Details for: EEF1B2

Gene ID: 1933

Symbol: EEF1B2

Ensembl ID: ENSG00000114942

Description: eukaryotic translation elongation factor 1 beta 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 9.04
    Marker Score: 6820.5
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 5.46
    Marker Score: 3077
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 5.38
    Marker Score: 11271
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 4.8
    Marker Score: 47540
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 4.75
    Marker Score: 8157
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.61
    Marker Score: 243730
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.6
    Marker Score: 14504
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.59
    Marker Score: 156009
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 4.5
    Marker Score: 60413
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 4.45
    Marker Score: 2868
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 4.42
    Marker Score: 3943.5
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 4.25
    Marker Score: 6550.5
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.05
    Marker Score: 9901
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 4.05
    Marker Score: 11367
  • Cell Name: blood cell (CL0000081)
    Fold Change: 4.05
    Marker Score: 47032.5
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.03
    Marker Score: 53191
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 4.03
    Marker Score: 17290
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 3.99
    Marker Score: 11651
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.98
    Marker Score: 3919
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 3.92
    Marker Score: 4351
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 3.91
    Marker Score: 2010
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3.91
    Marker Score: 3777
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 3.9
    Marker Score: 9508
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 3.89
    Marker Score: 2366
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3.88
    Marker Score: 3043
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.83
    Marker Score: 4087
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.78
    Marker Score: 3554
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.78
    Marker Score: 5565
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 3.75
    Marker Score: 4399
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 3.75
    Marker Score: 6841
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.74
    Marker Score: 3901
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 3.74
    Marker Score: 1378
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 3.73
    Marker Score: 2708
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.73
    Marker Score: 8500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 3.7
    Marker Score: 1185
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.69
    Marker Score: 3109
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 3.67
    Marker Score: 6563.5
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.65
    Marker Score: 10073
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.64
    Marker Score: 27126.5
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 3.62
    Marker Score: 2120
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.61
    Marker Score: 23455
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.61
    Marker Score: 201610
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.58
    Marker Score: 3185
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.56
    Marker Score: 3037
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 3.56
    Marker Score: 4297
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 3.53
    Marker Score: 1149
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.52
    Marker Score: 3090
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 3.52
    Marker Score: 2996
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 3.51
    Marker Score: 2658
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 3.47
    Marker Score: 2843
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.46
    Marker Score: 1140
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 3.44
    Marker Score: 2155
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.39
    Marker Score: 3882
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.38
    Marker Score: 26357
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.37
    Marker Score: 805.5
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 3.36
    Marker Score: 2247
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 3.34
    Marker Score: 2214
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.33
    Marker Score: 2386
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 3.32
    Marker Score: 1944
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 3.32
    Marker Score: 2755.5
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 3.3
    Marker Score: 3088
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 3.29
    Marker Score: 16149.5
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.29
    Marker Score: 1642
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.28
    Marker Score: 21411
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 3.27
    Marker Score: 2363
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 3.27
    Marker Score: 1470
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 3.25
    Marker Score: 4597
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.24
    Marker Score: 6089
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.24
    Marker Score: 2550.5
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 3.24
    Marker Score: 1129
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 3.23
    Marker Score: 5305
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.23
    Marker Score: 7339
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 3.2
    Marker Score: 1766
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 3.2
    Marker Score: 2715
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.19
    Marker Score: 110461
  • Cell Name: basophil (CL0000767)
    Fold Change: 3.18
    Marker Score: 1510
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 3.17
    Marker Score: 3505
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 3.17
    Marker Score: 2129
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 3.15
    Marker Score: 2776
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 3.15
    Marker Score: 2189
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 3.14
    Marker Score: 4998
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 3.14
    Marker Score: 1007
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.14
    Marker Score: 2797
  • Cell Name: centroblast (CL0009112)
    Fold Change: 3.13
    Marker Score: 1541
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 3.12
    Marker Score: 4305
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 3.11
    Marker Score: 1025
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 3.11
    Marker Score: 3383.5
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.11
    Marker Score: 16327
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 3.09
    Marker Score: 1862.5
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 3.09
    Marker Score: 2180
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 3.09
    Marker Score: 3087.5
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.09
    Marker Score: 11902
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 3.08
    Marker Score: 2311
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.07
    Marker Score: 9106.5
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 3.07
    Marker Score: 6129
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 3.06
    Marker Score: 1082
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 3.05
    Marker Score: 1369
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.05
    Marker Score: 5934
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 3.04
    Marker Score: 805.5
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 3.04
    Marker Score: 1212

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * EEF1B2 is a protein of the EF1 family, which are a group of proteins that are involved in the initiation and elongation of protein synthesis. * It is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is expressed in a variety of cell types, including hematopoietic stem cells, epithelial cells of the exocrine pancreas, CD38-negative naive B cells, mature T cells, naive thymus-derived CD4-positive, alpha-beta T cell, mature alpha-beta T cell, mature gamma-delta T cell, and fibroblasts of the mammary gland. **Pathways and functions:** * EEF1B2 is a key regulator of protein synthesis by interacting with the EEF1 complex. * The EEF1 complex is responsible for the initial step in protein synthesis, which is the binding of initiator tRNA to the ribosome. * EEF1B2 helps to recruit EEF1 to the ribosome and to facilitate the initiation of translation. * Once translation has begun, EEF1B2 remains bound to the ribosome and helps to promote the elongation of the polypeptide chain. * It is involved in a variety of cellular processes, including cell growth, differentiation, and apoptosis. **Clinical significance:** * Mutations in EEF1B2 have been linked to a number of human diseases, including cancer and autoimmune disorders. * EEF1B2 inhibitors are being investigated as a potential treatment for these diseases.

Genular Protein ID: 3616051159

Symbol: EF1B_HUMAN

Name: Elongation factor 1-beta

UniProtKB Accession Codes:

P24534 A8K795 Q6IBH9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CPTAC 2 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 EMBL 10 EPD 1 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PRIDE 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1886777

Title: Nucleotide sequence of human elongation factor-1 beta cDNA.

PubMed ID: 1886777

DOI: 10.1093/nar/19.16.4551

PubMed ID: 1710449

Title: Human elongation factor 1 beta: cDNA and derived amino acid sequence.

PubMed ID: 1710449

DOI: 10.1016/0006-291x(91)91984-k

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1286669

Title: Human liver protein map: a reference database established by microsequencing and gel comparison.

PubMed ID: 1286669

DOI: 10.1002/elps.11501301201

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 9677419

Title: Induction of acute translational response genes by homocysteine. Elongation factors-1alpha, -beta, and -delta.

PubMed ID: 9677419

DOI: 10.1074/jbc.273.31.19840

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17487921

Title: Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.

PubMed ID: 17487921

DOI: 10.1002/elps.200600782

PubMed ID: 17693683

Title: Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction.

PubMed ID: 17693683

DOI: 10.1074/mcp.m700120-mcp200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 225
  • Mass: 24764
  • Checksum: CDE763ADBF127822
  • Sequence:
    • MGFGDLKSPA GLQVLNDYLA DKSYIEGYVP SQADVAVFEA VSSPPPADLC HALRWYNHIK 
SYEKEKASLP GVKKALGKYG PADVEDTTGS GATDSKDDDD IDLFGSDDEE ESEEAKRLRE 
ERLAQYESKK AKKPALVAKS SILLDVKPWD DETDMAKLEE CVRSIQADGL VWGSSKLVPV 
GYGIKKLQIQ CVVEDDKVGT DMLEEQITAF EDYVQSMDVA AFNKI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.