Associated with
Cells (max top 100)
(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 4.69
Marker Score: 29913 - Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 4.49
Marker Score: 3512 - Cell Name: colon epithelial cell (CL0011108)
Fold Change: 4.23
Marker Score: 13298 - Cell Name: intestine goblet cell (CL0019031)
Fold Change: 3.96
Marker Score: 3794 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.87
Marker Score: 9455 - Cell Name: enterocyte (CL0000584)
Fold Change: 3.77
Marker Score: 18094 - Cell Name: type I pneumocyte (CL0002062)
Fold Change: 3.74
Marker Score: 4511 - Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 3.7
Marker Score: 27534 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 3.45
Marker Score: 13293 - Cell Name: mucous neck cell (CL0000651)
Fold Change: 3.44
Marker Score: 7817 - Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 3.44
Marker Score: 1104 - Cell Name: epithelial cell (CL0000066)
Fold Change: 3.43
Marker Score: 5461 - Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 3.34
Marker Score: 17566 - Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 3.31
Marker Score: 2607 - Cell Name: cell in vitro (CL0001034)
Fold Change: 3.21
Marker Score: 111228 - Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 3.2
Marker Score: 1105 - Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 3.19
Marker Score: 27710 - Cell Name: kidney loop of Henle epithelial cell (CL1000909)
Fold Change: 3.18
Marker Score: 1993 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 3.15
Marker Score: 1832 - Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 2.86
Marker Score: 4734 - Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 2.84
Marker Score: 7174 - Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 2.83
Marker Score: 1055 - Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 2.81
Marker Score: 1384 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.8
Marker Score: 6388 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 2.76
Marker Score: 4896 - Cell Name: duct epithelial cell (CL0000068)
Fold Change: 2.75
Marker Score: 1286 - Cell Name: stem cell (CL0000034)
Fold Change: 2.74
Marker Score: 6519 - Cell Name: secretory cell (CL0000151)
Fold Change: 2.74
Marker Score: 5000 - Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 2.73
Marker Score: 7444 - Cell Name: enterocyte of colon (CL1000347)
Fold Change: 2.72
Marker Score: 4192 - Cell Name: lung secretory cell (CL1000272)
Fold Change: 2.71
Marker Score: 2419 - Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 2.69
Marker Score: 853 - Cell Name: pneumocyte (CL0000322)
Fold Change: 2.67
Marker Score: 4284 - Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 2.66
Marker Score: 4355 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.62
Marker Score: 3866 - Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
Fold Change: 2.57
Marker Score: 744 - Cell Name: type II pneumocyte (CL0002063)
Fold Change: 2.57
Marker Score: 16751.5 - Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 2.56
Marker Score: 911 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 2.54
Marker Score: 9024 - Cell Name: granulosa cell (CL0000501)
Fold Change: 2.5
Marker Score: 25149 - Cell Name: peptic cell (CL0000155)
Fold Change: 2.48
Marker Score: 1040 - Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 2.48
Marker Score: 9193 - Cell Name: club cell (CL0000158)
Fold Change: 2.45
Marker Score: 2865 - Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 2.45
Marker Score: 4663 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.41
Marker Score: 2540.5 - Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 2.35
Marker Score: 1327 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.34
Marker Score: 9215 - Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 2.3
Marker Score: 1540 - Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 2.27
Marker Score: 1252 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 2.27
Marker Score: 3215 - Cell Name: serous secreting cell (CL0000313)
Fold Change: 2.26
Marker Score: 902 - Cell Name: taste receptor cell (CL0000209)
Fold Change: 2.25
Marker Score: 1948 - Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 2.25
Marker Score: 650 - Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 2.24
Marker Score: 5266 - Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 2.19
Marker Score: 9136.5 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 2.19
Marker Score: 2274 - Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 2.14
Marker Score: 806 - Cell Name: ciliated cell (CL0000064)
Fold Change: 2.11
Marker Score: 7268 - Cell Name: PP cell (CL0000696)
Fold Change: 2.07
Marker Score: 467 - Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 2.07
Marker Score: 928 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 2.03
Marker Score: 503 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2.02
Marker Score: 2011 - Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 1.96
Marker Score: 790 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.95
