Details for: PPP1R1A

Gene ID: 5502

Symbol: PPP1R1A

Ensembl ID: ENSG00000135447

Description: protein phosphatase 1 regulatory inhibitor subunit 1A

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.92
    Marker Score: 7818
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 2.07
    Marker Score: 544.5
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 2.05
    Marker Score: 764
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.7
    Marker Score: 572
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.68
    Marker Score: 553
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.52
    Marker Score: 9021
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.48
    Marker Score: 1572
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.45
    Marker Score: 2233.5
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.45
    Marker Score: 583
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 866
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.35
    Marker Score: 510
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.3
    Marker Score: 13123
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.22
    Marker Score: 1317
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.16
    Marker Score: 1304
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.13
    Marker Score: 556
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.06
    Marker Score: 1285.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 792
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71820
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48044
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1
    Marker Score: 531
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.94
    Marker Score: 2218
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.94
    Marker Score: 887
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5322
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2736
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.9
    Marker Score: 374
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.88
    Marker Score: 3128
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5283
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.84
    Marker Score: 1702
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.83
    Marker Score: 12961
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.82
    Marker Score: 800
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.81
    Marker Score: 480
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.78
    Marker Score: 791
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 699
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.75
    Marker Score: 437
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.75
    Marker Score: 497
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.74
    Marker Score: 385
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.72
    Marker Score: 339
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.71
    Marker Score: 472
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2909
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.69
    Marker Score: 162
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.64
    Marker Score: 684
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.62
    Marker Score: 179
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.59
    Marker Score: 1127
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.59
    Marker Score: 418
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.57
    Marker Score: 129
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.56
    Marker Score: 170
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.56
    Marker Score: 971
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.55
    Marker Score: 530
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.55
    Marker Score: 231
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.54
    Marker Score: 1281
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.54
    Marker Score: 299
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.53
    Marker Score: 1086
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.52
    Marker Score: 556
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.51
    Marker Score: 184
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.51
    Marker Score: 483
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.51
    Marker Score: 262
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.5
    Marker Score: 108
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.49
    Marker Score: 215
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 472
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.45
    Marker Score: 291
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.45
    Marker Score: 117
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.43
    Marker Score: 459
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.42
    Marker Score: 415
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.4
    Marker Score: 5345
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.4
    Marker Score: 193
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.4
    Marker Score: 1725
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.38
    Marker Score: 186
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.37
    Marker Score: 14209
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 371
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.37
    Marker Score: 175
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.36
    Marker Score: 115
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.36
    Marker Score: 263
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.35
    Marker Score: 102
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.35
    Marker Score: 585
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.35
    Marker Score: 96
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.35
    Marker Score: 115
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.35
    Marker Score: 1407
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.34
    Marker Score: 124
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.34
    Marker Score: 2200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.33
    Marker Score: 192
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.33
    Marker Score: 371
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.33
    Marker Score: 199.5
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.32
    Marker Score: 407
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 0.32
    Marker Score: 85
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.32
    Marker Score: 130
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.32
    Marker Score: 667
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.32
    Marker Score: 448
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.29
    Marker Score: 92

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Other Information

**Key Characteristics:** PPPR1A is a regulatory subunit of the PP1 complex, which is a serine/threonine phosphatase that dephosphorylates and thereby regulates the activity of numerous downstream targets. The PPP1R1A subunit is characterized by its ability to inhibit PP1 activity, thereby modulating the complex's phosphatase activity. This regulatory function is essential for maintaining the balance between phosphorylation and dephosphorylation events in various cellular processes. **Pathways and Functions:** The PPP1R1A subunit is involved in several key pathways, including: 1. **Glycogen Metabolic Process:** PPP1R1A regulates glycogen synthesis and breakdown by modulating the activity of PP1, which in turn affects the phosphorylation and dephosphorylation of key enzymes involved in glycogen metabolism. 2. **Intracellular Signal Transduction:** PPP1R1A modulates the activity of PP1, which is involved in various signaling pathways, including those related to cell growth, differentiation, and survival. 3. **Protein Binding:** PPP1R1A interacts with a range of proteins, including transcription factors, kinases, and phosphatases, to regulate their activity and modulate cellular processes. **Clinical Significance:** Dysregulation of PPP1R1A has been implicated in various diseases, including: 1. **Diabetes:** Abnormalities in glycogen metabolism, mediated by PPP1R1A, have been linked to diabetes mellitus type 2. 2. **Cardiovascular Disease:** Alterations in PP1 activity, regulated by PPP1R1A, have been implicated in the development of cardiovascular disease. 3. **Neurological Disorders:** PPP1R1A has been linked to various neurological disorders, including Alzheimer's disease and Parkinson's disease, where dysregulation of PP1 activity contributes to disease pathology. In conclusion, PPP1R1A plays a critical role in regulating cellular processes through its inhibition of PP1 activity. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining cellular homeostasis and overall health. Further research is needed to elucidate the mechanisms by which PPP1R1A regulates PP1 activity and its role in disease pathology.

Genular Protein ID: 1420756147

Symbol: PPR1A_HUMAN

Name: Protein phosphatase 1 regulatory subunit 1A

UniProtKB Accession Codes:

Q13522 Q6IB01 Q8TBJ2 Q8WWV2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 4 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8611507

Title: Multiple structural elements define the specificity of recombinant human inhibitor-1 as a protein phosphatase-1 inhibitor.

PubMed ID: 8611507

DOI: 10.1021/bi952940f

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11564868

Title: Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.

PubMed ID: 11564868

DOI: 10.1128/mcb.21.20.6841-6850.2001

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 171
  • Mass: 18939
  • Checksum: 6F629C68E430552B
  • Sequence:
    • MEQDNSPRKI QFTVPLLEPH LDPEAAEQIR RRRPTPATLV LTSDQSSPEI DEDRIPNPHL 
KSTLAMSPRQ RKKMTRITPT MKELQMMVEH HLGQQQQGEE PEGAAESTGT QESRPPGIPD 
TEVESRLGTS GTAKKTAECI PKTHERGSKE PSTKEPSTHI PPLDSKGANS V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.