Details for: TFF3

Gene ID: 7033

Symbol: TFF3

Ensembl ID: ENSG00000160180

Description: trefoil factor 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 6.62
    Marker Score: 5183
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 4.08
    Marker Score: 3908
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 3.26
    Marker Score: 894
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3
    Marker Score: 103839
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.96
    Marker Score: 1461
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.73
    Marker Score: 13098
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.71
    Marker Score: 4170
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.57
    Marker Score: 815
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.55
    Marker Score: 6058
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.55
    Marker Score: 22115
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.44
    Marker Score: 7657
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.35
    Marker Score: 9073
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.9
    Marker Score: 549
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.88
    Marker Score: 1879
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.86
    Marker Score: 701
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.46
    Marker Score: 504
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.44
    Marker Score: 1680
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.42
    Marker Score: 3232
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.4
    Marker Score: 772
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.37
    Marker Score: 309
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.36
    Marker Score: 8038
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.36
    Marker Score: 345
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.3
    Marker Score: 2304
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 1.27
    Marker Score: 336.5
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.27
    Marker Score: 2405.5
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1.23
    Marker Score: 765
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.15
    Marker Score: 331
  • Cell Name: epithelial fate stem cell (CL0000036)
    Fold Change: 1.14
    Marker Score: 328
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.14
    Marker Score: 588
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.09
    Marker Score: 969
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.06
    Marker Score: 501
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.05
    Marker Score: 646
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.01
    Marker Score: 1921
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 1.01
    Marker Score: 275
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71773
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47999
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.99
    Marker Score: 719
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.99
    Marker Score: 686
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.99
    Marker Score: 397
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.98
    Marker Score: 692
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 495
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 448
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5344
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2735
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 318
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5267
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.85
    Marker Score: 367
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.85
    Marker Score: 184
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.84
    Marker Score: 5353
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.83
    Marker Score: 808
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.81
    Marker Score: 1332
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 587
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.75
    Marker Score: 2795
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 385
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 295
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.74
    Marker Score: 274
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 469
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.73
    Marker Score: 340
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.73
    Marker Score: 176
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.72
    Marker Score: 222
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.72
    Marker Score: 187
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.71
    Marker Score: 2455
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.71
    Marker Score: 205
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 646
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.71
    Marker Score: 175
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.7
    Marker Score: 1117
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.7
    Marker Score: 3657
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2870
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.68
    Marker Score: 207
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 0.67
    Marker Score: 214
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.66
    Marker Score: 382
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.64
    Marker Score: 1304
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.63
    Marker Score: 290
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.63
    Marker Score: 765
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.62
    Marker Score: 530
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.62
    Marker Score: 285
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.61
    Marker Score: 310
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.58
    Marker Score: 212
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.58
    Marker Score: 253
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.58
    Marker Score: 241
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 178
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.56
    Marker Score: 354
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 233
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.55
    Marker Score: 367
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.55
    Marker Score: 1001
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 435
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.54
    Marker Score: 4032
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.53
    Marker Score: 140
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.51
    Marker Score: 264
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.5
    Marker Score: 852
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.48
    Marker Score: 623
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.48
    Marker Score: 1177.5
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.48
    Marker Score: 426
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.47
    Marker Score: 103
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.47
    Marker Score: 159
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.45
    Marker Score: 271

