Details for: VTN

Gene ID: 7448

Symbol: VTN

Ensembl ID: ENSG00000109072

Description: vitronectin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 6.2502
    Cell Significance Index: 23.5400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 4.1898
    Cell Significance Index: 62.7800
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 2.0829
    Cell Significance Index: 12.0000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.9045
    Cell Significance Index: 28.1100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.3362
    Cell Significance Index: 42.8000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.8380
    Cell Significance Index: 9.9900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.7465
    Cell Significance Index: 11.5500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6897
    Cell Significance Index: 31.2600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6324
    Cell Significance Index: 39.8600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5767
    Cell Significance Index: 109.7600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.5001
    Cell Significance Index: 8.4300
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 0.4966
    Cell Significance Index: 1.3100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.4892
    Cell Significance Index: 7.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3821
    Cell Significance Index: 75.8200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2587
    Cell Significance Index: 25.5900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2577
    Cell Significance Index: 232.6500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1594
    Cell Significance Index: 17.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1509
    Cell Significance Index: 24.5400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1499
    Cell Significance Index: 9.0000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1290
    Cell Significance Index: 1.3400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0793
    Cell Significance Index: 1.1400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0764
    Cell Significance Index: 5.2900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0505
    Cell Significance Index: 8.6200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0416
    Cell Significance Index: 1.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0308
    Cell Significance Index: 6.1700
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.0299
    Cell Significance Index: 0.0800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0140
    Cell Significance Index: 5.0400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0127
    Cell Significance Index: 0.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0080
    Cell Significance Index: 0.2300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0005
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0009
    Cell Significance Index: -0.6400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0025
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0028
    Cell Significance Index: -0.3200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0028
    Cell Significance Index: -1.7200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0028
    Cell Significance Index: -5.2600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0036
    Cell Significance Index: -4.9400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0041
    Cell Significance Index: -7.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0045
    Cell Significance Index: -6.9600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0051
    Cell Significance Index: -0.1800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0053
    Cell Significance Index: -0.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0068
    Cell Significance Index: -3.8600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0107
    Cell Significance Index: -8.0800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0116
    Cell Significance Index: -0.5000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0131
    Cell Significance Index: -7.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0142
    Cell Significance Index: -2.9900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0152
    Cell Significance Index: -9.6700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0174
    Cell Significance Index: -2.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0194
    Cell Significance Index: -8.8000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0262
    Cell Significance Index: -3.6000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0349
    Cell Significance Index: -1.7700
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.0355
    Cell Significance Index: -0.1700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0356
    Cell Significance Index: -4.0600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0377
    Cell Significance Index: -1.5500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0386
    Cell Significance Index: -0.6500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0400
    Cell Significance Index: -1.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0417
    Cell Significance Index: -6.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0442
    Cell Significance Index: -7.9600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0472
    Cell Significance Index: -0.9800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0676
    Cell Significance Index: -3.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0714
    Cell Significance Index: -8.7800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0760
    Cell Significance Index: -9.8200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0822
    Cell Significance Index: -1.7500
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.0876
    Cell Significance Index: -0.9800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0955
