Details for: NEUROD1

Gene ID: 4760

Symbol: NEUROD1

Ensembl ID: ENSG00000162992

Description: neuronal differentiation 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 10.0855
    Cell Significance Index: 635.6600
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 7.9854
    Cell Significance Index: 45.3900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 7.1291
    Cell Significance Index: 54.9500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.0184
    Cell Significance Index: 210.9800
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 3.9615
    Cell Significance Index: 55.6400
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 3.1208
    Cell Significance Index: 34.6500
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.5674
    Cell Significance Index: 17.8500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2228
    Cell Significance Index: 232.7100
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 1.1273
    Cell Significance Index: 9.9300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.0185
    Cell Significance Index: 24.6700
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.9984
    Cell Significance Index: 10.8400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8644
    Cell Significance Index: 85.5100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8037
    Cell Significance Index: 725.6900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.7247
    Cell Significance Index: 8.7900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.6867
    Cell Significance Index: 78.3900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.6312
    Cell Significance Index: 13.8200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5205
    Cell Significance Index: 56.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4952
    Cell Significance Index: 27.7900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4783
    Cell Significance Index: 77.8000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4291
    Cell Significance Index: 25.7600
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.2990
    Cell Significance Index: 3.4000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2838
    Cell Significance Index: 19.6300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2013
    Cell Significance Index: 3.4500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1611
    Cell Significance Index: 7.3000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1141
    Cell Significance Index: 1.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1045
    Cell Significance Index: 3.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0703
    Cell Significance Index: 14.1100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0619
    Cell Significance Index: 1.0200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0524
    Cell Significance Index: 1.1400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0205
    Cell Significance Index: 0.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.0194
    Cell Significance Index: 4.0800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0183
    Cell Significance Index: 0.1000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0080
    Cell Significance Index: 0.1200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0052
    Cell Significance Index: 0.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0046
    Cell Significance Index: 3.4100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0016
    Cell Significance Index: 0.1000
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0009
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0019
    Cell Significance Index: -1.1900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0028
    Cell Significance Index: -0.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0032
    Cell Significance Index: -0.1500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0054
    Cell Significance Index: -0.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0065
    Cell Significance Index: -2.3400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0067
    Cell Significance Index: -3.7900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0067
    Cell Significance Index: -1.1400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0132
    Cell Significance Index: -9.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0191
    Cell Significance Index: -10.4400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0244
    Cell Significance Index: -0.5200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0309
    Cell Significance Index: -0.9900
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: -0.0321
    Cell Significance Index: -0.2600
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0362
    Cell Significance Index: -0.5000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0410
    Cell Significance Index: -11.8100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0493
    Cell Significance Index: -7.1700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0504
    Cell Significance Index: -5.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0582
    Cell Significance Index: -10.4900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0631
    Cell Significance Index: -1.6600
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0689
    Cell Significance Index: -0.8600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0865
    Cell Significance Index: -10.6300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0871
    Cell Significance Index: -1.6100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0971
    Cell Significance Index: -5.0500
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0975
    Cell Significance Index: -0.7500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1017
    Cell Significance Index: -7.8100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1087
    Cell Significance Index: -11.1000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1222
    Cell Significance Index: -9.6800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1456
    Cell Significance Index: -9.7900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1561
    Cell Significance Index: -2.2800
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.1645
    Cell Significance Index: -1.8400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1790
    Cell Significance Index: -11.0000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2204
    Cell Significance Index: -7.7200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2252
    Cell Significance Index: -5.6300
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: -0.2364
    Cell Significance Index: -2.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2413
    Cell Significance Index: -11.3400
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.2474
    Cell Significance Index: -2.6600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2515
    Cell Significance Index: -3.9900
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.2666
    Cell Significance Index: -3.6500
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.2696
    Cell Significance Index: -3.1200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2776
    Cell Significance Index: -9.0900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2878
    Cell Significance Index: -3.5700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2888
    Cell Significance Index: -2.9900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2962
    Cell Significance Index: -6.2000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2968
    Cell Significance Index: -4.0500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2985
    Cell Significance Index: -4.1400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3291
    Cell Significance Index: -10.4800
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.3320
    Cell Significance Index: -3.2500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3480
    Cell Significance Index: -9.9300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.3568
    Cell Significance Index: -6.1500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3621
    Cell Significance Index: -11.4500
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.3821
    Cell Significance Index: -2.6500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3847
    Cell Significance Index: -10.4700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3925
    Cell Significance Index: -11.5600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3926
    Cell Significance Index: -10.0300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.3943
    Cell Significance Index: -4.0800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3967
    Cell Significance Index: -10.6300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4059
    Cell Significance Index: -11.6400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.4080
    Cell Significance Index: -10.4000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4153
    Cell Significance Index: -11.0900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.4337
    Cell Significance Index: -8.4800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4370
    Cell Significance Index: -10.9000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4564
    Cell Significance Index: -9.8600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.4636
    Cell Significance Index: -6.6000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.4674
    Cell Significance Index: -9.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Transcription Factor**: NEUROD1 is a transcription factor that regulates gene expression by binding to specific DNA sequences, thereby influencing the transcription of target genes. 2. **Neuronal Differentiation**: NEUROD1 is essential for the differentiation of neurons from progenitor cells, promoting the expression of neuronal-specific genes. 3. **Endocrine Cell Differentiation**: NEUROD1 also regulates the differentiation of endocrine cells, including pancreatic beta cells and enteroendocrine cells. 4. **Regulation of Gene Expression**: NEUROD1 interacts with other transcription factors and signaling pathways to regulate the expression of genes involved in neuronal and endocrine development, survival, and function. 5. **Disease Implications**: Dysregulation of NEUROD1 has been implicated in various neurological and metabolic disorders, including diabetes, epilepsy, and neurodegenerative diseases. **Pathways and Functions** 1. **Amacrine Cell Differentiation**: NEUROD1 regulates the differentiation of amacrine cells, a type of interneuron in the retina, which is essential for visual processing. 2. **Anterior/Posterior Pattern Specification**: NEUROD1 interacts with other transcription factors to regulate the specification of anterior-posterior patterning in the developing nervous system. 3. **Axon Development**: NEUROD1 regulates the development of axons, which is essential for neuronal migration and connectivity. 4. **Cellular Response to Glucose Stimulus**: NEUROD1 regulates the response of pancreatic beta cells to glucose, which is critical for glucose homeostasis. 5. **Chromatin Regulation**: NEUROD1 interacts with chromatin-modifying enzymes to regulate chromatin structure and gene expression. **Clinical Significance** 1. **Diabetes**: Dysregulation of NEUROD1 has been implicated in the development of type 2 diabetes, as it affects pancreatic beta cell function and insulin secretion. 2. **Epilepsy**: NEUROD1 dysregulation has been linked to epilepsy, as it affects neuronal development and function. 3. **Neurodegenerative Diseases**: NEUROD1 dysregulation has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, as it affects neuronal survival and function. 4. **Endocrine Disorders**: NEUROD1 dysregulation has been linked to endocrine disorders, including pancreatic islet cell tumors and hypoglycemia. 5. **Gene Therapy**: NEUROD1 may serve as a therapeutic target for the treatment of neurological and metabolic disorders, particularly in the context of gene editing technologies. In conclusion, NEUROD1 is a critical transcription factor that regulates neuronal and endocrine development, survival, and function. Its dysregulation has been implicated in various neurological and metabolic disorders, highlighting the importance of NEUROD1 in maintaining normal physiological function. Further research is needed to fully understand the mechanisms of NEUROD1 and its role in human disease.

