Details for: DPEP1

Gene ID: 1800

Symbol: DPEP1

Ensembl ID: ENSG00000015413

Description: dipeptidase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 20.0675
    Cell Significance Index: -5.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 8.4333
    Cell Significance Index: 242.9800
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 8.2236
    Cell Significance Index: 4.1300
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 6.3801
    Cell Significance Index: 31.0300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 6.2739
    Cell Significance Index: -5.9900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.1202
    Cell Significance Index: -5.0800
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 3.8531
    Cell Significance Index: 38.8700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.1801
    Cell Significance Index: 130.8800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.7487
    Cell Significance Index: 1578.9000
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.6427
    Cell Significance Index: 11.5600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.2975
    Cell Significance Index: -5.1200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.2922
    Cell Significance Index: 27.5200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2007
    Cell Significance Index: 118.7800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0023
    Cell Significance Index: 198.9000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9913
    Cell Significance Index: 161.2300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.9807
    Cell Significance Index: 7.8300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9511
    Cell Significance Index: 65.7800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7453
    Cell Significance Index: 81.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5659
    Cell Significance Index: 107.7000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4232
    Cell Significance Index: 72.2600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.4101
    Cell Significance Index: 14.4100
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.3424
    Cell Significance Index: 0.8700
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: 0.0903
    Cell Significance Index: 0.6300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0774
    Cell Significance Index: 1.9900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0401
    Cell Significance Index: 0.4200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0368
    Cell Significance Index: 0.6300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0234
    Cell Significance Index: 6.7400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0186
    Cell Significance Index: 0.9700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0143
    Cell Significance Index: 0.2000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0099
    Cell Significance Index: 0.4500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0053
    Cell Significance Index: 1.0700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0052
    Cell Significance Index: 0.6700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0017
    Cell Significance Index: 0.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0006
    Cell Significance Index: -1.1100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0012
    Cell Significance Index: -0.0800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0014
    Cell Significance Index: -0.5100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0016
    Cell Significance Index: -3.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0019
    Cell Significance Index: -2.8600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0027
    Cell Significance Index: -0.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0030
    Cell Significance Index: -4.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0034
    Cell Significance Index: -2.5200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0050
    Cell Significance Index: -3.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0066
    Cell Significance Index: -3.7100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0067
    Cell Significance Index: -5.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0071
    Cell Significance Index: -3.9000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0072
    Cell Significance Index: -0.1200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0080
    Cell Significance Index: -5.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0090
    Cell Significance Index: -5.7400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0116
    Cell Significance Index: -5.2500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0123
    Cell Significance Index: -0.1400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0136
    Cell Significance Index: -0.2100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0147
    Cell Significance Index: -0.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0162
    Cell Significance Index: -1.8600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0224
    Cell Significance Index: -0.3400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0235
    Cell Significance Index: -4.9500
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0249
    Cell Significance Index: -0.1900
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0250
    Cell Significance Index: -0.3500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0252
    Cell Significance Index: -4.5400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0260
    Cell Significance Index: -0.6700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0292
    Cell Significance Index: -0.7300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0315
    Cell Significance Index: -0.8800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0325
    Cell Significance Index: -0.4900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0326
    Cell Significance Index: -4.7400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0372
    Cell Significance Index: -2.2800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0381
    Cell Significance Index: -4.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0386
    Cell Significance Index: -4.7500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0404
    Cell Significance Index: -0.8800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0408
