Details for: EGR2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 81.9697
Cell Significance Index: -12.7500 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 50.4646
Cell Significance Index: -12.8000 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 27.8457
Cell Significance Index: -11.3100 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 26.7303
Cell Significance Index: -12.6200 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 11.9194
Cell Significance Index: -11.3800 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 10.3410
Cell Significance Index: -12.7500 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 4.3675
Cell Significance Index: -11.7000 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 4.0632
Cell Significance Index: -12.4800 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 3.2285
Cell Significance Index: -12.7400 - Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.3421
Cell Significance Index: 11.1000 - Cell Name: kidney cell (CL1000497)
Fold Change: 1.0352
Cell Significance Index: 8.2700 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.9981
Cell Significance Index: 441.2800 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.7036
Cell Significance Index: 20.1700 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.5973
Cell Significance Index: 113.6700 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.5840
Cell Significance Index: 41.3000 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.5382
Cell Significance Index: 11.6600 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.4026
Cell Significance Index: 11.6000 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.3645
Cell Significance Index: 5.6400 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.3468
Cell Significance Index: 3.7700 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3409
Cell Significance Index: 33.7300 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.3086
Cell Significance Index: 14.3900 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3005
Cell Significance Index: 271.3200 - Cell Name: theca cell (CL0000503)
Fold Change: 0.2996
Cell Significance Index: 1.7600 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2771
Cell Significance Index: 12.5600 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.2658
Cell Significance Index: 13.8100 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.2481
Cell Significance Index: 28.3200 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.2216
Cell Significance Index: 7.7000 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.2083
Cell Significance Index: 25.6100 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.1948
Cell Significance Index: 24.9700 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.1769
Cell Significance Index: 4.8200 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1735
Cell Significance Index: 28.2100 - Cell Name: peg cell (CL4033014)
Fold Change: 0.1718
Cell Significance Index: 3.9700 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.1392
Cell Significance Index: 15.1500 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1114
Cell Significance Index: 20.0900 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0951
Cell Significance Index: 51.9100 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0891
Cell Significance Index: 3.1300 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.0882
Cell Significance Index: 2.3200 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.0498
Cell Significance Index: 2.9900 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0411
Cell Significance Index: 2.8500 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0128
Cell Significance Index: 1.5100 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0083
Cell Significance Index: 1.6600 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0043
Cell Significance Index: 3.1700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0028
Cell Significance Index: 0.3800 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0014
Cell Significance Index: -0.1900 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0032
Cell Significance Index: -2.0200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0060
Cell Significance Index: -11.2300 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0067
Cell Significance Index: -4.9600 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0087
Cell Significance Index: -16.0000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0100
Cell Significance Index: -15.4200 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0103
Cell Significance Index: -5.8100 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0118
Cell Significance Index: -16.0700 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0133
Cell Significance Index: -10.1000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0174
Cell Significance Index: -11.0700 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0198
Cell Significance Index: -0.2700 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.0208
Cell Significance Index: -0.1700 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0216
Cell Significance Index: -2.2100 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.0249
Cell Significance Index: -0.4100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0260
Cell Significance Index: -1.2200 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0286
Cell Significance Index: -12.9900 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0332
Cell Significance Index: -11.9100 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0348
Cell Significance Index: -7.3200 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0419
Cell Significance Index: -7.1500 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0428
Cell Significance Index: -12.3100 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0450
Cell Significance Index: -5.2400 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0513
Cell Significance Index: -10.1800 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0537
Cell Significance Index: -0.6100 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0569
Cell Significance Index: -2.3300 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0578
Cell Significance Index: -6.6200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0656
Cell Significance Index: -9.5300 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0704
Cell Significance Index: -3.5600 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0708
Cell Significance Index: -1.9800 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0943
Cell Significance Index: -5.7800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0982
Cell Significance Index: -7.3200 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0996
Cell Significance Index: -2.4900 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1065
Cell Significance Index: -7.1600 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1233
Cell Significance Index: -12.8400 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.1271
Cell Significance Index: -1.9200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1311
Cell Significance Index: -6.8300 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1431
Cell Significance Index: -11.3300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1483
Cell Significance Index: -4.7500 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.1515
Cell Significance Index: -2.8000 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.1521
Cell Significance Index: -3.2400 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1558
Cell Significance Index: -10.0500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1681
Cell Significance Index: -12.9000 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1742
Cell Significance Index: -5.1300 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1851
Cell Significance Index: -9.7200 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1934
Cell Significance Index: -12.1900 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2017
Cell Significance Index: -11.3200 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.2194
Cell Significance Index: -2.8100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2200
Cell Significance Index: -13.5300 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.2207
Cell Significance Index: -3.1600 - Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: -0.2231
Cell Significance Index: -1.9300 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2277
Cell Significance Index: -6.0900 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2585
Cell Significance Index: -9.4900 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2604
Cell Significance Index: -11.5200 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.2803
Cell Significance Index: -8.0000 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.2814
Cell Significance Index: -4.7100 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.2960
Cell Significance Index: -10.3700 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: -0.3056
Cell Significance Index: -3.1900 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.3109
Cell Significance Index: -6.4500
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1212850806
Symbol: EGR2_HUMAN
Name: E3 SUMO-protein ligase EGR2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3140236
Title: Molecular cloning, sequencing, and mapping of EGR2, a human early growth response gene encoding a protein with 'zinc-binding finger' structure.
