Details for: TFF3

Gene ID: 7033

Symbol: TFF3

Ensembl ID: ENSG00000160180

Description: trefoil factor 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 69.5234
    Cell Significance Index: -28.6400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 58.3535
    Cell Significance Index: -27.5500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 38.9555
    Cell Significance Index: -26.1400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 13.8109
    Cell Significance Index: 85.0000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 9.5406
    Cell Significance Index: 943.7800
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 9.4134
    Cell Significance Index: 102.0200
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 7.9273
    Cell Significance Index: 79.9700
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: 6.7981
    Cell Significance Index: 45.4000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 5.9604
    Cell Significance Index: 3255.0900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 5.1243
    Cell Significance Index: 381.9100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.9928
    Cell Significance Index: -13.3800
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 3.9737
    Cell Significance Index: 40.9900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.8125
    Cell Significance Index: -11.7100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 3.7800
    Cell Significance Index: 56.6400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.9152
    Cell Significance Index: 67.3500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.6348
    Cell Significance Index: 75.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 2.5072
    Cell Significance Index: 88.1000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.4674
    Cell Significance Index: 148.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.4099
    Cell Significance Index: 109.2400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.6298
    Cell Significance Index: 265.0800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.2636
    Cell Significance Index: 10.7400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0347
    Cell Significance Index: 196.9000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.8688
    Cell Significance Index: 27.8300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6978
    Cell Significance Index: 75.9000
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.6845
    Cell Significance Index: 8.8200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4043
    Cell Significance Index: 8.6100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2607
    Cell Significance Index: 18.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2389
    Cell Significance Index: 43.0700
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.2071
    Cell Significance Index: 4.3200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1816
    Cell Significance Index: 2.8100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1558
    Cell Significance Index: 1.7700
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.1161
    Cell Significance Index: 0.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0692
    Cell Significance Index: 13.7400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0334
    Cell Significance Index: 25.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0006
    Cell Significance Index: 0.4800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0055
    Cell Significance Index: -3.4600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0116
    Cell Significance Index: -0.5900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0148
    Cell Significance Index: -27.8000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0157
    Cell Significance Index: -28.9400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0176
    Cell Significance Index: -5.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0187
    Cell Significance Index: -28.8000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0197
    Cell Significance Index: -17.7700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0258
    Cell Significance Index: -14.5700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0343
    Cell Significance Index: -1.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0399
    Cell Significance Index: -29.2800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0454
    Cell Significance Index: -5.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0458
    Cell Significance Index: -29.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0577
    Cell Significance Index: -12.1500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0579
    Cell Significance Index: -9.8900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0628
    Cell Significance Index: -1.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0637
    Cell Significance Index: -28.9000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0691
    Cell Significance Index: -1.9300
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0702
    Cell Significance Index: -0.5100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0840
    Cell Significance Index: -10.3300
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -0.0882
    Cell Significance Index: -0.4200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1001
    Cell Significance Index: -11.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1116
    Cell Significance Index: -12.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1453
    Cell Significance Index: -29.1500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1565
    Cell Significance Index: -1.6200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1753
    Cell Significance Index: -24.0700
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.1786
    Cell Significance Index: -1.3600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2004
    Cell Significance Index: -29.1300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2015
    Cell Significance Index: -23.0000
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.2484
    Cell Significance Index: -2.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2500
    Cell Significance Index: -25.5400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2878
    Cell Significance Index: -1.9500
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.2982
    Cell Significance Index: -1.8500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3297
    Cell Significance Index: -6.8400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.3411
    Cell Significance Index: -4.7900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3701
    Cell Significance Index: -13.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3723
    Cell Significance Index: -17.3600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3727
    Cell Significance Index: -29.5200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3874
    Cell Significance Index: -29.7300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3931
    Cell Significance Index: -24.1000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4023
    Cell Significance Index: -18.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4115
    Cell Significance Index: -27.6700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4513
    Cell Significance Index: -11.6000
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.4798
    Cell Significance Index: -4.3400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4852
    Cell Significance Index: -29.8200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4878
    Cell Significance Index: -8.6200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.5057
    Cell Significance Index: -7.6200
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.5471
    Cell Significance Index: -3.8500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5523
    Cell Significance Index: -30.9900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5657
    Cell Significance Index: -11.8400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.5896
    Cell Significance Index: -6.2200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6006
    Cell Significance Index: -31.2000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6138
    Cell Significance Index: -21.3300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6705
    Cell Significance Index: -17.6300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.6979
    Cell Significance Index: -30.3500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7013
    Cell Significance Index: -31.0200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.7302
    Cell Significance Index: -12.2200
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.7440
    Cell Significance Index: -6.4100
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.7828
    Cell Significance Index: -7.1900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.7847
    Cell Significance Index: -12.9300
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.8094
    Cell Significance Index: -8.6000
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.8292
    Cell Significance Index: -8.8800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8433
    Cell Significance Index: -24.8400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.8703
    Cell Significance Index: -23.6900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8705
    Cell Significance Index: -27.7300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.9041
    Cell Significance Index: -22.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** TFF3 is highly expressed in epithelial cells of the GI tract, particularly in goblet cells, enterocytes, and glandular cells of the esophagus, tracheobronchial tree, and colon. 2. **Peptide Structure:** TFF3 is a 15-amino acid peptide, consisting of a disulfide-bonded structure, which confers stability and resistance to proteolysis. 3. **Cellular Localization:** TFF3 is primarily localized to the mucosal surface of the GI tract, where it interacts with other proteins and molecules to maintain epithelial integrity. **Pathways and Functions:** 1. **Maintenance of Gastrointestinal Epithelium:** TFF3 plays a critical role in maintaining the integrity and homeostasis of the GI epithelium by promoting cell proliferation, differentiation, and survival. 2. **Wound Healing:** TFF3 is involved in the wound-healing process by stimulating the migration and proliferation of epithelial cells, thereby promoting tissue repair and regeneration. 3. **Secretion and Signaling:** TFF3 is secreted by epithelial cells and interacts with other proteins, such as integrins and growth factors, to regulate cell signaling pathways involved in cell growth, differentiation, and survival. 4. **Protection against Oxidative Stress:** TFF3 has been shown to protect against oxidative stress by scavenging reactive oxygen species (ROS) and modulating the activity of antioxidant enzymes. **Clinical Significance:** 1. **Gastrointestinal Disorders:** Alterations in TFF3 expression have been observed in various gastrointestinal disorders, including inflammatory bowel disease (IBD), cancer, and gastroesophageal reflux disease (GERD). 2. **Therapeutic Applications:** TFF3 has been investigated as a potential therapeutic target for the treatment of GI disorders, including IBD, cancer, and GERD. 3. **Cancer Prevention:** TFF3 has been shown to possess anti-tumor properties, inhibiting cancer cell growth and inducing apoptosis in various cancer cell lines. 4. **Neuroprotection:** TFF3 has been found to have neuroprotective effects, protecting against oxidative stress and inflammation in the central nervous system. In conclusion, TFF3 is a multifaceted peptide that plays a crucial role in maintaining the integrity and homeostasis of the GI tract. Its dysregulation has been implicated in various gastrointestinal disorders, and its therapeutic potential is an area of active research. Further studies are needed to fully elucidate the mechanisms of action of TFF3 and its clinical significance in maintaining GI health.

