SRF | ENSG00000112658 | NCBI 6722

Details for: SRF

Gene ID: 6722

Symbol: SRF

Ensembl ID: ENSG00000112658

Description: serum response factor

Associated with

Cardiogenesis
(R-HSA-9733709)
Developmental biology
(R-HSA-1266738)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent nuclear events downstream of esr-membrane signaling
(R-HSA-9634638)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Ngf-stimulated transcription
(R-HSA-9031628)
Nuclear events (kinase and transcription factor activation)
(R-HSA-198725)
Regulation of npas4 gene expression
(R-HSA-9768759)
Regulation of npas4 gene transcription
(R-HSA-9768777)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate formins
(R-HSA-5663220)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Transcriptional regulation by npas4
(R-HSA-9634815)
Actin cytoskeleton organization
(GO:0030036)
Angiogenesis involved in wound healing
(GO:0060055)
Associative learning
(GO:0008306)
Axon extension
(GO:0048675)
Branching involved in blood vessel morphogenesis
(GO:0001569)
Cardiac muscle cell myoblast differentiation
(GO:0060379)
Cardiac myofibril assembly
(GO:0055003)
Cell-matrix adhesion
(GO:0007160)
Cell migration involved in sprouting angiogenesis
(GO:0002042)
Chromatin dna binding
(GO:0031490)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription factor binding
(GO:0140297)
Dorsal aorta morphogenesis
(GO:0035912)
Epithelial structure maintenance
(GO:0010669)
Erythrocyte development
(GO:0048821)
Face development
(GO:0060324)
Filopodium assembly
(GO:0046847)
Heart development
(GO:0007507)
Heart looping
(GO:0001947)
Heart trabecula formation
(GO:0060347)
Hematopoietic stem cell differentiation
(GO:0060218)
Hippocampus development
(GO:0021766)
Histone deacetylase binding
(GO:0042826)
Long-term memory
(GO:0007616)
Long-term synaptic depression
(GO:0060292)
Lung morphogenesis
(GO:0060425)
Megakaryocyte development
(GO:0035855)
Mesoderm formation
(GO:0001707)
Morphogenesis of an epithelial sheet
(GO:0002011)
Muscle cell cellular homeostasis
(GO:0046716)
Negative regulation of cell migration
(GO:0030336)
Negative regulation of cell population proliferation
(GO:0008285)
Neuron development
(GO:0048666)
Neuron migration
(GO:0001764)
Platelet activation
(GO:0030168)
Platelet formation
(GO:0030220)
Positive regulation of axon extension
(GO:0045773)
Positive regulation of cell differentiation
(GO:0045597)
Positive regulation of dna-binding transcription factor activity
(GO:0051091)
Positive regulation of filopodium assembly
(GO:0051491)
Positive regulation of smooth muscle contraction
(GO:0045987)
Positive regulation of transcription by glucose
(GO:0046016)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transcription initiation by rna polymerase ii
(GO:0060261)
Positive thymic t cell selection
(GO:0045059)
Primary mirna binding
(GO:0070878)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Regulation of cell adhesion
(GO:0030155)
Regulation of smooth muscle cell differentiation
(GO:0051150)
Response to cytokine
(GO:0034097)
Response to hormone
(GO:0009725)
Response to hypoxia
(GO:0001666)
Response to toxic substance
(GO:0009636)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sarcomere organization
(GO:0045214)
Sequence-specific double-stranded dna binding
(GO:1990837)
Serum response element binding
(GO:0010736)
Skin morphogenesis
(GO:0043589)
Stress fiber assembly
(GO:0043149)
Tangential migration from the subventricular zone to the olfactory bulb
(GO:0022028)
Thymus development
(GO:0048538)
Thyroid gland development
(GO:0030878)
Transcription by rna polymerase ii
(GO:0006366)
Trophectodermal cell differentiation
(GO:0001829)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 104.5355
Cell Significance Index: -16.2600
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 65.0914
Cell Significance Index: -16.5100
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 35.8886
Cell Significance Index: -14.5800
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 15.4178
Cell Significance Index: -14.7200
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 13.9178
Cell Significance Index: -17.1600
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 6.3982
Cell Significance Index: -17.1400
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 4.4069
Cell Significance Index: -17.3900
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 2.4099
Cell Significance Index: 25.6100
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 2.3851
Cell Significance Index: -5.2200
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.1340
Cell Significance Index: 58.0900
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.2516
Cell Significance Index: 36.0600
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.2469
Cell Significance Index: 86.2300
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.2389
Cell Significance Index: 26.8400
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 0.8888
Cell Significance Index: 5.4700
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.8491
Cell Significance Index: 766.7000
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.8289
Cell Significance Index: 37.5700
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.7527
Cell Significance Index: 10.2700
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.6340
Cell Significance Index: 68.9600
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.5963
Cell Significance Index: 113.4700
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5425
Cell Significance Index: 88.2300
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.5261
Cell Significance Index: 27.3300
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.3894
Cell Significance Index: 47.8900
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.3323
Cell Significance Index: 23.5000
Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 0.3160
Cell Significance Index: 1.2100
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.3118
Cell Significance Index: 137.8500
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.3040
Cell Significance Index: 6.4800
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.2919
Cell Significance Index: 13.7200
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.2827
Cell Significance Index: 21.0700
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.2691
Cell Significance Index: 53.9800
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.2080
Cell Significance Index: 37.4900
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1827
Cell Significance Index: 6.4200
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.1820
Cell Significance Index: 4.5500
Cell Name: early promyelocyte (CL0002154)
Fold Change: 0.1801
Cell Significance Index: 1.1500
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1797
Cell Significance Index: 17.7800
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1719
Cell Significance Index: 23.6100
Cell Name: lactocyte (CL0002325)
Fold Change: 0.1708
Cell Significance Index: 22.0700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1604
Cell Significance Index: 7.4800
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1434
Cell Significance Index: 78.3200
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.1417
Cell Significance Index: 28.1200
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.1386
Cell Significance Index: 0.9200
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1220
Cell Significance Index: 3.4100
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0952
Cell Significance Index: 16.2500
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.0937
Cell Significance Index: 4.8800
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.0771
Cell Significance Index: 2.0700
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0701
Cell Significance Index: 8.9900
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0652
Cell Significance Index: 23.3900
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.0528