    Cell Significance Index: -9.7600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0962
    Cell Significance Index: -1.1700
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.1010
    Cell Significance Index: -0.9600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1066
    Cell Significance Index: -7.1700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1115
    Cell Significance Index: -4.9300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1118
    Cell Significance Index: -1.2700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1166
    Cell Significance Index: -2.4400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1242
    Cell Significance Index: -6.9700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1256
    Cell Significance Index: -7.7200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1263
    Cell Significance Index: -4.4300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1268
    Cell Significance Index: -10.0400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1305
    Cell Significance Index: -4.9400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1322
    Cell Significance Index: -9.8500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1380
    Cell Significance Index: -2.0800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1463
    Cell Significance Index: -4.7900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1510
    Cell Significance Index: -7.0400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1526
    Cell Significance Index: -4.8600
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.1549
    Cell Significance Index: -1.5600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1560
    Cell Significance Index: -2.0400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1653
    Cell Significance Index: -4.5000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1655
    Cell Significance Index: -4.4200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1679
    Cell Significance Index: -8.7200
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.1683
    Cell Significance Index: -1.5400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1697
    Cell Significance Index: -8.8400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1833
    Cell Significance Index: -1.5400
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.1849
    Cell Significance Index: -1.8100
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.1877
    Cell Significance Index: -2.1200
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.1881
    Cell Significance Index: -1.4900
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1912
    Cell Significance Index: -2.7200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1913
    Cell Significance Index: -4.0600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1936
    Cell Significance Index: -3.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1998
    Cell Significance Index: -9.3900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2033
    Cell Significance Index: -5.0700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2226
    Cell Significance Index: -4.8100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2269
    Cell Significance Index: -5.5000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2272
    Cell Significance Index: -2.4700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2301
    Cell Significance Index: -3.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Vitronectin is a 41-kDa glycoprotein composed of a single chain of 35 amino acids, with a molecular weight of approximately 45 kDa. It is rich in amino groups, which confer its ability to bind to various molecules, including integrins, collagen, and heparin. VTN is highly conserved across species, with high sequence identity between human and mouse. Its expression is widespread, with significant presence in various tissues, including the liver, pancreas, and epithelial cells of the colon and large intestine. **Pathways and Functions:** VTN plays a critical role in several biological pathways, including: 1. **Cell-Matrix Adhesion:** VTN interacts with integrins and collagen to regulate cell-matrix interactions, influencing cell adhesion, migration, and differentiation. 2. **Immune Response:** VTN modulates the immune response by regulating the activity of immune cells, such as macrophages and endothelial cells, and influencing the production of cytokines and chemokines. 3. **Endocytosis and Exocytosis:** VTN is involved in the regulation of endocytosis and exocytosis, influencing the trafficking of molecules and cells within the ECM. 4. **Cell Migration and Invasion:** VTN regulates cell migration and invasion, which are critical processes in cancer metastasis and tissue repair. **Clinical Significance:** VTN has been implicated in various diseases, including: 1. **Cancer:** VTN is overexpressed in several types of cancer, including breast, lung, and colon cancer, and is associated with poor prognosis and metastasis. 2. **Inflammatory Diseases:** VTN is involved in the regulation of the immune response in inflammatory diseases, such as atherosclerosis, rheumatoid arthritis, and inflammatory bowel disease. 3. **Liver Disease:** VTN is overexpressed in liver disease, including liver fibrosis and cirrhosis, and is associated with liver regeneration and repair. 4. **Wound Healing:** VTN plays a critical role in wound healing, regulating the activity of cells involved in tissue repair and remodeling. In conclusion, vitronectin is a multifunctional glycoprotein that plays a crucial role in various biological processes, including cell adhesion, migration, and regulation of the immune response. Its clinical significance in immunology and disease makes it an important target for therapeutic interventions in cancer, inflammatory diseases, and liver disease. Further research is needed to fully elucidate the mechanisms by which VTN influences cellular behavior and disease progression.

