Details for: CL0000786

Cell ID: CL0000786

Cell Name: plasma cell

Marker Score Threshold: 1117
(Derived using integrated single-cell and genomic data)

Description: A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin.

Synonyms: plasma B cell, plasma B-cell, plasmacyte, plasmocyte, effector B cell, effector B-cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: AMELY (ENSG00000099721)
    Fold Change: 2
    Ensembl ID: ENSG00000099721
  • Gene Symbol: PHOX2A (ENSG00000165462)
    Fold Change: 1.99
    Ensembl ID: ENSG00000165462
  • Gene Symbol: ATP2B3 (ENSG00000067842)
    Fold Change: 1.99
    Ensembl ID: ENSG00000067842
  • Gene Symbol: BRS3 (ENSG00000102239)
    Fold Change: 1.99
    Ensembl ID: ENSG00000102239
  • Gene Symbol: AMY1C (ENSG00000187733)
    Fold Change: 1.99
    Ensembl ID: ENSG00000187733
  • Gene Symbol: CACNG1 (ENSG00000108878)
    Fold Change: 1.99
    Ensembl ID: ENSG00000108878
  • Gene Symbol: NR0B1 (ENSG00000169297)
    Fold Change: 1.99
    Ensembl ID: ENSG00000169297
  • Gene Symbol: ATP4B (ENSG00000186009)
    Fold Change: 1.98
    Ensembl ID: ENSG00000186009
  • Gene Symbol: ART1 (ENSG00000129744)
    Fold Change: 1.98
    Ensembl ID: ENSG00000129744
  • Gene Symbol: AMY1B (ENSG00000174876)
    Fold Change: 1.98
    Ensembl ID: ENSG00000174876
  • Gene Symbol: AMY2A (ENSG00000243480)
    Fold Change: 1.98
    Ensembl ID: ENSG00000243480
  • Gene Symbol: CRISP1 (ENSG00000124812)
    Fold Change: 1.97
    Ensembl ID: ENSG00000124812
  • Gene Symbol: KLK3 (ENSG00000142515)
    Fold Change: 1.97
    Ensembl ID: ENSG00000142515
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.96
    Ensembl ID: ENSG00000075624
  • Gene Symbol: APOC4 (ENSG00000267467)
    Fold Change: 1.94
    Ensembl ID: ENSG00000267467
  • Gene Symbol: ALPG (ENSG00000163286)
    Fold Change: 1.92
    Ensembl ID: ENSG00000163286
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.92
    Ensembl ID: ENSG00000169100
  • Gene Symbol: AFM (ENSG00000079557)
    Fold Change: 1.91
    Ensembl ID: ENSG00000079557
  • Gene Symbol: NKX3 2 (ENSG00000109705)
    Fold Change: 1.9
    Ensembl ID: ENSG00000109705
  • Gene Symbol: ADCYAP1R1 (ENSG00000078549)
    Fold Change: 1.89
    Ensembl ID: ENSG00000078549
  • Gene Symbol: AHSG (ENSG00000145192)
    Fold Change: 1.88
    Ensembl ID: ENSG00000145192
  • Gene Symbol: AVPR1B (ENSG00000198049)
    Fold Change: 1.88
    Ensembl ID: ENSG00000198049
  • Gene Symbol: ATOH1 (ENSG00000172238)
    Fold Change: 1.87
    Ensembl ID: ENSG00000172238
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.86
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ARSF (ENSG00000062096)
    Fold Change: 1.83
    Ensembl ID: ENSG00000062096
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.82
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CALB1 (ENSG00000104327)
    Fold Change: 1.78
    Ensembl ID: ENSG00000104327
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.77
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ADRA1B (ENSG00000170214)
    Fold Change: 1.75
    Ensembl ID: ENSG00000170214
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.74
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.72
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ARR3 (ENSG00000120500)
    Fold Change: 1.72
    Ensembl ID: ENSG00000120500
  • Gene Symbol: AMY1A (ENSG00000237763)
    Fold Change: 1.65
    Ensembl ID: ENSG00000237763
  • Gene Symbol: KIF1A (ENSG00000130294)
    Fold Change: 1.65
    Ensembl ID: ENSG00000130294
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.64
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.62
    Ensembl ID: ENSG00000154723
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.61
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.6
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.6
    Ensembl ID: ENSG00000110955
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.59
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.58
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.58
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.54
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ALDH3B2 (ENSG00000132746)
    Fold Change: 1.52
    Ensembl ID: ENSG00000132746
  • Gene Symbol: AQP2 (ENSG00000167580)
    Fold Change: 1.52
    Ensembl ID: ENSG00000167580
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.52
    Ensembl ID: ENSG00000152234
  • Gene Symbol: AGTR2 (ENSG00000180772)
    Fold Change: 1.5
    Ensembl ID: ENSG00000180772
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.5
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.47
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ADH1A (ENSG00000187758)
    Fold Change: 1.46
    Ensembl ID: ENSG00000187758
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.44
    Ensembl ID: ENSG00000124172
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.43
    Ensembl ID: ENSG00000134825
  • Gene Symbol: CA7 (ENSG00000168748)
    Fold Change: 1.42
    Ensembl ID: ENSG00000168748
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.39
    Ensembl ID: ENSG00000241837
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.38
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.37
    Ensembl ID: ENSG00000085224
  • Gene Symbol: AFP (ENSG00000081051)
    Fold Change: 1.37
    Ensembl ID: ENSG00000081051
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.36
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.34
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ALPI (ENSG00000163295)
