Details for: TPST2

Gene ID: 8459

Symbol: TPST2

Ensembl ID: ENSG00000128294

Description: tyrosylprotein sulfotransferase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 141.2451
    Cell Significance Index: -21.9700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 79.3634
    Cell Significance Index: -20.1300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 63.4943
    Cell Significance Index: -25.8000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 55.1532
    Cell Significance Index: -28.3700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.3924
    Cell Significance Index: -23.9100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.0597
    Cell Significance Index: -24.7600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.1507
    Cell Significance Index: -15.6500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.6041
    Cell Significance Index: -26.0600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.3460
    Cell Significance Index: -17.0000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 2.7575
    Cell Significance Index: 45.4400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.6790
    Cell Significance Index: 72.9200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.8149
    Cell Significance Index: 48.4600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3836
    Cell Significance Index: 225.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.2737
    Cell Significance Index: 217.4900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2091
    Cell Significance Index: 1091.6900
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.1163
    Cell Significance Index: 11.8600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8679
    Cell Significance Index: 94.4000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8555
    Cell Significance Index: 51.3600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.8555
    Cell Significance Index: 21.9900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.8232
    Cell Significance Index: 11.8400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7881
    Cell Significance Index: 158.1000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.7596
    Cell Significance Index: 12.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6505
    Cell Significance Index: 75.8100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.6316
    Cell Significance Index: 9.0500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6280
    Cell Significance Index: 62.1200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.6021
    Cell Significance Index: 17.6800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5703
    Cell Significance Index: 113.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5543
    Cell Significance Index: 99.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5378
    Cell Significance Index: 27.9400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4806
    Cell Significance Index: 5.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4801
    Cell Significance Index: 59.0300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4319
    Cell Significance Index: 29.8700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3523
    Cell Significance Index: 41.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3133
    Cell Significance Index: 171.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2976
    Cell Significance Index: 22.8400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2926
    Cell Significance Index: 18.8800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.2796
    Cell Significance Index: 2.2800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.2462
    Cell Significance Index: 4.5500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1942
    Cell Significance Index: 36.9600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1866
    Cell Significance Index: 82.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1337
    Cell Significance Index: 47.9400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1327
    Cell Significance Index: 2.3500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0998
    Cell Significance Index: 69.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0998
    Cell Significance Index: 13.7100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0877
    Cell Significance Index: 0.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0493
    Cell Significance Index: 66.9900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0376
    Cell Significance Index: 27.6000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0247
    Cell Significance Index: 1.8400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0221
    Cell Significance Index: 0.5900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0056
    Cell Significance Index: 10.4600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0016
    Cell Significance Index: -2.5000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0079
    Cell Significance Index: -14.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0128
    Cell Significance Index: -0.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0156
    Cell Significance Index: -11.5400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0170
    Cell Significance Index: -10.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0190
    Cell Significance Index: -14.3700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0209
    Cell Significance Index: -1.4800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0212
    Cell Significance Index: -0.4600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0249
    Cell Significance Index: -11.3200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0285
    Cell Significance Index: -18.0800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0303
    Cell Significance Index: -3.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0392
    Cell Significance Index: -22.1000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0476
    Cell Significance Index: -1.3300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0790
    Cell Significance Index: -22.7200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0825
    Cell Significance Index: -10.5800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0858
    Cell Significance Index: -18.0700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0960
    Cell Significance Index: -10.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1024
    Cell Significance Index: -2.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1094
    Cell Significance Index: -4.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1097
    Cell Significance Index: -15.9400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1184
    Cell Significance Index: -13.5700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1186
    Cell Significance Index: -1.7500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1250
    Cell Significance Index: -3.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1440
    Cell Significance Index: -18.6100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1472
    Cell Significance Index: -8.2600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1484
    Cell Significance Index: -3.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2171
    Cell Significance Index: -14.6000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2249
    Cell Significance Index: -23.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2385
    Cell Significance Index: -11.2100
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -0.2837
    Cell Significance Index: -0.7600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2866
    Cell Significance Index: -3.9100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2899
    Cell Significance Index: -22.9600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2917
    Cell Significance Index: -17.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2997
    Cell Significance Index: -18.8900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3034
    Cell Significance Index: -7.0100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3133
    Cell Significance Index: -16.3200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3423
    Cell Significance Index: -17.9700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3501
    Cell Significance Index: -5.8600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3638
    Cell Significance Index: -7.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3718
    Cell Significance Index: -16.4500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3788
    Cell Significance Index: -8.0400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3928
    Cell Significance Index: -24.0800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4630
    Cell Significance Index: -14.8300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4655
    Cell Significance Index: -15.2400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4689
    Cell Significance Index: -12.3300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4738
    Cell Significance Index: -17.9400
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.4806
    Cell Significance Index: -3.1900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4859
    Cell Significance Index: -13.8700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4901
    Cell Significance Index: -12.5200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4942
    Cell Significance Index: -23.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Tyrosine sulfotransferase activity**: TPST2 catalyzes the sulfonation of tyrosine residues on proteins, which is a critical post-translational modification that regulates protein function and interactions. 2. **High expression in immune cells**: TPST2 is highly expressed in immune cells, including NKp46-positive innate lymphoid cells, effector memory CD8-positive T cells, and decidual natural killer cells, suggesting its importance in immune regulation and function. 3. **Endothelial cell expression**: TPST2 is also expressed in endothelial cells, including alveolar capillary type 1 endothelial cells and pulmonary artery endothelial cells, highlighting its role in vascular function and blood coagulation. 4. **Sulfonation of proteins**: TPST2 is involved in the sulfonation of proteins, which can regulate protein-protein interactions, protein stability, and protein degradation. **Pathways and Functions** 1. **Contact activation system**: TPST2 is involved in the sulfonation of proteins that regulate the contact activation system, a crucial pathway in blood coagulation. 2. **Kallikrein-kinin system**: TPST2 is also involved in the sulfonation of proteins that regulate the kallikrein-kinin system, which plays a key role in inflammation and blood pressure regulation. 3. **Protein function regulation**: TPST2's activity can regulate protein function and interactions, including the sulfonation of proteins involved in signaling pathways and protein-protein interactions. 4. **Hemostasis and coagulation**: TPST2's activity is essential for the proper functioning of the contact activation system and the kallikrein-kinin system, which are critical for blood coagulation and hemostasis. **Clinical Significance** 1. **Hemophilia A**: Defects in TPST2 expression or function have been linked to hemophilia A, a bleeding disorder caused by defective factor VIII sulfation. 2. **Defective factor VIII sulfation**: TPST2's activity is essential for the sulfonation of factor VIII, which is critical for its proper functioning and stability. 3. **Endothelial dysfunction**: Abnormalities in TPST2 expression or function may contribute to endothelial dysfunction and cardiovascular disease. 4. **Immune regulation**: TPST2's activity is essential for the regulation of immune responses, and abnormalities in its expression or function may contribute to immune-related diseases. In conclusion, TPST2 is a critical enzyme involved in the sulfonation of tyrosine residues on proteins, playing a significant role in various cellular processes, including protein function, signaling, and regulation. Its abnormalities have been linked to various diseases, including hemophilia A and defective factor VIII sulfation. Further research is needed to fully understand the mechanisms of TPST2's function and its clinical significance.