Genular Protein ID: 1013151988

Symbol: VTNC_HUMAN

Name: Vitronectin

UniProtKB Accession Codes:

P04004 B2R7G0 P01141 Q9BSH7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 6 ELM 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 43 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2414098

Title: Complete amino acid sequence of human vitronectin deduced from cDNA. Similarity of cell attachment sites in vitronectin and fibronectin.

PubMed ID: 2414098

DOI: 10.1002/j.1460-2075.1985.tb03965.x

PubMed ID: 3004934

Title: Molecular cloning of S-protein, a link between complement, coagulation and cell-substrate adhesion.

PubMed ID: 3004934

DOI: 10.1002/j.1460-2075.1985.tb04058.x

PubMed ID: 2447940

Title: Nucleotide sequence and organization of the human S-protein gene: repeating peptide motifs in the 'pexin' family and a model for their evolution.

PubMed ID: 2447940

DOI: 10.1021/bi00395a024

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 631332

Title: Primary structure of somatomedin B: a growth hormone-dependent serum factor with protease inhibiting activity.

PubMed ID: 631332

DOI: 10.1016/0014-5793(78)80132-x

PubMed ID: 7522053

Title: Identification of a PAI-1 binding site in vitronectin.

PubMed ID: 7522053

DOI: 10.1016/0167-4838(94)90166-x

PubMed ID: 1709100

Title: Insulin binds to type V collagen with retention of mitogenic activity.

PubMed ID: 1709100

DOI: 10.1016/0014-4827(91)90351-t

PubMed ID: 2448300

Title: Phosphorylation of vitronectin by a protein kinase in human plasma. Identification of a unique phosphorylation site in the heparin-binding domain.

PubMed ID: 2448300

DOI: 10.1016/s0021-9258(19)77969-1

PubMed ID: 2479556

Title: Sulfation of two tyrosine-residues in human complement S-protein (vitronectin).

PubMed ID: 2479556

DOI: 10.1111/j.1432-1033.1989.tb15127.x

PubMed ID: 1696913

Title: The phosphorylation of the two-chain form of vitronectin by protein kinase A is heparin dependent.

PubMed ID: 1696913

DOI: 10.1016/0014-5793(90)81159-l

PubMed ID: 1704366

Title: Evidence that type 1 plasminogen activator inhibitor binds to the somatomedin B domain of vitronectin.

PubMed ID: 1704366

DOI: 10.1016/s0021-9258(18)49921-8

PubMed ID: 8900153

Title: The binding protein for globular heads of complement C1q, gC1qR. Functional expression and characterization as a novel vitronectin binding factor.

PubMed ID: 8900153

DOI: 10.1074/jbc.271.43.26739

PubMed ID: 9733784

Title: Phosphorylation of vitronectin by casein kinase II. Identification of the sites and their promotion of cell adhesion and spreading.

PubMed ID: 9733784

DOI: 10.1074/jbc.273.38.24805

PubMed ID: 12019263

Title: Identification of the disulfide bonds in the recombinant somatomedin B domain of human vitronectin.

PubMed ID: 12019263

DOI: 10.1074/jbc.m200354200

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16807684

Title: Phosphoproteomic analysis of the human pituitary.

PubMed ID: 16807684

DOI: 10.1007/s11102-006-8916-x

PubMed ID: 17558413

Title: Determination of the sites of tyrosine O-sulfation in peptides and proteins.

PubMed ID: 17558413

DOI: 10.1038/nmeth1056

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25136834

Title: Complement factor H, vitronectin, and opticin are tyrosine-sulfated proteins of the retinal pigment epithelium.

PubMed ID: 25136834

DOI: 10.1371/journal.pone.0105409

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29567995

Title: Molecular Camouflage of Plasmodium falciparum Merozoites by Binding of Host Vitronectin to P47 Fragment of SERA5.

PubMed ID: 29567995

DOI: 10.1038/s41598-018-23194-9

PubMed ID: 12808446

Title: How vitronectin binds PAI-1 to modulate fibrinolysis and cell migration.

PubMed ID: 12808446

DOI: 10.1038/nsb943

Sequence Information:

  • Length: 478
  • Mass: 54306
  • Checksum: 0D6DB5591CBFEF45
  • Sequence:
    • MAPLRPLLIL ALLAWVALAD QESCKGRCTE GFNVDKKCQC DELCSYYQSC CTDYTAECKP 
QVTRGDVFTM PEDEYTVYDD GEEKNNATVH EQVGGPSLTS DLQAQSKGNP EQTPVLKPEE 
EAPAPEVGAS KPEGIDSRPE TLHPGRPQPP AEEELCSGKP FDAFTDLKNG SLFAFRGQYC 
YELDEKAVRP GYPKLIRDVW GIEGPIDAAF TRINCQGKTY LFKGSQYWRF EDGVLDPDYP 
RNISDGFDGI PDNVDAALAL PAHSYSGRER VYFFKGKQYW EYQFQHQPSQ EECEGSSLSA 
VFEHFAMMQR DSWEDIFELL FWGRTSAGTR QPQFISRDWH GVPGQVDAAM AGRIYISGMA 
PRPSLAKKQR FRHRNRKGYR SQRGHSRGRN QNSRRPSRAT WLSLFSSEES NLGANNYDDY 
RMDWLVPATC EPIQSVFFFS GDKYYRVNLR TRRVDTVDPP YPRSIAQYWL GCPAPGHL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.