Details for: CL0002268

Cell ID: CL0002268

Cell Name: P/D1 enteroendocrine cell

Marker Score Threshold: 373
(Derived using integrated single-cell and genomic data)

Description: An enteroendocrine cell that stores and secretes Ghrelin.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.94
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.92
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.84
    Ensembl ID: ENSG00000184009
  • Gene Symbol: APOA1 (ENSG00000118137)
    Fold Change: 2.84
    Ensembl ID: ENSG00000118137
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 2.75
    Ensembl ID: ENSG00000165092
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.69
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.63
    Ensembl ID: ENSG00000135390
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.5
    Ensembl ID: ENSG00000169100
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.43
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.33
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 2.31
    Ensembl ID: ENSG00000143153
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.27
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.26
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.22
    Ensembl ID: ENSG00000154723
  • Gene Symbol: AZGP1 (ENSG00000160862)
    Fold Change: 2.22
    Ensembl ID: ENSG00000160862
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 2.21
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.14
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.13
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.1
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 2.08
    Ensembl ID: ENSG00000138279
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.08
    Ensembl ID: ENSG00000067560
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.06
    Ensembl ID: ENSG00000142192
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 2.06
    Ensembl ID: ENSG00000104964
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.03
    Ensembl ID: ENSG00000198931
  • Gene Symbol: BHMT (ENSG00000145692)
    Fold Change: 2.03
    Ensembl ID: ENSG00000145692
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.99
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.92
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.92
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.9
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.89
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.83
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.81
    Ensembl ID: ENSG00000162772
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.77
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.76
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.75
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ASGR1 (ENSG00000141505)
    Fold Change: 1.74
    Ensembl ID: ENSG00000141505
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.73
    Ensembl ID: ENSG00000072778
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.73
    Ensembl ID: ENSG00000151914
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.72
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ANG (ENSG00000214274)
    Fold Change: 1.72
    Ensembl ID: ENSG00000214274
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.68
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.64
    Ensembl ID: ENSG00000116459
  • Gene Symbol: APLP1 (ENSG00000105290)
    Fold Change: 1.63
    Ensembl ID: ENSG00000105290
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 1.63
    Ensembl ID: ENSG00000176171
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 1.62
    Ensembl ID: ENSG00000151729
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.61
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.6
    Ensembl ID: ENSG00000071553
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.59
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.57
    Ensembl ID: ENSG00000164111
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.52
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.51
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.5
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.5
    Ensembl ID: ENSG00000130402
  • Gene Symbol: BAD (ENSG00000002330)
    Fold Change: 1.46
    Ensembl ID: ENSG00000002330
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.44
    Ensembl ID: ENSG00000104765
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.43
    Ensembl ID: ENSG00000090013
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.43
    Ensembl ID: ENSG00000107262
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.41
    Ensembl ID: ENSG00000087088
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.36
    Ensembl ID: ENSG00000127837
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.35
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ALDH9A1 (ENSG00000143149)
    Fold Change: 1.35
    Ensembl ID: ENSG00000143149
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.34
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.34
    Ensembl ID: ENSG00000174437
  • Gene Symbol: KIF1A (ENSG00000130294)
    Fold Change: 1.34
    Ensembl ID: ENSG00000130294
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.32
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ASS1 (ENSG00000130707)
    Fold Change: 1.31
    Ensembl ID: ENSG00000130707
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.3
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.3
    Ensembl ID: ENSG00000197894
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.29
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.28
    Ensembl ID: ENSG00000131100
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.27
    Ensembl ID: ENSG00000122359
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.25
    Ensembl ID: ENSG00000085662
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.25
    Ensembl ID: ENSG00000120805
  • Gene Symbol: ACLY (ENSG00000131473)
    Fold Change: 1.23
    Ensembl ID: ENSG00000131473
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.21
    Ensembl ID: ENSG00000138175
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.19
    Ensembl ID: ENSG00000100823
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.18
    Ensembl ID: ENSG00000198356
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.18
    Ensembl ID: ENSG00000196975
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.16
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ARF3 (ENSG00000134287)
    Fold Change: 1.15
    Ensembl ID: ENSG00000134287
  • Gene Symbol: BCL2 (ENSG00000171791)
    Fold Change: 1.15
    Ensembl ID: ENSG00000171791
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.14
    Ensembl ID: ENSG00000160710
  • Gene Symbol: APBB1 (ENSG00000166313)
    Fold Change: 1.14
    Ensembl ID: ENSG00000166313
  • Gene Symbol: KLF5 (ENSG00000102554)
    Fold Change: 1.13
    Ensembl ID: ENSG00000102554
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.13
    Ensembl ID: ENSG00000117054
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.12
    Ensembl ID: ENSG00000101966
  • Gene Symbol: ATP6V0A1 (ENSG00000033627)
    Fold Change: 1.12
    Ensembl ID: ENSG00000033627
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.11
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ATP6V1B2 (ENSG00000147416)
    Fold Change: 1.11
    Ensembl ID: ENSG00000147416
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.11
    Ensembl ID: ENSG00000111348
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.1
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.07
    Ensembl ID: ENSG00000111275
  • Gene Symbol: AQP3 (ENSG00000165272)
    Fold Change: 1.07
    Ensembl ID: ENSG00000165272
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.06
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.05
    Ensembl ID: ENSG00000213465
  • Gene Symbol: ARSA (ENSG00000100299)
    Fold Change: 1.05
    Ensembl ID: ENSG00000100299
  • Gene Symbol: ARSD (ENSG00000006756)
    Fold Change: 1.04
    Ensembl ID: ENSG00000006756
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.04
    Ensembl ID: ENSG00000140836
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 1.03
    Ensembl ID: ENSG00000151150
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.03
    Ensembl ID: ENSG00000165527
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Enteroendocrine cell**: The P/D1 enteroendocrine cell is a type of endocrine cell found in the gastrointestinal tract, responsible for producing and secreting hormones, including Ghrelin. 2. **Ghrelin storage and secretion**: The cell stores and secretes Ghrelin, a peptide hormone involved in energy homeostasis and appetite regulation. 3. **MHC class I protein complex**: The cell's gene symbol, B2M, encodes for beta-2 microglobulin, a component of the MHC class I protein complex, which plays a crucial role in antigen processing and presentation. 4. **Adaptive immune system**: The cell is involved in the adaptive immune system, including antigen processing and presentation, and interacts with various immune cells, such as T cells. 5. **Amyloid fiber formation**: The cell is involved in amyloid fiber formation, which is a process related to neurodegenerative diseases. **Clinical Significance** 1. **Energy homeostasis and appetite regulation**: Ghrelin, secreted by the P/D1 enteroendocrine cell, plays a crucial role in energy homeostasis and appetite regulation, and dysregulation of Ghrelin has been implicated in various metabolic disorders, such as obesity and diabetes. 2. **Neurodegenerative diseases**: The cell's involvement in amyloid fiber formation has implications for neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where amyloid plaques and Lewy bodies are characteristic features. 3. **Immune system dysfunction**: The cell's interactions with immune cells, such as T cells, and its involvement in antigen processing and presentation, have implications for immune system dysfunction and autoimmune diseases. 4. **Cancer**: The cell's involvement in protein binding and folding, including the regulation of protein localization to plasma membrane, has implications for cancer development and progression. In conclusion, the P/D1 enteroendocrine cell, represented by the cell ID CL0002268, plays a crucial role in energy homeostasis, appetite regulation, and immune system function, and its dysregulation has been implicated in various metabolic and neurodegenerative disorders.