Genular Protein ID: 2178278989

Symbol: TPST2_HUMAN

Name: Protein-tyrosine sulfotransferase 2

UniProtKB Accession Codes:

O60704 B3KQA7 Q6FI98 Q9H0V4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 12 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 Rhea 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9736702

Title: Existence of distinct tyrosylprotein sulfotransferase genes: molecular characterization of tyrosylprotein sulfotransferase-2.

PubMed ID: 9736702

DOI: 10.1073/pnas.95.19.11134

PubMed ID: 9733778

Title: Molecular cloning and expression of human and mouse tyrosylprotein sulfotransferase-2 and a tyrosylprotein sulfotransferase homologue in Caenorhabditis elegans.

PubMed ID: 9733778

DOI: 10.1074/jbc.273.38.24770

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 25660941

Title: Heterodimers of tyrosylprotein sulfotransferases suggest existence of a higher organization level of transferases in the membrane of the trans-Golgi apparatus.

PubMed ID: 25660941

DOI: 10.1016/j.jmb.2015.01.021

PubMed ID: 23481380

Title: Crystal structure of human tyrosylprotein sulfotransferase-2 reveals the mechanism of protein tyrosine sulfation reaction.

PubMed ID: 23481380

DOI: 10.1038/ncomms2593

Sequence Information:

  • Length: 377
  • Mass: 41912
  • Checksum: A658E50151FDBC12
  • Sequence:
    • MRLSVRRVLL AAGCALVLVL AVQLGQQVLE CRAVLAGLRS PRGAMRPEQE ELVMVGTNHV 
EYRYGKAMPL IFVGGVPRSG TTLMRAMLDA HPEVRCGEET RIIPRVLAMR QAWSKSGREK 
LRLDEAGVTD EVLDAAMQAF ILEVIAKHGE PARVLCNKDP FTLKSSVYLS RLFPNSKFLL 
MVRDGRASVH SMITRKVTIA GFDLSSYRDC LTKWNKAIEV MYAQCMEVGK EKCLPVYYEQ 
LVLHPRRSLK LILDFLGIAW SDAVLHHEDL IGKPGGVSLS KIERSTDQVI KPVNLEALSK 
WTGHIPGDVV RDMAQIAPML AQLGYDPYAN PPNYGNPDPF VINNTQRVLK GDYKTPANLK 
GYFQVNQNST SSHLGSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.