Details for: KRT8

Gene ID: 3856

Symbol: KRT8

Ensembl ID: ENSG00000170421

Description: keratin 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 296.3125
    Cell Significance Index: -46.0900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 170.2784
    Cell Significance Index: -43.1900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 117.6363
    Cell Significance Index: -48.4600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 108.3405
    Cell Significance Index: -51.1500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 75.1167
    Cell Significance Index: -50.4100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 37.4060
    Cell Significance Index: -46.1200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 18.6499
    Cell Significance Index: 114.7800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.8380
    Cell Significance Index: -37.0700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 11.5559
    Cell Significance Index: 106.4200
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 10.9790
    Cell Significance Index: 61.1100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 9.5208
    Cell Significance Index: 709.5800
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 9.4489
    Cell Significance Index: 45.9600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 8.8416
    Cell Significance Index: 240.6600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 6.9639
    Cell Significance Index: 160.8900
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 6.9183
    Cell Significance Index: 26.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 6.1909
    Cell Significance Index: 799.8200
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 6.1678
    Cell Significance Index: 62.2200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 6.1325
    Cell Significance Index: 91.8900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 6.0803
    Cell Significance Index: 37.7800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 6.0655
    Cell Significance Index: 282.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 5.3114
    Cell Significance Index: 275.9100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 5.0512
    Cell Significance Index: 910.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 4.5888
    Cell Significance Index: 2506.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 4.5884
    Cell Significance Index: 564.1800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 4.4147
    Cell Significance Index: 127.2000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.0026
    Cell Significance Index: -8.7600
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 3.6240
    Cell Significance Index: 1.8200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 3.6018
    Cell Significance Index: 356.3000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.2213
    Cell Significance Index: 25.7200
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.1896
    Cell Significance Index: 19.7400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.8637
    Cell Significance Index: 75.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.7433
    Cell Significance Index: 124.3500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.7414
    Cell Significance Index: 73.2000
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 2.5384
    Cell Significance Index: 52.9400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.4698
    Cell Significance Index: 116.0800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.2690
    Cell Significance Index: 246.8000
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.1477
    Cell Significance Index: 17.7600
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.8624
    Cell Significance Index: 11.1600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.7220
    Cell Significance Index: 17.8200
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 1.7126
    Cell Significance Index: 6.4500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5310
    Cell Significance Index: 303.8400
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 1.3783
    Cell Significance Index: 0.9900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.3118
    Cell Significance Index: 224.0000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 1.0409
    Cell Significance Index: 36.5800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.8739
    Cell Significance Index: 27.9900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8519
    Cell Significance Index: 162.1300
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.7108
    Cell Significance Index: 3.7400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4773
    Cell Significance Index: 13.3400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.4748
    Cell Significance Index: 359.3800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4111
    Cell Significance Index: 4.6700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3477
    Cell Significance Index: 153.7400
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.2451
    Cell Significance Index: 2.1200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.2055
    Cell Significance Index: 23.4600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0634
    Cell Significance Index: 46.4900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0586
    Cell Significance Index: 7.5100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0348
    Cell Significance Index: 0.3600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0223
    Cell Significance Index: 1.5800
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0032
    Cell Significance Index: 0.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0004
    Cell Significance Index: -0.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0121
    Cell Significance Index: -22.7300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0251
    Cell Significance Index: -46.2100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0287
    Cell Significance Index: -0.3700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0321
