Details for: TFF2

Gene ID: 7032

Symbol: TFF2

Ensembl ID: ENSG00000160181

Description: trefoil factor 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.67
    Marker Score: 8243
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 4.78
    Marker Score: 30482
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.18
    Marker Score: 7207
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 3.1
    Marker Score: 1069
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 3
    Marker Score: 4136
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.28
    Marker Score: 1199
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 2.07
    Marker Score: 1071
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.74
    Marker Score: 730
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.64
    Marker Score: 685
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 1.6
    Marker Score: 1360
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.37
    Marker Score: 510
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 848
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4786
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 1.09
    Marker Score: 558
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.03
    Marker Score: 744
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.01
    Marker Score: 419
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71779
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48008
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.97
    Marker Score: 551
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5217
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.9
    Marker Score: 1545
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.89
    Marker Score: 588
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.81
    Marker Score: 774
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.79
    Marker Score: 757
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 680
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.71
    Marker Score: 684
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.62
    Marker Score: 162
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.62
    Marker Score: 395
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.61
    Marker Score: 1454
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.59
    Marker Score: 252
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.58
    Marker Score: 337
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.57
    Marker Score: 262
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 448
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.54
    Marker Score: 1019
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.52
    Marker Score: 519
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.47
    Marker Score: 148
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.46
    Marker Score: 509
  • Cell Name: parietal cell (CL0000162)
    Fold Change: 0.45
    Marker Score: 126
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.42
    Marker Score: 248
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.42
    Marker Score: 670
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.4
    Marker Score: 174
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.39
    Marker Score: 170
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.38
    Marker Score: 256
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.38
    Marker Score: 1059
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.36
    Marker Score: 105
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.35
    Marker Score: 341
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.35
    Marker Score: 70
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.34
    Marker Score: 141
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.32
    Marker Score: 71
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.31
    Marker Score: 573
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.31
    Marker Score: 626
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.29
    Marker Score: 176
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.27
    Marker Score: 70.5
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.27
    Marker Score: 71
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.26
    Marker Score: 239
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.26
    Marker Score: 262
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.26
    Marker Score: 102
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 90
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.25
    Marker Score: 266
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.25
    Marker Score: 79
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.24
    Marker Score: 69
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.24
    Marker Score: 66
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 67
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.23
    Marker Score: 67.5
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.23
    Marker Score: 56
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.23
    Marker Score: 58
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.23
    Marker Score: 104
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 76
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.22
    Marker Score: 7767
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.22
    Marker Score: 1053
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.22
    Marker Score: 334
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.21
    Marker Score: 3332
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.21
    Marker Score: 2846
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.21
    Marker Score: 141
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.21
    Marker Score: 213
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.2
    Marker Score: 183
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.2
    Marker Score: 63
  • Cell Name: brush cell of trachebronchial tree (CL0002075)
    Fold Change: 0.2
    Marker Score: 62
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.2
    Marker Score: 111
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.19
    Marker Score: 70
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.19
    Marker Score: 136
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.18
    Marker Score: 71
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.18
    Marker Score: 310
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.18
    Marker Score: 45
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.18
    Marker Score: 192
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.18
    Marker Score: 71
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.17
    Marker Score: 69
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.17
    Marker Score: 41
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.17
    Marker Score: 54

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Other Information

**Key Characteristics:** TFF2 is a member of the trefoil factor family, which consists of three proteins: TFF1, TFF2, and TFF3. These proteins are characterized by their ability to bind to specific receptors and interact with various signaling pathways, modulating cellular processes such as proliferation, differentiation, and survival. TFF2 is specifically expressed in epithelial cells of the gastrointestinal tract, including the stomach, small intestine, and colon, as well as in other tissues like the skin and respiratory tract. **Pathways and Functions:** TFF2 interacts with various signaling pathways to exert its effects on epithelial cells. The most notable pathways include: 1. **Chemokine-mediated signaling pathway**: TFF2 binds to chemokine receptors, such as Cxcr4, to regulate chemokine-mediated signaling, which is essential for the recruitment and migration of immune cells to the site of inflammation. 2. **Maintenance of gastrointestinal epithelium**: TFF2 promotes epithelial cell survival, proliferation, and differentiation, maintaining the integrity of the epithelial barrier and preventing damage from pathogens and toxins. 3. **Negative regulation of gastric acid secretion**: TFF2 inhibits gastric acid secretion by binding to specific receptors on parietal cells, thereby reducing inflammation and protecting the gastric mucosa from acid-induced damage. **Clinical Significance:** Dysregulation of TFF2 has been implicated in various gastrointestinal disorders, including: 1. **Gastroesophageal reflux disease (GERD)**: Reduced TFF2 expression has been observed in patients with GERD, suggesting its role in maintaining the integrity of the esophageal epithelium. 2. **Inflammatory bowel disease (IBD)**: TFF2 has been shown to be downregulated in IBD patients, contributing to the development of intestinal inflammation and damage. 3. **Cancer**: TFF2 has been found to be overexpressed in certain types of cancer, such as colon and gastric cancer, where it may contribute to tumor progression and metastasis. In conclusion, TFF2 is a multifaceted protein that plays a crucial role in maintaining epithelial homeostasis and regulating immune responses in the gastrointestinal tract. Its dysregulation has been implicated in various gastrointestinal disorders, highlighting the importance of TFF2 in understanding the pathogenesis of these diseases and developing novel therapeutic strategies.

Genular Protein ID: 2836754019

Symbol: TFF2_HUMAN

Name: Trefoil factor 2

UniProtKB Accession Codes:

Q03403 Q15854

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 7 Ensembl 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2303034

Title: hSP, the domain-duplicated homolog of pS2 protein, is co-expressed with pS2 in stomach but not in breast carcinoma.

PubMed ID: 2303034

DOI: 10.1002/j.1460-2075.1990.tb08125.x

PubMed ID: 9070946

Title: The three human trefoil genes TFF1, TFF2, and TFF3 are located within a region of 55 kb on chromosome 21q22.3.

PubMed ID: 9070946

DOI: 10.1006/geno.1996.4511

PubMed ID: 10950923

Title: Refined localization of autosomal recessive nonsyndromic deafness DFNB10 locus using 34 novel microsatellite markers, genomic structure, and exclusion of six known genes in the region.

PubMed ID: 10950923

DOI: 10.1006/geno.2000.6253

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 129
  • Mass: 14284
  • Checksum: 6A296A11AD9CCC5D
  • Sequence:
    • MGRRDAQLLA ALLVLGLCAL AGSEKPSPCQ CSRLSPHNRT NCGFPGITSD QCFDNGCCFD 
SSVTGVPWCF HPLPKQESDQ CVMEVSDRRN CGYPGISPEE CASRKCCFSN FIFEVPWCFF 
PKSVEDCHY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.