Details for: MIF

Gene ID: 4282

Symbol: MIF

Ensembl ID: ENSG00000240972

Description: macrophage migration inhibitory factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 738.4990
    Cell Significance Index: -114.8700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 385.0288
    Cell Significance Index: -97.6600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 304.4562
    Cell Significance Index: -125.4200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 255.1032
    Cell Significance Index: -120.4400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 246.9744
    Cell Significance Index: -127.0400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 180.4262
    Cell Significance Index: -121.0700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 94.7236
    Cell Significance Index: -116.7900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 34.5341
    Cell Significance Index: -106.0700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 30.0782
    Cell Significance Index: -118.6900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 25.0053
    Cell Significance Index: 214.8700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 24.3611
    Cell Significance Index: -65.2600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 15.1147
    Cell Significance Index: 349.2000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 13.2938
    Cell Significance Index: 170.2500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 12.8855
    Cell Significance Index: 79.3000
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 9.6683
    Cell Significance Index: 73.3200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 9.4236
    Cell Significance Index: 276.7600
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 9.2042
    Cell Significance Index: 44.7700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 7.5060
    Cell Significance Index: 69.1200
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 6.5790
    Cell Significance Index: 47.2500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 5.5265
    Cell Significance Index: 158.4200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 5.3275
    Cell Significance Index: 628.2800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 5.1591
    Cell Significance Index: 58.6100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 5.1181
    Cell Significance Index: 922.6300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 5.0681
    Cell Significance Index: 623.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 4.3439
    Cell Significance Index: 323.7500
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 4.3376
    Cell Significance Index: 11.6200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 4.1900
    Cell Significance Index: 196.9300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 4.0336
    Cell Significance Index: 553.9300
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 3.9374
    Cell Significance Index: 18.1800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.8312
    Cell Significance Index: 2092.2900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 3.8144
    Cell Significance Index: 32.0400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.7163
    Cell Significance Index: 97.7200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.7091
    Cell Significance Index: 100.9600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 3.3943
    Cell Significance Index: 435.1300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.1168
    Cell Significance Index: 24.8900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.4394
    Cell Significance Index: 51.0600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.4275
    Cell Significance Index: 26.3900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.2278
    Cell Significance Index: 287.8200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.1387
    Cell Significance Index: 945.5700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.7686
    Cell Significance Index: 125.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.3169
    Cell Significance Index: 69.1400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.3051
    Cell Significance Index: 60.8500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2936
    Cell Significance Index: 37.2700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0666
    Cell Significance Index: 28.4800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0253
    Cell Significance Index: 101.4200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7810
    Cell Significance Index: 50.3900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.7250
    Cell Significance Index: 13.4000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6616
    Cell Significance Index: 125.9200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.5847
    Cell Significance Index: 442.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5365
    Cell Significance Index: 107.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4408
    Cell Significance Index: 22.9000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.4136
    Cell Significance Index: 2.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3889
    Cell Significance Index: 139.4800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3625
    Cell Significance Index: 58.9600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1268
    Cell Significance Index: 4.4600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0373
    Cell Significance Index: 0.6300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0194
    Cell Significance Index: 14.1900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0033
    Cell Significance Index: -3.0100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0209
    Cell Significance Index: -2.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0511
    Cell Significance Index: -96.2400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0544
    Cell Significance Index: -15.6600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0596
