Details for: PPP1R1A

Gene ID: 5502

Symbol: PPP1R1A

Ensembl ID: ENSG00000135447

Description: protein phosphatase 1 regulatory inhibitor subunit 1A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.9785
    Cell Significance Index: 5.6700
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.9188
    Cell Significance Index: 21.4500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.4460
    Cell Significance Index: 75.9200
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 1.3034
    Cell Significance Index: 21.0300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 1.0880
    Cell Significance Index: 86.1700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.0001
    Cell Significance Index: 14.5200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9920
    Cell Significance Index: 98.1400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9523
    Cell Significance Index: 57.1700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.9297
    Cell Significance Index: 22.6900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9053
    Cell Significance Index: 172.2900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7565
    Cell Significance Index: 82.2900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.7493
    Cell Significance Index: 10.5100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7073
    Cell Significance Index: 638.6800
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.6697
    Cell Significance Index: 7.9200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.6631
    Cell Significance Index: 14.5200
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.6394
    Cell Significance Index: 3.1900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.6225
    Cell Significance Index: 4.9700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.6195
    Cell Significance Index: 16.2900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.5909
    Cell Significance Index: 433.2700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5329
    Cell Significance Index: 86.6800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4791
    Cell Significance Index: 21.1900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3632
    Cell Significance Index: 46.9300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3602
    Cell Significance Index: 13.6400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.3476
    Cell Significance Index: 2.9200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3423
    Cell Significance Index: 23.6800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.3017
    Cell Significance Index: 3.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2230
    Cell Significance Index: 6.4300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1994
    Cell Significance Index: 39.9900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1536
    Cell Significance Index: 10.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1007
    Cell Significance Index: 19.9800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0981
    Cell Significance Index: 11.2000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0942
    Cell Significance Index: 1.9600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0819
    Cell Significance Index: 29.3600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0753
    Cell Significance Index: 5.6100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0704
    Cell Significance Index: 1.5000
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.0589
    Cell Significance Index: 0.3100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0415
    Cell Significance Index: 2.5500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0240
    Cell Significance Index: 0.5200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0148
    Cell Significance Index: 2.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0076
    Cell Significance Index: 5.6600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0057
    Cell Significance Index: 0.2700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0019
    Cell Significance Index: 0.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.0007
    Cell Significance Index: 0.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0001
    Cell Significance Index: -0.0800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0043
    Cell Significance Index: -0.1500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0045
    Cell Significance Index: -1.9900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0059
    Cell Significance Index: -3.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0059
    Cell Significance Index: -11.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0141
    Cell Significance Index: -10.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0169
    Cell Significance Index: -10.7600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0197
    Cell Significance Index: -2.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0207
    Cell Significance Index: -11.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0305
    Cell Significance Index: -13.8300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0328
    Cell Significance Index: -9.4400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0342
    Cell Significance Index: -1.5500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0380
    Cell Significance Index: -3.8800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0416
    Cell Significance Index: -0.7000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0518
    Cell Significance Index: -1.6600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0584
    Cell Significance Index: -1.0000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0606
    Cell Significance Index: -10.9200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0617
    Cell Significance Index: -0.7900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0619
    Cell Significance Index: -4.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0641
    Cell Significance Index: -8.8000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0669
    Cell Significance Index: -3.1200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0751
    Cell Significance Index: -1.9300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0760
    Cell Significance Index: -8.7100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0833
