Details for: DPEP1

Gene ID: 1800

Symbol: DPEP1

Ensembl ID: ENSG00000015413

Description: dipeptidase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: acinar cell (CL0000622)
    Fold Change: 6.32
    Marker Score: 4457
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 5.75
    Marker Score: 2234
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.26
    Marker Score: 6886.5
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.74
    Marker Score: 4228
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 2.5
    Marker Score: 722
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.09
    Marker Score: 21067
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.91
    Marker Score: 6777.5
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.71
    Marker Score: 4659
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.62
    Marker Score: 609
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.4
    Marker Score: 6703
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.25
    Marker Score: 2944
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.14
    Marker Score: 1574
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.12
    Marker Score: 6791
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251796
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.04
    Marker Score: 658
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 791
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71814
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48038
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.96
    Marker Score: 936
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.94
    Marker Score: 1529
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5304
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.89
    Marker Score: 194
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.89
    Marker Score: 885.5
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.82
    Marker Score: 214
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.74
    Marker Score: 1395.5
  • Cell Name: epithelial fate stem cell (CL0000036)
    Fold Change: 0.72
    Marker Score: 206
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 650
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2932
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.69
    Marker Score: 275
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.66
    Marker Score: 155
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.64
    Marker Score: 613
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.62
    Marker Score: 416
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.61
    Marker Score: 1449
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.61
    Marker Score: 190
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.59
    Marker Score: 143
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 146
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 439
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.55
    Marker Score: 284
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.54
    Marker Score: 947
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.54
    Marker Score: 376
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.54
    Marker Score: 246
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.49
    Marker Score: 123
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.48
    Marker Score: 305
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.47
    Marker Score: 7305
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.46
    Marker Score: 923
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.46
    Marker Score: 126
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 0.46
    Marker Score: 259
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.45
    Marker Score: 907
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.44
    Marker Score: 184
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.44
    Marker Score: 469
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.43
    Marker Score: 113
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.42
    Marker Score: 184
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.42
    Marker Score: 251
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.4
    Marker Score: 148
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.39
    Marker Score: 369
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.38
    Marker Score: 94
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.37
    Marker Score: 192
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.35
    Marker Score: 157
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.34
    Marker Score: 195
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.34
    Marker Score: 222
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.33
    Marker Score: 351
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.33
    Marker Score: 341
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.33
    Marker Score: 135
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.31
    Marker Score: 76
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3
    Marker Score: 219
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.3
    Marker Score: 431
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.3
    Marker Score: 119
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.29
    Marker Score: 311
  • Cell Name: type D enteroendocrine cell (CL0000502)
    Fold Change: 0.29
    Marker Score: 89
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.29
    Marker Score: 907
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.29
    Marker Score: 76
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.29
    Marker Score: 86
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.28
    Marker Score: 533
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.27
    Marker Score: 574
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.27
    Marker Score: 100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.26
    Marker Score: 75
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.25
    Marker Score: 118
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.25
    Marker Score: 57
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.23
    Marker Score: 60.5
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.23
    Marker Score: 67
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.23
    Marker Score: 271.5
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.22
    Marker Score: 50
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.22
    Marker Score: 79
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.22
    Marker Score: 126
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.22
    Marker Score: 182
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 62
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.22
    Marker Score: 70
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.21
    Marker Score: 183
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.21
    Marker Score: 127
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.2
    Marker Score: 163
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.2
    Marker Score: 57
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.2
    Marker Score: 126

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Other Information

**Key characteristics:** * DPEP1 is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is a member of the peptidase family of enzymes. * It has a conserved catalytic domain that is responsible for the hydrolysis of various substrates. * It is expressed in a tissue-dependent manner, with higher expression in immune cells. **Pathways and functions:** * DPEP1 is involved in the activation of the immune response against Leishmania parasites. * It is a key regulator of the inflammatory response, favoring the development of a type 2 immune response. * It helps to clear intracellular pathogens, such as bacteria and fungi, by cleaving their surface proteins. * It also plays a role in the regulation of lipid metabolism and inflammation. **Clinical significance:** * Mutations in the DPEP1 gene have been linked to an increased susceptibility to leishmaniasis. * DPEP1 inhibitors have shown promising results in preclinical models of leishmaniasis, suggesting that it could be a potential therapeutic target. * Understanding the role of DPEP1 in leishmaniasis could lead to the development of new diagnostic and therapeutic strategies. **Additional notes:** * DPEP1 is also involved in other immune responses, such as allergic responses and inflammation. * It is a key regulator of the immune response to pathogens, and its expression and activity are tightly controlled by various factors, including cytokines and chemokines.

