Details for: GC
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: hepatoblast (CL0005026)
Fold Change: 5.47
Marker Score: 17,934 - Cell Name: double negative thymocyte (CL0002489)
Fold Change: 3.43
Marker Score: 4,737 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 2.49
Marker Score: 13,409 - Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 2.32
Marker Score: 936 - Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 2.31
Marker Score: 797 - Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 2.25
Marker Score: 837 - Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 2.09
Marker Score: 2,105 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2
Marker Score: 1,994 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.92
Marker Score: 8,285 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.8
Marker Score: 11,593 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.61
Marker Score: 1,169 - Cell Name: plasma cell (CL0000786)
Fold Change: 1.61
Marker Score: 1,796 - Cell Name: erythrocyte (CL0000232)
Fold Change: 1.55
Marker Score: 860 - Cell Name: PP cell (CL0000696)
Fold Change: 1.5
Marker Score: 337 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.42
Marker Score: 2,696 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 1.37
Marker Score: 572 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 1.31
Marker Score: 1,634 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.26
Marker Score: 853 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4,813 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.13
Marker Score: 1,208 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.12
Marker Score: 422 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.09
Marker Score: 501 - Cell Name: precursor B cell (CL0000817)
Fold Change: 1.07
Marker Score: 708 - Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 1.03
Marker Score: 321 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.02
Marker Score: 2,071 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.01
Marker Score: 420 - Cell Name: hepatocyte (CL0000182)
Fold Change: 1.01
Marker Score: 687 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,822 - Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 1
Marker Score: 517 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,047 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 507 - Cell Name: erythroblast (CL0000765)
Fold Change: 0.98
Marker Score: 613 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,408 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 460 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,412 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5,347 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 372 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,740 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 325 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,296 - Cell Name: mast cell (CL0000097)
Fold Change: 0.84
Marker Score: 487 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.79
Marker Score: 474 - Cell Name: peptic cell (CL0000155)
Fold Change: 0.79
Marker Score: 330 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1,258 - Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 707 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 395 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.73
Marker Score: 11,397 - Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 0.73
Marker Score: 283 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 460 - Cell Name: type I enteroendocrine cell (CL0002277)
Fold Change: 0.72
Marker Score: 178 - Cell Name: amacrine cell (CL0000561)
Fold Change: 0.69
Marker Score: 2,226 - Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.68
Marker Score: 188 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.66
Marker Score: 663 - Cell Name: pericyte (CL0000669)
Fold Change: 0.59
Marker Score: 346 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.58
Marker Score: 1,378 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 442 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.55
Marker Score: 173 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.51
Marker Score: 111 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.5
Marker Score: 186 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.46
Marker Score: 276 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.45
Marker Score: 440 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.44
Marker Score: 212 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.43
Marker Score: 186 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.42
Marker Score: 420 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.41
Marker Score: 422 - Cell Name: endocrine cell (CL0000163)
Fold Change: 0.38
Marker Score: 199 - Cell Name: myeloid cell (CL0000763)
Fold Change: 0.38
Marker Score: 612 - Cell Name: acinar cell (CL0000622)
Fold Change: 0.32
Marker Score: 228 - Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 0.32
Marker Score: 69 - Cell Name: mucous neck cell (CL0000651)
Fold Change: 0.3
Marker Score: 685 - Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.3
Marker Score: 133 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.3
Marker Score: 157 - Cell Name: pancreatic epsilon cell (CL0005019)
Fold Change: 0.26
Marker Score: 84 - Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.26
Marker Score: 543 - Cell Name: B cell (CL0000236)
Fold Change: 0.24
Marker Score: 225 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.24
Marker Score: 497 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.23
Marker Score: 78 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.23
Marker Score: 65 - Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 0.23
Marker Score: 172 - Cell Name: M cell of gut (CL0000682)
Fold Change: 0.23
Marker Score: 59 - Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.2
Marker Score: 64 - Cell Name: macrophage (CL0000235)
Fold Change: 0.19
Marker Score: 212 - Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.19
Marker Score: 85 - Cell Name: goblet cell (CL0000160)
Fold Change: 0.19
Marker Score: 1,245 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.19
Marker Score: 63 - Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.18
Marker Score: 63 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.17
Marker Score: 43 - Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 0.17
Marker Score: 96 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.16
Marker Score: 55 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.16
Marker Score: 84 - Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.15
Marker Score: 145 - Cell Name: secretory cell (CL0000151)
Fold Change: 0.15
Marker Score: 271 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.14
Marker Score: 44 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.14
Marker Score: 105 - Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.13
Marker Score: 75 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.13
Marker Score: 42 - Cell Name: ependymal cell (CL0000065)
Fold Change: 0.13
Marker Score: 45 - Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.13
Marker Score: 59 - Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.13
Marker Score: 30 - Cell Name: GIP cell (CL0002278)
Fold Change: 0.13
Marker Score: 41
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 837591088
Symbol: VTDB_HUMAN
Name: Vitamin D-binding protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2416779
Title: Serum vitamin D-binding protein is a third member of the albumin and alpha fetoprotein gene family.
