IGKV3 20 | ENSG00000239951 | NCBI 28912

Details for: IGKV3 20

Gene ID: 28912

Symbol: IGKV3 20

Ensembl ID: ENSG00000239951

Description: immunoglobulin kappa variable 3-20

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Antibacterial humoral response
(GO:0019731)
Antigen binding
(GO:0003823)
Blood microparticle
(GO:0072562)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Glomerular filtration
(GO:0003094)
Immune response
(GO:0006955)
Immunoglobulin production
(GO:0002377)
Monomeric iga immunoglobulin complex
(GO:0071748)
Pentameric igm immunoglobulin complex
(GO:0071756)
Plasma membrane
(GO:0005886)
Secretory iga immunoglobulin complex
(GO:0071751)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 6.3
Marker Score: 4,875
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 3.66
Marker Score: 9,105
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 2.98
Marker Score: 3,221
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.59
Marker Score: 1,157
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.35
Marker Score: 859
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.25
Marker Score: 844
Cell Name: plasmablast (CL0000980)
Fold Change: 1.17
Marker Score: 1,549
Cell Name: blood cell (CL0000081)
Fold Change: 1.15
Marker Score: 13,405
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.15
Marker Score: 477
Cell Name: goblet cell (CL0000160)
Fold Change: 1.15
Marker Score: 7,612
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251,777
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.03
Marker Score: 785
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 1.01
Marker Score: 978
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,406
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 499
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.96
Marker Score: 452
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,411
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5,284
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.92
Marker Score: 367
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,739
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.89
Marker Score: 319
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,293
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.84
Marker Score: 388
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.79
Marker Score: 3,329
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 0.78
Marker Score: 1,644
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 0.78
Marker Score: 697
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,269
Cell Name: brush cell (CL0002204)
Fold Change: 0.76
Marker Score: 698
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.73
Marker Score: 387
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.73
Marker Score: 305
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 0.73
Marker Score: 618
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.71
Marker Score: 453
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 0.69
Marker Score: 241
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 175
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.65
Marker Score: 1,281
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 443
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 0.55
Marker Score: 520
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.55
Marker Score: 145
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.54
Marker Score: 453
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.54
Marker Score: 315
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 0.53
Marker Score: 444
Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.48
Marker Score: 165
Cell Name: immature B cell (CL0000816)
Fold Change: 0.45
Marker Score: 299
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.45
Marker Score: 254
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 0.44
Marker Score: 121
Cell Name: glial cell (CL0000125)
Fold Change: 0.43
Marker Score: 478
Cell Name: IgG plasma cell (CL0000985)
Fold Change: 0.42
Marker Score: 182
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 0.38
Marker Score: 101
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.36
Marker Score: 256
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 0.35
Marker Score: 159
Cell Name: naive B cell (CL0000788)
Fold Change: 0.35
Marker Score: 309
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.34
Marker Score: 106
Cell Name: B cell (CL0000236)
Fold Change: 0.33
Marker Score: 315
Cell Name: memory B cell (CL0000787)
Fold Change: 0.33
Marker Score: 250
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.29
Marker Score: 475
Cell Name: follicular B cell (CL0000843)
Fold Change: 0.28
Marker Score: 305
Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: 0.27
Marker Score: 165
Cell Name: ILC1, human (CL0001077)
Fold Change: 0.26
Marker Score: 65
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 0.25
Marker Score: 305
Cell Name: mast cell (CL0000097)
Fold Change: 0.25
Marker Score: 146
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.24
Marker Score: 52
Cell Name: plasma cell (CL0000786)
Fold Change: 0.23
Marker Score: 259
Cell Name: B-1b B cell (CL0000821)
Fold Change: 0.23
Marker Score: 53
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 64
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.22
Marker Score: 124
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 74
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 0.21
Marker Score: 153
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 0.21
Marker Score: 55
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 0.2
Marker Score: 878
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 0.2
Marker Score: 70
Cell Name: colon macrophage (CL0009038)
Fold Change: 0.2
Marker Score: 55
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.2
Marker Score: 121
Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.2
Marker Score: 54
Cell Name: M cell of gut (CL0000682)
Fold Change: 0.2
Marker Score: 51
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 0.19
Marker Score: 142
Cell Name: B-1 B cell (CL0000819)
Fold Change: 0.19
Marker Score: 336
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 0.19
Marker Score: 540
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.19
Marker Score: 125
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.19
Marker Score: 310
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.19
Marker Score: 10,523
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.19
Marker Score: 55
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 0.19
Marker Score: 152
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 0.18
Marker Score: 581
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.18
Marker Score: 165
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.18
Marker Score: 184
Cell Name: enucleated reticulocyte (CL0002422)
Fold Change: 0.18
Marker Score: 67
Cell Name: memory T cell (CL0000813)
Fold Change: 0.18
Marker Score: 77
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 0.18
Marker Score: 40
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 0.18
Marker Score: 181
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 0.18
Marker Score: 52
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.18
Marker Score: 122
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.18
Marker Score: 66
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.17
Marker Score: 43
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.17
Marker Score: 41
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.17
Marker Score: 113
Cell Name: fibroblast (CL0000057)
Fold Change: 0.17
Marker Score: 162
Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.17
Marker Score: 52
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 0.16
Marker Score: 52
Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
Fold Change: 0.16
Marker Score: 55
Cell Name: platelet (CL0000233)
Fold Change: 0.16
Marker Score: 73

