Details for: KCNJ6

Gene ID: 3763

Symbol: KCNJ6

Ensembl ID: ENSG00000157542

Description: potassium inwardly rectifying channel subfamily J member 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 5.2012
    Cell Significance Index: 349.7300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 4.8099
    Cell Significance Index: 137.2600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 4.3776
    Cell Significance Index: 75.0200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.7634
    Cell Significance Index: 230.7300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.5630
    Cell Significance Index: 514.1500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.3780
    Cell Significance Index: 29.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.2818
    Cell Significance Index: 818.4500
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 1.6980
    Cell Significance Index: 22.0200
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.5632
    Cell Significance Index: 11.9900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.3106
    Cell Significance Index: 906.4800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 1.1724
    Cell Significance Index: 15.6400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.9156
    Cell Significance Index: 56.2800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.8249
    Cell Significance Index: 26.4200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.7835
    Cell Significance Index: 18.7900
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.7362
    Cell Significance Index: 8.3600
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.5928
    Cell Significance Index: 6.5400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5878
    Cell Significance Index: 58.1500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5695
    Cell Significance Index: 514.2300
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.5455
    Cell Significance Index: 5.1900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.5330
    Cell Significance Index: 11.6700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4741
    Cell Significance Index: 24.8900
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: 0.3332
    Cell Significance Index: 2.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2925
    Cell Significance Index: 47.5700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.2676
    Cell Significance Index: 167.1300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2088
    Cell Significance Index: 22.7100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.1400
    Cell Significance Index: 4.5900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1102
    Cell Significance Index: 20.9700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.0516
    Cell Significance Index: 1.0200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0462
    Cell Significance Index: 1.3300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0396
    Cell Significance Index: 1.3900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0236
    Cell Significance Index: 0.5000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0155
    Cell Significance Index: 1.0700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0092
    Cell Significance Index: 0.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0031
    Cell Significance Index: 2.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0022
    Cell Significance Index: 4.0600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0018
    Cell Significance Index: 0.1100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0010
    Cell Significance Index: 1.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0016
    Cell Significance Index: -2.9500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0026
    Cell Significance Index: -3.9500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0159
    Cell Significance Index: -8.9400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0195
    Cell Significance Index: -0.6200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0232
    Cell Significance Index: -4.8800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0296
    Cell Significance Index: -0.4500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0307
    Cell Significance Index: -19.4900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0356
    Cell Significance Index: -26.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0372
    Cell Significance Index: -28.1300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0391
    Cell Significance Index: -0.5600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0413
    Cell Significance Index: -22.5500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0427
    Cell Significance Index: -19.3900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0493
    Cell Significance Index: -9.7900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0505
    Cell Significance Index: -22.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0600
    Cell Significance Index: -10.2400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0711
    Cell Significance Index: -1.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0718
    Cell Significance Index: -20.6700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0941
    Cell Significance Index: -2.6300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0996
    Cell Significance Index: -2.0000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1064
    Cell Significance Index: -19.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1083
    Cell Significance Index: -15.7400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1087
    Cell Significance Index: -4.9300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1110
    Cell Significance Index: -2.7700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1412
    Cell Significance Index: -3.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1613
    Cell Significance Index: -19.8300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1720
    Cell Significance Index: -3.5900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1948
    Cell Significance Index: -25.1700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1973
    Cell Significance Index: -27.1000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2144
    Cell Significance Index: -24.5600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2227
    Cell Significance Index: -25.4200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2328
    Cell Significance Index: -27.4600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2580
    Cell Significance Index: -5.5000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2632
    Cell Significance Index: -3.0700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2632
    Cell Significance Index: -27.4100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2658
    Cell Significance Index: -27.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2796
    Cell Significance Index: -21.4600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2877
    Cell Significance Index: -12.5100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2901
    Cell Significance Index: -2.7500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3220
    Cell Significance Index: -11.2800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3259
    Cell Significance Index: -23.0500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3304
    Cell Significance Index: -26.1700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.3403
    Cell Significance Index: -4.0700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3453
    Cell Significance Index: -25.7400
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.3539
    Cell Significance Index: -4.9600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3879
    Cell Significance Index: -4.9000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.4131
    Cell Significance Index: -8.1300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4141
    Cell Significance Index: -26.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4159
    Cell Significance Index: -23.3400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4266
    Cell Significance Index: -8.8500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.4359
    Cell Significance Index: -5.8100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4445
    Cell Significance Index: -23.0900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4450
    Cell Significance Index: -28.7100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4493
    Cell Significance Index: -6.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4646
    Cell Significance Index: -21.6600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5143
    Cell Significance Index: -24.1700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5595
    Cell Significance Index: -24.7500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.5795
    Cell Significance Index: -11.5600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6314
    Cell Significance Index: -23.9100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.6376
    Cell Significance Index: -4.3200
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.6439
    Cell Significance Index: -6.6200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6458
    Cell Significance Index: -16.6000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6486
    Cell Significance Index: -23.8100
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.6526
    Cell Significance Index: -5.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KCNJ6 is a member of the inwardly rectifying potassium channel subfamily J, which is characterized by its ability to conduct potassium ions in the inward direction, thereby regulating the resting membrane potential of cells. The KCNJ6 protein is a G protein-activated inward rectifier potassium channel, meaning it is activated by G protein-coupled receptors, such as GABA receptors. This unique feature allows KCNJ6 to modulate the activity of GABA receptors, which are crucial for inhibitory neurotransmission in the central nervous system. **Pathways and Functions:** The KCNJ6 gene is involved in several key pathways, including: 1. **GABAergic Signaling:** KCNJ6 regulates the activity of GABA receptors, which are essential for inhibitory neurotransmission in the central nervous system. By modulating GABA receptor activity, KCNJ6 contributes to the regulation of neuronal excitability and synaptic plasticity. 2. **G-protein activated inward rectifier potassium channel activity:** KCNJ6 is activated by G protein-coupled receptors, which leads to the opening of potassium channels and the subsequent hyperpolarization of the cell membrane. This process is critical for maintaining cellular homeostasis and regulating the activity of neurons. 3. **Regulation of monoatomic ion transmembrane transport:** KCNJ6 is involved in regulating the transport of monoatomic ions, such as potassium, across the plasma membrane. This function is essential for maintaining cellular homeostasis and regulating the activity of neurons. **Clinical Significance:** Dysregulation of KCNJ6 has been implicated in various neurological and psychiatric disorders, including: 1. **Epilepsy:** KCNJ6 mutations have been associated with epilepsy, a neurological disorder characterized by recurrent seizures. 2. **Mental Retardation:** KCNJ6 mutations have also been linked to mental retardation, a condition characterized by cognitive and developmental delays. 3. **Neurodegenerative Diseases:** KCNJ6 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In conclusion, KCNJ6 is a critical gene involved in GABAergic signaling, cellular homeostasis, and monoatomic ion transmembrane transport. Its dysregulation has been implicated in various neurological and psychiatric disorders, highlighting the importance of further research into the function and regulation of this gene.

