Details for: EPCAM

Gene ID: 4072

Symbol: EPCAM

Ensembl ID: ENSG00000119888

Description: epithelial cell adhesion molecule

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 165.0324
    Cell Significance Index: -25.6700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 117.0147
    Cell Significance Index: -29.6800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 80.4714
    Cell Significance Index: -33.1500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 70.7680
    Cell Significance Index: -28.7500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 66.5081
    Cell Significance Index: -31.4000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 45.7511
    Cell Significance Index: -30.7000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 29.6939
    Cell Significance Index: -28.3500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.2507
    Cell Significance Index: -29.9000
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 12.0893
    Cell Significance Index: 46.2900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 9.5920
    Cell Significance Index: 76.5900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 9.2852
    Cell Significance Index: 214.5200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.7687
    Cell Significance Index: -23.4900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.8332
    Cell Significance Index: -30.9100
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 7.0143
    Cell Significance Index: 70.7600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 6.5531
    Cell Significance Index: 178.3700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 6.4657
    Cell Significance Index: 186.2900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 5.6319
    Cell Significance Index: 34.6600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 5.3412
    Cell Significance Index: 249.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 4.5753
    Cell Significance Index: 2498.6900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 4.4556
    Cell Significance Index: 440.7600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 3.7954
    Cell Significance Index: 56.8700
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 3.7039
    Cell Significance Index: 22.2000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.3735
    Cell Significance Index: 435.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.1994
    Cell Significance Index: 238.4500
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 3.0704
    Cell Significance Index: 17.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.5892
    Cell Significance Index: 134.5000
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 2.0989
    Cell Significance Index: 1.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.9789
    Cell Significance Index: 356.7400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.9402
    Cell Significance Index: 67.4200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.9137
    Cell Significance Index: 86.7400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.8008
    Cell Significance Index: 357.3800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.7051
    Cell Significance Index: 80.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.6869
    Cell Significance Index: 207.4200
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 1.4466
    Cell Significance Index: 30.1700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.4084
    Cell Significance Index: 45.1100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.3471
    Cell Significance Index: 12.4100
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.2902
    Cell Significance Index: 4.4300
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.2764
    Cell Significance Index: 9.6400
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.2093
    Cell Significance Index: 8.5100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 1.1559
    Cell Significance Index: 40.6200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.1236
    Cell Significance Index: 23.9300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1148
    Cell Significance Index: 15.2100
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 1.0962
    Cell Significance Index: 11.8800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.0937
    Cell Significance Index: 186.7600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.0920
    Cell Significance Index: -2.3900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.8060
    Cell Significance Index: 12.4700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.4205
    Cell Significance Index: 48.0000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3656
    Cell Significance Index: 161.6400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.3575
    Cell Significance Index: 262.1100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3481
    Cell Significance Index: 66.2400
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.2695
    Cell Significance Index: 2.7800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2394
    Cell Significance Index: 6.4200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2291
    Cell Significance Index: 29.3700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2185
    Cell Significance Index: 165.3500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1313
    Cell Significance Index: 3.6700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1125
    Cell Significance Index: 7.7800
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.0961
    Cell Significance Index: 0.6000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0137
    Cell Significance Index: 0.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0094
    Cell Significance Index: 17.6500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0001
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0009
    Cell Significance Index: -0.1800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0053
