SCG3 | ENSG00000104112 | NCBI 29106

Details for: SCG3

Gene ID: 29106

Symbol: SCG3

Ensembl ID: ENSG00000104112

Description: secretogranin III

Associated with

Hemostasis
(R-HSA-109582)
Metabolism of proteins
(R-HSA-392499)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet degranulation
(R-HSA-114608)
Post-translational protein modification
(R-HSA-597592)
Post-translational protein phosphorylation
(R-HSA-8957275)
Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
(R-HSA-381426)
Response to elevated platelet cytosolic ca2+
(R-HSA-76005)
Endoplasmic reticulum lumen
(GO:0005788)
Extracellular region
(GO:0005576)
Protein binding
(GO:0005515)
Protein localization to secretory granule
(GO:0033366)
Rna binding
(GO:0003723)
Secretory granule lumen
(GO:0034774)
Secretory granule membrane
(GO:0030667)
Transport vesicle membrane
(GO:0030658)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: GABAergic neuron (CL0000617)
Fold Change: 3.33
Marker Score: 13,875
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 2.74
Marker Score: 943
Cell Name: endocrine cell (CL0000163)
Fold Change: 2.63
Marker Score: 1,363
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 2.32
Marker Score: 937
Cell Name: PP cell (CL0000696)
Fold Change: 2.3
Marker Score: 519
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 2.29
Marker Score: 4,656
Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 2.27
Marker Score: 11,922
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 2.25
Marker Score: 840
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 2.06
Marker Score: 2,485
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 2
Marker Score: 2,248
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 1.98
Marker Score: 1,868
Cell Name: chromaffin cell (CL0000166)
Fold Change: 1.97
Marker Score: 2,775
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 1.96
Marker Score: 660
Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 1.76
Marker Score: 829
Cell Name: retinal rod cell (CL0000604)
Fold Change: 1.74
Marker Score: 4,976
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.68
Marker Score: 15,953
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.64
Marker Score: 32,645
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.61
Marker Score: 1,168
Cell Name: stellate neuron (CL0000122)
Fold Change: 1.61
Marker Score: 8,622
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.58
Marker Score: 97,383
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.58
Marker Score: 60,002
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.57
Marker Score: 33,442
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.56
Marker Score: 13,405
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.55
Marker Score: 23,133
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 1.55
Marker Score: 7,151
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.53
Marker Score: 1,526
Cell Name: granule cell (CL0000120)
Fold Change: 1.5
Marker Score: 11,344
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.48
Marker Score: 15,310
Cell Name: motor neuron (CL0000100)
Fold Change: 1.43
Marker Score: 850
Cell Name: neuronal brush cell (CL0000555)
Fold Change: 1.42
Marker Score: 4,768
Cell Name: Purkinje cell (CL0000121)
Fold Change: 1.41
Marker Score: 47,571
Cell Name: neuron (CL0000540)
Fold Change: 1.41
Marker Score: 5,730
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.38
Marker Score: 5,344
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.36
Marker Score: 50,346
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.31
Marker Score: 10,059
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.28
Marker Score: 1,983
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 1.23
Marker Score: 770
Cell Name: macroglial cell (CL0000126)
Fold Change: 1.19
Marker Score: 2,725
Cell Name: rod bipolar cell (CL0000751)
Fold Change: 1.16
Marker Score: 605
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 1.14
Marker Score: 339
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.12
Marker Score: 712
Cell Name: astrocyte (CL0000127)
Fold Change: 1.11
Marker Score: 962
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.1
Marker Score: 4,565
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.09
Marker Score: 503
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.09
Marker Score: 10,249
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 1.09
Marker Score: 473
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 1.09
Marker Score: 562
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 1.08
Marker Score: 439
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.07
Marker Score: 2,185
Cell Name: mature astrocyte (CL0002627)
Fold Change: 1.07
Marker Score: 704
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.05
Marker Score: 708
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.04
Marker Score: 795
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251,799
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,818
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,043
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 509
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,408
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 463
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,413
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5,350
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.94
Marker Score: 1,159
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.94
Marker Score: 375
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,739
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 327
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,287
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.85
Marker Score: 325
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.84
Marker Score: 3,518
Cell Name: mast cell (CL0000097)
Fold Change: 0.84
Marker Score: 485
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.82
Marker Score: 807
Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 0.79
Marker Score: 457
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,261
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 704
Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 0.77
Marker Score: 244
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 398
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.76
Marker Score: 501
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 463
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 180
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.69
Marker Score: 859
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.69
Marker Score: 287
Cell Name: photoreceptor cell (CL0000210)
Fold Change: 0.68
Marker Score: 512
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.64
Marker Score: 235
Cell Name: type L enteroendocrine cell (CL0002279)
Fold Change: 0.64
Marker Score: 174
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.63
Marker Score: 1,185
Cell Name: retina horizontal cell (CL0000745)
Fold Change: 0.6
Marker Score: 578
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.59
Marker Score: 1,228
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 0.59
Marker Score: 553
Cell Name: M cell of gut (CL0000682)
Fold Change: 0.58
Marker Score: 151
Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 0.58
Marker Score: 126
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.56
Marker Score: 149
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 442
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.55
Marker Score: 229
Cell Name: CNS interneuron (CL0000402)
Fold Change: 0.55
Marker Score: 265
Cell Name: type I enteroendocrine cell (CL0002277)
Fold Change: 0.55
Marker Score: 136
Cell Name: ganglion interneuron (CL0000397)
Fold Change: 0.54
Marker Score: 165
Cell Name: neural crest cell (CL0011012)
Fold Change: 0.54
Marker Score: 572
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 0.53
Marker Score: 299
Cell Name: sympathetic neuron (CL0011103)
Fold Change: 0.51
Marker Score: 168
Cell Name: epithelial cell of thymus (CL0002293)
Fold Change: 0.51
Marker Score: 162
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 0.5
Marker Score: 845
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.49
Marker Score: 1,401