Genular Protein ID: 2344796580

Symbol: DPEP1_HUMAN

Name: Dipeptidase 1

UniProtKB Accession Codes:

P16444 D3DX80 Q96AK2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 25 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 DrugCentral 1 EC 2 EMBL 9 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 32 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 5 Rhea 5 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8439558

Title: Cloning and structural analysis of genomic DNA for human renal dipeptidase.

PubMed ID: 8439558

DOI: 10.1016/0167-4781(93)90289-p

PubMed ID: 2303490

Title: Primary structure of human microsomal dipeptidase deduced from molecular cloning.

PubMed ID: 2303490

DOI: 10.1016/s0021-9258(19)39692-9

PubMed ID: 7764673

Title: Gene structural analysis and expression of human renal dipeptidase.

PubMed ID: 7764673

DOI: 10.1021/bp00026a002

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2137335

Title: Characterization of the glycosyl-phosphatidylinositol-anchored human renal dipeptidase reveals that it is more extensively glycosylated than the pig enzyme.

PubMed ID: 2137335

DOI: 10.1042/bj2650429

PubMed ID: 2768222

Title: Purification and characterization of human microsomal dipeptidase.

PubMed ID: 2768222

DOI: 10.1093/oxfordjournals.jbchem.a122787

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 6334084

Title: Beta-lactamase activity of purified and partially characterized human renal dipeptidase.

PubMed ID: 6334084

DOI: 10.1016/s0021-9258(17)42642-1

PubMed ID: 2168407

Title: Identification of membrane anchoring site of human renal dipeptidase and construction and expression of a cDNA for its secretory form.

PubMed ID: 2168407

DOI: 10.1016/s0021-9258(18)77261-x

PubMed ID: 8097406

Title: Importance of Glu-125 in the catalytic activity of human renal dipeptidase.

PubMed ID: 8097406

DOI: 10.1016/0167-4838(93)90276-w

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 12144777

Title: Crystal structure of human renal dipeptidase involved in beta-lactam hydrolysis.

PubMed ID: 12144777

DOI: 10.1016/s0022-2836(02)00632-0

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 28413640

Title: Clinicopathological examination of dipeptidase 1 expression in colorectal cancer.

PubMed ID: 28413640

DOI: 10.3892/br.2017.870

PubMed ID: 31442408

Title: Dipeptidase-1 is an adhesion receptor for neutrophil recruitment in lungs and liver.

PubMed ID: 31442408

DOI: 10.1016/j.cell.2019.07.017

PubMed ID: 32325220

Title: Structure of human DPEP3 in complex with the SC-003 antibody Fab fragment reveals basis for lack of dipeptidase activity.

PubMed ID: 32325220

DOI: 10.1016/j.jsb.2020.107512

Sequence Information:

  • Length: 411
  • Mass: 45674
  • Checksum: C8C6474C3479D20D
  • Sequence:
    • MWSGWWLWPL VAVCTADFFR DEAERIMRDS PVIDGHNDLP WQLLDMFNNR LQDERANLTT 
LAGTHTNIPK LRAGFVGGQF WSVYTPCDTQ NKDAVRRTLE QMDVVHRMCR MYPETFLYVT 
SSAGIRQAFR EGKVASLIGV EGGHSIDSSL GVLRALYQLG MRYLTLTHSC NTPWADNWLV 
DTGDSEPQSQ GLSPFGQRVV KELNRLGVLI DLAHVSVATM KATLQLSRAP VIFSHSSAYS 
VCASRRNVPD DVLRLVKQTD SLVMVNFYNN YISCTNKANL SQVADHLDHI KEVAGARAVG 
FGGDFDGVPR VPEGLEDVSK YPDLIAELLR RNWTEAEVKG ALADNLLRVF EAVEQASNLT 
QAPEEEPIPL DQLGGSCRTH YGYSSGASSL HRHWGLLLAS LAPLVLCLSL L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.