Details for: S100A1

Gene ID: 6271

Symbol: S100A1

Ensembl ID: ENSG00000160678

Description: S100 calcium binding protein A1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 88.4630
    Cell Significance Index: -13.7600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 54.7225
    Cell Significance Index: -13.8800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 33.8150
    Cell Significance Index: -13.9300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 30.6948
    Cell Significance Index: -12.4700
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 20.6432
    Cell Significance Index: 88.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 13.4558
    Cell Significance Index: 627.3700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.1764
    Cell Significance Index: -13.7800
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 8.9812
    Cell Significance Index: 49.9900
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 8.2584
    Cell Significance Index: 172.2400
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 4.1889
    Cell Significance Index: 53.0500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 3.2763
    Cell Significance Index: 79.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.1417
    Cell Significance Index: 405.8900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.6202
    Cell Significance Index: 123.1500
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 2.1345
    Cell Significance Index: 34.4400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.5493
    Cell Significance Index: 23.9700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1866
    Cell Significance Index: 225.8300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.0397
    Cell Significance Index: 24.0200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5515
    Cell Significance Index: 498.0000
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.5429
    Cell Significance Index: 3.9400
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.4927
    Cell Significance Index: 3.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4904
    Cell Significance Index: 267.8200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.4737
    Cell Significance Index: 7.6000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3444
    Cell Significance Index: 22.2200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3154
    Cell Significance Index: 51.3000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2517
    Cell Significance Index: 27.3800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2455
    Cell Significance Index: 18.8400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.1668
    Cell Significance Index: 1.3600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1533
    Cell Significance Index: 15.1600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1017
    Cell Significance Index: 7.0400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0962
    Cell Significance Index: 7.1700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0723
    Cell Significance Index: 4.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0366
    Cell Significance Index: 7.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0188
    Cell Significance Index: 35.4500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0184
    Cell Significance Index: 8.1500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0092
    Cell Significance Index: 1.0700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0043
    Cell Significance Index: 0.1500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0027
    Cell Significance Index: -0.1700
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0043
    Cell Significance Index: -0.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0088
    Cell Significance Index: -16.1400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0108
    Cell Significance Index: -16.5800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0121
    Cell Significance Index: -16.5100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0137
    Cell Significance Index: -0.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0141
    Cell Significance Index: -1.4400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0142
    Cell Significance Index: -0.4100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0143
    Cell Significance Index: -0.3100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0155
    Cell Significance Index: -11.3900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0184
    Cell Significance Index: -13.9300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0189
    Cell Significance Index: -11.9900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0193
    Cell Significance Index: -14.2600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0237
    Cell Significance Index: -3.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0244
    Cell Significance Index: -7.0300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0244
    Cell Significance Index: -15.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0245
    Cell Significance Index: -13.7900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0273
    Cell Significance Index: -9.8000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0279
    Cell Significance Index: -3.8300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0296
    Cell Significance Index: -13.4200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0354
    Cell Significance Index: -4.0500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0478
    Cell Significance Index: -2.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0501
    Cell Significance Index: -10.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0637
    Cell Significance Index: -11.4900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0657
    Cell Significance Index: -0.9700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0709
    Cell Significance Index: -12.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0734
    Cell Significance Index: -15.4700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0787
    Cell Significance Index: -3.2200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0860
    Cell Significance Index: -4.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0894
    Cell Significance Index: -13.0000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0940
    Cell Significance Index: -11.5600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0981
    Cell Significance Index: -3.6000
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1017
    Cell Significance Index: -1.3100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1046
    Cell Significance Index: -12.3400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1076
    Cell Significance Index: -2.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1183
    Cell Significance Index: -12.3200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1291
    Cell Significance Index: -6.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1360
    Cell Significance Index: -9.6200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1371
    Cell Significance Index: -2.3700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1412
    Cell Significance Index: -11.1900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1414
    Cell Significance Index: -4.5300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1571
    Cell Significance Index: -4.3900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1762
    Cell Significance Index: -10.8100
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1782
    Cell Significance Index: -1.5200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1916
    Cell Significance Index: -4.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1936
    Cell Significance Index: -13.0200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2310
    Cell Significance Index: -14.2000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2587
    Cell Significance Index: -5.3700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2613
    Cell Significance Index: -9.0800
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.2613
    Cell Significance Index: -2.0100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2707
    Cell Significance Index: -15.1900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2760
    Cell Significance Index: -8.1300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3018
    Cell Significance Index: -8.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3152
    Cell Significance Index: -13.9400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.3182
    Cell Significance Index: -4.0800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3348
    Cell Significance Index: -8.9600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.3443
    Cell Significance Index: -3.9400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3541
    Cell Significance Index: -7.5700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3560
    Cell Significance Index: -9.1500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3689
    Cell Significance Index: -13.9700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3716
    Cell Significance Index: -5.6000
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: -0.3753
    Cell Significance Index: -4.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3825
    Cell Significance Index: -19.8700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3929
    Cell Significance Index: -13.7700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** S100A1 is a small, acidic protein that is highly expressed in various tissues, including the salivary gland, pancreas, thyroid, and lung. It is a calcium-binding protein, which allows it to interact with other proteins and regulate their activity. S100A1 has been shown to form homodimers and interact with other S100 proteins, as well as with various cellular compartments, including the cytosol, Golgi apparatus, and mitochondria. **Pathways and Functions:** S100A1 has been implicated in several key pathways, including: 1. **Adaptive Immune System:** S100A1 has been shown to regulate the adaptive immune response by modulating the activity of immune cells, such as T cells and dendritic cells. 2. **Antigen Processing and Presentation:** S100A1 has been implicated in the regulation of antigen processing and presentation by MHC class I molecules. 3. **TLR Signaling Cascades:** S100A1 has been shown to regulate the activity of Toll-like receptors (TLRs), which are critical for the recognition of pathogen-associated molecular patterns (PAMPs) and the activation of innate immune responses. 4. **Cell Signaling:** S100A1 has been shown to regulate various cell signaling pathways, including the regulation of nitric oxide synthase activity and the regulation of heart contraction. 5. **Tissue Development:** S100A1 has been implicated in the regulation of tissue development, including the development of the thyroid gland and the lung. **Clinical Significance:** Dysregulation of S100A1 has been implicated in various diseases, including: 1. **Immune System Disorders:** S100A1 has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer:** S100A1 has been shown to regulate the activity of cancer cells, including the regulation of tumor growth and metastasis. 3. **Cardiovascular Disease:** S100A1 has been implicated in the regulation of heart contraction and has been shown to be associated with cardiovascular disease. 4. **Neurological Disorders:** S100A1 has been implicated in the regulation of neural development and has been shown to be associated with neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, S100A1 is a multifunctional protein that plays a critical role in regulating various cellular processes, including immune responses, cell signaling, and tissue development. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of S100A1 function and its role in human disease.

