Details for: EEF1B2

Gene ID: 1933

Symbol: EEF1B2

Ensembl ID: ENSG00000114942

Description: eukaryotic translation elongation factor 1 beta 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 746.9210
    Cell Significance Index: -116.1800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 420.9759
    Cell Significance Index: -173.4200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 414.1220
    Cell Significance Index: -168.2400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 363.6996
    Cell Significance Index: -92.2500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 357.7672
    Cell Significance Index: -168.9100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 350.0295
    Cell Significance Index: -180.0500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 252.2868
    Cell Significance Index: -169.2900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 180.7607
    Cell Significance Index: -172.5800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 118.7309
    Cell Significance Index: -146.3900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 45.3485
    Cell Significance Index: 1130.8600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 41.6898
    Cell Significance Index: -164.5100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 36.9857
    Cell Significance Index: -113.6000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 31.9427
    Cell Significance Index: -85.5700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 25.1349
    Cell Significance Index: -55.0100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 9.2948
    Cell Significance Index: 436.8500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 8.4501
    Cell Significance Index: 195.2300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 8.0638
    Cell Significance Index: 103.2700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 7.4971
    Cell Significance Index: 214.9100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 7.0355
    Cell Significance Index: 497.5800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 6.9815
    Cell Significance Index: 958.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 6.6729
    Cell Significance Index: 862.1000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 6.4170
    Cell Significance Index: 72.9000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 6.2871
    Cell Significance Index: 165.3200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 6.1259
    Cell Significance Index: 395.2200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 5.9395
    Cell Significance Index: 64.5700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 5.6884
    Cell Significance Index: 670.8400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 5.6670
    Cell Significance Index: 696.8100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 5.6170
    Cell Significance Index: 2483.4100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 5.5035
    Cell Significance Index: 992.1200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 5.0434
    Cell Significance Index: 148.1200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 5.0347
    Cell Significance Index: 88.9700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 4.8076
    Cell Significance Index: 100.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 4.6785
    Cell Significance Index: 2555.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.4188
    Cell Significance Index: 206.0300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.8617
    Cell Significance Index: 287.8100
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 3.7961
    Cell Significance Index: 32.6200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.6971
    Cell Significance Index: 34.0500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 3.5204
    Cell Significance Index: 3178.6800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.4001
    Cell Significance Index: 580.5800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.3480
    Cell Significance Index: 91.1300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.8737
    Cell Significance Index: 99.8600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.8629
    Cell Significance Index: 568.1500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.0379
    Cell Significance Index: 201.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.6785
    Cell Significance Index: 215.1700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5197
    Cell Significance Index: 68.8900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.3916
    Cell Significance Index: 25.7200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.1820
    Cell Significance Index: 61.5700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1731
    Cell Significance Index: 60.9400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.1303
    Cell Significance Index: 30.1800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0900
    Cell Significance Index: 177.2900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 1.0272
    Cell Significance Index: 777.5400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4646
    Cell Significance Index: 88.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.2635
    Cell Significance Index: 193.2000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2171
    Cell Significance Index: 11.4000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0860
    Cell Significance Index: 1.4400
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.0477
    Cell Significance Index: 0.2800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0089
    Cell Significance Index: -0.9100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0600
    Cell Significance Index: -44.4400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0613
    Cell Significance Index: -3.6800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0665
    Cell Significance Index: -125.2900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0759
    Cell Significance Index: -3.8400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0912
    Cell Significance Index: -168.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0921
    Cell Significance Index: -18.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1107
    Cell Significance Index: -170.4300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1402
    Cell Significance Index: -190.6500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1418
    Cell Significance Index: -88.5800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1475
    Cell Significance Index: -6.0400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1502
    Cell Significance Index: -4.8100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1710
    Cell Significance Index: -19.5300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1907
    Cell Significance Index: -107.5500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.2419
    Cell Significance Index: -153.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.2710
    Cell Significance Index: -97.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2876
    Cell Significance Index: -60.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.3661
    Cell Significance Index: -166.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3950
    Cell Significance Index: -11.0400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4318
    Cell Significance Index: -11.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.5022
    Cell Significance Index: -144.5100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.6340
    Cell Significance Index: -10.9300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.7052
    Cell Significance Index: -4.3400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.7107
    Cell Significance Index: -81.4200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7825
    Cell Significance Index: -19.5600
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.9800
    Cell Significance Index: -7.4000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.0186
    Cell Significance Index: -80.6700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.0898
    Cell Significance Index: -158.4200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.1041
    Cell Significance Index: -76.3600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -1.1082
    Cell Significance Index: -129.1500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.3936
    Cell Significance Index: -48.9700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.5775
    Cell Significance Index: -164.2600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.7183
    Cell Significance Index: -108.3000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.8061
    Cell Significance Index: -101.3500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.8397
    Cell Significance Index: -19.0500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -1.9351
    Cell Significance Index: -15.4500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -2.1646
    Cell Significance Index: -166.1100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -2.2337
    Cell Significance Index: -12.1800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -2.3327
    Cell Significance Index: -67.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.3615
    Cell Significance Index: -144.7800
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -2.6098
    Cell Significance Index: -54.4300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -2.7144
    Cell Significance Index: -16.4000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -2.9578
    Cell Significance Index: -44.3200
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -2.9671
    Cell Significance Index: -13.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EEF1B2 is a highly conserved protein that belongs to the elongation factor 1 family. It is a guanyl-nucleotide exchange factor (GEF) that activates the eEF1E1 complex, which is responsible for the elongation of protein synthesis. EEF1B2 is specifically localized to the cytosol and is highly expressed in various cell types, including hematopoietic stem cells, epithelial cells, and T cells. Its expression is also elevated in malignant cells, suggesting its potential as a biomarker for cancer. **Pathways and Functions:** EEF1B2 is involved in several key pathways, including: 1. **Eukaryotic Translation Elongation:** EEF1B2 plays a crucial role in the elongation phase of protein synthesis, facilitating the binding of aminoacyl-tRNA to the ribosome. 2. **Guanyl-nucleotide Exchange Factor Activity:** EEF1B2 activates the eEF1E1 complex by exchanging GDP for GTP, enabling its activation and subsequent protein synthesis. 3. **Metabolism of Proteins:** EEF1B2 is involved in the regulation of protein synthesis, which in turn affects various cellular processes, including cell growth, differentiation, and survival. 4. **Protein Binding:** EEF1B2 interacts with various proteins, including ribosomal proteins and aminoacyl-tRNA, to regulate protein synthesis. **Clinical Significance:** Dysregulation of EEF1B2 has been implicated in several diseases, including: 1. **Cancer:** Elevated expression of EEF1B2 has been observed in various types of cancer, including leukemia, lymphoma, and breast cancer. This suggests its potential as a biomarker for cancer diagnosis and prognosis. 2. **Neurological Disorders:** EEF1B2 has been implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, where it plays a role in the regulation of protein synthesis and aggregation. 3. **Infectious Diseases:** EEF1B2 has been identified as a target for the treatment of infectious diseases, including tuberculosis and malaria, where it plays a role in the regulation of protein synthesis and cell growth. In conclusion, EEF1B2 is a critical component of the eukaryotic translation elongation factor 1 complex, playing a vital role in the regulation of protein synthesis. Its dysregulation has been implicated in various diseases, highlighting its importance as a therapeutic target. Further research is needed to fully elucidate the mechanisms by which EEF1B2 regulates protein synthesis and its role in disease pathogenesis.