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0081
    Cell Significance Index: -5.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0175
    Cell Significance Index: -32.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0213
    Cell Significance Index: -32.8000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0218
    Cell Significance Index: -15.0900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0232
    Cell Significance Index: -0.5800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0272
    Cell Significance Index: -15.3300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0290
    Cell Significance Index: -39.4200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0404
    Cell Significance Index: -25.6500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0406
    Cell Significance Index: -14.5700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0457
    Cell Significance Index: -0.9900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0492
    Cell Significance Index: -14.1700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0531
    Cell Significance Index: -5.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0619
    Cell Significance Index: -4.3800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0651
    Cell Significance Index: -7.4600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0663
    Cell Significance Index: -1.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0687
    Cell Significance Index: -31.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0701
    Cell Significance Index: -9.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0719
    Cell Significance Index: -7.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0720
    Cell Significance Index: -14.4400
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0967
    Cell Significance Index: -0.6000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1160
    Cell Significance Index: -1.2000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1456
    Cell Significance Index: -21.1600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1566
    Cell Significance Index: -18.2500
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.1582
    Cell Significance Index: -1.1500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1688
    Cell Significance Index: -2.8300
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1792
    Cell Significance Index: -2.6800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1898
    Cell Significance Index: -5.5900
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: -0.2096
    Cell Significance Index: -0.1600
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.2164
    Cell Significance Index: -0.8200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2367
    Cell Significance Index: -12.3300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2524
    Cell Significance Index: -1.7100
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: -0.2551
    Cell Significance Index: -0.3300
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.2639
    Cell Significance Index: -2.1000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2742
    Cell Significance Index: -32.3400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2781
    Cell Significance Index: -6.0900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2785
    Cell Significance Index: -22.0600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2941
    Cell Significance Index: -30.6200
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.3142
    Cell Significance Index: -4.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EPCAM is a type of cadherin, specifically a member of the cadherin superfamily, which are cell adhesion molecules that mediate calcium-dependent cell-cell interactions. It is a transmembrane glycoprotein composed of six extracellular cadherin domains, three intracellular cytoplasmic domains, and a short cytoplasmic tail. EPCAM is highly expressed in epithelial cells and is involved in the formation of tight junctions, which are critical for maintaining the barrier function of epithelial tissues. **Pathways and Functions:** EPCAM is involved in various cellular processes, including: 1. **Cell-cell adhesion**: EPCAM mediates calcium-dependent cell-cell interactions, which are essential for maintaining tissue structure and function. 2. **Signaling**: EPCAM can interact with various signaling molecules, including Wnt proteins, which are involved in regulating cell proliferation, differentiation, and survival. 3. **Stem cell regulation**: EPCAM is involved in the regulation of stem cell proliferation and differentiation in various tissues, including the kidney and thyroid. 4. **Transcriptional regulation**: EPCAM can interact with RNA polymerase II, which is involved in regulating gene expression. 5. **Extracellular matrix interactions**: EPCAM can interact with extracellular matrix proteins, which are involved in maintaining tissue architecture and function. **Clinical Significance:** EPCAM has been implicated in various diseases, including: 1. **Cancer**: EPCAM is often overexpressed in various types of cancer, including colorectal cancer, breast cancer, and lung cancer. 2. **Kidney disease**: EPCAM is involved in the regulation of renal tubular function and is often upregulated in kidney diseases, such as chronic kidney disease and acute kidney injury. 3. **Thyroid disease**: EPCAM is involved in the regulation of thyroid function and is often affected in thyroid diseases, such as thyroid cancer and hypothyroidism. 4. **Inflammatory diseases**: EPCAM is involved in the regulation of inflammatory responses and is often upregulated in inflammatory diseases, such as atherosclerosis and arthritis. In conclusion, EPCAM is a critical regulator of cell-cell interactions and tissue development, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the role of EPCAM in human health and disease.