Cell Significance Index: 3.4100
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0494
Cell Significance Index: 5.8300
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0413
Cell Significance Index: 3.1700
Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.0347
Cell Significance Index: 0.2300
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0069
Cell Significance Index: 12.9900
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0025
Cell Significance Index: -0.2900
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0054
Cell Significance Index: -3.3600
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0063
Cell Significance Index: -9.6800
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0069
Cell Significance Index: -4.8000
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0072
Cell Significance Index: -5.2900
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0081
Cell Significance Index: -6.0100
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0083
Cell Significance Index: -15.2200
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0085
Cell Significance Index: -6.4500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0091
Cell Significance Index: -12.3500
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0169
Cell Significance Index: -7.6900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0185
Cell Significance Index: -10.4100
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0189
Cell Significance Index: -12.0200
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0194
Cell Significance Index: -0.5100
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0228
Cell Significance Index: -1.4400
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0286
Cell Significance Index: -8.2300
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: -0.0326
Cell Significance Index: -0.2700
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0398
Cell Significance Index: -8.3800
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0445
Cell Significance Index: -4.5500
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0449
Cell Significance Index: -1.2000
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0479
Cell Significance Index: -5.4900
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0607
Cell Significance Index: -1.7400
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0700
Cell Significance Index: -10.1700
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0711
Cell Significance Index: -1.1900
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0816
Cell Significance Index: -9.5100
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0846
Cell Significance Index: -2.7100
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1175
Cell Significance Index: -7.9000
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1407
Cell Significance Index: -4.8900
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1501
Cell Significance Index: -15.6300
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1503
Cell Significance Index: -8.4400
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.1857
Cell Significance Index: -2.1100
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1926
Cell Significance Index: -15.2500
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.2094
Cell Significance Index: -3.8700
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2193
Cell Significance Index: -9.7000
Cell Name: peg cell (CL4033014)
Fold Change: -0.2203
Cell Significance Index: -5.0900
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2288
Cell Significance Index: -14.0300
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.2293
Cell Significance Index: -4.8000
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2354
Cell Significance Index: -14.4700
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: -0.2376
Cell Significance Index: -2.4800
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2725
Cell Significance Index: -7.2900
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.2750
Cell Significance Index: -4.1200
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.2786
Cell Significance Index: -10.5500
Cell Name: melanocyte of skin (CL1000458)
Fold Change: -0.2811
Cell Significance Index: -3.9400
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2931
Cell Significance Index: -15.3900
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.3043
Cell Significance Index: -11.1700
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.3045
Cell Significance Index: -8.6900
Cell Name: myometrial cell (CL0002366)
Fold Change: -0.3161
Cell Significance Index: -3.6400
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.3247
Cell Significance Index: -16.4100
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: -0.3261
Cell Significance Index: -4.2000
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.3310
Cell Significance Index: -2.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** SRF is a DNA-binding transcription factor that belongs to the basic helix-loop-helix (bHLH) family. It is characterized by its ability to bind to specific sequences within the promoter regions of target genes, known as serum response elements (SREs). SRF is highly conserved across species, with high sequence identity among vertebrates. Its expression is widespread, with significant levels observed in neural progenitor cells, skeletal muscle satellite stem cells, cardiac muscle myoblasts, and other cell types. **Pathways and Functions:** SRF is intricately involved in various cellular processes, including: 1. **Cardiac development and muscle cell differentiation**: SRF regulates the expression of cardiac muscle-specific genes, such as myosin heavy chain (MHC) and troponin T (TNN), essential for cardiac muscle cell differentiation and contraction. 2. **Neural development and neural network formation**: SRF plays a crucial role in regulating the expression of neural-specific genes, including myelin basic protein (MBP) and neuron-specific enolase (NSE), essential for neural development and network formation. 3. **Smooth muscle cell differentiation and contraction**: SRF regulates the expression of smooth muscle-specific genes, including actin and myosin heavy chain, essential for smooth muscle cell differentiation and contraction. 4. **Cell adhesion and migration**: SRF modulates the expression of cell adhesion molecules, such as integrins and cadherins, facilitating cell migration and tissue morphogenesis. 5. **Gene expression regulation**: SRF acts as a transcriptional activator, regulating the expression of target genes involved in various cellular processes, including differentiation, proliferation, and survival. **Clinical Significance:** Dysregulation of SRF has been implicated in various diseases, including: 1. **Cardiovascular diseases**: Altered SRF expression has been linked to cardiac hypertrophy, heart failure, and arrhythmias. 2. **Neurological disorders**: Changes in SRF expression have been associated with neurodegenerative diseases, such as Alzheimer's and Parkinson's, as well as neurological disorders, such as schizophrenia and autism. 3. **Cancer**: SRF has been implicated in the regulation of cancer cell proliferation, differentiation, and survival, with altered expression observed in various types of cancer, including breast, lung, and colon cancer. 4. **Muscular dystrophy**: SRF plays a critical role in regulating muscle cell differentiation and contraction, making it a potential therapeutic target for muscular dystrophy. In conclusion, SRF is a multifunctional transcription factor that plays a vital role in regulating gene expression and cellular processes across various tissues and developmental stages. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms underlying SRF function and its potential therapeutic applications.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Serum response factor
B4DU24_HUMAN