    Fold Change: 1.33
    Ensembl ID: ENSG00000163295
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.32
    Ensembl ID: ENSG00000159199
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.32
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.31
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.29
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ADH7 (ENSG00000196344)
    Fold Change: 1.28
    Ensembl ID: ENSG00000196344
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.26
    Ensembl ID: ENSG00000149925
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.24
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.22
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.21
    Ensembl ID: ENSG00000141522
  • Gene Symbol: MPPED1 (ENSG00000186732)
    Fold Change: 1.21
    Ensembl ID: ENSG00000186732
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.21
    Ensembl ID: ENSG00000185650
  • Gene Symbol: C8B (ENSG00000021852)
    Fold Change: 1.2
    Ensembl ID: ENSG00000021852
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.19
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.18
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.16
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.14
    Ensembl ID: ENSG00000104763
  • Gene Symbol: APOA2 (ENSG00000158874)
    Fold Change: 1.13
    Ensembl ID: ENSG00000158874
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.12
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.12
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.12
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.1
    Ensembl ID: ENSG00000182718
  • Gene Symbol: C8A (ENSG00000157131)
    Fold Change: 1.09
    Ensembl ID: ENSG00000157131
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.08
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ADRA1A (ENSG00000120907)
    Fold Change: 1.08
    Ensembl ID: ENSG00000120907
  • Gene Symbol: ADRA2C (ENSG00000184160)
    Fold Change: 1.08
    Ensembl ID: ENSG00000184160
  • Gene Symbol: AVPR2 (ENSG00000126895)
    Fold Change: 1.08
    Ensembl ID: ENSG00000126895
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.07
    Ensembl ID: ENSG00000130402
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.07
    Ensembl ID: ENSG00000084234
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.05
    Ensembl ID: ENSG00000108561
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.05
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.04
    Ensembl ID: ENSG00000149311
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.04
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.04
    Ensembl ID: ENSG00000138279
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.03
    Ensembl ID: ENSG00000115307
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.03
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.02
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.02
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.01
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1
    Ensembl ID: ENSG00000071553
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1
    Ensembl ID: ENSG00000197043
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Terminally differentiated, post-mitotic cells**: Plasma cells have undergone extensive differentiation and no longer undergo mitosis. 2. **CD138-positive**: Plasma cells express the CD138 antigen, also known as Syto-16, which is a marker of plasma cells. 3. **Surface immunoglobulin-negative**: Plasma cells do not express surface immunoglobulin, which is a characteristic of B cells that have not yet differentiated into plasma cells. 4. **MHC Class II-negative**: Plasma cells do not express MHC Class II molecules, which are involved in the presentation of antigens to T cells. 5. **Oval or round shape**: Plasma cells are typically oval or round in shape, with a diameter of 10-30 μm. 6. **Extensive rough endoplasmic reticulum**: Plasma cells have a large amount of rough endoplasmic reticulum, which is involved in protein synthesis and secretion. 7. **Well-developed Golgi apparatus**: Plasma cells have a well-developed Golgi apparatus, which is involved in protein modification and secretion. 8. **Round nucleus with cartwheel heterochromatin**: The nucleus of plasma cells is round and contains a characteristic cartwheel pattern of heterochromatin. **Clinical Significance** 1. **Humoral immune response**: Plasma cells play a crucial role in the humoral immune response, producing antibodies that help to neutralize pathogens. 2. **Autoimmune diseases**: Plasma cells can contribute to autoimmune diseases, such as rheumatoid arthritis and lupus, by producing autoantibodies. 3. **Cancer**: Plasma cells can be involved in the development of certain types of cancer, such as multiple myeloma, which is characterized by the proliferation of malignant plasma cells. 4. **Immunodeficiency**: Plasma cells can be affected in immunodeficiency disorders, such as X-linked agammaglobulinemia, which is characterized by the absence of plasma cells. 5. **Immunotherapy**: Plasma cells can be targeted for immunotherapy, such as rituximab, which is used to treat certain types of cancer and autoimmune diseases. In summary, plasma cells are specialized cells that play a crucial role in the adaptive immune response, producing antibodies that help to neutralize pathogens. Their dysfunction or dysregulation can contribute to autoimmune diseases, cancer, and immunodeficiency disorders.