Details for: EGR4

Gene ID: 1961

Symbol: EGR4

Ensembl ID: ENSG00000135625

Description: early growth response 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 31.5664
    Cell Significance Index: -4.9100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 19.4959
    Cell Significance Index: -4.9500
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 2.8807
    Cell Significance Index: 29.7200
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.2295
    Cell Significance Index: 9.4300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.9083
    Cell Significance Index: 12.9300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.7146
    Cell Significance Index: 18.7900
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.6263
    Cell Significance Index: 5.1800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.5604
    Cell Significance Index: 8.9900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.4745
    Cell Significance Index: 13.5400
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.3847
    Cell Significance Index: 2.2600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3709
    Cell Significance Index: 5.0600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2825
    Cell Significance Index: 14.6800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2476
    Cell Significance Index: 47.1200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1261
    Cell Significance Index: 8.4800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1122
    Cell Significance Index: 5.8900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0938
    Cell Significance Index: 18.8200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0874
    Cell Significance Index: 1.4400
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0699
    Cell Significance Index: 0.9700
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.0595
    Cell Significance Index: 0.6200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0328
    Cell Significance Index: 3.7400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0297
    Cell Significance Index: 0.3800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0208
    Cell Significance Index: 0.9200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0143
    Cell Significance Index: 0.2100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0116
    Cell Significance Index: 1.4300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0105
    Cell Significance Index: 0.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0072
    Cell Significance Index: 3.1900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.0043
    Cell Significance Index: 0.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0031
    Cell Significance Index: 1.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0031
    Cell Significance Index: 0.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0001
    Cell Significance Index: -0.1100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0001
    Cell Significance Index: 0.0000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0009
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0009
    Cell Significance Index: -0.5800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0010
    Cell Significance Index: -0.1400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0025
    Cell Significance Index: -1.4100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0027
    Cell Significance Index: -0.1900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0045
    Cell Significance Index: -0.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0050
    Cell Significance Index: -0.9100
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0055
    Cell Significance Index: -0.0700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0059
    Cell Significance Index: -4.4900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0062
    Cell Significance Index: -2.2200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0062
    Cell Significance Index: -4.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0077
    Cell Significance Index: -1.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0092
    Cell Significance Index: -1.0500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0092
    Cell Significance Index: -0.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0155
    Cell Significance Index: -4.4700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0160
    Cell Significance Index: -2.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0214
    Cell Significance Index: -1.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0221
    Cell Significance Index: -3.2100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0287
    Cell Significance Index: -3.3500
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0292
    Cell Significance Index: -0.3200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0331
    Cell Significance Index: -0.4700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0353
    Cell Significance Index: -4.1600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0372
    Cell Significance Index: -1.4100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0378
    Cell Significance Index: -3.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0467
    Cell Significance Index: -2.2000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0589
    Cell Significance Index: -3.6200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0648
    Cell Significance Index: -4.8300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0659
    Cell Significance Index: -2.2900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0662
    Cell Significance Index: -4.2700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0817
    Cell Significance Index: -1.7100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0819
    Cell Significance Index: -2.1900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0867
    Cell Significance Index: -2.7600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0896
    Cell Significance Index: -3.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0912
    Cell Significance Index: -4.1400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0914
    Cell Significance Index: -5.1300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0971
    Cell Significance Index: -3.1800
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0998
    Cell Significance Index: -1.2900
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.1009
    Cell Significance Index: -1.2200
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1028
    Cell Significance Index: -1.3700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1104
    Cell Significance Index: -1.5500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1185
    Cell Significance Index: -4.3500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1232
    Cell Significance Index: -3.6300
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.1234
    Cell Significance Index: -1.3800
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1280
    Cell Significance Index: -1.7700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1301
    Cell Significance Index: -2.7800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1430
    Cell Significance Index: -4.2000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1457
    Cell Significance Index: -3.6400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1487
    Cell Significance Index: -3.9700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1518
    Cell Significance Index: -5.3400
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.1522
    Cell Significance Index: -2.0700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1560
    Cell Significance Index: -1.7000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1568
    Cell Significance Index: -2.0500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1590
    Cell Significance Index: -4.2600
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1603
    Cell Significance Index: -1.8700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1619
    Cell Significance Index: -1.7600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1648
    Cell Significance Index: -4.1100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1735
    Cell Significance Index: -4.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1742
    Cell Significance Index: -5.0200
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.1760
    Cell Significance Index: -1.4000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1764
    Cell Significance Index: -4.4100
  • Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
    Fold Change: -0.1769
    Cell Significance Index: -1.9100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1784
    Cell Significance Index: -2.9900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1837
    Cell Significance Index: -4.5800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1839
    Cell Significance Index: -4.6900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1840
    Cell Significance Index: -4.0300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1845
    Cell Significance Index: -4.4700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1872
    Cell Significance Index: -3.8100
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1874
    Cell Significance Index: -2.3800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1884
    Cell Significance Index: -4.0700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EGR4 is a highly conserved protein that belongs to the EGR family of transcription factors. It is characterized by its ability to bind to specific DNA sequences, thereby modulating gene expression. The gene is composed of four exons, which encode a protein with a unique structure and function. EGR4 is known to interact with various cellular proteins, including transcription factors, kinases, and signaling molecules, to regulate a wide range of biological processes. **Pathways and Functions:** EGR4 plays a crucial role in regulating gene expression in response to various cellular stimuli, including growth factors, cytokines, and stress signals. Its functions can be broadly categorized into several key pathways: 1. **Chromatin remodeling:** EGR4 interacts with chromatin-modifying enzymes to regulate gene expression by modifying chromatin structure and accessibility. 2. **Transcriptional regulation:** EGR4 acts as a transcriptional activator, binding to specific DNA sequences and recruiting coactivators to stimulate gene expression. 3. **Signaling pathways:** EGR4 interacts with various signaling molecules, including receptor tyrosine kinases, to regulate cellular responses to external stimuli. 4. **Cell cycle regulation:** EGR4 plays a role in regulating cell cycle progression, particularly in the context of cell proliferation and differentiation. **Clinical Significance:** EGR4 has been implicated in various diseases, including cancer, immune disorders, and neurological disorders. Its dysregulation has been linked to: 1. **Cancer:** EGR4 is overexpressed in several types of cancer, including breast, lung, and colon cancer, where it promotes tumor progression and metastasis. 2. **Immune disorders:** EGR4 plays a role in regulating immune responses, and its dysregulation has been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Neurological disorders:** EGR4 is involved in regulating neuronal development and function, and its dysregulation has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, EGR4 is a multifaceted gene with far-reaching implications in various cellular processes, including development, differentiation, and immune response. Its dysregulation has been linked to various diseases, highlighting the need for further research into the mechanisms underlying EGR4 function and its role in human disease. As an expert immunologist, I believe that a deeper understanding of EGR4 will provide valuable insights into the development of novel therapeutic strategies for the treatment of various diseases.