Genular Protein ID: 3252028203

Symbol: KCNJ6_HUMAN

Name: G protein-activated inward rectifier potassium channel 2

UniProtKB Accession Codes:

P48051 Q3MJ74 Q53WW6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EMBL 8 Ensembl 2 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7592809

Title: Pancreatic islet cells express a family of inwardly rectifying K+ channel subunits which interact to form G-protein-activated channels.

PubMed ID: 7592809

DOI: 10.1074/jbc.270.44.26086

PubMed ID: 10659995

Title: Co-expression of human Kir3 subunits can yield channels with different functional properties.

PubMed ID: 10659995

DOI: 10.1016/s0898-6568(99)00059-5

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7796919

Title: Characterization and variation of a human inwardly-rectifying-K-channel gene (KCNJ6): a putative ATP-sensitive K-channel subunit.

PubMed ID: 7796919

DOI: 10.1016/0014-5793(95)00498-x

PubMed ID: 7729621

Title: Isolation of a cDNA clone encoding a KATP channel-like protein expressed in insulin-secreting cells, localization of the human gene to chromosome band 21q22.1, and linkage studies with NIDDM.

PubMed ID: 7729621

DOI: 10.2337/diab.44.5.592

PubMed ID: 25620207

Title: Keppen-Lubinsky syndrome is caused by mutations in the inwardly rectifying K+ channel encoded by KCNJ6.

PubMed ID: 25620207

DOI: 10.1016/j.ajhg.2014.12.011

Sequence Information:

  • Length: 423
  • Mass: 48451
  • Checksum: 7A02F6B0FBF8B7D4
  • Sequence:
    • MAKLTESMTN VLEGDSMDQD VESPVAIHQP KLPKQARDDL PRHISRDRTK RKIQRYVRKD 
GKCNVHHGNV RETYRYLTDI FTTLVDLKWR FNLLIFVMVY TVTWLFFGMI WWLIAYIRGD 
MDHIEDPSWT PCVTNLNGFV SAFLFSIETE TTIGYGYRVI TDKCPEGIIL LLIQSVLGSI 
VNAFMVGCMF VKISQPKKRA ETLVFSTHAV ISMRDGKLCL MFRVGDLRNS HIVEASIRAK 
LIKSKQTSEG EFIPLNQTDI NVGYYTGDDR LFLVSPLIIS HEINQQSPFW EISKAQLPKE 
ELEIVVILEG MVEATGMTCQ ARSSYITSEI LWGYRFTPVL TLEDGFYEVD YNSFHETYET 
STPSLSAKEL AELASRAELP LSWSVSSKLN QHAELETEEE EKNLEEQTER NGDVANLENE 
SKV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.