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

**Key Characteristics:** SCG3 is a small, secreted protein (~12 kDa) that is predominantly expressed in the endocrine and nervous systems. It is highly conserved across species, suggesting its essential role in maintaining cellular homeostasis. SCG3 is characterized by its ability to bind to various proteins, including insulin-like growth factor binding proteins (IGFBPs), which regulates the transport and uptake of insulin-like growth factor (IGF). This interaction is crucial for maintaining IGF homeostasis, which is vital for cell growth, differentiation, and survival. **Pathways and Functions:** SCG3 is involved in several cellular pathways, including: 1. **Protein Degradation:** SCG3 is a protease that cleaves and regulates the activity of various proteins, including proteases, kinases, and receptors. This process is essential for maintaining protein homeostasis and regulating cellular signaling. 2. **Insulin-like Growth Factor (IGF) Transport and Uptake:** SCG3 binds to IGFBPs, regulating the transport and uptake of IGF. This interaction is crucial for maintaining IGF homeostasis and preventing excessive IGF activity, which can lead to cellular overgrowth and tumorigenesis. 3. **Platelet Activation and Aggregation:** SCG3 is involved in platelet activation and aggregation, which is essential for blood clotting and wound healing. 4. **Regulation of Calcium Homeostasis:** SCG3 regulates calcium homeostasis by modulating the activity of calcium-dependent proteases and kinases. **Clinical Significance:** Dysregulation of SCG3 has been implicated in various human diseases, including: 1. **Neurological Disorders:** SCG3 mutations have been associated with neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Cancer:** SCG3 overexpression has been linked to tumorigenesis and cancer progression in various types of cancer, including breast, lung, and colon cancer. 3. **Endocrine Disorders:** SCG3 dysregulation has been implicated in endocrine disorders, such as diabetes and hypoglycemia. 4. **Cardiovascular Disease:** SCG3 overexpression has been linked to cardiovascular disease, including hypertension and atherosclerosis. In conclusion, SCG3 is a multifunctional protein that plays a critical role in various cellular processes, including protein degradation, IGF transport and uptake, platelet activation, and calcium homeostasis. Dysregulation of SCG3 has been implicated in various human diseases, highlighting the importance of understanding its role in maintaining cellular homeostasis. Further research is needed to elucidate the mechanisms underlying SCG3 dysregulation and to explore its potential as a therapeutic target for disease prevention and treatment.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Secretogranin-3