    Cell Significance Index: -5.6000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0452
    Cell Significance Index: -1.2300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0490
    Cell Significance Index: -5.1000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0525
    Cell Significance Index: -1.3800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0536
    Cell Significance Index: -2.3300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0553
    Cell Significance Index: -7.1500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0588
    Cell Significance Index: -1.2300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0615
    Cell Significance Index: -7.2500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0638
    Cell Significance Index: -1.5500
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0648
    Cell Significance Index: -0.7100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0656
    Cell Significance Index: -1.7600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0662
    Cell Significance Index: -0.9400
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0703
    Cell Significance Index: -0.8900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0703
    Cell Significance Index: -4.7300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0767
    Cell Significance Index: -0.5200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0781
    Cell Significance Index: -5.9900
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0788
    Cell Significance Index: -0.6700
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0797
    Cell Significance Index: -1.0300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0800
    Cell Significance Index: -3.7300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0830
    Cell Significance Index: -1.4300
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0839
    Cell Significance Index: -1.0200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0881
    Cell Significance Index: -1.3200
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0896
    Cell Significance Index: -1.3400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0897
    Cell Significance Index: -1.7500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0960
    Cell Significance Index: -7.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0999
    Cell Significance Index: -6.1400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1018
    Cell Significance Index: -5.7100
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1038
    Cell Significance Index: -1.3600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1134
    Cell Significance Index: -3.9700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1147
    Cell Significance Index: -6.0200
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.1156
    Cell Significance Index: -0.8300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1161
    Cell Significance Index: -3.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** DPEP1 is a metalloexopeptidase enzyme that belongs to the prolyl peptidase family. It is primarily expressed in various tissues, including the pancreas, intestine, and ovaries. The protein has a molecular weight of approximately 50 kDa and is characterized by its ability to bind zinc ions. DPEP1 is involved in the degradation of peptides and proteins, particularly those containing proline and hydroxylated amino acids. **Pathways and Functions** DPEP1 is involved in several cellular processes, including: 1. **Antibiotic Metabolic Process**: DPEP1 is responsible for the degradation of antibiotics, such as penicillin, which is essential for maintaining antibiotic resistance. 2. **Anti-inflammatory Response**: DPEP1 has been shown to modulate the anti-inflammatory response, favoring Leishmania parasite infection. This suggests that DPEP1 may play a role in the regulation of immune responses during parasitic infections. 3. **Cellular Response to Calcium Ion**: DPEP1 is involved in the regulation of calcium ion homeostasis, which is crucial for various cellular processes, including muscle contraction and cell signaling. 4. **Infectious Disease**: DPEP1 has been implicated in the regulation of infectious diseases, such as Leishmania parasite growth and survival. 5. **Protein Binding**: DPEP1 has been shown to bind to various proteins, including those involved in cell signaling and immune responses. **Functions** The primary function of DPEP1 is to degrade peptides and proteins, particularly those containing proline and hydroxylated amino acids. This degradation process is essential for various cellular processes, including: 1. **Antibiotic Resistance**: DPEP1 helps to maintain antibiotic resistance by degrading antibiotics, such as penicillin. 2. **Immune Regulation**: DPEP1 modulates the anti-inflammatory response, favoring Leishmania parasite infection. 3. **Cell Signaling**: DPEP1 regulates cell signaling pathways, including those involved in calcium ion homeostasis. 4. **Protein Degradation**: DPEP1 is involved in the degradation of proteins, including those involved in cell signaling and immune responses. **Clinical Significance** DPEP1 has significant implications in various clinical contexts, including: 1. **Leishmania Infections**: DPEP1 has been implicated in the regulation of Leishmania parasite growth and survival, making it a potential target for therapeutic interventions. 2. **Antibiotic Resistance**: DPEP1's role in maintaining antibiotic resistance highlights the importance of its regulation in preventing the spread of antibiotic-resistant bacteria. 3. **Immune Regulation**: DPEP1's involvement in modulating the anti-inflammatory response suggests its potential as a therapeutic target for treating immune-related disorders. 4. **Cancer**: DPEP1's role in protein degradation and cell signaling pathways may have implications for cancer research, particularly in the context of tumor growth and metastasis. In conclusion, DPEP1 is a multifunctional enzyme involved in various cellular processes, including antibiotic metabolic process, anti-inflammatory response, cellular response to calcium ion, infectious disease, protein binding, and protein degradation. Its significance in clinical contexts, such as Leishmania infections, antibiotic resistance, immune regulation, and cancer, highlights the importance of further research into its role and regulation.