Marker Score: 4122 - Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 1.93
Marker Score: 379 - Cell Name: endocrine cell (CL0000163)
Fold Change: 1.93
Marker Score: 1000 - Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 1.93
Marker Score: 466 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 1.92
Marker Score: 2036 - Cell Name: renal intercalated cell (CL0005010)
Fold Change: 1.89
Marker Score: 1006 - Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 1.87
Marker Score: 615 - Cell Name: Unknown (CL0002371)
Fold Change: 1.86
Marker Score: 1972 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 1.86
Marker Score: 4973 - Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 1.85
Marker Score: 9083.5 - Cell Name: kidney cell (CL1000497)
Fold Change: 1.8
Marker Score: 1203 - Cell Name: basal cell (CL0000646)
Fold Change: 1.74
Marker Score: 2242 - Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 1.72
Marker Score: 404 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: 1.7
Marker Score: 876 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.69
Marker Score: 933 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 1.69
Marker Score: 1175 - Cell Name: papillary tips cell (CL1000597)
Fold Change: 1.68
Marker Score: 339 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.65
Marker Score: 26539 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 1.64
Marker Score: 1120 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 1.63
Marker Score: 1449 - Cell Name: acinar cell (CL0000622)
Fold Change: 1.63
Marker Score: 1149 - Cell Name: mucus secreting cell (CL0000319)
Fold Change: 1.61
Marker Score: 409 - Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 1.6
Marker Score: 605 - Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 1.53
Marker Score: 794.5 - Cell Name: pulmonary ionocyte (CL0017000)
Fold Change: 1.52
Marker Score: 930 - Cell Name: mesothelial cell (CL0000077)
Fold Change: 1.51
Marker Score: 606 - Cell Name: mesodermal cell (CL0000222)
Fold Change: 1.49
Marker Score: 19700 - Cell Name: paneth cell (CL0000510)
Fold Change: 1.48
Marker Score: 1031 - Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 1.47
Marker Score: 1209 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 1.47
Marker Score: 469 - Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 167398 - Cell Name: IgA plasma cell (CL0000987)
Fold Change: 1.46
Marker Score: 1240 - Cell Name: lung ciliated cell (CL1000271)
Fold Change: 1.4
Marker Score: 666 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: 1.37
Marker Score: 596 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 1.36
Marker Score: 1383 - Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 1.35
Marker Score: 294 - Cell Name: Sertoli cell (CL0000216)
Fold Change: 1.34
Marker Score: 7947
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Other Information
Genular Protein ID: 2361017819
Symbol: K2C8_HUMAN
Name: Keratin, type II cytoskeletal 8
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1691124
Title: Organization and sequence of the human gene encoding cytokeratin 8.
PubMed ID: 1691124
PubMed ID: 1692965
Title: Cloning and sequence of cDNA for human placental cytokeratin 8. Regulation of the mRNA in trophoblastic cells by cAMP.
PubMed ID: 1692965
DOI: 10.1210/mend-4-3-370
PubMed ID: 1705144
Title: Embryonic simple epithelial keratins 8 and 18: chromosomal location emphasizes difference from other keratin pairs.
PubMed ID: 1705144
PubMed ID: 9054461
Title: Phosphorylation of human keratin 8 in vivo at conserved head domain serine 23 and at epidermal growth factor-stimulated tail domain serine 431.
PubMed ID: 9054461
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16541075
Title: The finished DNA sequence of human chromosome 12.
PubMed ID: 16541075
DOI: 10.1038/nature04569
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2471065
Title: Posttranslational regulation of keratins: degradation of mouse and human keratins 18 and 8.
PubMed ID: 2471065
PubMed ID: 2434381
Title: Cytokeratin expression in simple epithelia. III. Detection of mRNAs encoding human cytokeratins nos. 8 and 18 in normal and tumor cells by hybridization with cDNA sequences in vitro and in situ.
PubMed ID: 2434381
PubMed ID: 9150948
Title: A two-dimensional gel database of human colon carcinoma proteins.
PubMed ID: 9150948
PubMed ID: 1371281
Title: Characterization and dynamics of O-linked glycosylation of human cytokeratin 8 and 18.
PubMed ID: 1371281
PubMed ID: 1374067
Title: PKC epsilon-related kinase associates with and phosphorylates cytokeratin 8 and 18.
PubMed ID: 1374067
PubMed ID: 10973561
Title: An immunohistological study of cytokeratin 20 in human and mammalian oral epithelium.
PubMed ID: 10973561
PubMed ID: 10809736
Title: Dissection of protein linkage between keratins and pinin, a protein with dual location at desmosome-intermediate filament complex and in the nucleus.
PubMed ID: 10809736
PubMed ID: 10852826
Title: Interaction of plakophilins with desmoplakin and intermediate filament proteins: an in vitro analysis.