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Other Information

**Key Characteristics:** 1. **Expression Pattern:** TFF3 is highly expressed in epithelial cells of the GI tract, particularly in goblet cells, enterocytes, and glandular cells of the esophagus, tracheobronchial tree, and colon. 2. **Peptide Structure:** TFF3 is a 15-amino acid peptide, consisting of a disulfide-bonded structure, which confers stability and resistance to proteolysis. 3. **Cellular Localization:** TFF3 is primarily localized to the mucosal surface of the GI tract, where it interacts with other proteins and molecules to maintain epithelial integrity. **Pathways and Functions:** 1. **Maintenance of Gastrointestinal Epithelium:** TFF3 plays a critical role in maintaining the integrity and homeostasis of the GI epithelium by promoting cell proliferation, differentiation, and survival. 2. **Wound Healing:** TFF3 is involved in the wound-healing process by stimulating the migration and proliferation of epithelial cells, thereby promoting tissue repair and regeneration. 3. **Secretion and Signaling:** TFF3 is secreted by epithelial cells and interacts with other proteins, such as integrins and growth factors, to regulate cell signaling pathways involved in cell growth, differentiation, and survival. 4. **Protection against Oxidative Stress:** TFF3 has been shown to protect against oxidative stress by scavenging reactive oxygen species (ROS) and modulating the activity of antioxidant enzymes. **Clinical Significance:** 1. **Gastrointestinal Disorders:** Alterations in TFF3 expression have been observed in various gastrointestinal disorders, including inflammatory bowel disease (IBD), cancer, and gastroesophageal reflux disease (GERD). 2. **Therapeutic Applications:** TFF3 has been investigated as a potential therapeutic target for the treatment of GI disorders, including IBD, cancer, and GERD. 3. **Cancer Prevention:** TFF3 has been shown to possess anti-tumor properties, inhibiting cancer cell growth and inducing apoptosis in various cancer cell lines. 4. **Neuroprotection:** TFF3 has been found to have neuroprotective effects, protecting against oxidative stress and inflammation in the central nervous system. In conclusion, TFF3 is a multifaceted peptide that plays a crucial role in maintaining the integrity and homeostasis of the GI tract. Its dysregulation has been implicated in various gastrointestinal disorders, and its therapeutic potential is an area of active research. Further studies are needed to fully elucidate the mechanisms of action of TFF3 and its clinical significance in maintaining GI health.

Genular Protein ID: 1872357251

Symbol: TFF3_HUMAN

Name: Trefoil factor 3

UniProtKB Accession Codes:

Q07654 A0A0A6YYJ4 E9PBB5 Q96NX0 Q9UDA5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UniLectin 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9070946

Title: The three human trefoil genes TFF1, TFF2, and TFF3 are located within a region of 55 kb on chromosome 21q22.3.

PubMed ID: 9070946

DOI: 10.1006/geno.1996.4511

PubMed ID: 10950923

Title: Refined localization of autosomal recessive nonsyndromic deafness DFNB10 locus using 34 novel microsatellite markers, genomic structure, and exclusion of six known genes in the region.

PubMed ID: 10950923

DOI: 10.1006/geno.2000.6253

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 14637006

Title: mRNA 5' region sequence incompleteness: a potential source of systematic errors in translation initiation codon assignment in human mRNAs.

PubMed ID: 14637006

DOI: 10.1016/s0378-1119(03)00835-7

PubMed ID: 8346203

Title: hP1.B, a human P-domain peptide homologous with rat intestinal trefoil factor, is expressed also in the ulcer-associated cell lineage and the uterus.

PubMed ID: 8346203

DOI: 10.1073/pnas.90.15.6961

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8454642

Title: Identification of human intestinal trefoil factor. Goblet cell-specific expression of a peptide targeted for apical secretion.

PubMed ID: 8454642

DOI: 10.1016/s0021-9258(18)53305-6

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 19670903

Title: Comprehensive proteomic analysis of human endometrial fluid aspirate.

PubMed ID: 19670903

DOI: 10.1021/pr9004426

PubMed ID: 10824705

Title: Coexistence of intestinal trefoil factor (hITF) and oxytocin in magnocellular neurons in the human hypothalamus.

PubMed ID: 10824705

DOI: 10.1055/s-2007-978604

PubMed ID: 11694446

Title: Trefoil factor family-peptides promote migration of human bronchial epithelial cells: synergistic effect with epidermal growth factor.

PubMed ID: 11694446

DOI: 10.1165/ajrcmb.25.4.4429

PubMed ID: 18209

Title: Incorporation of mannose and glucose into prenylphosphate sugars in isolated human platelet membranes.

PubMed ID: 18209

DOI: 10.1016/0304-4165(77)90272-0

PubMed ID: 14690424

Title: Solution structure of the disulfide-linked dimer of human intestinal trefoil factor (TFF3): the intermolecular orientation and interactions are markedly different from those of other dimeric trefoil proteins.

PubMed ID: 14690424

DOI: 10.1021/bi030182k

Sequence Information:

  • Length: 80
  • Mass: 8641
  • Checksum: 8E117A58C0342013
  • Sequence:
    • MAARALCMLG LVLALLSSSS AEEYVGLSAN QCAVPAKDRV DCGYPHVTPK ECNNRGCCFD 
SRIPGVPWCF KPLQEAECTF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.