Genular Protein ID: 1872357251

Symbol: TFF3_HUMAN

Name: Trefoil factor 3

UniProtKB Accession Codes:

Q07654 A0A0A6YYJ4 E9PBB5 Q96NX0 Q9UDA5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UniLectin 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9070946

Title: The three human trefoil genes TFF1, TFF2, and TFF3 are located within a region of 55 kb on chromosome 21q22.3.

PubMed ID: 9070946

DOI: 10.1006/geno.1996.4511

PubMed ID: 10950923

Title: Refined localization of autosomal recessive nonsyndromic deafness DFNB10 locus using 34 novel microsatellite markers, genomic structure, and exclusion of six known genes in the region.

PubMed ID: 10950923

DOI: 10.1006/geno.2000.6253

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 14637006

Title: mRNA 5' region sequence incompleteness: a potential source of systematic errors in translation initiation codon assignment in human mRNAs.

PubMed ID: 14637006

DOI: 10.1016/s0378-1119(03)00835-7

PubMed ID: 8346203

Title: hP1.B, a human P-domain peptide homologous with rat intestinal trefoil factor, is expressed also in the ulcer-associated cell lineage and the uterus.

PubMed ID: 8346203

DOI: 10.1073/pnas.90.15.6961

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8454642

Title: Identification of human intestinal trefoil factor. Goblet cell-specific expression of a peptide targeted for apical secretion.

PubMed ID: 8454642

DOI: 10.1016/s0021-9258(18)53305-6

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 19670903

Title: Comprehensive proteomic analysis of human endometrial fluid aspirate.

PubMed ID: 19670903

DOI: 10.1021/pr9004426

PubMed ID: 10824705

Title: Coexistence of intestinal trefoil factor (hITF) and oxytocin in magnocellular neurons in the human hypothalamus.

PubMed ID: 10824705

DOI: 10.1055/s-2007-978604

PubMed ID: 11694446

Title: Trefoil factor family-peptides promote migration of human bronchial epithelial cells: synergistic effect with epidermal growth factor.

PubMed ID: 11694446

DOI: 10.1165/ajrcmb.25.4.4429

PubMed ID: 18209

Title: Incorporation of mannose and glucose into prenylphosphate sugars in isolated human platelet membranes.

PubMed ID: 18209

DOI: 10.1016/0304-4165(77)90272-0

PubMed ID: 14690424

Title: Solution structure of the disulfide-linked dimer of human intestinal trefoil factor (TFF3): the intermolecular orientation and interactions are markedly different from those of other dimeric trefoil proteins.

PubMed ID: 14690424

DOI: 10.1021/bi030182k

Sequence Information:

  • Length: 80
  • Mass: 8641
  • Checksum: 8E117A58C0342013
  • Sequence:
    • MAARALCMLG LVLALLSSSS AEEYVGLSAN QCAVPAKDRV DCGYPHVTPK ECNNRGCCFD 
SRIPGVPWCF KPLQEAECTF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.