Genular Protein ID: 2344796580

Symbol: DPEP1_HUMAN

Name: Dipeptidase 1

UniProtKB Accession Codes:

P16444 D3DX80 Q96AK2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 25 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 DrugCentral 1 EC 2 EMBL 9 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 32 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 5 Rhea 5 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8439558

Title: Cloning and structural analysis of genomic DNA for human renal dipeptidase.

PubMed ID: 8439558

DOI: 10.1016/0167-4781(93)90289-p

PubMed ID: 2303490

Title: Primary structure of human microsomal dipeptidase deduced from molecular cloning.

PubMed ID: 2303490

DOI: 10.1016/s0021-9258(19)39692-9

PubMed ID: 7764673

Title: Gene structural analysis and expression of human renal dipeptidase.

PubMed ID: 7764673

DOI: 10.1021/bp00026a002

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2137335

Title: Characterization of the glycosyl-phosphatidylinositol-anchored human renal dipeptidase reveals that it is more extensively glycosylated than the pig enzyme.

PubMed ID: 2137335

DOI: 10.1042/bj2650429

PubMed ID: 2768222

Title: Purification and characterization of human microsomal dipeptidase.

PubMed ID: 2768222

DOI: 10.1093/oxfordjournals.jbchem.a122787

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 6334084

Title: Beta-lactamase activity of purified and partially characterized human renal dipeptidase.

PubMed ID: 6334084

DOI: 10.1016/s0021-9258(17)42642-1

PubMed ID: 2168407

Title: Identification of membrane anchoring site of human renal dipeptidase and construction and expression of a cDNA for its secretory form.

PubMed ID: 2168407

DOI: 10.1016/s0021-9258(18)77261-x

PubMed ID: 8097406

Title: Importance of Glu-125 in the catalytic activity of human renal dipeptidase.

PubMed ID: 8097406

DOI: 10.1016/0167-4838(93)90276-w

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 12144777

Title: Crystal structure of human renal dipeptidase involved in beta-lactam hydrolysis.

PubMed ID: 12144777

DOI: 10.1016/s0022-2836(02)00632-0

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 28413640

Title: Clinicopathological examination of dipeptidase 1 expression in colorectal cancer.

PubMed ID: 28413640

DOI: 10.3892/br.2017.870

PubMed ID: 31442408

Title: Dipeptidase-1 is an adhesion receptor for neutrophil recruitment in lungs and liver.

PubMed ID: 31442408

DOI: 10.1016/j.cell.2019.07.017

PubMed ID: 32325220

Title: Structure of human DPEP3 in complex with the SC-003 antibody Fab fragment reveals basis for lack of dipeptidase activity.

PubMed ID: 32325220

DOI: 10.1016/j.jsb.2020.107512

Sequence Information:

  • Length: 411
  • Mass: 45674
  • Checksum: C8C6474C3479D20D
  • Sequence:
    • MWSGWWLWPL VAVCTADFFR DEAERIMRDS PVIDGHNDLP WQLLDMFNNR LQDERANLTT 
LAGTHTNIPK LRAGFVGGQF WSVYTPCDTQ NKDAVRRTLE QMDVVHRMCR MYPETFLYVT 
SSAGIRQAFR EGKVASLIGV EGGHSIDSSL GVLRALYQLG MRYLTLTHSC NTPWADNWLV 
DTGDSEPQSQ GLSPFGQRVV KELNRLGVLI DLAHVSVATM KATLQLSRAP VIFSHSSAYS 
VCASRRNVPD DVLRLVKQTD SLVMVNFYNN YISCTNKANL SQVADHLDHI KEVAGARAVG 
FGGDFDGVPR VPEGLEDVSK YPDLIAELLR RNWTEAEVKG ALADNLLRVF EAVEQASNLT 
QAPEEEPIPL DQLGGSCRTH YGYSSGASSL HRHWGLLLAS LAPLVLCLSL L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.