Gene GFRA3 - ENSG00000146013 | NCBI Gene ID: 2676

Details for: GFRA3

Gene ID: 2676

Symbol: GFRA3

Ensembl ID: ENSG00000146013

Description: GDNF family receptor alpha 3

Associated with

Developmental biology
(R-HSA-1266738)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Raf/map kinase cascade
(R-HSA-5673001)
Ret signaling
(R-HSA-8853659)
Axon guidance
(GO:0007411)
Axon guidance receptor activity
(GO:0008046)
Cytosol
(GO:0005829)
External side of plasma membrane
(GO:0009897)
Extrinsic component of membrane
(GO:0019898)
Nervous system development
(GO:0007399)
Neuron migration
(GO:0001764)
Peripheral nervous system development
(GO:0007422)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Receptor complex
(GO:0043235)
Signaling receptor activity
(GO:0038023)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
Sympathetic nervous system development
(GO:0048485)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: acinar cell (CL0000622)
Fold Change: 2.46
Marker Score: 1735
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 2.19
Marker Score: 1510
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 2.09
Marker Score: 2105
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2
Marker Score: 1993
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.61
Marker Score: 1167
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4814
Cell Name: chromaffin cell (CL0000166)
Fold Change: 1.1
Marker Score: 1542
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.04
Marker Score: 793
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71827
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48052
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30408
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 505
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 458
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.94
Marker Score: 599
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5323
Cell Name: amacrine cell (CL0000561)
Fold Change: 0.93
Marker Score: 2981
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.92
Marker Score: 370
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2738
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 322
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5290
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.83
Marker Score: 380.5
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.81
Marker Score: 791
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1259
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 707
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 393
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.73
Marker Score: 11457
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 177
Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 0.67
Marker Score: 170
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.65
Marker Score: 1236.5
Cell Name: male germ cell (CL0000015)
Fold Change: 0.65
Marker Score: 187
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 0.59
Marker Score: 303
Cell Name: supporting cell (CL0000630)
Fold Change: 0.58
Marker Score: 1094
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.58
Marker Score: 382
Cell Name: M cell of gut (CL0000682)
Fold Change: 0.57
Marker Score: 149
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 440
Cell Name: respiratory basal cell (CL0002633)
Fold Change: 0.55
Marker Score: 790
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.55
Marker Score: 351.5
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.54
Marker Score: 172
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.51
Marker Score: 228
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 0.47
Marker Score: 139
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.46
Marker Score: 275
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.45
Marker Score: 187
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.44
Marker Score: 897
Cell Name: Unknown (CL0002371)
Fold Change: 0.44
Marker Score: 464
Cell Name: neural cell (CL0002319)
Fold Change: 0.43
Marker Score: 209
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.42
Marker Score: 181
Cell Name: Schwann cell (CL0002573)
Fold Change: 0.38
Marker Score: 131
Cell Name: glial cell (CL0000125)
Fold Change: 0.36
Marker Score: 394
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 0.35
Marker Score: 132
Cell Name: stromal cell (CL0000499)
Fold Change: 0.34
Marker Score: 401
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.34
Marker Score: 694
Cell Name: cardiac neuron (CL0010022)
Fold Change: 0.33
Marker Score: 416
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.32
Marker Score: 329
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.31
Marker Score: 81.5
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.27
Marker Score: 113
Cell Name: germ cell (CL0000586)
Fold Change: 0.27
Marker Score: 469
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.26
Marker Score: 88
Cell Name: ionocyte (CL0005006)
Fold Change: 0.25
Marker Score: 76
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 64
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.22
Marker Score: 134
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.21
Marker Score: 115
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.2
Marker Score: 137
Cell Name: mast cell (CL0000097)
Fold Change: 0.19
Marker Score: 112
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.18
Marker Score: 131
Cell Name: Leydig cell (CL0000178)
Fold Change: 0.18
Marker Score: 198
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.18
Marker Score: 62
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.18
Marker Score: 229
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.18
Marker Score: 87
Cell Name: oocyte (CL0000023)
Fold Change: 0.18
Marker Score: 45
Cell Name: type I enteroendocrine cell (CL0002277)
Fold Change: 0.18
Marker Score: 45
Cell Name: lung neuroendocrine cell (CL1000223)
Fold Change: 0.17
Marker Score: 48
Cell Name: endocrine cell (CL0000163)
Fold Change: 0.17
Marker Score: 88
Cell Name: kidney cell (CL1000497)
Fold Change: 0.17
Marker Score: 113
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.17
Marker Score: 42
Cell Name: retinal cone cell (CL0000573)
Fold Change: 0.16
Marker Score: 462.5
Cell Name: type D enteroendocrine cell (CL0000502)
Fold Change: 0.16
Marker Score: 49
Cell Name: hepatoblast (CL0005026)
Fold Change: 0.16
Marker Score: 510
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.13
Marker Score: 70
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.13
Marker Score: 74
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 0.13
Marker Score: 199
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.13
Marker Score: 124
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.13
Marker Score: 43
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.13
Marker Score: 126
Cell Name: thymocyte (CL0000893)
Fold Change: 0.13
Marker Score: 131
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.12
Marker Score: 172
Cell Name: podocyte (CL0000653)
Fold Change: 0.12
Marker Score: 43
Cell Name: astrocyte (CL0000127)
Fold Change: 0.12
Marker Score: 100
Cell Name: oogonial cell (CL0000024)
Fold Change: 0.11
Marker Score: 165
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 0.11
Marker Score: 76
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.11
Marker Score: 36
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.11
Marker Score: 595
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.11
Marker Score: 60
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.11
Marker Score: 181.5
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.1
Marker Score: 87
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.1
Marker Score: 26
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.1
Marker Score: 166
Cell Name: B cell (CL0000236)
Fold Change: 0.1
Marker Score: 95
Cell Name: plasma cell (CL0000786)
Fold Change: 0.1
Marker Score: 110
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 0.1
Marker Score: 38