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

Description

**Key Characteristics** IGKV3-20 is a kappa light chain gene that is part of the heavy chain region of IgG antibodies. It is characterized by its ability to undergo somatic recombination, a process that randomizes the V(D)J recombination of the variable region of the heavy chain, resulting in a diverse repertoire of antibodies. IGKV3-20 is also notable for its involvement in the regulation of the B cell receptor (BCR) signaling pathway, which is essential for the activation of B cells and the initiation of the humoral immune response. **Pathways and Functions** IGKV3-20 is involved in several key immune pathways, including: 1. **Adaptive immune response**: IGKV3-20 plays a crucial role in the production of IgG antibodies, which are essential for the adaptive immune response against pathogens. 2. **Antibacterial humoral response**: IGKV3-20 is involved in the production of IgG antibodies that recognize and bind to bacterial pathogens, leading to their elimination. 3. **Anti-inflammatory response**: IGKV3-20 is also involved in the regulation of the anti-inflammatory response, which helps to prevent excessive inflammation and tissue damage. 4. **Complement cascade**: IGKV3-20 is part of the complement cascade, a series of reactions that help to eliminate pathogens from the body. IGKV3-20 functions as a light chain component of IgG antibodies, which are produced by B cells in response to antigen stimulation. The IGKV3-20 gene is also involved in the regulation of the BCR signaling pathway, which is essential for the activation of B cells and the initiation of the humoral immune response. **Clinical Significance** IGKV3-20 has several clinical significance, including: 1. **Immune deficiencies**: Mutations in the IGKV3-20 gene can lead to immune deficiencies, such as IgG deficiency, which can increase the risk of infections. 2. **Cancer**: IGKV3-20 is also involved in the regulation of the immune response against cancer cells, and its dysregulation can contribute to the development of cancer. 3. **Autoimmune diseases**: IGKV3-20 is involved in the regulation of the immune response against self-antigens, and its dysregulation can contribute to the development of autoimmune diseases, such as rheumatoid arthritis and lupus. 4. **Vaccine development**: IGKV3-20 is also a target for vaccine development, as it is involved in the production of IgG antibodies against pathogens. In conclusion, IGKV3-20 is a critical gene that plays a key role in the adaptive immune system, and its dysregulation can contribute to various immune-related disorders. Further research is needed to fully understand the functions and clinical significance of IGKV3-20.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.