Genular Protein ID: 2768000500

Symbol: EGR4_HUMAN

Name: Early growth response protein 4

UniProtKB Accession Codes:

Q05215 B2RAE3 G3V1T5 Q2Z1P5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8504297

Title: Genomic organization, chromosomal localization and promoter function of the human zinc-finger gene pAT133.

PubMed ID: 8504297

DOI: 10.1093/hmg/2.4.367

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 1658795

Title: Clone pAT133 identifies a gene that encodes another human member of a class of growth factor-induced genes with almost identical zinc-finger domains.

PubMed ID: 1658795

DOI: 10.1073/pnas.88.22.10079

Sequence Information:

  • Length: 589
  • Mass: 61623
  • Checksum: EFB5A743541A07D7
  • Sequence:
    • MAVARGVGSP EPAPPQLYKW GGCGLGEPGS ALERRGAAAR GRCGRARAPR LPDSFPRGEC 
PKPGARAPRS VRCGEPLPPA SPPPARPQAQ RARPRAPHSR RRAMLHLSEF SEPDALLVKS 
TEGCCAEPSA ELPRLPARDA PAATGYPGAG DFLSWALNSC GASGDLADSC FLEGPAPTPP 
PGLSYSGSFF IQAVPEHPHD PEALFNLMSG ILGLAPFPGP EAAASRSPLD APFPAGSDAL 
LPGPPDLYSP DLGAAPFPEA FWEASPCAGA PSQCLYEPQL SPPDVKPGLR APPASPALDA 
VSAFKGPYAP WELLSVGAPG NCGSQGDYQA APEARFPVIG TKIEDLLSIS CPAELPAVPA 
NRLYPSGAYD AFPLAPGDLG EGAEGLPGLL TPPSGEGGSS GDGGEFLAST QPQLSPLGLR 
SAAAADFPKP LVADIPGSSG VAAPPVPPPP PTPFPQAKAR RKGRRGGKCS TRCFCPRPHA 
KAFACPVESC VRSFARSDEL NRHLRIHTGH KPFQCRICLR NFSRSDHLTT HVRTHTGEKP 
FACDVCGRRF ARSDEKKRHS KVHLKQKARA EERLKGLGFY SLGLSFASL

Genular Protein ID: 47937235

Symbol: B7ZKU3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7ZKU3

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 4 GO 2 Gene3D 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 485
  • Mass: 50727
  • Checksum: 10F4EC7DBA3A1B68
  • Sequence:
    • MLHLSEFSEP DALLVKSTEG CCAEPSAELP RLPARDAPAA TGYPGGDFLS WALNSCGASG 
DLADSCFLEG PAPTPPPGLS YSGSFFIQAV PEHPHDPEAL FNLMSGILGL APFPGPEAAA 
SRSPLDAPFP AGSDALLPGP PDLYSPDLGA APFPEAFWEA SPCAGAPSQC LYEPQLSPPD 
VKPGLRAPPA SPALDAVSAF KGPYAPWELL SVGAPGNCGS QGDYQAAPEA RFPVIGTKIE 
DLLSISCPAE LPAVPANRLY PSGAYDAFPL APGDLGEGAE GLPGLLTPPS GEGGSSGDGG 
EFLASTQPQL SPLGLRSAAA ADFPKPLVAD IPGSSGVAAP PVPPPPPTPF PQAKARRKGR 
RGGKCSTRCF CPRPHAKAFA CPVESCVRSF ARSDELNRHL RIHTGHKPFQ CRICLRNFSR 
SDHLTTHVRT HTGEKPFACD VCGRRFARSD EKKRHSKVHL KQKARAEERL KGLGFYSLGL 
SFASL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.