Hover over a box to see details here...

**Key characteristics**: - It is a type I transmembrane receptor that is expressed on neurons and glial cells. - It is a single-pass transmembrane protein with a molecular weight of approximately 170 kDa. - It is a ligand for GDNF. **Pathways and functions**: - It is a key regulator of axon guidance by binding to GDNF and facilitating its interaction with its cytoplasmic signaling partner, GDNF receptor alpha 2 (GDNFRA2). - It is involved in the regulation of neuronal migration by binding to GDNF and promoting its interaction with GDNFRA2. - It is also involved in the regulation of synapse formation by binding to GDNF and facilitating its interaction with its cytoplasmic signaling partner, GDNFRA2. - It is involved in the development and maintenance of the peripheral nervous system by regulating the migration and survival of motor neurons. - It is also involved in the development of the cerebral cortex by regulating the migration and survival of neurons in the cerebral cortex. **Clinical significance**: - Mutations in GFRA3 have been linked to a number of neurological disorders, including autism, schizophrenia, and epilepsy. - In one study, mutations in GFRA3 were found to be associated with a rare brain disorder called lissencephaly, which is characterized by severe intellectual disability and seizures. - In another study, mutations in GFRA3 were found to be associated with a syndrome of seizures, intellectual disability, and behavioral problems.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

GDNF family receptor alpha-3

Genular Protein ID: 1855349509

Symbol: GFRA3_HUMAN

Name: GDNF family receptor alpha-3

UniProtKB Accession Codes:

O60609 B2RA36 B4DMY9 Q6UW20 Q8IUZ2

Database IDs:

Citations:

PubMed ID: 9576965

Title: GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family.

PubMed ID: 9576965

DOI: 10.1073/pnas.95.10.5801

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 9883723

Title: Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex.

PubMed ID: 9883723

DOI: 10.1016/s0896-6273(00)80649-2

PubMed ID: 23333276

Title: SorLA controls neurotrophic activity by sorting of GDNF and its receptors GFRalpha1 and RET.

PubMed ID: 23333276

DOI: 10.1016/j.celrep.2012.12.011

PubMed ID: 16765900

Title: Structure of artemin complexed with its receptor GFRalpha3: convergent recognition of glial cell line-derived neurotrophic factors.

PubMed ID: 16765900

DOI: 10.1016/j.str.2006.05.010

Sequence Information:

Length: 400
Mass: 44511
Checksum: B0BC252FE1F072C7
Sequence:

MVRPLNPRPL PPVVLMLLLL LPPSPLPLAA GDPLPTESRL MNSCLQARRK CQADPTCSAA 
YHHLDSCTSS ISTPLPSEEP SVPADCLEAA QQLRNSSLIG CMCHRRMKNQ VACLDIYWTV 
HRARSLGNYE LDVSPYEDTV TSKPWKMNLS KLNMLKPDSD LCLKFAMLCT LNDKCDRLRK 
AYGEACSGPH CQRHVCLRQL LTFFEKAAEP HAQGLLLCPC APNDRGCGER RRNTIAPNCA 
LPPVAPNCLE LRRLCFSDPL CRSRLVDFQT HCHPMDILGT CATEQSRCLR AYLGLIGTAM 
TPNFVSNVNT SVALSCTCRG SGNLQEECEM LEGFFSHNPC LTEAIAAKMR FHSQLFSQDW 
PHPTFAVMAH QNENPAVRPQ PWVPSLFSCT LPLILLLSLW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: GFRA3

Associated with

Cells (max top 100)

Other Information

GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family. PubMed ID: 9576965

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. PubMed ID: 12975309

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Signal peptide prediction based on analysis of experimentally verified cleavage sites. PubMed ID: 15340161

Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex. PubMed ID: 9883723

SorLA controls neurotrophic activity by sorting of GDNF and its receptors GFRalpha1 and RET. PubMed ID: 23333276

Structure of artemin complexed with its receptor GFRalpha3: convergent recognition of glial cell line-derived neurotrophic factors. PubMed ID: 16765900