PubMed ID: 2416779
DOI: 10.1172/jci112256
PubMed ID: 2415977
Title: Human group-specific component (Gc) is a member of the albumin family.
PubMed ID: 2415977
PubMed ID: 7505619
Title: Sequence and organization of the human vitamin D-binding protein gene.
PubMed ID: 7505619
PubMed ID: 8325650
Title: Complete structure of the human Gc gene: differences and similarities between members of the albumin gene family.
PubMed ID: 8325650
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2958390
Title: The vitamin D-binding protein gene contains conserved nucleotide sequences that respond to heavy metal, adipocyte and mitotic signals.
PubMed ID: 2958390
PubMed ID: 2423133
Title: Complete amino acid sequence of human vitamin D-binding protein (group-specific component): evidence of a three-fold internal homology as in serum albumin and alpha-fetoprotein.
PubMed ID: 2423133
PubMed ID: 218624
Title: Molecular basis for the three major forms of human serum vitamin D binding protein (group-specific component).
PubMed ID: 218624
DOI: 10.1021/bi00575a036
PubMed ID: 20079467
Title: The glycosylation and characterization of the candidate Gc macrophage activating factor.
PubMed ID: 20079467
PubMed ID: 7725672
Title: Characterization of mutants of the vitamin-D-binding protein/group specific component: GC aborigine (1A1) from Australian aborigines and South African blacks, and 2A9 from south Germany.
PubMed ID: 7725672
PubMed ID: 16302727
Title: Gc protein (vitamin D-binding protein): Gc genotyping and GcMAF precursor activity.
PubMed ID: 16302727
PubMed ID: 17360250
Title: Protein chemical characterization of Gc globulin (vitamin D-binding protein) isoforms; Gc-1f, Gc-1s and Gc-2.
PubMed ID: 17360250
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 1352271
Title: Molecular analysis of the gene for the human vitamin-D-binding protein (group-specific component): allelic differences of the common genetic GC types.
PubMed ID: 1352271
DOI: 10.1007/bf00194311
PubMed ID: 11799400
Title: A structural basis for the unique binding features of the human vitamin D-binding protein.
PubMed ID: 11799400
DOI: 10.1038/nsb754
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 474
- Mass: 52918
- Checksum: 484BF163B54A43E6
- Sequence:
MKRVLVLLLA VAFGHALERG RDYEKNKVCK EFSHLGKEDF TSLSLVLYSR KFPSGTFEQV SQLVKEVVSL TEACCAEGAD PDCYDTRTSA LSAKSCESNS PFPVHPGTAE CCTKEGLERK LCMAALKHQP QEFPTYVEPT NDEICEAFRK DPKEYANQFM WEYSTNYGQA PLSLLVSYTK SYLSMVGSCC TSASPTVCFL KERLQLKHLS LLTTLSNRVC SQYAAYGEKK SRLSNLIKLA QKVPTADLED VLPLAEDITN ILSKCCESAS EDCMAKELPE HTVKLCDNLS TKNSKFEDCC QEKTAMDVFV CTYFMPAAQL PELPDVELPT NKDVCDPGNT KVMDKYTFEL SRRTHLPEVF LSKVLEPTLK SLGECCDVED STTCFNAKGP LLKKELSSFI DKGQELCADY SENTFTEYKK KLAERLKAKL PDATPTELAK LVNKHSDFAS NCCSINSPPL YCDSEIDAEL KNIL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.