Details for: SCG3

Gene ID: 29106

Symbol: SCG3

Ensembl ID: ENSG00000104112

Description: secretogranin III

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 4.2622
    Cell Significance Index: 268.6300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 3.8662
    Cell Significance Index: 29.8000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.8524
    Cell Significance Index: 149.7600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.0764
    Cell Significance Index: 94.1200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.9601
    Cell Significance Index: 120.4800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.8734
    Cell Significance Index: 44.9300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5058
    Cell Significance Index: 302.0600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.3858
    Cell Significance Index: 16.5200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.1936
    Cell Significance Index: 14.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.9723
    Cell Significance Index: 31.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9426
    Cell Significance Index: 338.1000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8195
    Cell Significance Index: 739.9200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7208
    Cell Significance Index: 71.3000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4305
    Cell Significance Index: 70.0100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3545
    Cell Significance Index: 19.8900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3151
    Cell Significance Index: 59.9700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3075
    Cell Significance Index: 33.4500
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.3072
    Cell Significance Index: 3.2000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2770
    Cell Significance Index: 191.5600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2619
    Cell Significance Index: 17.6100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2224
    Cell Significance Index: 4.8700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0902
    Cell Significance Index: 2.6000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0837
    Cell Significance Index: 5.7900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0420
    Cell Significance Index: 0.7200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0326
    Cell Significance Index: 1.9600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0228
    Cell Significance Index: 0.8000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0081
    Cell Significance Index: 5.9700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.0075
    Cell Significance Index: 1.5700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0065
    Cell Significance Index: -0.2800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0090
    Cell Significance Index: -5.5900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0204
    Cell Significance Index: -37.6800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0213
    Cell Significance Index: -40.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0247
    Cell Significance Index: -38.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0286
    Cell Significance Index: -38.8200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0332
    Cell Significance Index: -18.7100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0514
    Cell Significance Index: -22.7300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0517
    Cell Significance Index: -1.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0562
    Cell Significance Index: -42.5400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0618
    Cell Significance Index: -39.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0628
    Cell Significance Index: -34.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0828
    Cell Significance Index: -37.5900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1103
    Cell Significance Index: -18.8400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1171
    Cell Significance Index: -33.7000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1655
    Cell Significance Index: -7.3200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1768
    Cell Significance Index: -22.6700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1894
    Cell Significance Index: -2.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1936
    Cell Significance Index: -34.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.2031
    Cell Significance Index: -40.3100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2076
    Cell Significance Index: -12.7300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2523
    Cell Significance Index: -7.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2674
    Cell Significance Index: -38.8700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2720
    Cell Significance Index: -37.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2862
    Cell Significance Index: -35.1900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2963
    Cell Significance Index: -11.2200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3040
    Cell Significance Index: -31.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3095
    Cell Significance Index: -39.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3165
    Cell Significance Index: -36.2600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3335
    Cell Significance Index: -38.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3411
    Cell Significance Index: -39.7500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3560
    Cell Significance Index: -10.1600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3693
    Cell Significance Index: -7.8700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3969
    Cell Significance Index: -41.3300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4142
    Cell Significance Index: -8.7900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4177
    Cell Significance Index: -8.2600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4288
    Cell Significance Index: -14.0400
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.4411
    Cell Significance Index: -2.8700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.4621
    Cell Significance Index: -4.3800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5102
    Cell Significance Index: -16.2500
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.5352
    Cell Significance Index: -7.0100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5422
    Cell Significance Index: -41.6100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5444
    Cell Significance Index: -10.9300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6846
    Cell Significance Index: -35.6600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.7156
    Cell Significance Index: -15.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.7421
    Cell Significance Index: -34.6000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.8160
    Cell Significance Index: -22.2100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.8195
    Cell Significance Index: -42.5700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.8398
    Cell Significance Index: -39.4700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.8627
    Cell Significance Index: -22.1800
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.8737
    Cell Significance Index: -9.8700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8846
    Cell Significance Index: -30.9900
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.9439
    Cell Significance Index: -8.3200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.9667
    Cell Significance Index: -6.5500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.9677
    Cell Significance Index: -20.0800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.0016
    Cell Significance Index: -12.4900
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -1.0326
    Cell Significance Index: -14.4400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -1.0556
    Cell Significance Index: -11.5000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.0833
    Cell Significance Index: -18.7300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -1.0856
    Cell Significance Index: -26.3000
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -1.0890
    Cell Significance Index: -13.2000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -1.1260
    Cell Significance Index: -16.1300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.1368
    Cell Significance Index: -24.3000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.1445
    Cell Significance Index: -28.5500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -1.1453
    Cell Significance Index: -17.7200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -1.1551
    Cell Significance Index: -13.2200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.1692
    Cell Significance Index: -40.6300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -1.2119
    Cell Significance Index: -19.9700
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -1.2130
    Cell Significance Index: -10.0100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -1.2590
    Cell Significance Index: -15.8900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.2641
    Cell Significance Index: -31.6000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.2710
    Cell Significance Index: -26.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SCG3 is a small, secreted protein (~12 kDa) that is predominantly expressed in the endocrine and nervous systems. It is highly conserved across species, suggesting its essential role in maintaining cellular homeostasis. SCG3 is characterized by its ability to bind to various proteins, including insulin-like growth factor binding proteins (IGFBPs), which regulates the transport and uptake of insulin-like growth factor (IGF). This interaction is crucial for maintaining IGF homeostasis, which is vital for cell growth, differentiation, and survival. **Pathways and Functions:** SCG3 is involved in several cellular pathways, including: 1. **Protein Degradation:** SCG3 is a protease that cleaves and regulates the activity of various proteins, including proteases, kinases, and receptors. This process is essential for maintaining protein homeostasis and regulating cellular signaling. 2. **Insulin-like Growth Factor (IGF) Transport and Uptake:** SCG3 binds to IGFBPs, regulating the transport and uptake of IGF. This interaction is crucial for maintaining IGF homeostasis and preventing excessive IGF activity, which can lead to cellular overgrowth and tumorigenesis. 3. **Platelet Activation and Aggregation:** SCG3 is involved in platelet activation and aggregation, which is essential for blood clotting and wound healing. 4. **Regulation of Calcium Homeostasis:** SCG3 regulates calcium homeostasis by modulating the activity of calcium-dependent proteases and kinases. **Clinical Significance:** Dysregulation of SCG3 has been implicated in various human diseases, including: 1. **Neurological Disorders:** SCG3 mutations have been associated with neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Cancer:** SCG3 overexpression has been linked to tumorigenesis and cancer progression in various types of cancer, including breast, lung, and colon cancer. 3. **Endocrine Disorders:** SCG3 dysregulation has been implicated in endocrine disorders, such as diabetes and hypoglycemia. 4. **Cardiovascular Disease:** SCG3 overexpression has been linked to cardiovascular disease, including hypertension and atherosclerosis. In conclusion, SCG3 is a multifunctional protein that plays a critical role in various cellular processes, including protein degradation, IGF transport and uptake, platelet activation, and calcium homeostasis. Dysregulation of SCG3 has been implicated in various human diseases, highlighting the importance of understanding its role in maintaining cellular homeostasis. Further research is needed to elucidate the mechanisms underlying SCG3 dysregulation and to explore its potential as a therapeutic target for disease prevention and treatment.

