Details for: GC
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 7.0322
Cell Significance Index: 26.4900 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 4.4274
Cell Significance Index: 74.5800 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 3.3938
Cell Significance Index: 208.0700 - Cell Name: precursor B cell (CL0000817)
Fold Change: 2.7837
Cell Significance Index: 36.0200 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 2.0474
Cell Significance Index: 65.5800 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.8340
Cell Significance Index: 27.0700 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.7973
Cell Significance Index: 10.3500 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.5744
Cell Significance Index: 312.4400 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.2805
Cell Significance Index: 58.0400 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.8601
Cell Significance Index: 21.5000 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.7146
Cell Significance Index: 7.0500 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.6641
Cell Significance Index: 12.9900 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.6482
Cell Significance Index: 15.7000 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.5975
Cell Significance Index: 12.7300 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5622
Cell Significance Index: 55.6200 - Cell Name: hepatic pit cell (CL2000054)
Fold Change: 0.5413
Cell Significance Index: 1.4500 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.5096
Cell Significance Index: 460.1700 - Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.5030
Cell Significance Index: 1.7500 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.5023
Cell Significance Index: 57.3400 - Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 0.4978
Cell Significance Index: 0.2500 - Cell Name: PP cell (CL0000696)
Fold Change: 0.4535
Cell Significance Index: 4.6100 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.4008
Cell Significance Index: 24.0600 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.3909
Cell Significance Index: 42.5200 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.3838
Cell Significance Index: 3.0300 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.3736
Cell Significance Index: 3.0300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.3440
Cell Significance Index: 50.0000 - Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.3397
Cell Significance Index: 2.6100 - Cell Name: cytotoxic T cell (CL0000910)
Fold Change: 0.3177
Cell Significance Index: 4.6300 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3123
Cell Significance Index: 50.8000 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.2242
Cell Significance Index: 26.1300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2185
Cell Significance Index: 41.5900 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2160
Cell Significance Index: 14.9400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.2092
Cell Significance Index: 23.9700 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.1118
Cell Significance Index: 2.3200 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.0847
Cell Significance Index: 0.8100 - Cell Name: pancreatic epsilon cell (CL0005019)
Fold Change: 0.0507
Cell Significance Index: 0.4700 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0489
Cell Significance Index: 1.7200 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.0467
Cell Significance Index: 1.2500 - Cell Name: duodenum glandular cell (CL1001589)
Fold Change: 0.0279
Cell Significance Index: 0.2000 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.0255
Cell Significance Index: 0.3700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0236
Cell Significance Index: 0.6800 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0175
Cell Significance Index: 0.3800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0129
Cell Significance Index: 2.2000 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.0127
Cell Significance Index: 9.4200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.0051
Cell Significance Index: 1.0700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0008
Cell Significance Index: 0.5200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0001
Cell Significance Index: -0.0100 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0002
Cell Significance Index: -0.0400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0002
Cell Significance Index: -0.3300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0005
Cell Significance Index: -0.9800 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0009
Cell Significance Index: -1.4100 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: -0.0019
Cell Significance Index: -0.0200 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0019
Cell Significance Index: -1.0600 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0019
Cell Significance Index: -2.5600 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0028
Cell Significance Index: -0.0400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0063
Cell Significance Index: -2.2500 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0071
Cell Significance Index: -4.5300 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0083
Cell Significance Index: -6.0600 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0103
Cell Significance Index: -2.9500 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0104
Cell Significance Index: -4.7000 - Cell Name: liver dendritic cell (CL2000055)
Fold Change: -0.0114
Cell Significance Index: -0.0300 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0232
Cell Significance Index: -0.6000 - Cell Name: hepatocyte (CL0000182)
Fold Change: -0.0234
Cell Significance Index: -0.3300 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0280
Cell Significance Index: -5.0400 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0291
Cell Significance Index: -1.4700 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0296
Cell Significance Index: -1.2100 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.0305
