Details for: MT1G

Gene ID: 4495

Symbol: MT1G

Ensembl ID: ENSG00000125144

Description: metallothionein 1G

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 281.0569
    Cell Significance Index: 141.1500
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 147.9955
    Cell Significance Index: -23.0200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 91.7430
    Cell Significance Index: -23.2700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 62.1195
    Cell Significance Index: -25.5900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 51.4273
    Cell Significance Index: -24.2800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 35.9750
    Cell Significance Index: -24.1400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.7192
    Cell Significance Index: -23.0800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.5671
    Cell Significance Index: -22.9500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.8616
    Cell Significance Index: -23.1300
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 4.8002
    Cell Significance Index: 17.8900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 4.0022
    Cell Significance Index: 240.2700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 3.9730
    Cell Significance Index: 65.4700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 3.7400
    Cell Significance Index: 56.3600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.4121
    Cell Significance Index: -10.4800
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 3.3873
    Cell Significance Index: 12.9700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.1940
    Cell Significance Index: 545.4000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 2.5125
    Cell Significance Index: 198.9900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.3245
    Cell Significance Index: 15.7500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.0858
    Cell Significance Index: 60.1000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 2.0516
    Cell Significance Index: 64.8900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.9510
    Cell Significance Index: 212.2100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.9307
    Cell Significance Index: 1743.3000
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.8848
    Cell Significance Index: 8.1100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.8771
    Cell Significance Index: 31.6200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.4882
    Cell Significance Index: 22.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2082
    Cell Significance Index: 54.7700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.1132
    Cell Significance Index: 16.4300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9748
    Cell Significance Index: 67.4200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.9288
    Cell Significance Index: 69.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.9232
    Cell Significance Index: 29.5700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.5723
    Cell Significance Index: 65.3300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5124
    Cell Significance Index: 50.6900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5010
    Cell Significance Index: 64.7200
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.4913
    Cell Significance Index: 3.4600
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.4584
    Cell Significance Index: 2.6400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4512
    Cell Significance Index: 12.2800
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.4282
    Cell Significance Index: 4.3200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.4262
    Cell Significance Index: 122.6300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.3915
    Cell Significance Index: 44.8600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3732
    Cell Significance Index: 71.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3283
    Cell Significance Index: 15.4300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3263
    Cell Significance Index: 64.7500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.2801
    Cell Significance Index: 2.9000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.2735
    Cell Significance Index: 4.6000
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.2589
    Cell Significance Index: 1.5200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2374
    Cell Significance Index: 129.6300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2128
    Cell Significance Index: 24.8000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1912
    Cell Significance Index: 84.5400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1551
    Cell Significance Index: 117.3700
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.1191
    Cell Significance Index: 0.7400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1143
    Cell Significance Index: 83.7800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0461
    Cell Significance Index: 71.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0304
    Cell Significance Index: 56.1400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0259
    Cell Significance Index: 0.9100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0210
    Cell Significance Index: 28.5700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0022
    Cell Significance Index: -1.6100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0037
    Cell Significance Index: -2.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0071
    Cell Significance Index: -13.3600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0090
    Cell Significance Index: -5.6100
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0131
    Cell Significance Index: -0.1000
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0151
    Cell Significance Index: -0.1200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0205
    Cell Significance Index: -0.2800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0210
    Cell Significance Index: -2.8800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0369
    Cell Significance Index: -4.7300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0407
    Cell Significance Index: -25.8700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0420
    Cell Significance Index: -1.7200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.0439
    Cell Significance Index: -0.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0442
    Cell Significance Index: -9.3100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0466
    Cell Significance Index: -1.0100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0536