Genular Protein ID: 3616051159

Symbol: EF1B_HUMAN

Name: Elongation factor 1-beta

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1886777

Title: Nucleotide sequence of human elongation factor-1 beta cDNA.

PubMed ID: 1886777

DOI: 10.1093/nar/19.16.4551

PubMed ID: 1710449

Title: Human elongation factor 1 beta: cDNA and derived amino acid sequence.

PubMed ID: 1710449

DOI: 10.1016/0006-291x(91)91984-k

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1286669

Title: Human liver protein map: a reference database established by microsequencing and gel comparison.

PubMed ID: 1286669

DOI: 10.1002/elps.11501301201

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 9677419

Title: Induction of acute translational response genes by homocysteine. Elongation factors-1alpha, -beta, and -delta.

PubMed ID: 9677419

DOI: 10.1074/jbc.273.31.19840

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17487921

Title: Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.

PubMed ID: 17487921

DOI: 10.1002/elps.200600782

PubMed ID: 17693683

Title: Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction.

PubMed ID: 17693683

DOI: 10.1074/mcp.m700120-mcp200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 225
  • Mass: 24764
  • Checksum: CDE763ADBF127822
  • Sequence:
  • MGFGDLKSPA GLQVLNDYLA DKSYIEGYVP SQADVAVFEA VSSPPPADLC HALRWYNHIK 
    SYEKEKASLP GVKKALGKYG PADVEDTTGS GATDSKDDDD IDLFGSDDEE ESEEAKRLRE 
    ERLAQYESKK AKKPALVAKS SILLDVKPWD DETDMAKLEE CVRSIQADGL VWGSSKLVPV 
    GYGIKKLQIQ CVVEDDKVGT DMLEEQITAF EDYVQSMDVA AFNKI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.