PubMed ID: 10852826
PubMed ID: 11781324
Title: The intermediate filament protein keratin 8 is a novel cytoplasmic substrate for c-Jun N-terminal kinase.
PubMed ID: 11781324
PubMed ID: 11788583
Title: Keratin 8 phosphorylation by p38 kinase regulates cellular keratin filament reorganization: modulation by a keratin 1-like disease causing mutation.
PubMed ID: 11788583
PubMed ID: 15731013
Title: Identification of trichoplein, a novel keratin filament-binding protein.
PubMed ID: 15731013
DOI: 10.1242/jcs.01667
PubMed ID: 16000376
Title: Specific interaction of the actin-binding domain of dystrophin with intermediate filaments containing keratin 19.
PubMed ID: 16000376
PubMed ID: 15846844
Title: Proteomic profiling of cellular proteins interacting with the hepatitis C virus core protein.
PubMed ID: 15846844
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16608857
Title: Keratin 20 serine 13 phosphorylation is a stress and intestinal goblet cell marker.
PubMed ID: 16608857
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19188445
Title: APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.
PubMed ID: 19188445
DOI: 10.1128/mcb.01337-08
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20729549
Title: O-GlcNAcylation determines the solubility, filament organization, and stability of keratins 8 and 18.
PubMed ID: 20729549
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21908771
Title: The first identification of lysine malonylation substrates and its regulatory enzyme.
PubMed ID: 21908771
PubMed ID: 21149639
Title: G protein-coupled estrogen receptor 1/G protein-coupled receptor 30 localizes in the plasma membrane and traffics intracellularly on cytokeratin intermediate filaments.
PubMed ID: 21149639
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22967762
Title: Characterization of O-GlcNAc cycling and proteomic identification of differentially O-GlcNAcylated proteins during G1/S transition.
PubMed ID: 22967762
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24940650
Title: Interaction of plectin with keratins 5 and 14: dependence on several plectin domains and keratin quaternary structure.
PubMed ID: 24940650
DOI: 10.1038/jid.2014.255
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24129315
Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
PubMed ID: 24129315
PubMed ID: 25218447
Title: Uncovering global SUMOylation signaling networks in a site-specific manner.
PubMed ID: 25218447
DOI: 10.1038/nsmb.2890
PubMed ID: 25114211
Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.
PubMed ID: 25114211
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 12724528
Title: Keratin 8 and 18 mutations are risk factors for developing liver disease of multiple etiologies.
PubMed ID: 12724528
Sequence Information:
- Length: 483
- Mass: 53704
- Checksum: B0BC730B65929D37
- Sequence:
MSIRVTQKSY KVSTSGPRAF SSRSYTSGPG SRISSSSFSR VGSSNFRGGL GGGYGGASGM GGITAVTVNQ SLLSPLVLEV DPNIQAVRTQ EKEQIKTLNN KFASFIDKVR FLEQQNKMLE TKWSLLQQQK TARSNMDNMF ESYINNLRRQ LETLGQEKLK LEAELGNMQG LVEDFKNKYE DEINKRTEME NEFVLIKKDV DEAYMNKVEL ESRLEGLTDE INFLRQLYEE EIRELQSQIS DTSVVLSMDN SRSLDMDSII AEVKAQYEDI ANRSRAEAES MYQIKYEELQ SLAGKHGDDL RRTKTEISEM NRNISRLQAE IEGLKGQRAS LEAAIADAEQ RGELAIKDAN AKLSELEAAL QRAKQDMARQ LREYQELMNV KLALDIEIAT YRKLLEGEES RLESGMQNMS IHTKTTSGYA GGLSSAYGGL TSPGLSYSLG SSFGSGAGSS SFSRTSSSRA VVVKKIETRD GKLVSESSDV LPK
Genular Protein ID: 2157958652
Symbol: Q7L4M3_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 279
- Mass: 30820
- Checksum: D9B2EB27FD985629
- Sequence:
MNKVELESRL EGLTDEINFL RQLYEEEIRE LQSQISDTSV VLSMDNSRSL DMDSIIAEVK AQYEDIANRS RAEAESMYQI KYEELQSLAG KHGDDLRRTK TEISEMNRNI SRLQAEIEGL KGQRASLEAA IADAEQRGEL AIKDANAKLS ELEAALQRAK QDMARQLREY QELMNVKLAL DIEIATYRKL LEGEESRLES GMQNMSIHTK TTSGYAGGLS SAYGGLTSPG LSYSLGSSFG SGAGSSSFSR TSSSRAVVVK KIETRDGKLV SESSDVLPK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.