Genular Protein ID: 1069239180

Symbol: EPCAM_HUMAN

Name: Epithelial cell adhesion molecule

UniProtKB Accession Codes:

P16422 P18180 Q6FG26 Q6FG49 Q96C47 Q9UCD0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 2 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EMBL 18 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2463074

Title: Molecular cloning and characterization of a human adenocarcinoma/epithelial cell surface antigen complementary DNA.

PubMed ID: 2463074

PubMed ID: 2469722

Title: Isolation and characterization of a cDNA encoding the KS1/4 epithelial carcinoma marker.

PubMed ID: 2469722

PubMed ID: 2108441

Title: Epithelial glycoprotein is a member of a family of epithelial cell surface antigens homologous to nidogen, a matrix adhesion protein.

PubMed ID: 2108441

DOI: 10.1073/pnas.87.7.2755

PubMed ID: 2333300

Title: Molecular cloning of cDNA for the carcinoma-associated antigen GA733-2.

PubMed ID: 2333300

DOI: 10.1073/pnas.87.9.3542

PubMed ID: 8382772

Title: Retroposition in a family of carcinoma-associated antigen genes.

PubMed ID: 8382772

DOI: 10.1128/mcb.13.3.1507-1515.1993

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2911574

Title: Sequence investigation of the major gastrointestinal tumor-associated antigen gene family, GA733.

PubMed ID: 2911574

DOI: 10.1073/pnas.86.1.27

PubMed ID: 7693697

Title: Isolation, partial characterization, and molecular cloning of a human colon adenocarcinoma cell-surface glycoprotein recognized by the C215 mouse monoclonal antibody.

PubMed ID: 7693697

DOI: 10.1016/s0021-9258(20)80515-8

PubMed ID: 11080501

Title: Determination of disulfide bond assignments and N-glycosylation sites of the human gastrointestinal carcinoma antigen GA733-2 (CO17-1A, EGP, KS1-4, KSA, and Ep-CAM).

PubMed ID: 11080501

DOI: 10.1074/jbc.m008839200

PubMed ID: 15195135

Title: The carcinoma-associated antigen EpCAM upregulates c-myc and induces cell proliferation.

PubMed ID: 15195135

DOI: 10.1038/sj.onc.1207610

PubMed ID: 15922867

Title: The tumour-associated antigen EpCAM upregulates the fatty acid binding protein E-FABP.

PubMed ID: 15922867

DOI: 10.1016/j.canlet.2004.11.048

PubMed ID: 16054130

Title: The cell-cell adhesion molecule EpCAM interacts directly with the tight junction protein claudin-7.

PubMed ID: 16054130

DOI: 10.1016/j.yexcr.2005.06.013

PubMed ID: 18508581

Title: Glycosylation is crucial for stability of tumour and cancer stem cell antigen EpCAM.

PubMed ID: 18508581

DOI: 10.2741/3075

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19098912

Title: Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3' exons of TACSTD1.

PubMed ID: 19098912

DOI: 10.1038/ng.283

PubMed ID: 20064925

Title: Epithelial cell adhesion molecule regulation is associated with the maintenance of the undifferentiated phenotype of human embryonic stem cells.

PubMed ID: 20064925

DOI: 10.1074/jbc.m109.077081

PubMed ID: 19785009

Title: Characterization of epithelial cell adhesion molecule as a surface marker on undifferentiated human embryonic stem cells.

PubMed ID: 19785009

DOI: 10.1002/stem.221

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 18572020

Title: Identification of EpCAM as the gene for congenital tufting enteropathy.

PubMed ID: 18572020

DOI: 10.1053/j.gastro.2008.05.036

PubMed ID: 24142340

Title: Genetic characterization of congenital tufting enteropathy: epcam associated phenotype and involvement of SPINT2 in the syndromic form.

PubMed ID: 24142340

DOI: 10.1007/s00439-013-1380-6

Sequence Information:

  • Length: 314
  • Mass: 34932
  • Checksum: 023FCE418B2F1079
  • Sequence:
    • MAPPQVLAFG LLLAAATATF AAAQEECVCE NYKLAVNCFV NNNRQCQCTS VGAQNTVICS 
KLAAKCLVMK AEMNGSKLGR RAKPEGALQN NDGLYDPDCD ESGLFKAKQC NGTSMCWCVN 
TAGVRRTDKD TEITCSERVR TYWIIIELKH KAREKPYDSK SLRTALQKEI TTRYQLDPKF 
ITSILYENNV ITIDLVQNSS QKTQNDVDIA DVAYYFEKDV KGESLFHSKK MDLTVNGEQL 
DLDPGQTLIY YVDEKAPEFS MQGLKAGVIA VIVVVVIAVV AGIVVLVISR KKRMAKYEKA 
EIKEMGEMHR ELNA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.