Details for: RET
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 14.2720
Cell Significance Index: -3.6200 - Cell Name: taste receptor cell (CL0000209)
Fold Change: 3.1322
Cell Significance Index: 36.4100 - Cell Name: keratocyte (CL0002363)
Fold Change: 1.8065
Cell Significance Index: 28.6600 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.1324
Cell Significance Index: 36.2700 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.0451
Cell Significance Index: 22.3400 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.9585
Cell Significance Index: 182.4100 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.9467
Cell Significance Index: 20.7300 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.4562
Cell Significance Index: 9.7200 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3963
Cell Significance Index: 357.8100 - Cell Name: ganglion interneuron (CL0000397)
Fold Change: 0.3787
Cell Significance Index: 3.1000 - Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: 0.3458
Cell Significance Index: 3.6000 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.3346
Cell Significance Index: 4.1500 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.3168
Cell Significance Index: 7.9200 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2829
Cell Significance Index: 30.7700 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.2607
Cell Significance Index: 15.6500 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.2544
Cell Significance Index: 2.1000 - Cell Name: germ cell (CL0000586)
Fold Change: 0.2516
Cell Significance Index: 1.9000 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2510
Cell Significance Index: 40.8300 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.1973
Cell Significance Index: 3.8500 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1456
Cell Significance Index: 10.0700 - Cell Name: enteric neuron (CL0007011)
Fold Change: 0.1409
Cell Significance Index: 1.0200 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 0.1360
Cell Significance Index: 1.4200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.1048
Cell Significance Index: 5.5000 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.0987
Cell Significance Index: 4.9900 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0966
Cell Significance Index: 9.5600 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0911
Cell Significance Index: 2.6300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0905
Cell Significance Index: 18.1600 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.0824
Cell Significance Index: 1.7100 - Cell Name: chandelier cell (CL4023083)
Fold Change: 0.0656
Cell Significance Index: 0.5300 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.0448
Cell Significance Index: 1.2000 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0433
Cell Significance Index: 1.5200 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0386
Cell Significance Index: 13.8300 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0322
Cell Significance Index: 2.0300 - Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 0.0309
Cell Significance Index: 0.2400 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.0264
Cell Significance Index: 0.5600 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: 0.0241
Cell Significance Index: 0.3000 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.0206
Cell Significance Index: 0.4300 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.0140
Cell Significance Index: 0.3800 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0139
Cell Significance Index: 9.5900 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0115
Cell Significance Index: 0.5200 - Cell Name: decidual cell (CL2000002)
Fold Change: 0.0100
Cell Significance Index: 0.1600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0045
Cell Significance Index: 2.0300 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0018
Cell Significance Index: 0.0400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0005
Cell Significance Index: -0.8900 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0016
Cell Significance Index: -3.0300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0019
Cell Significance Index: -2.8900 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0020
Cell Significance Index: -1.4500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0023
Cell Significance Index: -3.1700 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0035
Cell Significance Index: -1.9500 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0048
Cell Significance Index: -3.0500 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0048
Cell Significance Index: -3.6500 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0050
Cell Significance Index: -3.6700 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0059
Cell Significance Index: -2.6100 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0061
Cell Significance Index: -3.7800 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0061
Cell Significance Index: -3.3100 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0063
Cell Significance Index: -0.0900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0064
Cell Significance Index: -1.0900 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0067
Cell Significance Index: -1.9200 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0076
Cell Significance Index: -0.5700 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: -0.0085
Cell Significance Index: -0.1100 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.0092
Cell Significance Index: -0.0900 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0096
Cell Significance Index: -1.2300 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0098
Cell Significance Index: -1.3400 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.0113
Cell Significance Index: -0.1700 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0129
Cell Significance Index: -1.8800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0151