Genular Protein ID: 4056837395

Symbol: SCG3_HUMAN

Name: Secretogranin-3

UniProtKB Accession Codes:

Q8WXD2 A8K2B0 B3KQP6 B4DK99 F5H3R8 Q96C83 Q96GE8 Q9Y6G7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 2 ExpressionAtlas 1 GO 7 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12098761

Title: Cloning and characterization of a novel human secretory protein: secretogranin III.

PubMed ID: 12098761

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17200173

Title: Functional single-nucleotide polymorphisms in the secretogranin III (SCG3) gene that form secretory granules with appetite-related neuropeptides are associated with obesity.

PubMed ID: 17200173

DOI: 10.1210/jc.2006-1808

PubMed ID: 19357184

Title: Secretogranin II binds to secretogranin III and forms secretory granules with orexin, neuropeptide Y, and POMC.

PubMed ID: 19357184

DOI: 10.1677/joe-08-0531

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

PubMed ID: 25326458

Title: Identification of chondroitin sulfate linkage region glycopeptides reveals prohormones as a novel class of proteoglycans.

PubMed ID: 25326458

DOI: 10.1074/mcp.m114.043703

PubMed ID: 29154827

Title: Secretogranin III promotes angiogenesis through MEK/ERK signaling pathway.

PubMed ID: 29154827

DOI: 10.1016/j.bbrc.2017.11.080

Sequence Information:

  • Length: 468
  • Mass: 53005
  • Checksum: 5E6BBDDFFF3B8D82
  • Sequence:
    • MGFLGTGTWI LVLVLPIQAF PKPGGSQDKS LHNRELSAER PLNEQIAEAE EDKIKKTYPP 
ENKPGQSNYS FVDNLNLLKA ITEKEKIEKE RQSIRSSPLD NKLNVEDVDS TKNRKLIDDY 
DSTKSGLDHK FQDDPDGLHQ LDGTPLTAED IVHKIAARIY EENDRAVFDK IVSKLLNLGL 
ITESQAHTLE DEVAEVLQKL ISKEANNYEE DPNKPTSWTE NQAGKIPEKV TPMAAIQDGL 
AKGENDETVS NTLTLTNGLE RRTKTYSEDN FEELQYFPNF YALLKSIDSE KEAKEKETLI 
TIMKTLIDFV KMMVKYGTIS PEEGVSYLEN LDEMIALQTK NKLEKNATDN ISKLFPAPSE 
KSHEETDSTK EEAAKMEKEY GSLKDSTKDD NSNPGGKTDE PKGKTEAYLE AIRKNIEWLK 
KHDKKGNKED YDLSKMRDFI NKQADAYVEK GILDKEEAEA IKRIYSSL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.