Details for: H2AC13

Gene ID: 8329

Symbol: H2AC13

Ensembl ID: ENSG00000196747

Description: H2A clustered histone 13

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1164
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.27
    Marker Score: 1335
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7659
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.1
    Marker Score: 2988
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71820
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48045
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 1
    Marker Score: 387
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5310
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2736
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.9
    Marker Score: 611
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5284
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.83
    Marker Score: 607
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 674
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 561
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.72
    Marker Score: 957.5
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.7
    Marker Score: 193
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.68
    Marker Score: 274
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2792
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.61
    Marker Score: 447
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.56
    Marker Score: 423
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.54
    Marker Score: 326
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.52
    Marker Score: 553
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.52
    Marker Score: 332
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.51
    Marker Score: 344
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.49
    Marker Score: 708
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.47
    Marker Score: 473
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.46
    Marker Score: 810
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.45
    Marker Score: 271
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.43
    Marker Score: 292
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.41
    Marker Score: 232
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.41
    Marker Score: 120
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.38
    Marker Score: 124
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.35
    Marker Score: 3528
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.35
    Marker Score: 173
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.33
    Marker Score: 984
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.33
    Marker Score: 391
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.32
    Marker Score: 112
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.32
    Marker Score: 127
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.32
    Marker Score: 83
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.29
    Marker Score: 157
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.28
    Marker Score: 73
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.27
    Marker Score: 181
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.27
    Marker Score: 79
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.26
    Marker Score: 165
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.26
    Marker Score: 251
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.26
    Marker Score: 536
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.24
    Marker Score: 291
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.23
    Marker Score: 294
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.23
    Marker Score: 386
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.22
    Marker Score: 185
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.22
    Marker Score: 55
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.22
    Marker Score: 271
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.22
    Marker Score: 77
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.22
    Marker Score: 192
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.22
    Marker Score: 113.5
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 72
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.21
    Marker Score: 152
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.2
    Marker Score: 284
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.2
    Marker Score: 56
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.2
    Marker Score: 82
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.2
    Marker Score: 62
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.19
    Marker Score: 56
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.19
    Marker Score: 101
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.19
    Marker Score: 95
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.19
    Marker Score: 86
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.19
    Marker Score: 196
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.19
    Marker Score: 1196
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.18
    Marker Score: 108
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.18
    Marker Score: 500
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.18
    Marker Score: 121
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.17
    Marker Score: 2303
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.17
    Marker Score: 137
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.17
    Marker Score: 490
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.17
    Marker Score: 71
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.17
    Marker Score: 53
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.17
    Marker Score: 93
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.17
    Marker Score: 75
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.17
    Marker Score: 57
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.16
    Marker Score: 119
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.16
    Marker Score: 195
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.16
    Marker Score: 40
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.16
    Marker Score: 121
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.16
    Marker Score: 122
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.16
    Marker Score: 157
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.16
    Marker Score: 419
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.15
    Marker Score: 270
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.15
    Marker Score: 71
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.15
    Marker Score: 221
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.15
    Marker Score: 169
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.15
    Marker Score: 74

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Other Information

**Key Characteristics:** H2A13 is a histone protein that is part of the H2A cluster, which accounts for approximately 15% of the total histone content in mammalian cells. This gene is characterized by its ability to interact with various proteins and enzymes, including acetyltransferases, deacetylases, and ubiquitin ligases, which are essential for chromatin regulation. The unique structure of H2A13 allows it to form heterochromatin, a compact chromatin structure that is typically associated with gene silencing. **Pathways and Functions:** H2A13 is involved in multiple pathways that govern chromatin structure and function, including: 1. **Chromatin Organization**: H2A13 plays a critical role in the formation and maintenance of heterochromatin, which is essential for regulating gene expression. 2. **Histone Modification**: H2A13 is a substrate for various histone-modifying enzymes, including acetyltransferases and deacetylases, which regulate chromatin structure and function. 3. **Protein Binding**: H2A13 interacts with multiple proteins, including transcription factors, chromatin remodeling complexes, and histone-modifying enzymes, which regulate gene expression and chromatin structure. 4. **Post-Translational Modification**: H2A13 undergoes various post-translational modifications, including phosphorylation, ubiquitination, and acetylation, which regulate its function and interactions. **Clinical Significance:** Dysregulation of H2A13 has been implicated in various diseases, including: 1. **Autoimmune Disorders**: Altered expression and function of H2A13 have been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer**: Aberrant expression and modification of H2A13 have been observed in various cancers, including breast, lung, and colon cancer. 3. **Neurological Disorders**: H2A13 has been implicated in neurological disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. In conclusion, H2A Clustered Histone 13 is a complex gene that plays a critical role in chromatin regulation and immune response. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of H2A13 and its potential as a therapeutic target.

Genular Protein ID: 153980397

Symbol: H2A1_HUMAN

Name: Histone H2A type 1

UniProtKB Accession Codes:

P0C0S8 P02261 Q2M1R2 Q76PA6

Database IDs:

ABCD 1 AGR 5 AlphaFoldDB 1 Antibodypedia 5 Bgee 1 BioGRID 5 BioGRID-ORCS 5 BioMuta 1 CCDS 5 CDD 1 CTD 5 ChiTaRS 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 5 EMBL 21 EMDB 20 EPD 1 Ensembl 5 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 5 GeneTree 1 GeneWiki 5 Genevisible 1 GlyGen 1 HGNC 10 HOGENOM 1 HPA 5 InParanoid 1 IntAct 1 InterPro 5 KEGG 5 MANE-Select 5 MIM 5 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 5 OrthoDB 1 PANTHER 2 PDB 28 PDBsum 21 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 Pumba 1 RNAct 1 Reactome 8 RefSeq 5 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 5 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9439656

Title: The human histone gene cluster at the D6S105 locus.