Cell Significance Index: -0.4600 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0310
Cell Significance Index: -3.2300 - Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: -0.0313
Cell Significance Index: -0.3500 - Cell Name: hepatoblast (CL0005026)
Fold Change: -0.0333
Cell Significance Index: -0.5600 - Cell Name: Kupffer cell (CL0000091)
Fold Change: -0.0350
Cell Significance Index: -0.3200 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0365
Cell Significance Index: -2.4600 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0365
Cell Significance Index: -1.0200 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0377
Cell Significance Index: -0.9400 - Cell Name: mucous neck cell (CL0000651)
Fold Change: -0.0441
Cell Significance Index: -0.2100 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.0442
Cell Significance Index: -0.9000 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0447
Cell Significance Index: -5.5000 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.0538
Cell Significance Index: -0.8200 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0625
Cell Significance Index: -3.8400 - Cell Name: endocrine cell (CL0000163)
Fold Change: -0.0645
Cell Significance Index: -0.7800 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.0645
Cell Significance Index: -1.1100 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0653
Cell Significance Index: -5.1700 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0684
Cell Significance Index: -3.1900 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.0704
Cell Significance Index: -1.1600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0732
Cell Significance Index: -3.4400 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0754
Cell Significance Index: -2.6400 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0766
Cell Significance Index: -2.4400 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0794
Cell Significance Index: -2.6000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0798
Cell Significance Index: -6.1200 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.0832
Cell Significance Index: -2.6300 - Cell Name: erythroblast (CL0000765)
Fold Change: -0.0851
Cell Significance Index: -1.0200 - Cell Name: plasmablast (CL0000980)
Fold Change: -0.0862
Cell Significance Index: -0.8000 - Cell Name: epithelial cell (CL0000066)
Fold Change: -0.0991
Cell Significance Index: -1.0500 - Cell Name: alpha-beta T cell (CL0000789)
Fold Change: -0.1027
Cell Significance Index: -0.8800 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.1034
Cell Significance Index: -2.9500 - Cell Name: proerythroblast (CL0000547)
Fold Change: -0.1061
Cell Significance Index: -1.5200 - Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: -0.1090
Cell Significance Index: -1.0100 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.1094
Cell Significance Index: -2.7300 - Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
Fold Change: -0.1105
Cell Significance Index: -1.2100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1112
Cell Significance Index: -6.2400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 837591088
Symbol: VTDB_HUMAN
Name: Vitamin D-binding protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2416779
Title: Serum vitamin D-binding protein is a third member of the albumin and alpha fetoprotein gene family.
PubMed ID: 2416779
DOI: 10.1172/jci112256
PubMed ID: 2415977
Title: Human group-specific component (Gc) is a member of the albumin family.
PubMed ID: 2415977
PubMed ID: 7505619
Title: Sequence and organization of the human vitamin D-binding protein gene.
PubMed ID: 7505619
PubMed ID: 8325650
Title: Complete structure of the human Gc gene: differences and similarities between members of the albumin gene family.
PubMed ID: 8325650
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2958390
Title: The vitamin D-binding protein gene contains conserved nucleotide sequences that respond to heavy metal, adipocyte and mitotic signals.
PubMed ID: 2958390
PubMed ID: 2423133
Title: Complete amino acid sequence of human vitamin D-binding protein (group-specific component): evidence of a three-fold internal homology as in serum albumin and alpha-fetoprotein.
PubMed ID: 2423133
PubMed ID: 218624
Title: Molecular basis for the three major forms of human serum vitamin D binding protein (group-specific component).
PubMed ID: 218624
DOI: 10.1021/bi00575a036
PubMed ID: 20079467
Title: The glycosylation and characterization of the candidate Gc macrophage activating factor.
PubMed ID: 20079467
PubMed ID: 7725672
Title: Characterization of mutants of the vitamin-D-binding protein/group specific component: GC aborigine (1A1) from Australian aborigines and South African blacks, and 2A9 from south Germany.
PubMed ID: 7725672
PubMed ID: 16302727
Title: Gc protein (vitamin D-binding protein): Gc genotyping and GcMAF precursor activity.
PubMed ID: 16302727
PubMed ID: 17360250
Title: Protein chemical characterization of Gc globulin (vitamin D-binding protein) isoforms; Gc-1f, Gc-1s and Gc-2.
PubMed ID: 17360250
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 1352271
Title: Molecular analysis of the gene for the human vitamin-D-binding protein (group-specific component): allelic differences of the common genetic GC types.
PubMed ID: 1352271
DOI: 10.1007/bf00194311
PubMed ID: 11799400
Title: A structural basis for the unique binding features of the human vitamin D-binding protein.
PubMed ID: 11799400
DOI: 10.1038/nsb754
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 474
- Mass: 52918
- Checksum: 484BF163B54A43E6
- Sequence:
MKRVLVLLLA VAFGHALERG RDYEKNKVCK EFSHLGKEDF TSLSLVLYSR KFPSGTFEQV SQLVKEVVSL TEACCAEGAD PDCYDTRTSA LSAKSCESNS PFPVHPGTAE CCTKEGLERK LCMAALKHQP QEFPTYVEPT NDEICEAFRK DPKEYANQFM WEYSTNYGQA PLSLLVSYTK SYLSMVGSCC TSASPTVCFL KERLQLKHLS LLTTLSNRVC SQYAAYGEKK SRLSNLIKLA QKVPTADLED VLPLAEDITN ILSKCCESAS EDCMAKELPE HTVKLCDNLS TKNSKFEDCC QEKTAMDVFV CTYFMPAAQL PELPDVELPT NKDVCDPGNT KVMDKYTFEL SRRTHLPEVF LSKVLEPTLK SLGECCDVED STTCFNAKGP LLKKELSSFI DKGQELCADY SENTFTEYKK KLAERLKAKL PDATPTELAK LVNKHSDFAS NCCSINSPPL YCDSEIDAEL KNIL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.