Details for: SSTR2

Gene ID: 6752

Symbol: SSTR2

Ensembl ID: ENSG00000180616

Description: somatostatin receptor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 64.0971
    Cell Significance Index: -9.9700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 38.3215
    Cell Significance Index: -9.7200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.1349
    Cell Significance Index: -10.0300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.5316
    Cell Significance Index: -9.9900
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 2.3398
    Cell Significance Index: 13.3000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.1589
    Cell Significance Index: 33.0700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.8945
    Cell Significance Index: 11.1000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7121
    Cell Significance Index: 70.4500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.7091
    Cell Significance Index: 47.6800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6996
    Cell Significance Index: 631.6900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6743
    Cell Significance Index: 128.3200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.6215
    Cell Significance Index: 8.2900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.5683
    Cell Significance Index: 21.5200
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.5548
    Cell Significance Index: 6.3900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.5048
    Cell Significance Index: 4.2400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4609
    Cell Significance Index: 50.1400
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.4552
    Cell Significance Index: 4.0100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4143
    Cell Significance Index: 67.3800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3949
    Cell Significance Index: 23.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3805
    Cell Significance Index: 76.3400
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.3255
    Cell Significance Index: 1.5500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3212
    Cell Significance Index: 41.1700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3042
    Cell Significance Index: 8.7200
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.2938
    Cell Significance Index: 2.4300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2503
    Cell Significance Index: 11.0700
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.2391
    Cell Significance Index: 2.6100
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.2333
    Cell Significance Index: 2.5900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2316
    Cell Significance Index: 16.0200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.2309
    Cell Significance Index: 1.7800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.2184
    Cell Significance Index: 3.8600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2178
    Cell Significance Index: 9.8700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2164
    Cell Significance Index: 11.3600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1972
    Cell Significance Index: 107.7100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1637
    Cell Significance Index: 10.0600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1506
    Cell Significance Index: 4.3400
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.1462
    Cell Significance Index: 1.6600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1296
    Cell Significance Index: 25.7200
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.0851
    Cell Significance Index: 0.8100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0589
    Cell Significance Index: 21.1100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0463
    Cell Significance Index: 20.4900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0188
    Cell Significance Index: 13.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0179
    Cell Significance Index: 0.6300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0070
    Cell Significance Index: 0.8200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0055
    Cell Significance Index: 4.0800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.0041
    Cell Significance Index: 0.1300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0039
    Cell Significance Index: 0.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0017
    Cell Significance Index: -0.3600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0034
    Cell Significance Index: -2.1400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0036
    Cell Significance Index: -0.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0042
    Cell Significance Index: -0.0900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0095
    Cell Significance Index: -5.3700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0118
    Cell Significance Index: -8.6400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0136
    Cell Significance Index: -10.2800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0153
    Cell Significance Index: -1.7500
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.0172
    Cell Significance Index: -0.1900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0199
    Cell Significance Index: -0.4300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0221
    Cell Significance Index: -2.5800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0247
    Cell Significance Index: -4.2200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0262
    Cell Significance Index: -7.5500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0263
    Cell Significance Index: -4.7400
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0293
    Cell Significance Index: -0.3800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0354
    Cell Significance Index: -4.0600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0370
    Cell Significance Index: -2.3300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0379
    Cell Significance Index: -1.9200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0380
    Cell Significance Index: -5.2200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0384
    Cell Significance Index: -0.9200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0449
    Cell Significance Index: -1.1600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0462
    Cell Significance Index: -1.4800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0492
    Cell Significance Index: -0.7800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0562
    Cell Significance Index: -2.9200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0576
    Cell Significance Index: -1.6100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0588
    Cell Significance Index: -7.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0590
    Cell Significance Index: -8.5700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0596
    Cell Significance Index: -1.2700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0629
    Cell Significance Index: -8.1300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0660
    Cell Significance Index: -2.7100
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.0728
    Cell Significance Index: -0.7900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0740
    Cell Significance Index: -1.6200
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0742
    Cell Significance Index: -0.9000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0773
    Cell Significance Index: -2.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0784
    Cell Significance Index: -8.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0802
    Cell Significance Index: -4.9200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0931
    Cell Significance Index: -1.2700
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.1024
    Cell Significance Index: -1.1300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1024
    Cell Significance Index: -7.2400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1026
    Cell Significance Index: -7.6500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1085
    Cell Significance Index: -2.2500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1128
    Cell Significance Index: -7.2800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1168
    Cell Significance Index: -9.2500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1183
    Cell Significance Index: -9.0800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1185
    Cell Significance Index: -2.3800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1265
    Cell Significance Index: -4.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1686
    Cell Significance Index: -7.9300
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1694
    Cell Significance Index: -2.3500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1697
    Cell Significance Index: -1.8500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1730
    Cell Significance Index: -4.7100
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.1999
    Cell Significance Index: -0.8700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2021
    Cell Significance Index: -4.2300
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.2120
    Cell Significance Index: -1.1100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2130
    Cell Significance Index: -2.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **G Protein-Coupled Receptor (GPCR) Structure:** SSTR2 is a transmembrane receptor with seven transmembrane alpha-helices, characteristic of GPCRs. It has a distinct N-terminal domain, a seven-transmembrane domain, and a C-terminal intracellular domain. 2. **Ligand Binding:** SSTR2 binds to somatostatin, a peptide hormone that inhibits the release of various hormones and neurotransmitters. 3. **Signaling Pathways:** SSTR2 is coupled to Gαi proteins, which inhibit adenylate cyclase activity, reducing cAMP levels and modulating downstream signaling pathways. 4. **Expression Patterns:** SSTR2 is expressed in various cell types, including enteroendocrine cells, neurons, and immune cells. **Pathways and Functions:** 1. **Adenylate Cyclase-Inhibiting G Protein-Coupled Receptor Signaling Pathway:** SSTR2 inhibits adenylate cyclase activity, reducing cAMP levels and modulating downstream signaling pathways. 2. **Somatostatin Signaling Pathway:** SSTR2 binds to somatostatin, inhibiting the release of hormones and neurotransmitters. 3. **Neurotransmitter Release:** SSTR2 modulates neurotransmitter release, including GABA, glutamate, and dopamine. 4. **Cell Proliferation and Differentiation:** SSTR2 regulates cell proliferation and differentiation, particularly in the context of somatostatin signaling. 5. **Immune Cell Function:** SSTR2 is expressed on immature innate lymphoid cells, where it modulates their function and cytokine production. **Clinical Significance:** 1. **Cancer Treatment:** SSTR2 is overexpressed in certain types of cancer, including neuroendocrine tumors, where it can serve as a therapeutic target for somatostatin analogs. 2. **Neurological Disorders:** SSTR2 is implicated in various neurological disorders, including Parkinson's disease, where it modulates dopamine release. 3. **Gastrointestinal Disorders:** SSTR2 is involved in the regulation of gastrointestinal hormones and neurotransmitters, where it can contribute to disorders such as irritable bowel syndrome. 4. **Prostate Cancer:** SSTR2 is overexpressed in prostate cancer, where it can serve as a biomarker for diagnosis and treatment. In conclusion, SSTR2 is a critical component of G protein-coupled receptor signaling pathways, modulating various physiological and pathological processes. Its expression and function in different tissues make it a valuable target for therapeutic interventions in various diseases.

