Details for: REG3A

Gene ID: 5068

Symbol: REG3A

Ensembl ID: ENSG00000172016

Description: regenerating family member 3 alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 54.3797
    Cell Significance Index: -36.4900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 13.1894
    Cell Significance Index: 197.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.0331
    Cell Significance Index: 517.9200
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 2.9028
    Cell Significance Index: 36.4600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.6546
    Cell Significance Index: 76.4900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.5873
    Cell Significance Index: 117.2800
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.9188
    Cell Significance Index: 14.5500
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.6406
    Cell Significance Index: 7.8200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.4621
    Cell Significance Index: 46.8300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.4097
    Cell Significance Index: 139.4600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 1.1083
    Cell Significance Index: 692.0800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0632
    Cell Significance Index: 115.6500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8573
    Cell Significance Index: 774.0700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7620
    Cell Significance Index: 123.9300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.4280
    Cell Significance Index: 6.4500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4050
    Cell Significance Index: 28.0100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.3727
    Cell Significance Index: 42.5400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3440
    Cell Significance Index: 8.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2623
    Cell Significance Index: 52.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2410
    Cell Significance Index: 28.0900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1779
    Cell Significance Index: 33.8600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1221
    Cell Significance Index: 7.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0244
    Cell Significance Index: 18.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.0107
    Cell Significance Index: 2.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0006
    Cell Significance Index: -0.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0539
    Cell Significance Index: -6.1800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0709
    Cell Significance Index: -1.5100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0758
    Cell Significance Index: -0.9100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0848
    Cell Significance Index: -1.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1444
    Cell Significance Index: -28.9700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1842
    Cell Significance Index: -3.1700
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1947
    Cell Significance Index: -1.9300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.2139
    Cell Significance Index: -2.6000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2610
    Cell Significance Index: -5.1000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2678
    Cell Significance Index: -27.3600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.3308
    Cell Significance Index: -3.4900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3314
    Cell Significance Index: -20.3200
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: -0.3504
    Cell Significance Index: -2.4400
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.4573
    Cell Significance Index: -3.1700
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.4594
    Cell Significance Index: -2.9300
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.4666
    Cell Significance Index: -3.1000
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.4816
    Cell Significance Index: -5.7400
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.5013
    Cell Significance Index: -4.3800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.5417
    Cell Significance Index: -19.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6703
    Cell Significance Index: -34.8200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6794
    Cell Significance Index: -10.0300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.7261
    Cell Significance Index: -8.3100
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.7306
    Cell Significance Index: -3.9100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.7570
    Cell Significance Index: -9.8800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.7821
    Cell Significance Index: -11.2000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.8742
    Cell Significance Index: -11.2100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.8748
    Cell Significance Index: -14.6400
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.9389
    Cell Significance Index: -12.6600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.9874
    Cell Significance Index: -11.6100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -1.0036
    Cell Significance Index: -10.7600
  • Cell Name: PP cell (CL0000696)
    Fold Change: -1.0879
    Cell Significance Index: -11.0600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.0987
    Cell Significance Index: -28.8900
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -1.1348
    Cell Significance Index: -11.7400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.1592
    Cell Significance Index: -12.0000
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -1.1836
    Cell Significance Index: -12.5700
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -1.1929
    Cell Significance Index: -12.5600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -1.2112
    Cell Significance Index: -30.8600
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -1.3296
    Cell Significance Index: -16.7500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -1.3387
    Cell Significance Index: -22.0600
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -1.4395
    Cell Significance Index: -10.1300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.5080
    Cell Significance Index: -32.6700
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -1.5247
    Cell Significance Index: -15.8000
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -1.5562
    Cell Significance Index: -15.7800
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -1.6753
    Cell Significance Index: -18.7400
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -1.7010
    Cell Significance Index: -16.6600
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: -1.7538
    Cell Significance Index: -16.2500
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -1.7801
    Cell Significance Index: -15.3600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -1.8428
    Cell Significance Index: -11.4500
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -1.8467
    Cell Significance Index: -12.0400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -1.8655
    Cell Significance Index: -11.0700
  • Cell Name: parietal cell (CL0000162)
    Fold Change: -1.8854
    Cell Significance Index: -17.8400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.8951
    Cell Significance Index: -11.4500
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -1.9125
    Cell Significance Index: -11.8700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -1.9216
    Cell Significance Index: -32.3200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -1.9709
    Cell Significance Index: -33.6900
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: -1.9959
    Cell Significance Index: -21.1400
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -2.0807
    Cell Significance Index: -21.0200
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -2.1233
    Cell Significance Index: -21.4200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -2.1406
    Cell Significance Index: -34.6700
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -2.1851
    Cell Significance Index: -19.4200
  • Cell Name: stem cell (CL0000034)
    Fold Change: -2.2317
    Cell Significance Index: -16.2200
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -2.2599
    Cell Significance Index: -20.4400
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -2.3966
    Cell Significance Index: -27.5800
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -2.4421
    Cell Significance Index: -20.2400
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -2.4777
    Cell Significance Index: -11.4400
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -2.4802
    Cell Significance Index: -31.4100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -2.5238
    Cell Significance Index: -34.6100
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -2.5249
    Cell Significance Index: -25.6200
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -2.5508
    Cell Significance Index: -28.7500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -2.6345
    Cell Significance Index: -34.6700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -2.6600
    Cell Significance Index: -28.9800
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -2.6602
    Cell Significance Index: -27.5900
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -2.6802
    Cell Significance Index: -22.4000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -2.6898
    Cell Significance Index: -34.8100
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -2.6923
    Cell Significance Index: -32.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** REG3A is a member of the Regenerating islet-derived (REG) family of proteins, which are primarily expressed in the pancreas and other epithelial tissues. The gene is highly expressed in cells involved in the immune response, such as epithelial cells of the exocrine pancreas, Paneth cells, and goblet cells. REG3A is a small, secreted protein with a molecular weight of approximately 8 kDa, consisting of three disulfide-linked subunits. **Pathways and Functions:** REG3A is involved in various biological processes, including: 1. **Antimicrobial Defense:** REG3A exhibits antimicrobial activity against bacteria, fungi, and viruses, making it an essential component of the innate immune system. 2. **Inflammatory Response Regulation:** REG3A negatively regulates inflammatory responses, preventing excessive tissue damage and promoting wound healing. 3. **Cell Proliferation and Differentiation:** REG3A promotes cell proliferation and differentiation in epithelial cells, contributing to tissue repair and regeneration. 4. **Wound Healing:** REG3A is essential for wound healing, as it regulates the inflammatory response and promotes tissue repair. 5. **Immune System Regulation:** REG3A is involved in the regulation of immune cell function, including the activation and suppression of immune responses. **Clinical Significance:** REG3A has significant implications in various clinical contexts, including: 1. **Pancreatitis:** REG3A is highly expressed in pancreatic tissues and is involved in the regulation of inflammatory responses in pancreatitis. 2. **Inflammatory Bowel Disease (IBD):** REG3A is overexpressed in IBD, where it contributes to the regulation of inflammatory responses and tissue damage. 3. **Cancer:** REG3A has been implicated in cancer development and progression, where it regulates cell proliferation and differentiation. 4. **Wound Healing Disorders:** REG3A is essential for wound healing, and its dysregulation can lead to impaired wound healing and tissue damage. In conclusion, the REG3A gene plays a vital role in regulating immune responses, antimicrobial defense, and tissue repair. Its dysregulation can lead to various diseases, highlighting the need for further research into the molecular mechanisms underlying REG3A's functions. As an expert immunologist, I emphasize the importance of understanding the complex interactions between REG3A and other biological processes to develop novel therapeutic strategies for various diseases.