    Cell Significance Index: -49.4200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0323
    Cell Significance Index: -20.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0358
    Cell Significance Index: -22.7100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0371
    Cell Significance Index: -50.4100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0445
    Cell Significance Index: -4.5500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0477
    Cell Significance Index: -26.9000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0496
    Cell Significance Index: -1.2400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0544
    Cell Significance Index: -11.4500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0717
    Cell Significance Index: -20.6300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0801
    Cell Significance Index: -1.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0827
    Cell Significance Index: -9.4800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1055
    Cell Significance Index: -47.8800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1109
    Cell Significance Index: -16.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1112
    Cell Significance Index: -39.8900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1496
    Cell Significance Index: -1.2200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1503
    Cell Significance Index: -2.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1539
    Cell Significance Index: -21.1300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1624
    Cell Significance Index: -8.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.2004
    Cell Significance Index: -40.2100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2006
    Cell Significance Index: -23.3800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2064
    Cell Significance Index: -4.3200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2067
    Cell Significance Index: -3.4600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3236
    Cell Significance Index: -13.2600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.3280
    Cell Significance Index: -4.6000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3405
    Cell Significance Index: -26.9700
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.3533
    Cell Significance Index: -2.4500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.3678
    Cell Significance Index: -5.6900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.3972
    Cell Significance Index: -4.1900
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: -0.4193
    Cell Significance Index: -0.3200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4275
    Cell Significance Index: -6.3100
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.4400
    Cell Significance Index: -2.7300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4421
    Cell Significance Index: -46.0400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4529
    Cell Significance Index: -53.4100
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.4887
    Cell Significance Index: -4.0400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5049
    Cell Significance Index: -14.8700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.5461
    Cell Significance Index: -3.7000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.5969
    Cell Significance Index: -10.0600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5984
    Cell Significance Index: -45.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** KRT8 is expressed in a wide range of cell types, including epithelial cells, neural cells, and muscle cells. 2. **Intermediate Filament Formation:** KRT8 forms a homodimer with KRT18 to create a type II keratin intermediate filament, which is essential for maintaining cell shape and providing mechanical support. 3. **Cell-Cell Adhesion:** KRT8 interacts with other keratins and transmembrane proteins to regulate cell-cell adhesion and tissue integrity. 4. **Cytoplasmic Localization:** KRT8 is primarily localized to the cytoplasm, where it interacts with other proteins and regulates cytoskeletal dynamics. **Pathways and Functions:** 1. **Cell Differentiation and Development:** KRT8 is involved in regulating cell differentiation and development, particularly during embryonic development and tissue morphogenesis. 2. **Apoptosis and Necrosis:** KRT8 has been implicated in regulating apoptosis and necrosis, particularly in response to extrinsic apoptotic signaling pathways. 3. **Cytoskeletal Dynamics:** KRT8 regulates cytoskeletal dynamics, including microtubule and actin filament organization, to maintain cell shape and mechanical stability. 4. **Cell-Cell Adhesion and Tight Junctions:** KRT8 interacts with other proteins to regulate cell-cell adhesion and maintain tight junctions, which are essential for epithelial barrier function. **Clinical Significance:** 1. **Cancer:** Dysregulation of KRT8 has been implicated in various cancers, including breast, lung, and colon cancer, where it can contribute to tumor progression and metastasis. 2. **Cardiovascular Disorders:** KRT8 has been implicated in cardiovascular disorders, including atherosclerosis and cardiac hypertrophy, where it can contribute to vascular smooth muscle cell proliferation and migration. 3. **Neurodegenerative Conditions:** KRT8 has been implicated in neurodegenerative conditions, including Alzheimer's disease and Parkinson's disease, where it can contribute to neuronal loss and axonal degeneration. 4. **Surgical Complications:** KRT8 has been implicated in surgical complications, including wound healing disorders and tissue adhesions, where it can contribute to tissue damage and scarring. In conclusion, KRT8 plays a critical role in maintaining tissue integrity and function, particularly in epithelial tissues. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its regulation and function in disease prevention and treatment. Further research is needed to elucidate the complex interactions between KRT8 and other proteins to develop novel therapeutic strategies for diseases associated with KRT8 dysregulation.