Cell Significance Index: -2.9900 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.0151
Cell Significance Index: -0.1900 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0155
Cell Significance Index: -3.2700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0172
Cell Significance Index: -3.1000 - Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: -0.0177
Cell Significance Index: -0.1900 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0255
Cell Significance Index: -3.1400 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0261
Cell Significance Index: -3.3700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0270
Cell Significance Index: -3.0900 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0281
Cell Significance Index: -0.7000 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0297
Cell Significance Index: -3.4600 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.0299
Cell Significance Index: -0.6000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0303
Cell Significance Index: -3.1000 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0321
Cell Significance Index: -1.9700 - Cell Name: neural crest cell (CL0011012)
Fold Change: -0.0322
Cell Significance Index: -0.3500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0345
Cell Significance Index: -1.6200 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0347
Cell Significance Index: -3.6100 - Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.0349
Cell Significance Index: -0.4900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0371
Cell Significance Index: -2.8500 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0399
Cell Significance Index: -2.4600 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0449
Cell Significance Index: -2.3300 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0460
Cell Significance Index: -2.5800 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0470
Cell Significance Index: -3.1600 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0477
Cell Significance Index: -1.6700 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.0523
Cell Significance Index: -1.2600 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0536
Cell Significance Index: -1.0600 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0557
Cell Significance Index: -0.7600 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0578
Cell Significance Index: -3.7300 - Cell Name: neuron (CL0000540)
Fold Change: -0.0591
Cell Significance Index: -0.5600 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0593
Cell Significance Index: -2.7700 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0633
Cell Significance Index: -1.6700 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0659
Cell Significance Index: -2.1000 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0699
Cell Significance Index: -1.5100 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0703
Cell Significance Index: -2.3000 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0706
Cell Significance Index: -1.2100 - Cell Name: retina horizontal cell (CL0000745)
Fold Change: -0.0709
Cell Significance Index: -0.8900
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2346331158
Symbol: RET_HUMAN
Name: Cadherin family member 12
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15164054
Title: The DNA sequence and comparative analysis of human chromosome 10.
PubMed ID: 15164054
DOI: 10.1038/nature02462
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2660074
Title: Isolation of ret proto-oncogene cDNA with an amino-terminal signal sequence.
PubMed ID: 2660074
PubMed ID: 3078962
Title: Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains.
PubMed ID: 3078962
PubMed ID: 3037315
Title: ret transforming gene encodes a fusion protein homologous to tyrosine kinases.
PubMed ID: 3037315
PubMed ID: 2734021
Title: Activation of the ret-II oncogene without a sequence encoding a transmembrane domain and transforming activity of two ret-II oncogene products differing in carboxy-termini due to alternative splicing.
PubMed ID: 2734021
PubMed ID: 2406025
Title: PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas.
PubMed ID: 2406025
PubMed ID: 10980597
Title: RET/PCM-1: a novel fusion gene in papillary thyroid carcinoma.
PubMed ID: 10980597
PubMed ID: 9575150
Title: Expression of the receptor tyrosine kinase Ret on the plasma membrane is dependent on calcium.
PubMed ID: 9575150
PubMed ID: 10439047
Title: The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas.
PubMed ID: 10439047
PubMed ID: 11061555
Title: Tyrosines 1015 and 1062 are in vivo autophosphorylation sites in ret and ret-derived oncoproteins.
PubMed ID: 11061555
PubMed ID: 11445581
Title: Molecular modeling of the extracellular domain of the RET receptor tyrosine kinase reveals multiple cadherin-like domains and a calcium-binding site.
PubMed ID: 11445581
PubMed ID: 14711813
Title: Identification of RET autophosphorylation sites by mass spectrometry.
PubMed ID: 14711813
PubMed ID: 12787916
Title: Novel tumorigenic rearrangement, Delta rfp/ret, in a papillary thyroid carcinoma from externally irradiated patient.
PubMed ID: 12787916
PubMed ID: 16778204
Title: The receptor-type protein tyrosine phosphatase J antagonizes the biochemical and biological effects of RET-derived oncoproteins.
PubMed ID: 16778204
PubMed ID: 30552125
PubMed ID: 17884497
Title: The discovery of substituted 4-(3-hydroxyanilino)-quinolines as potent RET kinase inhibitors.
PubMed ID: 17884497
PubMed ID: 17664273
Title: Sorafenib functions to potently suppress RET tyrosine kinase activity by direct enzymatic inhibition and promoting RET lysosomal degradation independent of proteasomal targeting.
PubMed ID: 17664273
PubMed ID: 19053769
Title: Synthesis, modeling, and RET protein kinase inhibitory activity of 3- and 4-substituted beta-carbolin-1-ones.
PubMed ID: 19053769
DOI: 10.1021/jm8007823
PubMed ID: 18753381
Title: CD2AP and Cbl-3/Cbl-c constitute a critical checkpoint in the regulation of ret signal transduction.