PubMed ID: 3140236
PubMed ID: 9537424
Title: Mutations in the early growth response 2 (EGR2) gene are associated with hereditary myelinopathies.
PubMed ID: 9537424
DOI: 10.1038/ng0498-382
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 15164054
Title: The DNA sequence and comparative analysis of human chromosome 10.
PubMed ID: 15164054
DOI: 10.1038/nature02462
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2111009
Title: The serum and TPA responsive promoter and intron-exon structure of EGR2, a human early growth response gene encoding a zinc finger protein.
PubMed ID: 2111009
PubMed ID: 14532282
Title: HCF-1 functions as a coactivator for the zinc finger protein Krox20.
PubMed ID: 14532282
PubMed ID: 19651900
Title: The HECT-type E3 ubiquitin ligase AIP2 inhibits activation-induced T-cell death by catalyzing EGR2 ubiquitination.
PubMed ID: 19651900
DOI: 10.1128/mcb.00407-09
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 21836637
Title: The transcription factor Krox20 is an E3 ligase that sumoylates its Nab coregulators.
PubMed ID: 21836637
PubMed ID: 10502832
Title: A novel mutation (D305V) in the early growth response 2 gene is associated with severe Charcot-Marie-Tooth type 1 disease.
PubMed ID: 10502832
DOI: 10.1002/(sici)1098-1004(199910)14:4<353::aid-humu17>3.0.co;2-4
PubMed ID: 10371530
Title: Novel missense mutation in the early growth response 2 gene associated with Dejerine-Sottas syndrome phenotype.
PubMed ID: 10371530
PubMed ID: 10762521
Title: Cranial nerve involvement in CMT disease type 1 due to early growth response 2 gene mutation.
PubMed ID: 10762521
PubMed ID: 11239949
Title: A novel missense mutation in the early growth response 2 gene associated with late-onset Charcot-Marie-Tooth disease type 1.
PubMed ID: 11239949
PubMed ID: 12736090
Title: Screening of the early growth response 2 gene in Japanese patients with Charcot-Marie-Tooth disease type 1.
PubMed ID: 12736090
PubMed ID: 15241803
Title: Mutational analysis of PMP22, MPZ, GJB1, EGR2 and NEFL in Korean Charcot-Marie-Tooth neuropathy patients.
PubMed ID: 15241803
DOI: 10.1002/humu.9261
PubMed ID: 15947997
Title: Two missense mutations of EGR2 R359W and GJB1 V136A in a Charcot-Marie-Tooth disease family.
PubMed ID: 15947997
PubMed ID: 17717711
Title: Functional, histopathologic and natural history study of neuropathy associated with EGR2 mutations.
PubMed ID: 17717711
PubMed ID: 22522483
Title: Homozygous deletion of an EGR2 enhancer in congenital amyelinating neuropathy.
PubMed ID: 22522483
DOI: 10.1002/ana.23527
PubMed ID: 22734907
Title: A novel EGR2 mutation within a family with a mild demyelinating form of Charcot-Marie-Tooth disease.
PubMed ID: 22734907
PubMed ID: 22546699
Title: Charcot-Marie-Tooth neuropathy due to a novel EGR2 gene mutation with mild phenotype--usefulness of human mapping chip linkage analysis in a Czech family.
PubMed ID: 22546699
PubMed ID: 30843326
Title: A novel family with axonal Charcot-Marie-Tooth disease caused by a mutation in the EGR2 gene.
PubMed ID: 30843326
DOI: 10.1111/jns.12314
PubMed ID: 31852952
Title: A de novo EGR2 variant, c.1232A > G p.Asp411Gly, causes severe early-onset Charcot-Marie-Tooth Neuropathy Type 3 (Dejerine-Sottas Neuropathy).
PubMed ID: 31852952
Sequence Information:
- Length: 476
- Mass: 50302
- Checksum: 7810D1B1B418DF1F
- Sequence:
MMTAKAVDKI PVTLSGFVHQ LSDNIYPVED LAATSVTIFP NAELGGPFDQ MNGVAGDGMI NIDMTGEKRS LDLPYPSSFA PVSAPRNQTF TYMGKFSIDP QYPGASCYPE GIINIVSAGI LQGVTSPAST TASSSVTSAS PNPLATGPLG VCTMSQTQPD LDHLYSPPPP PPPYSGCAGD LYQDPSAFLS AATTSTSSSL AYPPPPSYPS PKPATDPGLF PMIPDYPGFF PSQCQRDLHG TAGPDRKPFP CPLDTLRVPP PLTPLSTIRN FTLGGPSAGV TGPGASGGSE GPRLPGSSSA AAAAAAAAAY NPHHLPLRPI LRPRKYPNRP SKTPVHERPY PCPAEGCDRR FSRSDELTRH IRIHTGHKPF QCRICMRNFS RSDHLTTHIR THTGEKPFAC DYCGRKFARS DERKRHTKIH LRQKERKSSA PSASVPAPST ASCSGGVQPG GTLCSSNSSS LGGGPLAPCS SRTRTP
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.