Genular Protein ID: 2361017819

Symbol: K2C8_HUMAN

Name: Keratin, type II cytoskeletal 8

UniProtKB Accession Codes:

P05787 A8K4H3 B0AZN5 F8VXB4 Q14099 Q14716 Q14717 Q53GJ0 Q6DHW5 Q6GMY0 Q6P4C7 Q96J60

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CPTAC 4 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 ELM 1 EMBL 18 Ensembl 5 ExpressionAtlas 1 GO 24 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1691124

Title: Organization and sequence of the human gene encoding cytokeratin 8.

PubMed ID: 1691124

DOI: 10.1016/0378-1119(90)90285-y

PubMed ID: 1692965

Title: Cloning and sequence of cDNA for human placental cytokeratin 8. Regulation of the mRNA in trophoblastic cells by cAMP.

PubMed ID: 1692965

DOI: 10.1210/mend-4-3-370

PubMed ID: 1705144

Title: Embryonic simple epithelial keratins 8 and 18: chromosomal location emphasizes difference from other keratin pairs.

PubMed ID: 1705144

PubMed ID: 9054461

Title: Phosphorylation of human keratin 8 in vivo at conserved head domain serine 23 and at epidermal growth factor-stimulated tail domain serine 431.

PubMed ID: 9054461

DOI: 10.1074/jbc.272.11.7556

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2471065

Title: Posttranslational regulation of keratins: degradation of mouse and human keratins 18 and 8.

PubMed ID: 2471065

DOI: 10.1128/mcb.9.4.1553-1565.1989

PubMed ID: 2434381

Title: Cytokeratin expression in simple epithelia. III. Detection of mRNAs encoding human cytokeratins nos. 8 and 18 in normal and tumor cells by hybridization with cDNA sequences in vitro and in situ.

PubMed ID: 2434381

DOI: 10.1111/j.1432-0436.1986.tb00412.x

PubMed ID: 9150948

Title: A two-dimensional gel database of human colon carcinoma proteins.

PubMed ID: 9150948

DOI: 10.1002/elps.1150180344

PubMed ID: 1371281

Title: Characterization and dynamics of O-linked glycosylation of human cytokeratin 8 and 18.

PubMed ID: 1371281

DOI: 10.1016/s0021-9258(19)50611-1

PubMed ID: 1374067

Title: PKC epsilon-related kinase associates with and phosphorylates cytokeratin 8 and 18.

PubMed ID: 1374067

DOI: 10.1083/jcb.117.3.583

PubMed ID: 10973561

Title: An immunohistological study of cytokeratin 20 in human and mammalian oral epithelium.

PubMed ID: 10973561

DOI: 10.1016/s0003-9969(00)00050-9

PubMed ID: 10809736

Title: Dissection of protein linkage between keratins and pinin, a protein with dual location at desmosome-intermediate filament complex and in the nucleus.

PubMed ID: 10809736

DOI: 10.1074/jbc.275.20.14910

PubMed ID: 10852826

Title: Interaction of plakophilins with desmoplakin and intermediate filament proteins: an in vitro analysis.

PubMed ID: 10852826

DOI: 10.1242/jcs.113.13.2471

PubMed ID: 11781324

Title: The intermediate filament protein keratin 8 is a novel cytoplasmic substrate for c-Jun N-terminal kinase.

PubMed ID: 11781324

DOI: 10.1074/jbc.m111436200

PubMed ID: 11788583

Title: Keratin 8 phosphorylation by p38 kinase regulates cellular keratin filament reorganization: modulation by a keratin 1-like disease causing mutation.

PubMed ID: 11788583

DOI: 10.1074/jbc.m107623200

PubMed ID: 15731013

Title: Identification of trichoplein, a novel keratin filament-binding protein.

PubMed ID: 15731013

DOI: 10.1242/jcs.01667

PubMed ID: 16000376

Title: Specific interaction of the actin-binding domain of dystrophin with intermediate filaments containing keratin 19.

PubMed ID: 16000376

DOI: 10.1091/mbc.e05-02-0112

PubMed ID: 15846844

Title: Proteomic profiling of cellular proteins interacting with the hepatitis C virus core protein.