PubMed ID: 18753381
PubMed ID: 19366855
Title: The tyrosine kinase receptor RET interacts in vivo with aryl hydrocarbon receptor-interacting protein to alter survivin availability.
PubMed ID: 19366855
DOI: 10.1210/jc.2008-1980
PubMed ID: 19853745
Title: Transcriptional regulation of RET by Nkx2-1, Phox2b, Sox10, and Pax3.
PubMed ID: 19853745
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 20064382
PubMed ID: 20605972
Title: The evolving field of tyrosine kinase inhibitors in the treatment of endocrine tumors.
PubMed ID: 20605972
DOI: 10.1210/er.2009-0031
PubMed ID: 20409618
Title: Inhibitors of the RET tyrosine kinase based on a 2-(alkylsulfanyl)-4-(3-thienyl)nicotinonitrile scaffold.
PubMed ID: 20409618
PubMed ID: 20616503
Title: Functional role of the RET dependence receptor, GFRa co-receptors and ligands in the pituitary.
PubMed ID: 20616503
DOI: 10.1159/000318502
PubMed ID: 20702524
Title: RET-mediated cell adhesion and migration require multiple integrin subunits.
PubMed ID: 20702524
DOI: 10.1210/jc.2010-0771
PubMed ID: 19823924
Title: Direct visualization of vesicle maturation and plasma membrane protein trafficking.
PubMed ID: 19823924
PubMed ID: 21134556
Title: A novel RET inhibitor with potent efficacy against medullary thyroid cancer in vivo.
PubMed ID: 21134556
PubMed ID: 21357690
Title: RET modulates cell adhesion via its cleavage by caspase in sympathetic neurons.
PubMed ID: 21357690
PubMed ID: 21454698
Title: Focal adhesion kinase (FAK) binds RET kinase via its FERM domain, priming a direct and reciprocal RET-FAK transactivation mechanism.
PubMed ID: 21454698
PubMed ID: 21994944
Title: Sorting protein-related receptor SorLA controls regulated secretion of glial cell line-derived neurotrophic factor.
PubMed ID: 21994944
PubMed ID: 23333276
Title: SorLA controls neurotrophic activity by sorting of GDNF and its receptors GFRalpha1 and RET.
PubMed ID: 23333276
PubMed ID: 28953886
Title: Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.
PubMed ID: 28953886
DOI: 10.1038/nature24042
PubMed ID: 29144449
Title: Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.
PubMed ID: 29144449
DOI: 10.1038/nature24481
PubMed ID: 28846097
Title: GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates.
PubMed ID: 28846097
DOI: 10.1038/nm.4392
PubMed ID: 28846099
Title: GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand.
PubMed ID: 28846099
DOI: 10.1038/nm.4394
PubMed ID: 26237509
Title: The active site of O-GlcNAc transferase imposes constraints on substrate sequence.
PubMed ID: 26237509
DOI: 10.1038/nsmb.3063
PubMed ID: 16928683
Title: Structure and chemical inhibition of the RET tyrosine kinase domain.
PubMed ID: 16928683
PubMed ID: 20117004
Title: Synthesis, structure-activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors.
PubMed ID: 20117004
PubMed ID: 20473317
Title: Mammal-restricted elements predispose human RET to folding impairment by HSCR mutations.
PubMed ID: 20473317
DOI: 10.1038/nsmb.1808
PubMed ID: 25242331
Title: RET recognition of GDNF-GFRalpha1 ligand by a composite binding site promotes membrane-proximal self-association.
PubMed ID: 25242331
PubMed ID: 24560924
Title: Oncogenic RET kinase domain mutations perturb the autophosphorylation trajectory by enhancing substrate presentation in trans.
PubMed ID: 24560924
PubMed ID: 31118272
Title: Structural basis of resistance of mutant RET protein-tyrosine kinase to its inhibitors nintedanib and vandetanib.
PubMed ID: 31118272
PubMed ID: 31535977
Title: Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands.
PubMed ID: 31535977
DOI: 10.7554/elife.47650
PubMed ID: 9359036
Title: Mutations in Hirschsprung disease: when does a mutation contribute to the phenotype.
PubMed ID: 9359036
PubMed ID: 9067749
Title: Mutations of the RET proto-oncogene in the multiple endocrine neoplasia type 2 syndromes, related sporadic tumours, and Hirschsprung disease.
