Details for: FFAR3

Gene ID: 2865

Symbol: FFAR3

Ensembl ID: ENSG00000185897

Description: free fatty acid receptor 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 6.2794
    Cell Significance Index: 70.1800
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 3.1535
    Cell Significance Index: 37.2700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.1817
    Cell Significance Index: 47.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.7663
    Cell Significance Index: 80.0600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2545
    Cell Significance Index: 238.7400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.0299
    Cell Significance Index: 15.5200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.0202
    Cell Significance Index: 12.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8900
    Cell Significance Index: 88.0400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7662
    Cell Significance Index: 691.8500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.7406
    Cell Significance Index: 23.7200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4690
    Cell Significance Index: 76.2700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4442
    Cell Significance Index: 48.3200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4296
    Cell Significance Index: 9.1500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4030
    Cell Significance Index: 10.7800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2531
    Cell Significance Index: 17.5000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2347
    Cell Significance Index: 14.0900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0017
    Cell Significance Index: -0.0600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0031
    Cell Significance Index: -0.0900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0036
    Cell Significance Index: -0.0900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0038
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0039
    Cell Significance Index: -2.8900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0039
    Cell Significance Index: -2.9400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0046
    Cell Significance Index: -2.5700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0054
    Cell Significance Index: -2.9600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0078
    Cell Significance Index: -0.2500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0126
    Cell Significance Index: -0.2500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0127
    Cell Significance Index: -2.5400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0150
    Cell Significance Index: -1.9200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0152
    Cell Significance Index: -3.0100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0171
    Cell Significance Index: -3.6000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0207
    Cell Significance Index: -3.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0227
    Cell Significance Index: -3.1200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0242
    Cell Significance Index: -2.4700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0267
    Cell Significance Index: -0.1800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0279
    Cell Significance Index: -3.6100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0328
    Cell Significance Index: -2.0100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0342
    Cell Significance Index: -4.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0356
    Cell Significance Index: -4.0800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0397
    Cell Significance Index: -1.3000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0400
    Cell Significance Index: -0.8300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0422
    Cell Significance Index: -1.4800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0448
    Cell Significance Index: -2.8900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0491
    Cell Significance Index: -3.6600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0570
    Cell Significance Index: -2.9600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0627
    Cell Significance Index: -3.5200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0649
    Cell Significance Index: -3.0500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0650
    Cell Significance Index: -1.3600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0696
    Cell Significance Index: -1.0100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0711
    Cell Significance Index: -2.4700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0796
    Cell Significance Index: -3.5200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0839
    Cell Significance Index: -2.4700
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0867
    Cell Significance Index: -1.1200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1008
    Cell Significance Index: -2.9600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1038
    Cell Significance Index: -2.7300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1083
    Cell Significance Index: -3.0900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1084
    Cell Significance Index: -2.6300
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1088
    Cell Significance Index: -1.2800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1093
    Cell Significance Index: -2.9300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1104
    Cell Significance Index: -2.0400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1111
    Cell Significance Index: -1.8600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1155
    Cell Significance Index: -2.9400
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.1157
    Cell Significance Index: -1.4700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1198
    Cell Significance Index: -3.0600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1221
    Cell Significance Index: -1.4900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1227
    Cell Significance Index: -3.0600
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.1241
    Cell Significance Index: -1.2800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1245
    Cell Significance Index: -3.5700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1251
    Cell Significance Index: -3.3400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1251
    Cell Significance Index: -1.0200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1253
    Cell Significance Index: -1.2400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1263
    Cell Significance Index: -2.6800
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.1349
    Cell Significance Index: -1.4600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1355
    Cell Significance Index: -2.6800
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1356
    Cell Significance Index: -1.4400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1360
    Cell Significance Index: -1.8700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1383
    Cell Significance Index: -2.2400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1430
    Cell Significance Index: -1.8500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1445
    Cell Significance Index: -2.4700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1461
    Cell Significance Index: -3.6500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1483
    Cell Significance Index: -2.9000
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.1486
    Cell Significance Index: -1.4600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1521
    Cell Significance Index: -2.2300
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.1549
    Cell Significance Index: -1.5600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1563
    Cell Significance Index: -3.6100
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.1568
    Cell Significance Index: -0.7500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1577
    Cell Significance Index: -2.2600
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1582
    Cell Significance Index: -1.9100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1612
    Cell Significance Index: -2.3500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1617
    Cell Significance Index: -4.4000
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.1645
    Cell Significance Index: -2.0600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1677
    Cell Significance Index: -2.9000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1748
    Cell Significance Index: -3.5100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1749
    Cell Significance Index: -2.9700
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.1809
    Cell Significance Index: -1.7500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1859
    Cell Significance Index: -2.4700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1860
    Cell Significance Index: -3.7100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1867
    Cell Significance Index: -3.3000
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.1911
    Cell Significance Index: -2.3100
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.1932
    Cell Significance Index: -1.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure and Function:** FFAR3 is a transmembrane receptor that belongs to the Class A/1 rhodopsin-like receptors. It is composed of seven transmembrane domains and possesses a long N-terminus that interacts with fatty acids. 2. **Ligand Binding:** FFAR3 binds to various free fatty acids, including oleic acid, palmitic acid, and linoleic acid, which triggers a signaling cascade that regulates various cellular processes. 3. **Signaling Pathways:** FFAR3 activation triggers the inhibition of adenylate cyclase, leading to a decrease in cAMP levels and subsequent activation of the Gαq signaling pathway. This pathway regulates various cellular processes, including inflammation, immune response, and metabolism. **Pathways and Functions:** 1. **Inflammatory Response:** FFAR3 plays a crucial role in regulating the inflammatory response, particularly in response to non-antigenic stimuli. Activation of FFAR3 leads to the production of pro-inflammatory cytokines and chemokines, which contribute to the recruitment of immune cells to the site of inflammation. 2. **Immune Response:** FFAR3 is expressed in various immune cells, including granulocytes, monocytes, and T cells. It regulates the production of cytokines and chemokines involved in immune response, including IL-1β, TNF-α, and MCP-1. 3. **Metabolism:** FFAR3 regulates glucose and lipid metabolism by modulating insulin signaling and glucose uptake in adipocytes. 4. **Cardiovascular Function:** FFAR3 has been implicated in the regulation of blood pressure and cardiac function, particularly in response to fatty acid intake. **Clinical Significance:** 1. **Metabolic Disorders:** Dysregulation of FFAR3 has been linked to metabolic disorders, including obesity, type 2 diabetes, and cardiovascular disease. 2. **Inflammatory Diseases:** FFAR3 plays a crucial role in regulating inflammatory responses, and its dysregulation has been implicated in various inflammatory diseases, including atherosclerosis, arthritis, and asthma. 3. **Cancer:** FFAR3 has been shown to regulate the production of pro-inflammatory cytokines in cancer cells, contributing to tumor progression and metastasis. 4. **Neurological Disorders:** FFAR3 has been implicated in the regulation of neuroinflammation and neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. In conclusion, the FFAR3 gene plays a critical role in regulating various physiological processes, including immune response, metabolism, and cardiovascular function. Its dysregulation has been implicated in various diseases, highlighting the importance of FFAR3 in maintaining immune homeostasis and overall health. Further research is needed to fully elucidate the functional significance of FFAR3 and its role in human disease.