    Cell Significance Index: -0.3600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0742
    Cell Significance Index: -136.7900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0864
    Cell Significance Index: -4.3700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0882
    Cell Significance Index: -135.7100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1012
    Cell Significance Index: -137.5800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1138
    Cell Significance Index: -84.2800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1485
    Cell Significance Index: -6.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1709
    Cell Significance Index: -96.4000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1829
    Cell Significance Index: -116.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2299
    Cell Significance Index: -143.5500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2406
    Cell Significance Index: -8.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2502
    Cell Significance Index: -113.5400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2854
    Cell Significance Index: -17.9900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.3066
    Cell Significance Index: -52.3600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4289
    Cell Significance Index: -7.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4428
    Cell Significance Index: -24.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.5924
    Cell Significance Index: -117.5600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.5990
    Cell Significance Index: -126.1600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6815
    Cell Significance Index: -18.2300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6884
    Cell Significance Index: -80.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.7440
    Cell Significance Index: -85.2400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.7778
    Cell Significance Index: -11.4800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.7955
    Cell Significance Index: -115.6300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8774
    Cell Significance Index: -69.4900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8803
    Cell Significance Index: -22.4900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9769
    Cell Significance Index: -31.2900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -1.1041
    Cell Significance Index: -8.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.1410
    Cell Significance Index: -118.8100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.1443
    Cell Significance Index: -24.7900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.3113
    Cell Significance Index: -100.6300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.4542
    Cell Significance Index: -65.9200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.6306
    Cell Significance Index: -112.7700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.6345
    Cell Significance Index: -22.3000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.6532
    Cell Significance Index: -46.2000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.7976
    Cell Significance Index: -120.8700
  • Cell Name: germ cell (CL0000586)
    Fold Change: -1.9601
    Cell Significance Index: -14.8000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.9775
    Cell Significance Index: -121.2400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.9839
    Cell Significance Index: -34.2000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -2.1516
    Cell Significance Index: -32.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MIF is a small, secreted protein that belongs to the L-dopachrome isomerase family. It is produced by various cell types, including myeloid dendritic cells, monocytes, and macrophages, and is secreted into the extracellular space. MIF is characterized by its ability to bind to the MIF receptor, which is expressed on the surface of various immune cells. The binding of MIF to its receptor triggers a signaling cascade that leads to the activation of immune cells and the regulation of various cellular processes. **Pathways and Functions** MIF plays a critical role in regulating immune responses, including: 1. **Chemoattractant activity**: MIF acts as a chemoattractant for immune cells, such as macrophages and T cells, promoting their migration to sites of inflammation. 2. **Cytokine activity**: MIF promotes the production of pro-inflammatory cytokines, such as TNF-α and IL-1β, which are involved in the regulation of immune responses. 3. **Cell surface receptor signaling pathway**: MIF binds to its receptor, which triggers a signaling cascade that leads to the activation of immune cells. 4. **Inflammatory response**: MIF promotes the activation of immune cells and the regulation of inflammatory responses. 5. **Apoptosis regulation**: MIF has been shown to regulate apoptosis in various cell types, including macrophages and T cells. 6. **Cellular senescence regulation**: MIF has been shown to regulate cellular senescence in various cell types, including macrophages and fibroblasts. **Clinical Significance** Abnormal expression or function of MIF has been implicated in various diseases, including: 1. **Autoimmune disorders**: MIF has been implicated in the pathogenesis of autoimmune disorders, such as rheumatoid arthritis and lupus. 2. **Cancer**: MIF has been shown to promote the growth and survival of cancer cells, and has been implicated in the development of various types of cancer. 3. **Infectious diseases**: MIF has been implicated in the pathogenesis of infectious diseases, such as tuberculosis and HIV. 4. **Neurological disorders**: MIF has been implicated in the pathogenesis of neurological disorders, such as multiple sclerosis and Alzheimer's disease. In summary, MIF is a critical regulator of immune responses, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the role of MIF in human disease and to develop therapeutic strategies to modulate its activity.

