Details for: SYP

Gene ID: 6855

Symbol: SYP

Ensembl ID: ENSG00000102003

Description: synaptophysin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 139.7021
    Cell Significance Index: -21.7300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 85.2772
    Cell Significance Index: -21.6300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 39.3101
    Cell Significance Index: -15.9700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 32.4132
    Cell Significance Index: -21.7500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.7095
    Cell Significance Index: -21.8400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 10.2721
    Cell Significance Index: 122.4500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 9.8648
    Cell Significance Index: 621.7500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 8.6249
    Cell Significance Index: 66.4800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.5549
    Cell Significance Index: -21.9200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 5.0960
    Cell Significance Index: 87.3300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.2009
    Cell Significance Index: 168.0600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.0339
    Cell Significance Index: -6.6400
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 2.7597
    Cell Significance Index: 24.3100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.7116
    Cell Significance Index: 77.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.4335
    Cell Significance Index: 488.1600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.1725
    Cell Significance Index: 47.5700
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 2.1111
    Cell Significance Index: 25.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.6130
    Cell Significance Index: 578.5500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.5720
    Cell Significance Index: 96.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.5056
    Cell Significance Index: 101.2400
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 1.3294
    Cell Significance Index: 17.2400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.2167
    Cell Significance Index: 29.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0590
    Cell Significance Index: 48.0000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0201
    Cell Significance Index: 100.9200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9815
    Cell Significance Index: 886.2100
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: 0.9115
    Cell Significance Index: 7.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7112
    Cell Significance Index: 20.4900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.6903
    Cell Significance Index: 26.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.6701
    Cell Significance Index: 29.6400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6037
    Cell Significance Index: 65.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5965
    Cell Significance Index: 97.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.5289
    Cell Significance Index: 18.5900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4406
    Cell Significance Index: 26.4500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2779
    Cell Significance Index: 19.2200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2335
    Cell Significance Index: 44.4400
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.2240
    Cell Significance Index: 2.5300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0614
    Cell Significance Index: 11.0600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.0561
    Cell Significance Index: 0.7000
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.0461
    Cell Significance Index: 0.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0438
    Cell Significance Index: 2.4600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0242
    Cell Significance Index: 2.8200
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.0152
    Cell Significance Index: 0.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0132
    Cell Significance Index: 2.6200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0129
    Cell Significance Index: 0.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0067
    Cell Significance Index: 4.9500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0054
    Cell Significance Index: 8.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0017
    Cell Significance Index: 3.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0012
    Cell Significance Index: 2.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0016
    Cell Significance Index: -2.1700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0042
    Cell Significance Index: -0.0900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0087
    Cell Significance Index: -3.8600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0106
    Cell Significance Index: -6.6100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0133
    Cell Significance Index: -1.6400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0144
    Cell Significance Index: -1.8400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0153
    Cell Significance Index: -3.2200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0157
    Cell Significance Index: -0.3100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0159
    Cell Significance Index: -10.0900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0164
    Cell Significance Index: -2.8100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0166
    Cell Significance Index: -12.1500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0174
    Cell Significance Index: -0.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0182
    Cell Significance Index: -9.9700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0198
    Cell Significance Index: -11.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0206
    Cell Significance Index: -15.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0239
    Cell Significance Index: -2.7400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0357
    Cell Significance Index: -16.2200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0398
    Cell Significance Index: -0.8000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0644
    Cell Significance Index: -2.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0648
    Cell Significance Index: -9.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0742
    Cell Significance Index: -21.3500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0788
    Cell Significance Index: -2.5100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.1001
    Cell Significance Index: -1.3400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1015
    Cell Significance Index: -13.9400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1062
    Cell Significance Index: -12.1200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1145
    Cell Significance Index: -11.7000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1212
    Cell Significance Index: -1.5300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1296
    Cell Significance Index: -2.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1377
    Cell Significance Index: -17.7900
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1391
    Cell Significance Index: -1.0700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1461
    Cell Significance Index: -17.2300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1513
    Cell Significance Index: -7.8600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1769
    Cell Significance Index: -4.9500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1958
    Cell Significance Index: -4.1700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1987
    Cell Significance Index: -12.8200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2072
    Cell Significance Index: -2.5700
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.2123
    Cell Significance Index: -2.0200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2157
    Cell Significance Index: -16.5600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2168
    Cell Significance Index: -22.5700
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.2169
    Cell Significance Index: -1.7900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2242
    Cell Significance Index: -17.7600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2269
    Cell Significance Index: -16.9100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2277
    Cell Significance Index: -13.9600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2626
    Cell Significance Index: -5.4800
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.2748
    Cell Significance Index: -3.1500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2866
    Cell Significance Index: -14.9300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2886
    Cell Significance Index: -7.2000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2993
    Cell Significance Index: -4.5100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3007
    Cell Significance Index: -21.2700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3055
    Cell Significance Index: -4.3800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3236
    Cell Significance Index: -15.2100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.3378
    Cell Significance Index: -4.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Synaptic Vesicle Component:** SYP is a key component of synaptic vesicles, where it plays a crucial role in the regulation of neurotransmitter release. 2. **Endocytosis and Exocytosis:** SYP is involved in the endocytosis and exocytosis of synaptic vesicles, allowing for the precise release of neurotransmitters into the synaptic cleft. 3. **Regulation of Neurotransmitter Release:** SYP modulates the release of neurotransmitters, influencing synaptic transmission and plasticity. 4. **Highly Conserved:** SYP is highly conserved across species, with its expression observed in various neuronal populations. 5. **Multiple Binding Partners:** SYP interacts with multiple proteins, including Sh2 domain-containing proteins, which regulate its activity and localization. **Pathways and Functions:** 1. **Excitatory Synapse:** SYP is involved in the regulation of excitatory synaptic transmission, influencing the release of neurotransmitters such as glutamate. 2. **Endocytosis:** SYP participates in the endocytosis of synaptic vesicles, allowing for the regulation of neurotransmitter release. 3. **Neurotransmitter Release:** SYP modulates the release of neurotransmitters, influencing synaptic transmission and plasticity. 4. **Regulation of Long-term Neuronal Synaptic Plasticity:** SYP is involved in the regulation of long-term synaptic plasticity, influencing the strength and efficacy of synaptic transmission. 5. **Regulation of Short-term Neuronal Synaptic Plasticity:** SYP also regulates short-term synaptic plasticity, allowing for the fine-tuning of synaptic transmission. **Clinical Significance:** 1. **Neurodegenerative Diseases:** Alterations in SYP expression have been observed in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, highlighting its potential as a therapeutic target. 2. **Neuromuscular Junction Disorders:** SYP mutations have been associated with neuromuscular junction disorders, such as myasthenia gravis, emphasizing its critical role in neurotransmitter release. 3. **Synaptic Dysfunction:** SYP dysfunction has been implicated in various neurological and psychiatric disorders, including anxiety and depression, highlighting its potential as a therapeutic target. 4. **Regulatory T Cell Function:** SYP has been shown to regulate the function of regulatory T cells, which play a crucial role in maintaining immune tolerance and preventing autoimmune diseases. In conclusion, synaptophysin is a critical protein involved in the regulation of neurotransmitter release and synaptic function. Its complex interplay with other synaptic proteins underscores its significance in the intricate mechanisms governing neuronal communication. Further research is needed to fully elucidate the role of SYP in various neurological and psychiatric disorders, as well as its potential as a therapeutic target.