PubMed ID: 9067749
DOI: 10.1002/(sici)1098-1004(1997)9:2<97::aid-humu1>3.0.co;2-m
PubMed ID: 8103403
Title: Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC.
PubMed ID: 8103403
DOI: 10.1093/hmg/2.7.851
PubMed ID: 8099202
Title: Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A.
PubMed ID: 8099202
DOI: 10.1038/363458a0
PubMed ID: 7704557
Title: Heterogeneity and low detection rate of RET mutations in Hirschsprung disease.
PubMed ID: 7704557
DOI: 10.1159/000472371
PubMed ID: 7911697
Title: Point mutation within the tyrosine kinase domain of the RET proto-oncogene in multiple endocrine neoplasia type 2B and related sporadic tumours.
PubMed ID: 7911697
DOI: 10.1093/hmg/3.2.237
PubMed ID: 7915165
Title: Germline RET mutations in MEN 2A and FMTC and their detection by simple DNA diagnostic tests.
PubMed ID: 7915165
DOI: 10.1093/hmg/3.4.635
PubMed ID: 7849720
Title: RET proto-oncogene mutations in inherited and sporadic medullary thyroid cancer.
PubMed ID: 7849720
PubMed ID: 7874109
Title: RET proto-oncogene mutations in French MEN 2A and FMTC families.
PubMed ID: 7874109
PubMed ID: 7881414
Title: Diverse phenotypes associated with exon 10 mutations of the RET proto-oncogene.
PubMed ID: 7881414
PubMed ID: 7906866
Title: A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma.
PubMed ID: 7906866
DOI: 10.1038/367375a0
PubMed ID: 8114938
Title: Point mutations affecting the tyrosine kinase domain of the RET proto-oncogene in Hirschsprung's disease.
PubMed ID: 8114938
DOI: 10.1038/367377a0
PubMed ID: 8114939
Title: Mutations of the RET proto-oncogene in Hirschsprung's disease.
PubMed ID: 8114939
DOI: 10.1038/367378a0
PubMed ID: 7906417
Title: Single missense mutation in the tyrosine kinase catalytic domain of the RET protooncogene is associated with multiple endocrine neoplasia type 2B.
PubMed ID: 7906417
PubMed ID: 8625130
Title: Analysis of RET protooncogene point mutations distinguishes heritable from nonheritable medullary thyroid carcinomas.
PubMed ID: 8625130
DOI: 10.1002/1097-0142(19950801)76:3<479::aid-cncr2820760319>3.0.co;2-m
PubMed ID: 7860065
Title: Germline mutations of the RET proto-oncogene in eight Japanese patients with multiple endocrine neoplasia type 2A (MEN2A).
PubMed ID: 7860065
DOI: 10.1007/bf00209399
PubMed ID: 7633441
Title: Mutation analysis of the RET receptor tyrosine kinase in Hirschsprung disease.
PubMed ID: 7633441
DOI: 10.1093/hmg/4.5.821
PubMed ID: 7581377
Title: Diversity of RET proto-oncogene mutations in familial and sporadic Hirschsprung disease.
PubMed ID: 7581377
DOI: 10.1093/hmg/4.8.1381
PubMed ID: 8595427
Title: Two maternally derived missense mutations in the tyrosine kinase domain of the RET protooncogene in a patient with de novo MEN 2B.
PubMed ID: 8595427
PubMed ID: 7845675
Title: A novel point mutation in the tyrosine kinase domain of the RET proto-oncogene in sporadic medullary thyroid carcinoma and in a family with FMTC.
PubMed ID: 7845675
PubMed ID: 7784092
Title: RET mutations in exons 13 and 14 of FMTC patients.
PubMed ID: 7784092
PubMed ID: 9043870
Title: Prevalence and parental origin of de novo RET mutations in Hirschsprung's disease.
PubMed ID: 9043870
DOI: 10.1159/000472232
PubMed ID: 8557249
Title: Mutation analysis of the RET proto-oncogene in Dutch families with MEN 2A, MEN 2B and FMTC: two novel mutations and one de novo mutation for MEN 2A.
PubMed ID: 8557249
DOI: 10.1007/bf00218825
PubMed ID: 8807338
Title: Diagnosis of multiple endocrine neoplasia [MEN] 2A, 2B and familial medullary thyroid cancer [FMTC] by multiplex PCR and heteroduplex analyses of RET proto-oncogene mutations.