PubMed ID: 9439656

DOI: 10.1007/s004390050630

PubMed ID: 10064132

Title: The human H2A and H2B histone gene complement.

PubMed ID: 10064132

DOI: 10.1515/bc.1999.002

PubMed ID: 1768865

Title: A novel divergently transcribed human histone H2A/H2B gene pair.

PubMed ID: 1768865

DOI: 10.3109/10425179109020799

PubMed ID: 8179821

Title: The relative expression of human histone H2A genes is similar in different types of proliferating cells.

PubMed ID: 8179821

DOI: 10.1089/dna.1994.13.161

PubMed ID: 12408966

Title: The human and mouse replication-dependent histone genes.

PubMed ID: 12408966

DOI: 10.1016/s0888-7543(02)96850-3

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7410338

Title: Human spleen histone H2A. Isolation and four variant sequences.

PubMed ID: 7410338

PubMed ID: 11709551

Title: Global regulation of post-translational modifications on core histones.

PubMed ID: 11709551

DOI: 10.1074/jbc.m107894200

PubMed ID: 15078818

Title: Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo.

PubMed ID: 15078818

DOI: 10.1101/gad.1184604

PubMed ID: 15010469

Title: Phosphorylation of histone H2A inhibits transcription on chromatin templates.

PubMed ID: 15010469

DOI: 10.1074/jbc.m400099200

PubMed ID: 15386022

Title: Role of histone H2A ubiquitination in Polycomb silencing.

PubMed ID: 15386022

DOI: 10.1038/nature02985

PubMed ID: 15823041

Title: Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes.

PubMed ID: 15823041

DOI: 10.1021/bi047505c

PubMed ID: 16359901

Title: Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing.

PubMed ID: 16359901

DOI: 10.1016/j.molcel.2005.12.002

PubMed ID: 16702407

Title: DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A.

PubMed ID: 16702407

DOI: 10.1101/gad.373706

PubMed ID: 16457589

Title: Precise characterization of human histones in the H2A gene family by top down mass spectrometry.

PubMed ID: 16457589

DOI: 10.1021/pr050269n

PubMed ID: 18001824

Title: RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins.

PubMed ID: 18001824

DOI: 10.1016/j.cell.2007.09.040

PubMed ID: 18001825

Title: RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly.

PubMed ID: 18001825

DOI: 10.1016/j.cell.2007.09.041

PubMed ID: 19203578

Title: The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage.

PubMed ID: 19203578

DOI: 10.1016/j.cell.2008.12.042

PubMed ID: 19203579

Title: RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins.

PubMed ID: 19203579

DOI: 10.1016/j.cell.2008.12.041

PubMed ID: 21925322

Title: Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification.

PubMed ID: 21925322

DOI: 10.1016/j.cell.2011.08.008

PubMed ID: 22980979

Title: RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA Damage signaling.

PubMed ID: 22980979

DOI: 10.1016/j.cell.2012.08.005

PubMed ID: 22713238

Title: A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase.

PubMed ID: 22713238

DOI: 10.4161/cc.20919

PubMed ID: 22389435

Title: Lysine succinylation and lysine malonylation in histones.

PubMed ID: 22389435

DOI: 10.1074/mcp.m111.015875

PubMed ID: 24140421

Title: VprBP has intrinsic kinase activity targeting histone H2A and represses gene transcription.

PubMed ID: 24140421

DOI: 10.1016/j.molcel.2013.09.017

PubMed ID: 24681537

Title: Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark.

PubMed ID: 24681537

DOI: 10.1038/nchembio.1497

PubMed ID: 24352239

Title: Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification.

PubMed ID: 24352239

DOI: 10.1038/nature12819

PubMed ID: 25470042

Title: TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein.

PubMed ID: 25470042

DOI: 10.1038/nature13955

PubMed ID: 27083998

Title: USP51 deubiquitylates H2AK13,15ub and regulates DNA damage response.

PubMed ID: 27083998

DOI: 10.1101/gad.271841.115

PubMed ID: 27105115

Title: Metabolic regulation of gene expression by histone lysine beta-hydroxybutyrylation.

PubMed ID: 27105115

DOI: 10.1016/j.molcel.2016.03.036

PubMed ID: 31542297

Title: Glutarylation of histone H4 lysine 91 regulates chromatin dynamics.

PubMed ID: 31542297

DOI: 10.1016/j.molcel.2019.08.018

PubMed ID: 32911481

Title: The molecular basis of tight nuclear tethering and inactivation of cGAS.

PubMed ID: 32911481

DOI: 10.1038/s41586-020-2749-z

PubMed ID: 32913000

Title: Structural basis of nucleosome-dependent cGAS inhibition.

PubMed ID: 32913000

DOI: 10.1126/science.abd0609

Sequence Information:

  • Length: 130
  • Mass: 14091
  • Checksum: 48DD539793FE8256
  • Sequence:
    • MSGRGKQGGK ARAKAKTRSS RAGLQFPVGR VHRLLRKGNY AERVGAGAPV YLAAVLEYLT 
AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGK VTIAQGGVLP NIQAVLLPKK 
TESHHKAKGK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.