Genular Protein ID: 2206225886

Symbol: SRF_HUMAN

Name: Serum response factor

UniProtKB Accession Codes:

P11831 Q5T648

Database IDs:

Citations:

PubMed ID: 3203386

Title: Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element.

PubMed ID: 3203386

DOI: 10.1016/0092-8674(88)90244-9

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8375385

Title: C-terminal phosphorylation of the serum-response factor.

PubMed ID: 8375385

DOI: 10.1111/j.1432-1033.1993.tb18165.x

PubMed ID: 1547771

Title: Identification of multiple SRF N-terminal phosphorylation sites affecting DNA binding properties.

PubMed ID: 1547771

DOI: 10.1002/j.1460-2075.1992.tb05143.x

PubMed ID: 1512232

Title: Localization of O-GlcNAc modification on the serum response transcription factor.

PubMed ID: 1512232

DOI: 10.1016/s0021-9258(18)41871-6

PubMed ID: 8407951

Title: The carboxyl-terminal transactivation domain of human serum response factor contains DNA-activated protein kinase phosphorylation sites.

PubMed ID: 8407951

DOI: 10.1016/s0021-9258(19)36904-2

PubMed ID: 14565952

Title: Megakaryoblastic leukemia-1/2, a transcriptional co-activator of serum response factor, is required for skeletal myogenic differentiation.

PubMed ID: 14565952

DOI: 10.1074/jbc.m305679200

PubMed ID: 16054032

Title: Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and myocardin.

PubMed ID: 16054032

DOI: 10.1016/j.devcel.2005.05.017

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17670796

Title: Functional interactions between the Forkhead transcription factor FOXK1 and the MADS-box protein SRF.

