Details for: TFF2

Gene ID: 7032

Symbol: TFF2

Ensembl ID: ENSG00000160181

Description: trefoil factor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 50.3770
    Cell Significance Index: 638.0000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 11.6512
    Cell Significance Index: 1329.9800
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 7.2151
    Cell Significance Index: 34.3700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.4330
    Cell Significance Index: 41.5900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.9935
    Cell Significance Index: 63.8500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1729
    Cell Significance Index: 53.1700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4581
    Cell Significance Index: 413.6700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4306
    Cell Significance Index: 42.6000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.4204
    Cell Significance Index: 5.4400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2719
    Cell Significance Index: 51.7500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2393
    Cell Significance Index: 38.9200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1364
    Cell Significance Index: 14.8400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1351
    Cell Significance Index: 73.7600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0578
    Cell Significance Index: 4.0000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0112
    Cell Significance Index: 0.6700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0132
    Cell Significance Index: -24.7900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0132
    Cell Significance Index: -0.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0250
    Cell Significance Index: -18.5300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0262
    Cell Significance Index: -16.3400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0328
    Cell Significance Index: -24.8200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0329
    Cell Significance Index: -24.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0387
    Cell Significance Index: -21.8000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0597
    Cell Significance Index: -12.5800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0765
    Cell Significance Index: -2.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0801
    Cell Significance Index: -15.8900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0863
    Cell Significance Index: -24.8200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0918
    Cell Significance Index: -2.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1016
    Cell Significance Index: -3.5700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1199
    Cell Significance Index: -13.9700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1257
    Cell Significance Index: -25.2200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1314
    Cell Significance Index: -23.6900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1491
    Cell Significance Index: -3.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1602
    Cell Significance Index: -27.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1823
    Cell Significance Index: -25.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1873
    Cell Significance Index: -21.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1921
    Cell Significance Index: -19.6300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2547
    Cell Significance Index: -11.0700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2686
    Cell Significance Index: -5.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2695
    Cell Significance Index: -33.1400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2826
    Cell Significance Index: -17.3300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3404
    Cell Significance Index: -43.9800
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.3743
    Cell Significance Index: -2.4400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5158
    Cell Significance Index: -10.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5607
    Cell Significance Index: -41.7900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6358
    Cell Significance Index: -33.0300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7088
    Cell Significance Index: -24.8300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.7297
    Cell Significance Index: -11.2900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.7628
    Cell Significance Index: -12.5700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8550
    Cell Significance Index: -27.2300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.8939
    Cell Significance Index: -10.6900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.9711
    Cell Significance Index: -12.2700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.0052
    Cell Significance Index: -34.9300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0720
    Cell Significance Index: -31.5800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.0778
    Cell Significance Index: -39.5700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -1.2038
    Cell Significance Index: -18.1400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.2340
    Cell Significance Index: -26.1900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.2613
    Cell Significance Index: -27.2500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -1.2647
    Cell Significance Index: -25.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -1.2802
    Cell Significance Index: -60.1700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -1.3275
    Cell Significance Index: -21.5000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.3304
    Cell Significance Index: -29.1300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.3781
    Cell Significance Index: -27.2500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -1.4176
    Cell Significance Index: -19.4400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -1.4935
    Cell Significance Index: -25.1200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.5025
    Cell Significance Index: -43.0700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.5250
    Cell Significance Index: -40.1000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -1.5263
    Cell Significance Index: -22.1600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.5703
    Cell Significance Index: -41.9300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -1.5879
    Cell Significance Index: -16.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.5981
    Cell Significance Index: -74.5100
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -1.6141
    Cell Significance Index: -18.3100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -1.6172
    Cell Significance Index: -23.1600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.6924
    Cell Significance Index: -39.1000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.7448
    Cell Significance Index: -29.2000
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -1.8477
    Cell Significance Index: -19.0600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -1.8541
    Cell Significance Index: -25.0200
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -1.8770
    Cell Significance Index: -25.0200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -1.8791
    Cell Significance Index: -36.7400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.8883
    Cell Significance Index: -34.9000
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -1.9337
    Cell Significance Index: -11.9500
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -1.9768
    Cell Significance Index: -24.8300
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -1.9940
    Cell Significance Index: -24.1000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -2.0271
    Cell Significance Index: -25.5800
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -2.0805
    Cell Significance Index: -24.1600
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -2.0924
    Cell Significance Index: -24.8400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -2.0975
    Cell Significance Index: -29.0900
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -2.1054
    Cell Significance Index: -43.9100
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -2.1072
    Cell Significance Index: -24.8300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -2.1433
    Cell Significance Index: -25.2000
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -2.1727
    Cell Significance Index: -24.8200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -2.2010
    Cell Significance Index: -25.1900
  • Cell Name: H1 horizontal cell (CL0004217)
    Fold Change: -2.2541
    Cell Significance Index: -28.3300
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -2.2577
    Cell Significance Index: -28.3300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -2.2604
    Cell Significance Index: -33.8700
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -2.2621
    Cell Significance Index: -28.3300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -2.2841
    Cell Significance Index: -28.3300
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -2.3338
    Cell Significance Index: -28.2900
  • Cell Name: T cell (CL0000084)
    Fold Change: -2.3466
    Cell Significance Index: -27.7100
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -2.3484
    Cell Significance Index: -29.1900
  • Cell Name: duodenum glandular cell (CL1001589)
    Fold Change: -2.3523
    Cell Significance Index: -16.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TFF2 is a member of the trefoil factor family, which consists of three proteins: TFF1, TFF2, and TFF3. These proteins are characterized by their ability to bind to specific receptors and interact with various signaling pathways, modulating cellular processes such as proliferation, differentiation, and survival. TFF2 is specifically expressed in epithelial cells of the gastrointestinal tract, including the stomach, small intestine, and colon, as well as in other tissues like the skin and respiratory tract. **Pathways and Functions:** TFF2 interacts with various signaling pathways to exert its effects on epithelial cells. The most notable pathways include: 1. **Chemokine-mediated signaling pathway**: TFF2 binds to chemokine receptors, such as Cxcr4, to regulate chemokine-mediated signaling, which is essential for the recruitment and migration of immune cells to the site of inflammation. 2. **Maintenance of gastrointestinal epithelium**: TFF2 promotes epithelial cell survival, proliferation, and differentiation, maintaining the integrity of the epithelial barrier and preventing damage from pathogens and toxins. 3. **Negative regulation of gastric acid secretion**: TFF2 inhibits gastric acid secretion by binding to specific receptors on parietal cells, thereby reducing inflammation and protecting the gastric mucosa from acid-induced damage. **Clinical Significance:** Dysregulation of TFF2 has been implicated in various gastrointestinal disorders, including: 1. **Gastroesophageal reflux disease (GERD)**: Reduced TFF2 expression has been observed in patients with GERD, suggesting its role in maintaining the integrity of the esophageal epithelium. 2. **Inflammatory bowel disease (IBD)**: TFF2 has been shown to be downregulated in IBD patients, contributing to the development of intestinal inflammation and damage. 3. **Cancer**: TFF2 has been found to be overexpressed in certain types of cancer, such as colon and gastric cancer, where it may contribute to tumor progression and metastasis. In conclusion, TFF2 is a multifaceted protein that plays a crucial role in maintaining epithelial homeostasis and regulating immune responses in the gastrointestinal tract. Its dysregulation has been implicated in various gastrointestinal disorders, highlighting the importance of TFF2 in understanding the pathogenesis of these diseases and developing novel therapeutic strategies.