PubMed ID: 8807338
DOI: 10.1002/(sici)1098-1004(1996)8:1<64::aid-humu9>3.0.co;2-p
PubMed ID: 8626834
Title: Mutations of the ret protooncogene in German multiple endocrine neoplasia families: relation between genotype and phenotype.
PubMed ID: 8626834
PubMed ID: 9097963
Title: A duplication of 12 bp in the critical cysteine rich domain of the RET proto-oncogene results in a distinct phenotype of multiple endocrine neoplasia type 2A.
PubMed ID: 9097963
DOI: 10.1093/hmg/6.4.587
PubMed ID: 9090527
Title: Frequency of RET mutations in long- and short-segment Hirschsprung disease.
PubMed ID: 9090527
DOI: 10.1002/(sici)1098-1004(1997)9:3<243::aid-humu5>3.0.co;2-8
PubMed ID: 9259198
Title: Cys 618 Arg mutation in the RET proto-oncogene associated with familial medullary thyroid carcinoma and maternally transmitted Hirschsprung's disease suggesting a role for imprinting.
PubMed ID: 9259198
DOI: 10.1002/(sici)1098-1004(1997)10:2<155::aid-humu7>3.0.co;2-j
PubMed ID: 9360560
Title: Germline dinucleotide mutation in codon 883 of the RET proto-oncogene in multiple endocrine neoplasia type 2B without codon 918 mutation.
PubMed ID: 9360560
PubMed ID: 9398735
Title: A novel point mutation in the intracellular domain of the ret protooncogene in a family with medullary thyroid carcinoma.
PubMed ID: 9398735
PubMed ID: 9094028
Title: Mutation analysis of the RET, the endothelin-B receptor, and the endothelin-3 genes in sporadic cases of Hirschsprung's disease.
PubMed ID: 9094028
PubMed ID: 9223675
Title: Novel germline RET proto-oncogene mutations associated with medullary thyroid carcinoma (MTC): mutation analysis in Japanese patients with MTC.
PubMed ID: 9223675
PubMed ID: 9294615
Title: Germline mutation of RET codon 883 in two cases of de novo MEN 2B.
PubMed ID: 9294615
PubMed ID: 9497256
Title: Mutations of the RET-GDNF signaling pathway in Ondine's curse.
PubMed ID: 9497256
DOI: 10.1086/301759
PubMed ID: 9677065
Title: Novel point mutation in exon 10 of the RET proto-oncogene in a family with medullary thyroid carcinoma.
PubMed ID: 9677065
DOI: 10.1002/(sici)1096-8628(19980707)78:3<271::aid-ajmg13>3.0.co;2-c
PubMed ID: 9760196
Title: Phenotypic variation in a family with mutations in two Hirschsprung-related genes (RET and endothelin receptor B).
PubMed ID: 9760196
PubMed ID: 9384613
Title: Hirschsprung disease in MEN 2A: increased spectrum of RET exon 10 genotypes and strong genotype-phenotype correlation.
PubMed ID: 9384613
DOI: 10.1093/hmg/7.1.129
PubMed ID: 9452064
Title: Duplication of 9 base pairs in the critical cysteine-rich domain of the RET proto-oncogene causes multiple endocrine neoplasia type 2A.
PubMed ID: 9452064
PubMed ID: 9452077
Title: A GTG to ATG novel point mutation at codon 804 in exon 14 of the RET proto-oncogene in two families affected by familial medullary thyroid carcinoma.
PubMed ID: 9452077
PubMed ID: 9506724
Title: A new hot spot for mutations in the ret protooncogene causing familial medullary thyroid carcinoma and multiple endocrine neoplasia type 2A.
PubMed ID: 9506724
PubMed ID: 9621513
Title: Mutational analysis of the RET proto-oncogene in 71 Japanese patients with medullary thyroid carcinoma.
PubMed ID: 9621513
PubMed ID: 10090908
Title: Double heterozygosity for a RET substitution interfering with splicing and an EDNRB missense mutation in Hirschsprung disease.
PubMed ID: 10090908
DOI: 10.1086/302329
PubMed ID: 10484767
Title: Two distinct mutations of the RET receptor causing Hirschsprung's disease impair the binding of signalling effectors to a multifunctional docking site.
PubMed ID: 10484767
PubMed ID: 10323403
Title: A novel 9-base pair duplication in RET exon 8 in familial medullary thyroid carcinoma.