Genular Protein ID: 2974675920

Symbol: S10A1_HUMAN

Name: Protein S100-A1

UniProtKB Accession Codes:

P23297 B2R5D9 Q5T7Y3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 1 CTD 1 ChEBI 7 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 8 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1384693

Title: S100 alpha, CAPL, and CACY: molecular cloning and expression analysis of three calcium-binding proteins from human heart.

PubMed ID: 1384693

DOI: 10.1021/bi00157a012

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11717446

Title: S100A1: a regulator of myocardial contractility.

PubMed ID: 11717446

DOI: 10.1073/pnas.241393598

PubMed ID: 12042313

Title: CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family.

PubMed ID: 12042313

DOI: 10.1074/jbc.m203602200

PubMed ID: 12804600

Title: Ca2+ -dependent interaction of S100A1 with the sarcoplasmic reticulum Ca2+ -ATPase2a and phospholamban in the human heart.

PubMed ID: 12804600

DOI: 10.1016/s0006-291x(03)00987-2

PubMed ID: 15171681

Title: Heterodimeric interaction and interfaces of S100A1 and S100P.

PubMed ID: 15171681

DOI: 10.1042/bj20040142

PubMed ID: 15885104

Title: Affinity of S100A1 protein for calcium increases dramatically upon glutathionylation.

PubMed ID: 15885104

DOI: 10.1111/j.1742-4658.2005.04680.x

PubMed ID: 18650434

Title: S100A1 and calmodulin compete for the same binding site on ryanodine receptor.

PubMed ID: 18650434

DOI: 10.1074/jbc.m804432200

PubMed ID: 20188096

Title: S100 proteins regulate the interaction of Hsp90 with cyclophilin 40 and FKBP52 through their tetratricopeptide repeats.

PubMed ID: 20188096

DOI: 10.1016/j.febslet.2010.02.055

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22399290

Title: S100 proteins modulate protein phosphatase 5 function: a link between CA2+ signal transduction and protein dephosphorylation.

PubMed ID: 22399290

DOI: 10.1074/jbc.m111.329771

PubMed ID: 21296671

Title: Solution NMR structure and dynamics of human apo-S100A1 protein.

PubMed ID: 21296671

DOI: 10.1016/j.jsb.2011.01.011

PubMed ID: 22989881

Title: Post-translational S-nitrosylation is an endogenous factor fine tuning the properties of human S100A1 protein.

PubMed ID: 22989881

DOI: 10.1074/jbc.m112.418392

PubMed ID: 23351007

Title: Impact of calcium binding and thionylation of S100A1 protein on its nuclear magnetic resonance-derived structure and backbone dynamics.

PubMed ID: 23351007

DOI: 10.1021/bi3015407

PubMed ID: 28368280

Title: X-ray crystal structure of human calcium-bound S100A1.

PubMed ID: 28368280

DOI: 10.1107/s2053230x17003983

Sequence Information:

  • Length: 94
  • Mass: 10546
  • Checksum: AD5E53AF326B25D2
  • Sequence:
    • MGSELETAME TLINVFHAHS GKEGDKYKLS KKELKELLQT ELSGFLDAQK DVDAVDKVMK 
ELDENGDGEV DFQEYVVLVA ALTVACNNFF WENS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.