Genular Protein ID: 3920582594

Symbol: NDF1_HUMAN

Name: Neurogenic differentiation factor 1

UniProtKB Accession Codes:

Q13562 B2R9I8 F1T0E1 O00343 Q13340 Q5U095 Q96TH0 Q99455 Q9UEC8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 CarbonylDB 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 17 Ensembl 3 ExpressionAtlas 1 GO 46 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8786144

Title: The NEUROD gene maps to human chromosome 2q32 and mouse chromosome 2.

PubMed ID: 8786144

DOI: 10.1006/geno.1996.0306

PubMed ID: 8915591

Title: Molecular cloning of a human neuroD from a neuroblastoma cell line specifically expressed in the fetal brain and adult cerebellum.

PubMed ID: 8915591

DOI: 10.1016/s0169-328x(96)00154-4

PubMed ID: 10366743

Title: Structure and regulation of the human NeuroD (BETA2/BHF1) gene.

PubMed ID: 10366743

DOI: 10.1016/s0169-328x(99)00112-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 21697133

Title: Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.

PubMed ID: 21697133

DOI: 10.1167/iovs.11-7479

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9144558

Title: cDNA cloning and expression analysis of NeuroD mRNA in human retina.

PubMed ID: 9144558

DOI: 10.1006/bbrc.1997.6483

PubMed ID: 12482979

Title: Novel transcriptional potentiation of BETA2/NeuroD on the secretin gene promoter by the DNA-binding protein Finb/RREB-1.

PubMed ID: 12482979

DOI: 10.1128/mcb.23.1.259-271.2003

PubMed ID: 14752053

Title: Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD.

PubMed ID: 14752053

DOI: 10.1210/me.2003-0311

PubMed ID: 10545951

Title: Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus.

PubMed ID: 10545951

DOI: 10.1038/15500

PubMed ID: 11719843

Title: MODY in Iceland is associated with mutations in HNF-1alpha and a novel mutation in NeuroD1.

PubMed ID: 11719843

DOI: 10.1007/s001250100016

PubMed ID: 25477324

Title: A homozygous missense mutation in NEUROD1 is associated with nonsyndromic autosomal recessive retinitis pigmentosa.

PubMed ID: 25477324

DOI: 10.1167/iovs.14-15382

PubMed ID: 26773576

Title: A family with the Arg103Pro mutation in the NEUROD1 gene detected by next-generation sequencing - Clinical characteristics of mutation carriers.

PubMed ID: 26773576

DOI: 10.1016/j.ejmg.2016.01.002

Sequence Information:

  • Length: 356
  • Mass: 39920
  • Checksum: B78075D1CF66E943
  • Sequence:
    • MTKSYSESGL MGEPQPQGPP SWTDECLSSQ DEEHEADKKE DDLETMNAEE DSLRNGGEEE 
DEDEDLEEEE EEEEEDDDQK PKRRGPKKKK MTKARLERFK LRRMKANARE RNRMHGLNAA 
LDNLRKVVPC YSKTQKLSKI ETLRLAKNYI WALSEILRSG KSPDLVSFVQ TLCKGLSQPT 
TNLVAGCLQL NPRTFLPEQN QDMPPHLPTA SASFPVHPYS YQSPGLPSPP YGTMDSSHVF 
HVKPPPHAYS AALEPFFESP LTDCTSPSFD GPLSPPLSIN GNFSFKHEPS AEFEKNYAFT 
MHYPAATLAG AQSHGSIFSG TAAPRCEIPI DNIMSFDSHS HHERVMSAQL NAIFHD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.