    Cell Significance Index: -1.3400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0549
    Cell Significance Index: -19.7000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0600
    Cell Significance Index: -27.2400
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -0.0777
    Cell Significance Index: -0.3700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0860
    Cell Significance Index: -6.0800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0907
    Cell Significance Index: -0.7400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1085
    Cell Significance Index: -21.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1202
    Cell Significance Index: -21.6700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1262
    Cell Significance Index: -6.3800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1269
    Cell Significance Index: -12.9700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1308
    Cell Significance Index: -2.7900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1464
    Cell Significance Index: -3.9100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1599
    Cell Significance Index: -4.4700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1663
    Cell Significance Index: -10.4800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1722
    Cell Significance Index: -21.1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1734
    Cell Significance Index: -25.2100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1973
    Cell Significance Index: -12.7300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2146
    Cell Significance Index: -13.1600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2228
    Cell Significance Index: -26.2800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2253
    Cell Significance Index: -23.4600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.3000
    Cell Significance Index: -2.5200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3023
    Cell Significance Index: -5.3400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3036
    Cell Significance Index: -5.2500
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.3256
    Cell Significance Index: -2.0200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3286
    Cell Significance Index: -25.2200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3300
    Cell Significance Index: -6.4400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.3374
    Cell Significance Index: -5.2200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3407
    Cell Significance Index: -22.9100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3510
    Cell Significance Index: -18.4300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3758
    Cell Significance Index: -9.6600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3975
    Cell Significance Index: -8.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MT1G is a type of metallothionein, a family of low-molecular-weight, cysteine-rich proteins that are capable of binding metals through thiol groups. MT1G is specifically expressed in cells that are exposed to high levels of metal ions, such as copper, zinc, and cadmium. Its high affinity for these metals allows MT1G to regulate their levels within the cell, preventing oxidative stress and damage to cellular components. MT1G is also involved in the regulation of growth and differentiation, as well as the negative regulation of cell proliferation. **Pathways and Functions:** MT1G plays a crucial role in maintaining cellular homeostasis by regulating the levels of essential and toxic metals. Its primary functions include: 1. **Detoxification of copper ion:** MT1G binds copper ions, preventing their accumulation in the cell and reducing the risk of oxidative stress. 2. **Intracellular zinc ion homeostasis:** MT1G regulates the levels of zinc ions within the cell, ensuring that they are available for essential biological processes while preventing their accumulation, which can lead to toxicity. 3. **Metal ion binding:** MT1G binds to various metal ions, including cadmium, copper, and zinc, preventing their accumulation in the cell and reducing the risk of oxidative stress. 4. **Regulation of growth and differentiation:** MT1G is involved in the regulation of cell growth and differentiation, as well as the negative regulation of cell proliferation. 5. **Monocyte activation and differentiation:** MT1G is also involved in the regulation of monocyte activation and differentiation, which is essential for the maintenance of immune homeostasis. **Clinical Significance:** The dysregulation of MT1G has been implicated in various diseases, including: 1. **Cancer:** Abnormal expression of MT1G has been observed in various types of cancer, including prostate, breast, and lung cancer. MT1G may play a role in the regulation of cell growth and differentiation, and its dysregulation may contribute to tumorigenesis. 2. **Neurodegenerative diseases:** MT1G has been implicated in the regulation of copper ion homeostasis in the brain, and its dysregulation may contribute to neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 3. **Copper toxicity:** MT1G may play a role in the regulation of copper ion homeostasis, and its dysregulation may contribute to copper toxicity, which can lead to various diseases, including liver and kidney damage. In conclusion, MT1G is a crucial gene that plays a vital role in maintaining cellular homeostasis by regulating the levels of essential and toxic metals. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and clinical significance of MT1G.

Genular Protein ID: 3774264841

Symbol: MT1G_HUMAN

Name: Metallothionein-1G

UniProtKB Accession Codes:

P13640 P80296

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 28 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3403543

Title: Structure and expression of the human metallothionein-IG gene. Differential promoter activity of two linked metallothionein-I genes in response to heavy metals.

PubMed ID: 3403543

DOI: 10.1016/s0021-9258(18)37990-0

PubMed ID: 2444457

Title: Structure and expression of the human metallothionein genes.

PubMed ID: 2444457

DOI: 10.1007/978-3-0348-6784-9_34

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8119276

Title: Induction by zinc of specific metallothionein isoforms in human monocytes.

PubMed ID: 8119276

DOI: 10.1111/j.1432-1033.1994.tb18603.x

Sequence Information:

  • Length: 62
  • Mass: 6141
  • Checksum: A1B390F5899DD040
  • Sequence:
    • MDPNCSCAAA GVSCTCASSC KCKECKCTSC KKSCCSCCPV GCAKCAQGCI CKGASEKCSC 
CA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.