Genular Protein ID: 2169022170

Symbol: REG3A_HUMAN

Name: Regenerating islet-derived protein 3-alpha

UniProtKB Accession Codes:

Q06141

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EMDB 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 UniLectin 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7679928

Title: Cloning and tissue-specific expression of cDNAs for the human and mouse homologues of rat pancreatitis-associated protein (PAP).

PubMed ID: 7679928

DOI: 10.1016/0167-4781(93)90290-t

PubMed ID: 1469087

Title: Human pancreatitis-associated protein. Messenger RNA cloning and expression in pancreatic diseases.

PubMed ID: 1469087

DOI: 10.1172/jci116115

PubMed ID: 1325291

Title: A novel gene (HIP) activated in human primary liver cancer.

PubMed ID: 1325291

PubMed ID: 8188210

Title: Molecular cloning, genomic organization, and chromosomal localization of the human pancreatitis-associated protein (PAP) gene.

PubMed ID: 8188210

DOI: 10.1006/geno.1994.1019

PubMed ID: 8076648

Title: Structural organization and chromosomal localization of a human gene (HIP/PAP) encoding a C-type lectin overexpressed in primary liver cancer.

PubMed ID: 8076648

DOI: 10.1111/j.1432-1033.1994.tb19991.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19254208

Title: Proteolytic activation of human pancreatitis-associated protein is required for peptidoglycan binding and bacterial aggregation.

PubMed ID: 19254208

DOI: 10.1042/bj20090005

PubMed ID: 16931762

Title: Symbiotic bacteria direct expression of an intestinal bactericidal lectin.

PubMed ID: 16931762

DOI: 10.1126/science.1127119

PubMed ID: 19158046

Title: Discovery of a human peptide sequence signaling islet neogenesis.

PubMed ID: 19158046

DOI: 10.4158/ep.14.9.1075

PubMed ID: 22727489

Title: The antimicrobial protein REG3A regulates keratinocyte proliferation and differentiation after skin injury.

PubMed ID: 22727489

DOI: 10.1016/j.immuni.2012.04.010

PubMed ID: 27830702

Title: Hyperglycaemia inhibits REG3A expression to exacerbate TLR3-mediated skin inflammation in diabetes.

PubMed ID: 27830702

DOI: 10.1038/ncomms13393

PubMed ID: 34099862

Title: REG3A/REG3B promotes acinar to ductal metaplasia through binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathway.

PubMed ID: 34099862

DOI: 10.1038/s42003-021-02193-z

PubMed ID: 20382864

Title: Molecular basis for peptidoglycan recognition by a bactericidal lectin.

PubMed ID: 20382864

DOI: 10.1073/pnas.0909449107

PubMed ID: 24256734

Title: Antibacterial membrane attack by a pore-forming intestinal C-type lectin.

PubMed ID: 24256734

DOI: 10.1038/nature12729

Sequence Information:

  • Length: 175
  • Mass: 19395
  • Checksum: C51149FAC22EB68C
  • Sequence:
    • MLPPMALPSV SWMLLSCLML LSQVQGEEPQ RELPSARIRC PKGSKAYGSH CYALFLSPKS 
WTDADLACQK RPSGNLVSVL SGAEGSFVSS LVKSIGNSYS YVWIGLHDPT QGTEPNGEGW 
EWSSSDVMNY FAWERNPSTI SSPGHCASLS RSTAFLRWKD YNCNVRLPYV CKFTD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.