Details for: SLC18A2

Gene ID: 6571

Symbol: SLC18A2

Ensembl ID: ENSG00000165646

Description: solute carrier family 18 member A2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 3.91
    Marker Score: 11227
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 3.48
    Marker Score: 8554
  • Cell Name: basophil (CL0000767)
    Fold Change: 3.3
    Marker Score: 1569
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 2.11
    Marker Score: 8184
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.01
    Marker Score: 20762
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1166
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169407
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.47
    Marker Score: 487
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.4
    Marker Score: 1977
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.35
    Marker Score: 1350
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 851
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4811
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.14
    Marker Score: 513
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 499
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251805
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71823
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48048
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.95
    Marker Score: 396
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.94
    Marker Score: 1943
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5315.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 371
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.8
    Marker Score: 465
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 597
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1259
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.77
    Marker Score: 344
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.76
    Marker Score: 308
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.74
    Marker Score: 383
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.74
    Marker Score: 379
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 459
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.69
    Marker Score: 1315
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.55
    Marker Score: 1123
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.55
    Marker Score: 205
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.54
    Marker Score: 677
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.54
    Marker Score: 386
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5
    Marker Score: 7764
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.47
    Marker Score: 462
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.46
    Marker Score: 2747
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.45
    Marker Score: 443
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.41
    Marker Score: 836
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.37
    Marker Score: 1537
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.36
    Marker Score: 237
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.35
    Marker Score: 169
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.33
    Marker Score: 187
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.33
    Marker Score: 847
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.31
    Marker Score: 93
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.3
    Marker Score: 396
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.3
    Marker Score: 101
  • Cell Name: eosinophil (CL0000771)
    Fold Change: 0.3
    Marker Score: 97.5
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.3
    Marker Score: 216
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.29
    Marker Score: 85
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.29
    Marker Score: 512
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.28
    Marker Score: 242
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.28
    Marker Score: 133
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.27
    Marker Score: 163
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.27
    Marker Score: 136
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.26
    Marker Score: 285
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.26
    Marker Score: 234
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.26
    Marker Score: 68
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.25
    Marker Score: 161.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.25
    Marker Score: 119
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.24
    Marker Score: 164
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.24
    Marker Score: 99
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.23
    Marker Score: 69
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.23
    Marker Score: 177
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.23
    Marker Score: 576
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.23
    Marker Score: 2588
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.23
    Marker Score: 132
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.22
    Marker Score: 246
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.22
    Marker Score: 519
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.22
    Marker Score: 95
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.22
    Marker Score: 61
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.21
    Marker Score: 327
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.21
    Marker Score: 132
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.21
    Marker Score: 104
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.21
    Marker Score: 95
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.21
    Marker Score: 124
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.21
    Marker Score: 257.5
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.2
    Marker Score: 106
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.2
    Marker Score: 200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.2
    Marker Score: 253
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.19
    Marker Score: 92
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.19
    Marker Score: 108
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: 0.18
    Marker Score: 55
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.18
    Marker Score: 57
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43

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Other Information

**Key Characteristics:** 1. **Expression Pattern:** SLC18A2 is expressed in a wide range of cell types, including neural progenitor cells, basophils, and enterocytes, demonstrating its diverse roles in the body. 2. **Protein Structure:** The VMAT2 protein is a transmembrane transporter with a high affinity for aminergic neurotransmitters, allowing for efficient loading into synaptic vesicles. 3. **Function:** The primary function of SLC18A2 is to regulate the release of aminergic neurotransmitters, which are involved in various physiological processes, including locomotion, mood regulation, and cognitive function. 4. **Regulation:** SLC18A2 is subject to various regulatory mechanisms, including post-translational modifications, protein-protein interactions, and transcriptional control, which fine-tune its activity in response to different physiological and pathological signals. **Pathways and Functions:** SLC18A2 is involved in several key pathways, including: 1. **Aminergic Neurotransmitter Loading into Synaptic Vesicle:** SLC18A2 plays a critical role in loading aminergic neurotransmitters, such as dopamine, serotonin, and norepinephrine, into synaptic vesicles, which is essential for neurotransmitter release and synaptic transmission. 2. **Neurotransmitter Release Cycle:** SLC18A2 is also involved in the release cycle of aminergic neurotransmitters, regulating the amount of neurotransmitter available for release into the synaptic cleft. 3. **Chemical Synaptic Transmission:** SLC18A2 is essential for chemical synaptic transmission, which is the primary mechanism of neurotransmission in the nervous system. 4. **Regulation of Reactive Oxygen Species:** SLC18A2 has been shown to regulate the production of reactive oxygen species (ROS), which are involved in various physiological and pathological processes. **Clinical Significance:** SLC18A2 has significant clinical implications, including: 1. **Neurological Disorders:** Mutations in SLC18A2 have been associated with various neurological disorders, including Parkinson's disease, schizophrenia, and attention deficit hyperactivity disorder (ADHD). 2. **Addiction:** SLC18A2 has been implicated in the development and maintenance of addiction, particularly in the context of substance abuse and dependence. 3. **Mood Regulation:** SLC18A2 plays a critical role in regulating mood and emotional responses, highlighting its potential as a therapeutic target for mood disorders, such as depression and bipolar disorder. 4. **Cancer:** SLC18A2 has been shown to be overexpressed in certain types of cancer, including breast and lung cancer, suggesting its potential as a therapeutic target for cancer treatment. In conclusion, SLC18A2 is a complex gene that plays a critical role in regulating aminergic neurotransmitter release and synaptic transmission. Its dysregulation has been implicated in various neurological and psychiatric disorders, highlighting its potential as a therapeutic target for the treatment of these conditions.