Genular Protein ID: 3084637255

Symbol: MIF_HUMAN

Name: L-dopachrome isomerase

UniProtKB Accession Codes:

P14174 A5Z1R8 B2R4S3 Q2V4Y5 Q6FHV0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 8 DrugCentral 1 EC 2 EMBL 20 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 52 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 100 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 2 SASBDB 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2552447

Title: Molecular cloning of a cDNA encoding a human macrophage migration inhibitory factor.

PubMed ID: 2552447

DOI: 10.1073/pnas.86.19.7522

PubMed ID: 8234256

Title: Molecular cloning and functional expression of a cDNA encoding glycosylation-inhibiting factor.

PubMed ID: 8234256

DOI: 10.1073/pnas.90.21.10056

PubMed ID: 7947826

Title: Purification, bioactivity, and secondary structure analysis of mouse and human macrophage migration inhibitory factor (MIF).

PubMed ID: 7947826

DOI: 10.1021/bi00251a025

PubMed ID: 8188240

Title: Cloning the human gene for macrophage migration inhibitory factor (MIF).

PubMed ID: 8188240

DOI: 10.1006/geno.1994.1011

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 1286669

Title: Human liver protein map: a reference database established by microsequencing and gel comparison.

PubMed ID: 1286669

DOI: 10.1002/elps.11501301201

PubMed ID: 7683862

Title: The major binding protein of the interferon antagonist sarcolectin in human placenta is a macrophage migration inhibitory factor.

PubMed ID: 7683862

DOI: 10.1006/abbi.1993.1257

PubMed ID: 7679497

Title: A macrophage migration inhibitory factor is expressed in the differentiating cells of the eye lens.

PubMed ID: 7679497

DOI: 10.1073/pnas.90.4.1272

PubMed ID: 11089976

Title: Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1.

PubMed ID: 11089976

DOI: 10.1038/35041591

PubMed ID: 11508429

Title: A novel 5'-flanking region polymorphism of macrophage migration inhibitory factor is associated with systemic-onset juvenile idiopathic arthritis.

PubMed ID: 11508429

DOI: 10.1002/1529-0131(200108)44:8<1782::aid-art314>3.0.co;2-#

PubMed ID: 11439086

Title: Macrophage migration inhibitory factor of the parasitic nematode Trichinella spiralis.

PubMed ID: 11439086

DOI: 10.1042/0264-6021:3570373

PubMed ID: 12681488

Title: The apoptosis-associated protein BNIPL interacts with two cell proliferation-related proteins, MIF and GFER.

PubMed ID: 12681488

DOI: 10.1016/s0014-5793(03)00229-1

PubMed ID: 12782713

Title: MIF signal transduction initiated by binding to CD74.

PubMed ID: 12782713

DOI: 10.1084/jem.20030286

PubMed ID: 15908412

Title: Macrophage migration inhibitory factor reduces the growth of virulent Mycobacterium tuberculosis in human macrophages.

PubMed ID: 15908412

DOI: 10.1128/iai.73.6.3783-3786.2005

PubMed ID: 17443469

Title: Association between high levels of blood macrophage migration inhibitory factor, inappropriate adrenal response, and early death in patients with severe sepsis.

PubMed ID: 17443469

DOI: 10.1086/514344

PubMed ID: 19454686

Title: The Golgi-associated protein p115 mediates the secretion of macrophage migration inhibitory factor.

PubMed ID: 19454686

DOI: 10.4049/jimmunol.0803710

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 8766818

Title: Crystal structure of macrophage migration inhibitory factor from human lymphocyte at 2.1-A resolution.

PubMed ID: 8766818

DOI: 10.1016/0014-5793(96)00553-4

PubMed ID: 8610159

Title: The crystal structure of human glycosylation-inhibiting factor is a trimeric barrel with three 6-stranded beta-sheets.

PubMed ID: 8610159

DOI: 10.1073/pnas.93.7.3007

PubMed ID: 8643551

Title: Crystal structure at 2.6-A resolution of human macrophage migration inhibitory factor.

PubMed ID: 8643551

DOI: 10.1073/pnas.93.11.5191

PubMed ID: 10353846

Title: Pro-1 of macrophage migration inhibitory factor functions as a catalytic base in the phenylpyruvate tautomerase activity.

PubMed ID: 10353846

DOI: 10.1021/bi990306m

PubMed ID: 11170644

Title: Coumarin and chromen-4-one analogues as tautomerase inhibitors of macrophage migration inhibitory factor: discovery and X-ray crystallography.

PubMed ID: 11170644

DOI: 10.1021/jm000386o

PubMed ID: 17526494

Title: Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor.

PubMed ID: 17526494

DOI: 10.1074/jbc.m701825200

PubMed ID: 19090677

Title: Structural and kinetic analyses of macrophage migration inhibitory factor active site interactions.

PubMed ID: 19090677

DOI: 10.1021/bi8014423

PubMed ID: 23776208

Title: MIF intersubunit disulfide mutant antagonist supports activation of CD74 by endogenous MIF trimer at physiologic concentrations.

PubMed ID: 23776208

DOI: 10.1073/pnas.1221817110

Sequence Information:

  • Length: 115
  • Mass: 12476
  • Checksum: 56D51107C05286B2
  • Sequence:
    • MPMFIVNTNV PRASVPDGFL SELTQQLAQA TGKPPQYIAV HVVPDQLMAF GGSSEPCALC 
SLHSIGKIGG AQNRSYSKLL CGLLAERLRI SPDRVYINYY DMNAANVGWN NSTFA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.