PubMed ID: 15846844

DOI: 10.1002/pmic.200401093

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16608857

Title: Keratin 20 serine 13 phosphorylation is a stress and intestinal goblet cell marker.

PubMed ID: 16608857

DOI: 10.1074/jbc.m512284200

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19188445

Title: APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.

PubMed ID: 19188445

DOI: 10.1128/mcb.01337-08

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20729549

Title: O-GlcNAcylation determines the solubility, filament organization, and stability of keratins 8 and 18.

PubMed ID: 20729549

DOI: 10.1074/jbc.m109.098996

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21908771

Title: The first identification of lysine malonylation substrates and its regulatory enzyme.

PubMed ID: 21908771

DOI: 10.1074/mcp.m111.012658

PubMed ID: 21149639

Title: G protein-coupled estrogen receptor 1/G protein-coupled receptor 30 localizes in the plasma membrane and traffics intracellularly on cytokeratin intermediate filaments.

PubMed ID: 21149639

DOI: 10.1124/mol.110.069500

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22967762

Title: Characterization of O-GlcNAc cycling and proteomic identification of differentially O-GlcNAcylated proteins during G1/S transition.

PubMed ID: 22967762

DOI: 10.1016/j.bbagen.2012.08.024

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24940650

Title: Interaction of plectin with keratins 5 and 14: dependence on several plectin domains and keratin quaternary structure.

PubMed ID: 24940650

DOI: 10.1038/jid.2014.255

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 12724528

Title: Keratin 8 and 18 mutations are risk factors for developing liver disease of multiple etiologies.

PubMed ID: 12724528

DOI: 10.1073/pnas.0936165100

Sequence Information:

  • Length: 483
  • Mass: 53704
  • Checksum: B0BC730B65929D37
  • Sequence:
    • MSIRVTQKSY KVSTSGPRAF SSRSYTSGPG SRISSSSFSR VGSSNFRGGL GGGYGGASGM 
GGITAVTVNQ SLLSPLVLEV DPNIQAVRTQ EKEQIKTLNN KFASFIDKVR FLEQQNKMLE 
TKWSLLQQQK TARSNMDNMF ESYINNLRRQ LETLGQEKLK LEAELGNMQG LVEDFKNKYE 
DEINKRTEME NEFVLIKKDV DEAYMNKVEL ESRLEGLTDE INFLRQLYEE EIRELQSQIS 
DTSVVLSMDN SRSLDMDSII AEVKAQYEDI ANRSRAEAES MYQIKYEELQ SLAGKHGDDL 
RRTKTEISEM NRNISRLQAE IEGLKGQRAS LEAAIADAEQ RGELAIKDAN AKLSELEAAL 
QRAKQDMARQ LREYQELMNV KLALDIEIAT YRKLLEGEES RLESGMQNMS IHTKTTSGYA 
GGLSSAYGGL TSPGLSYSLG SSFGSGAGSS SFSRTSSSRA VVVKKIETRD GKLVSESSDV 
LPK

Genular Protein ID: 2157958652

Symbol: Q7L4M3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7L4M3

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 7 Gene3D 3 IntAct 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SMR 1 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 279
  • Mass: 30820
  • Checksum: D9B2EB27FD985629
  • Sequence:
    • MNKVELESRL EGLTDEINFL RQLYEEEIRE LQSQISDTSV VLSMDNSRSL DMDSIIAEVK 
AQYEDIANRS RAEAESMYQI KYEELQSLAG KHGDDLRRTK TEISEMNRNI SRLQAEIEGL 
KGQRASLEAA IADAEQRGEL AIKDANAKLS ELEAALQRAK QDMARQLREY QELMNVKLAL 
DIEIATYRKL LEGEESRLES GMQNMSIHTK TTSGYAGGLS SAYGGLTSPG LSYSLGSSFG 
SGAGSSSFSR TSSSRAVVVK KIETRDGKLV SESSDVLPK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.