Genular Protein ID: 687984952

Symbol: VMAT2_HUMAN

Name: Synaptic vesicular amine transporter

UniProtKB Accession Codes:

Q05940 B2RC96 D3DRC4 Q15876 Q4G147 Q5VW49 Q9H3P6

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 6 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 24 DrugCentral 1 EMBL 13 EPD 1 Ensembl 1 GO 32 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 1 Rhea 6 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8095030

Title: A human synaptic vesicle monoamine transporter cDNA predicts posttranslational modifications, reveals chromosome 10 gene localization and identifies TaqI RFLPs.

PubMed ID: 8095030

DOI: 10.1016/0014-5793(93)80539-7

PubMed ID: 8245983

Title: Functional identification and molecular cloning of a human brain vesicle monoamine transporter.

PubMed ID: 8245983

DOI: 10.1111/j.1471-4159.1993.tb07476.x

PubMed ID: 7905859

Title: Chromosomal localization of the human vesicular amine transporter genes.

PubMed ID: 7905859

DOI: 10.1016/s0888-7543(05)80383-0

PubMed ID: 8373557

Title: Extensive sequence divergence between the human and rat brain vesicular monoamine transporter: possible molecular basis for species differences in the susceptibility to MPP+.

PubMed ID: 8373557

DOI: 10.1007/bf01244941

PubMed ID: 11443533

Title: Exon/intron boundaries, novel polymorphisms, and association analysis with schizophrenia of the human synaptic vesicle monoamine transporter (SVMT) gene.

PubMed ID: 11443533

DOI: 10.1038/sj.mp.4000895

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8860238

Title: Reserpine- and tetrabenazine-sensitive transport of (3)H-histamine by the neuronal isoform of the vesicular monoamine transporter.

PubMed ID: 8860238

DOI: 10.1007/bf02736786

PubMed ID: 8643547

Title: Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter.

PubMed ID: 8643547

DOI: 10.1073/pnas.93.10.5166

PubMed ID: 12009896

Title: Identification of human vesicle monoamine transporter (VMAT2) lumenal cysteines that form an intramolecular disulfide bond.

PubMed ID: 12009896

DOI: 10.1021/bi015779j

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 23363473

Title: Brain dopamine-serotonin vesicular transport disease and its treatment.

PubMed ID: 23363473

DOI: 10.1056/nejmoa1207281

Sequence Information:

  • Length: 514
  • Mass: 55713
  • Checksum: 42EA91A225485DB2
  • Sequence:
    • MALSELALVR WLQESRRSRK LILFIVFLAL LLDNMLLTVV VPIIPSYLYS IKHEKNATEI 
QTARPVHTAS ISDSFQSIFS YYDNSTMVTG NATRDLTLHQ TATQHMVTNA SAVPSDCPSE 
DKDLLNENVQ VGLLFASKAT VQLITNPFIG LLTNRIGYPI PIFAGFCIMF VSTIMFAFSS 
SYAFLLIARS LQGIGSSCSS VAGMGMLASV YTDDEERGNV MGIALGGLAM GVLVGPPFGS 
VLYEFVGKTA PFLVLAALVL LDGAIQLFVL QPSRVQPESQ KGTPLTTLLK DPYILIAAGS 
ICFANMGIAM LEPALPIWMM ETMCSRKWQL GVAFLPASIS YLIGTNIFGI LAHKMGRWLC 
ALLGMIIVGV SILCIPFAKN IYGLIAPNFG VGFAIGMVDS SMMPIMGYLV DLRHVSVYGS 
VYAIADVAFC MGYAIGPSAG GAIAKAIGFP WLMTIIGIID ILFAPLCFFL RSPPAKEEKM 
AILMDHNCPI KTKMYTQNNI QSYPIGEDEE SESD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.