Genular Protein ID: 1954948207

Symbol: FFAR3_HUMAN

Name: Free fatty acid receptor 3

UniProtKB Accession Codes:

O14843 B2RWM8 Q14CM7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 5 EMDB 2 Ensembl 2 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 9344866

Title: A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1.

PubMed ID: 9344866

DOI: 10.1006/bbrc.1997.7513

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12496283

Title: The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.

PubMed ID: 12496283

DOI: 10.1074/jbc.m211609200

PubMed ID: 12711604

Title: Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation.

PubMed ID: 12711604

DOI: 10.1074/jbc.m301403200

PubMed ID: 18801738

Title: Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short chain fatty acids.

PubMed ID: 18801738

DOI: 10.1074/jbc.m805601200

PubMed ID: 19630535

Title: Sequence polymorphisms provide a common consensus sequence for GPR41 and GPR42.

PubMed ID: 19630535

DOI: 10.1089/dna.2009.0916

PubMed ID: 21518883

Title: Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41).

PubMed ID: 21518883

DOI: 10.1073/pnas.1016088108

PubMed ID: 23066016

Title: Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3.

PubMed ID: 23066016

DOI: 10.1074/jbc.m112.396259

Sequence Information:

  • Length: 346
  • Mass: 38649
  • Checksum: B3B19D62D11B6BA1
  • Sequence:
    • MDTGPDQSYF SGNHWFVFSV YLLTFLVGLP LNLLALVVFV GKLQRRPVAV DVLLLNLTAS 
DLLLLLFLPF RMVEAANGMH WPLPFILCPL SGFIFFTTIY LTALFLAAVS IERFLSVAHP 
LWYKTRPRLG QAGLVSVACW LLASAHCSVV YVIEFSGDIS HSQGTNGTCY LEFRKDQLAI 
LLPVRLEMAV VLFVVPLIIT SYCYSRLVWI LGRGGSHRRQ RRVAGLLAAT LLNFLVCFGP 
YNVSHVVGYI CGESPAWRIY VTLLSTLNSC VDPFVYYFSS SGFQADFHEL LRRLCGLWGQ 
WQQESSMELK EQKGGEEQRA DRPAERKTSE HSQGCGTGGQ VACAES

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.