
Fold Change: -0.6791
Cell Significance Index: -8.5800
Cell Name: plasmablast (CL0000980)
Fold Change: -0.6831
Cell Significance Index: -6.3400
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: -0.6940
Cell Significance Index: -7.3700
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.6953
Cell Significance Index: -10.5600
Cell Name: stromal cell (CL0000499)
Fold Change: -0.7047
Cell Significance Index: -7.2000
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.7110
Cell Significance Index: -9.7500
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.7141
Cell Significance Index: -10.7000
Cell Name: blood cell (CL0000081)
Fold Change: -0.7145
Cell Significance Index: -6.0900
Cell Name: promonocyte (CL0000559)
Fold Change: -0.7149
Cell Significance Index: -7.6400
Cell Name: transit amplifying cell (CL0009010)
Fold Change: -0.7209
Cell Significance Index: -6.9200
Cell Name: hepatocyte (CL0000182)
Fold Change: -0.7253
Cell Significance Index: -10.0600
Cell Name: monocyte (CL0000576)
Fold Change: -0.7257
Cell Significance Index: -8.3500
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.7292
Cell Significance Index: -8.2600
Cell Name: double negative thymocyte (CL0002489)
Fold Change: -0.7295
Cell Significance Index: -8.6600
Cell Name: epithelial cell (CL0000066)
Fold Change: -0.7309
Cell Significance Index: -7.7100
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.7343
Cell Significance Index: -9.3100
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.7344
Cell Significance Index: -12.6600
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -0.7388
Cell Significance Index: -7.8500
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: -0.7390
Cell Significance Index: -8.9400
Cell Name: chondrocyte (CL0000138)
Fold Change: -0.7470
Cell Significance Index: -8.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** IGKV3-20 is a kappa light chain gene that is part of the heavy chain region of IgG antibodies. It is characterized by its ability to undergo somatic recombination, a process that randomizes the V(D)J recombination of the variable region of the heavy chain, resulting in a diverse repertoire of antibodies. IGKV3-20 is also notable for its involvement in the regulation of the B cell receptor (BCR) signaling pathway, which is essential for the activation of B cells and the initiation of the humoral immune response. **Pathways and Functions** IGKV3-20 is involved in several key immune pathways, including: 1. **Adaptive immune response**: IGKV3-20 plays a crucial role in the production of IgG antibodies, which are essential for the adaptive immune response against pathogens. 2. **Antibacterial humoral response**: IGKV3-20 is involved in the production of IgG antibodies that recognize and bind to bacterial pathogens, leading to their elimination. 3. **Anti-inflammatory response**: IGKV3-20 is also involved in the regulation of the anti-inflammatory response, which helps to prevent excessive inflammation and tissue damage. 4. **Complement cascade**: IGKV3-20 is part of the complement cascade, a series of reactions that help to eliminate pathogens from the body. IGKV3-20 functions as a light chain component of IgG antibodies, which are produced by B cells in response to antigen stimulation. The IGKV3-20 gene is also involved in the regulation of the BCR signaling pathway, which is essential for the activation of B cells and the initiation of the humoral immune response. **Clinical Significance** IGKV3-20 has several clinical significance, including: 1. **Immune deficiencies**: Mutations in the IGKV3-20 gene can lead to immune deficiencies, such as IgG deficiency, which can increase the risk of infections. 2. **Cancer**: IGKV3-20 is also involved in the regulation of the immune response against cancer cells, and its dysregulation can contribute to the development of cancer. 3. **Autoimmune diseases**: IGKV3-20 is involved in the regulation of the immune response against self-antigens, and its dysregulation can contribute to the development of autoimmune diseases, such as rheumatoid arthritis and lupus. 4. **Vaccine development**: IGKV3-20 is also a target for vaccine development, as it is involved in the production of IgG antibodies against pathogens. In conclusion, IGKV3-20 is a critical gene that plays a key role in the adaptive immune system, and its dysregulation can contribute to various immune-related disorders. Further research is needed to fully understand the functions and clinical significance of IGKV3-20.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.