Genular Protein ID: 2465614475

Symbol: SYPH_HUMAN

Name: Synaptophysin

UniProtKB Accession Codes:

P08247 B2R7L6 B7Z359 Q6P2F7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 22 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3120152

Title: The cDNA and derived amino acid sequences for rat and human synaptophysin.

PubMed ID: 3120152

DOI: 10.1093/nar/15.22.9607

PubMed ID: 1975480

Title: Synaptophysin: structure of the human gene and assignment to the X chromosome in man and mouse.

PubMed ID: 1975480

PubMed ID: 9344658

Title: Sequence-based exon prediction around the synaptophysin locus reveals a gene-rich area containing novel genes in human proximal Xp.

PubMed ID: 9344658

DOI: 10.1006/geno.1997.4941

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8838578

Title: Disappearance of actin-binding protein, drebrin, from hippocampal synapses in Alzheimer's disease.

PubMed ID: 8838578

DOI: 10.1002/jnr.490430111

PubMed ID: 17296554

Title: Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity.

PubMed ID: 17296554

DOI: 10.1016/j.neuron.2007.01.019

PubMed ID: 18662323

Title: Characterization of a multidomain adaptor protein, p140Cap, as part of a pre-synaptic complex.

PubMed ID: 18662323

DOI: 10.1111/j.1471-4159.2008.05585.x

PubMed ID: 19377476

Title: A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation.

PubMed ID: 19377476

DOI: 10.1038/ng.367

PubMed ID: 28669405

Title: Loss-of-function and gain-of-function mutations in KCNQ5 cause intellectual disability or epileptic encephalopathy.

PubMed ID: 28669405

DOI: 10.1016/j.ajhg.2017.05.016

Sequence Information:

  • Length: 313
  • Mass: 33845
  • Checksum: 592289C43B12EFA7
  • Sequence:
    • MLLLADMDVV NQLVAGGQFR VVKEPLGFVK VLQWVFAIFA FATCGSYSGE LQLSVDCANK 
TESDLSIEVE FEYPFRLHQV YFDAPTCRGG TTKVFLVGDY SSSAEFFVTV AVFAFLYSMG 
ALATYIFLQN KYRENNKGPM LDFLATAVFA FMWLVSSSAW AKGLSDVKMA TDPENIIKEM 
PVCRQTGNTC KELRDPVTSG LNTSVVFGFL NLVLWVGNLW FVFKETGWAA PFLRAPPGAP 
EKQPAPGDAY GDAGYGQGPG GYGPQDSYGP QGGYQPDYGQ PAGSGGSGYG PQGDYGQQGY 
GPQGAPTSFS NQM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.