Genular Protein ID: 4056837395

Symbol: SCG3_HUMAN

Name: Secretogranin-3

UniProtKB Accession Codes:

Q8WXD2 A8K2B0 B3KQP6 B4DK99 F5H3R8 Q96C83 Q96GE8 Q9Y6G7

Database IDs:

Citations:

PubMed ID: 12098761

Title: Cloning and characterization of a novel human secretory protein: secretogranin III.

PubMed ID: 12098761

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17200173

Title: Functional single-nucleotide polymorphisms in the secretogranin III (SCG3) gene that form secretory granules with appetite-related neuropeptides are associated with obesity.

PubMed ID: 17200173

DOI: 10.1210/jc.2006-1808

PubMed ID: 19357184

Title: Secretogranin II binds to secretogranin III and forms secretory granules with orexin, neuropeptide Y, and POMC.

PubMed ID: 19357184

DOI: 10.1677/joe-08-0531

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

PubMed ID: 25326458

Title: Identification of chondroitin sulfate linkage region glycopeptides reveals prohormones as a novel class of proteoglycans.

PubMed ID: 25326458

DOI: 10.1074/mcp.m114.043703

PubMed ID: 29154827

Title: Secretogranin III promotes angiogenesis through MEK/ERK signaling pathway.

PubMed ID: 29154827

DOI: 10.1016/j.bbrc.2017.11.080

Sequence Information:

Length: 468
Mass: 53005
Checksum: 5E6BBDDFFF3B8D82
Sequence:

MGFLGTGTWI LVLVLPIQAF PKPGGSQDKS LHNRELSAER PLNEQIAEAE EDKIKKTYPP 
ENKPGQSNYS FVDNLNLLKA ITEKEKIEKE RQSIRSSPLD NKLNVEDVDS TKNRKLIDDY 
DSTKSGLDHK FQDDPDGLHQ LDGTPLTAED IVHKIAARIY EENDRAVFDK IVSKLLNLGL 
ITESQAHTLE DEVAEVLQKL ISKEANNYEE DPNKPTSWTE NQAGKIPEKV TPMAAIQDGL 
AKGENDETVS NTLTLTNGLE RRTKTYSEDN FEELQYFPNF YALLKSIDSE KEAKEKETLI 
TIMKTLIDFV KMMVKYGTIS PEEGVSYLEN LDEMIALQTK NKLEKNATDN ISKLFPAPSE 
KSHEETDSTK EEAAKMEKEY GSLKDSTKDD NSNPGGKTDE PKGKTEAYLE AIRKNIEWLK 
KHDKKGNKED YDLSKMRDFI NKQADAYVEK GILDKEEAEA IKRIYSSL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SCG3

Associated with

Cells (max top 100)

Other Information

Cloning and characterization of a novel human secretory protein: secretogranin III. PubMed ID: 12098761

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. PubMed ID: 12975309

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Analysis of the DNA sequence and duplication history of human chromosome 15. PubMed ID: 16572171

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Functional single-nucleotide polymorphisms in the secretogranin III (SCG3) gene that form secretory granules with appetite-related neuropeptides are associated with obesity. PubMed ID: 17200173

Secretogranin II binds to secretogranin III and forms secretory granules with orexin, neuropeptide Y, and POMC. PubMed ID: 19357184

LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins. PubMed ID: 23234360

Identification of chondroitin sulfate linkage region glycopeptides reveals prohormones as a novel class of proteoglycans. PubMed ID: 25326458

Secretogranin III promotes angiogenesis through MEK/ERK signaling pathway. PubMed ID: 29154827