    Cell Significance Index: -5.1100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0841
    Cell Significance Index: -1.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0853
    Cell Significance Index: -10.4900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0866
    Cell Significance Index: -1.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0870
    Cell Significance Index: -12.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1010
    Cell Significance Index: -5.6700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1030
    Cell Significance Index: -7.9100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1037
    Cell Significance Index: -4.5100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1052
    Cell Significance Index: -2.8200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1074
    Cell Significance Index: -6.7700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1093
    Cell Significance Index: -11.3800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1282
    Cell Significance Index: -1.0900
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.1332
    Cell Significance Index: -1.2000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1711
    Cell Significance Index: -2.4500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1868
    Cell Significance Index: -6.4900
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.2201
    Cell Significance Index: -2.5900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2244
    Cell Significance Index: -5.6100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2250
    Cell Significance Index: -3.3900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2452
    Cell Significance Index: -5.8800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2517
    Cell Significance Index: -8.0200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2520
    Cell Significance Index: -4.2500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2578
    Cell Significance Index: -13.3900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2650
    Cell Significance Index: -4.1000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2680
    Cell Significance Index: -5.3800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2777
    Cell Significance Index: -8.1800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2838
    Cell Significance Index: -3.5200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3059
    Cell Significance Index: -10.7200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3091
    Cell Significance Index: -10.1200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3227
    Cell Significance Index: -9.2100
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.3262
    Cell Significance Index: -4.6400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3291
    Cell Significance Index: -12.0800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3319
    Cell Significance Index: -5.5600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3391
    Cell Significance Index: -5.0100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3435
    Cell Significance Index: -9.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PPPR1A is a regulatory subunit of the PP1 complex, which is a serine/threonine phosphatase that dephosphorylates and thereby regulates the activity of numerous downstream targets. The PPP1R1A subunit is characterized by its ability to inhibit PP1 activity, thereby modulating the complex's phosphatase activity. This regulatory function is essential for maintaining the balance between phosphorylation and dephosphorylation events in various cellular processes. **Pathways and Functions:** The PPP1R1A subunit is involved in several key pathways, including: 1. **Glycogen Metabolic Process:** PPP1R1A regulates glycogen synthesis and breakdown by modulating the activity of PP1, which in turn affects the phosphorylation and dephosphorylation of key enzymes involved in glycogen metabolism. 2. **Intracellular Signal Transduction:** PPP1R1A modulates the activity of PP1, which is involved in various signaling pathways, including those related to cell growth, differentiation, and survival. 3. **Protein Binding:** PPP1R1A interacts with a range of proteins, including transcription factors, kinases, and phosphatases, to regulate their activity and modulate cellular processes. **Clinical Significance:** Dysregulation of PPP1R1A has been implicated in various diseases, including: 1. **Diabetes:** Abnormalities in glycogen metabolism, mediated by PPP1R1A, have been linked to diabetes mellitus type 2. 2. **Cardiovascular Disease:** Alterations in PP1 activity, regulated by PPP1R1A, have been implicated in the development of cardiovascular disease. 3. **Neurological Disorders:** PPP1R1A has been linked to various neurological disorders, including Alzheimer's disease and Parkinson's disease, where dysregulation of PP1 activity contributes to disease pathology. In conclusion, PPP1R1A plays a critical role in regulating cellular processes through its inhibition of PP1 activity. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining cellular homeostasis and overall health. Further research is needed to elucidate the mechanisms by which PPP1R1A regulates PP1 activity and its role in disease pathology.

Genular Protein ID: 1420756147

Symbol: PPR1A_HUMAN

Name: Protein phosphatase 1 regulatory subunit 1A

UniProtKB Accession Codes:

Q13522 Q6IB01 Q8TBJ2 Q8WWV2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 4 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8611507

Title: Multiple structural elements define the specificity of recombinant human inhibitor-1 as a protein phosphatase-1 inhibitor.

PubMed ID: 8611507

DOI: 10.1021/bi952940f

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11564868

Title: Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.

PubMed ID: 11564868

DOI: 10.1128/mcb.21.20.6841-6850.2001

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 171
  • Mass: 18939
  • Checksum: 6F629C68E430552B
  • Sequence:
    • MEQDNSPRKI QFTVPLLEPH LDPEAAEQIR RRRPTPATLV LTSDQSSPEI DEDRIPNPHL 
KSTLAMSPRQ RKKMTRITPT MKELQMMVEH HLGQQQQGEE PEGAAESTGT QESRPPGIPD 
TEVESRLGTS GTAKKTAECI PKTHERGSKE PSTKEPSTHI PPLDSKGANS V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.