PubMed ID: 10323403
PubMed ID: 10522989
Title: A novel case of multiple endocrine neoplasia type 2A associated with two de novo mutations of the RET protooncogene.
PubMed ID: 10522989
PubMed ID: 10826520
Title: A RET double mutation in the germline of a kindred with FMTC.
PubMed ID: 10826520
DOI: 10.1055/s-2000-5806
PubMed ID: 10612852
Title: A new germline mutation, R600Q, within the coding region of RET proto-oncogene: a rare polymorphism or a MEN 2 causing mutation?
PubMed ID: 10612852
DOI: 10.1002/(sici)1098-1004(200001)15:1<122::aid-humu41>3.0.co;2-7
PubMed ID: 10618407
Title: A human model for multigenic inheritance: phenotypic expression in Hirschsprung disease requires both the RET gene and a new 9q31 locus.
PubMed ID: 10618407
PubMed ID: 11692159
Title: Three novel mutations in the RET proto-oncogene.
PubMed ID: 11692159
PubMed ID: 12000816
Title: Germ-line mutations in nonsyndromic pheochromocytoma.
PubMed ID: 12000816
DOI: 10.1056/nejmoa020152
PubMed ID: 12086152
Title: Congenital central hypoventilation syndrome: a novel mutation of the RET gene in an isolated case.
PubMed ID: 12086152
DOI: 10.1620/tjem.196.241
PubMed ID: 14566559
Title: Molecular analysis of congenital central hypoventilation syndrome.
PubMed ID: 14566559
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
Sequence Information:
- Length: 1114
- Mass: 124319
- Checksum: A3DA0CE01A19A441
- Sequence:
MAKATSGAAG LRLLLLLLLP LLGKVALGLY FSRDAYWEKL YVDQAAGTPL LYVHALRDAP EEVPSFRLGQ HLYGTYRTRL HENNWICIQE DTGLLYLNRS LDHSSWEKLS VRNRGFPLLT VYLKVFLSPT SLREGECQWP GCARVYFSFF NTSFPACSSL KPRELCFPET RPSFRIRENR PPGTFHQFRL LPVQFLCPNI SVAYRLLEGE GLPFRCAPDS LEVSTRWALD REQREKYELV AVCTVHAGAR EEVVMVPFPV TVYDEDDSAP TFPAGVDTAS AVVEFKRKED TVVATLRVFD ADVVPASGEL VRRYTSTLLP GDTWAQQTFR VEHWPNETSV QANGSFVRAT VHDYRLVLNR NLSISENRTM QLAVLVNDSD FQGPGAGVLL LHFNVSVLPV SLHLPSTYSL SVSRRARRFA QIGKVCVENC QAFSGINVQY KLHSSGANCS TLGVVTSAED TSGILFVNDT KALRRPKCAE LHYMVVATDQ QTSRQAQAQL LVTVEGSYVA EEAGCPLSCA VSKRRLECEE CGGLGSPTGR CEWRQGDGKG ITRNFSTCSP STKTCPDGHC DVVETQDINI CPQDCLRGSI VGGHEPGEPR GIKAGYGTCN CFPEEEKCFC EPEDIQDPLC DELCRTVIAA AVLFSFIVSV LLSAFCIHCY HKFAHKPPIS SAEMTFRRPA QAFPVSYSSS GARRPSLDSM ENQVSVDAFK ILEDPKWEFP RKNLVLGKTL GEGEFGKVVK ATAFHLKGRA GYTTVAVKML KENASPSELR DLLSEFNVLK QVNHPHVIKL YGACSQDGPL LLIVEYAKYG SLRGFLRESR KVGPGYLGSG GSRNSSSLDH PDERALTMGD LISFAWQISQ GMQYLAEMKL VHRDLAARNI LVAEGRKMKI SDFGLSRDVY EEDSYVKRSQ GRIPVKWMAI ESLFDHIYTT QSDVWSFGVL LWEIVTLGGN PYPGIPPERL FNLLKTGHRM ERPDNCSEEM YRLMLQCWKQ EPDKRPVFAD ISKDLEKMMV KRRDYLDLAA STPSDSLIYD DGLSEEETPL VDCNNAPLPR ALPSTWIENK LYGMSDPNWP GESPVPLTRA DGTNTGFPRY PNDSVYANWM LSPSAAKLMD TFDS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.