Genular Protein ID: 3212727138

Symbol: SSR2_HUMAN

Name: Somatostatin receptor type 2

UniProtKB Accession Codes:

P30874 A8K3Y0 B2R9P7 Q4VBP0 Q96GE0 Q96TF2 Q9BWH1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 8 DrugCentral 1 EMBL 12 EMDB 12 Ensembl 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 15 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1346068

Title: Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.

PubMed ID: 1346068

DOI: 10.1073/pnas.89.1.251

PubMed ID: 10619399

Title: Genomic structure and transcriptional regulation of the human somatostatin receptor type 2.

PubMed ID: 10619399

DOI: 10.1016/s0303-7207(99)00161-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8386508

Title: Multiple gene transcripts of the somatostatin receptor SSTR2: tissue selective distribution and cAMP regulation.

PubMed ID: 8386508

DOI: 10.1006/bbrc.1993.1412

PubMed ID: 10551867

Title: Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain.

PubMed ID: 10551867

DOI: 10.1074/jbc.274.46.32997

PubMed ID: 15231824

Title: Agonist-dependent dissociation of human somatostatin receptor 2 dimers: a role in receptor trafficking.

PubMed ID: 15231824

DOI: 10.1074/jbc.m407310200

PubMed ID: 18653781

Title: Cell growth inhibition and functioning of human somatostatin receptor type 2 are modulated by receptor heterodimerization.

PubMed ID: 18653781

DOI: 10.1210/me.2007-0334

PubMed ID: 19434240

Title: The somatostatin 2A receptor is enriched in migrating neurons during rat and human brain development and stimulates migration and axonal outgrowth.

PubMed ID: 19434240

DOI: 10.1371/journal.pone.0005509

PubMed ID: 22932785

Title: SSTR2 is the functionally dominant somatostatin receptor in human pancreatic beta- and alpha-cells.

PubMed ID: 22932785

DOI: 10.1152/ajpendo.00207.2012

PubMed ID: 22495673

Title: Identification of critical residues involved in ligand binding and G protein signaling in human somatostatin receptor subtype 2.

PubMed ID: 22495673

DOI: 10.1210/en.2011-1662

Sequence Information:

  • Length: 369
  • Mass: 41333
  • Checksum: 3B5D7D8A9AC246C6
  • Sequence:
    • MDMADEPLNG SHTWLSIPFD LNGSVVSTNT SNQTEPYYDL TSNAVLTFIY FVVCIIGLCG 
NTLVIYVILR YAKMKTITNI YILNLAIADE LFMLGLPFLA MQVALVHWPF GKAICRVVMT 
VDGINQFTSI FCLTVMSIDR YLAVVHPIKS AKWRRPRTAK MITMAVWGVS LLVILPIMIY 
AGLRSNQWGR SSCTINWPGE SGAWYTGFII YTFILGFLVP LTIICLCYLF IIIKVKSSGI 
RVGSSKRKKS EKKVTRMVSI VVAVFIFCWL PFYIFNVSSV SMAISPTPAL KGMFDFVVVL 
TYANSCANPI LYAFLSDNFK KSFQNVLCLV KVSGTDDGER SDSKQDKSRL NETTETQRTL 
LNGDLQTSI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.