Genular Protein ID: 2836754019

Symbol: TFF2_HUMAN

Name: Trefoil factor 2

UniProtKB Accession Codes:

Q03403 Q15854

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 7 Ensembl 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2303034

Title: hSP, the domain-duplicated homolog of pS2 protein, is co-expressed with pS2 in stomach but not in breast carcinoma.

PubMed ID: 2303034

DOI: 10.1002/j.1460-2075.1990.tb08125.x

PubMed ID: 9070946

Title: The three human trefoil genes TFF1, TFF2, and TFF3 are located within a region of 55 kb on chromosome 21q22.3.

PubMed ID: 9070946

DOI: 10.1006/geno.1996.4511

PubMed ID: 10950923

Title: Refined localization of autosomal recessive nonsyndromic deafness DFNB10 locus using 34 novel microsatellite markers, genomic structure, and exclusion of six known genes in the region.

PubMed ID: 10950923

DOI: 10.1006/geno.2000.6253

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 129
  • Mass: 14284
  • Checksum: 6A296A11AD9CCC5D
  • Sequence:
    • MGRRDAQLLA ALLVLGLCAL AGSEKPSPCQ CSRLSPHNRT NCGFPGITSD QCFDNGCCFD 
SSVTGVPWCF HPLPKQESDQ CVMEVSDRRN CGYPGISPEE CASRKCCFSN FIFEVPWCFF 
PKSVEDCHY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.