PubMed ID: 17670796

DOI: 10.1093/nar/gkm528

PubMed ID: 18497331

Title: The LIM protein leupaxin is enriched in smooth muscle and functions as an serum response factor cofactor to induce smooth muscle cell gene transcription.

PubMed ID: 18497331

DOI: 10.1161/circresaha.107.170357

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19350017

Title: SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin.

PubMed ID: 19350017

DOI: 10.1038/ncb1862

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25298399

Title: Olfactomedin 2, a novel regulator for transforming growth factor-beta-induced smooth muscle differentiation of human embryonic stem cell-derived mesenchymal cells.

PubMed ID: 25298399

DOI: 10.1091/mbc.e14-08-1255

PubMed ID: 7637780

Title: Structure of serum response factor core bound to DNA.

PubMed ID: 7637780

DOI: 10.1038/376490a0

Sequence Information:

Length: 508
Mass: 51593
Checksum: 25505828D3276F44
Sequence:

MLPTQAGAAA ALGRGSALGG SLNRTPTGRP GGGGGTRGAN GGRVPGNGAG LGPGRLEREA 
AAAAATTPAP TAGALYSGSE GDSESGEEEE LGAERRGLKR SLSEMEIGMV VGGPEASAAA 
TGGYGPVSGA VSGAKPGKKT RGRVKIKMEF IDNKLRRYTT FSKRKTGIMK KAYELSTLTG 
TQVLLLVASE TGHVYTFATR KLQPMITSET GKALIQTCLN SPDSPPRSDP TTDQRMSATG 
FEETDLTYQV SESDSSGETK DTLKPAFTVT NLPGTTSTIQ TAPSTSTTMQ VSSGPSFPIT 
NYLAPVSASV SPSAVSSANG TVLKSTGSGP VSSGGLMQLP TSFTLMPGGA VAQQVPVQAI 
QVHQAPQQAS PSRDSSTDLT QTSSSGTVTL PATIMTSSVP TTVGGHMMYP SPHAVMYAPT 
SGLGDGSLTV LNAFSQAPST MQVSHSQVQE PGGVPQVFLT ASSGTVQIPV SAVQLHQMAV 
IGQQAGSSSN LTELQVVNLD TAHSTKSE

Genular Protein ID: 3901881135

Symbol: B4DU24_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DU24

Database IDs:

Sequence Information:

Length: 304
Mass: 31018
Checksum: 1186812204ED7A29
Sequence:

MITSETGKAL IQTCLNSPDS PPRSDPTTDQ RMSATGFEET DLTYQVSESD SSGETKDTLK 
PAFTVTNPPG TTSTIQTAPS TSTTMQVSSG PSFPITNYLA PVSASVSPSA VSSANGTVLK 
STGSGPVSSG GLMQLPTSFT LMPGGAVAQQ VPVQAIQVHQ APQQASPSRD SSTDLTQTSS 
SGTVTLPATI MTSSVPTTVG GHMMYPSPHA VMYAPTSGLG DGSLTVLNAF SQAPSTMQVS 
HSQVQEPGGV PQVFLTASSG TVQIPVSAVQ LHQMAVIGQQ AGSSSNLTEL QVVNLDTAHS 
TKSE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SRF

Associated with

Cells (max top 100)

Other Information

Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element. PubMed ID: 3203386

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

C-terminal phosphorylation of the serum-response factor. PubMed ID: 8375385

Identification of multiple SRF N-terminal phosphorylation sites affecting DNA binding properties. PubMed ID: 1547771

Localization of O-GlcNAc modification on the serum response transcription factor. PubMed ID: 1512232

The carboxyl-terminal transactivation domain of human serum response factor contains DNA-activated protein kinase phosphorylation sites. PubMed ID: 8407951

Megakaryoblastic leukemia-1/2, a transcriptional co-activator of serum response factor, is required for skeletal myogenic differentiation. PubMed ID: 14565952

Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and myocardin. PubMed ID: 16054032

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Functional interactions between the Forkhead transcription factor FOXK1 and the MADS-box protein SRF. PubMed ID: 17670796

The LIM protein leupaxin is enriched in smooth muscle and functions as an serum response factor cofactor to induce smooth muscle cell gene transcription. PubMed ID: 18497331

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin. PubMed ID: 19350017

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Olfactomedin 2, a novel regulator for transforming growth factor-beta-induced smooth muscle differentiation of human embryonic stem cell-derived mesenchymal cells. PubMed ID: 25298399

Structure of serum response factor core bound to DNA. PubMed ID: 7637780