Details for: GAPDH

Gene ID: 2597

Symbol: GAPDH

Ensembl ID: ENSG00000111640

Description: glyceraldehyde-3-phosphate dehydrogenase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 1514.4791
    Cell Significance Index: -235.5700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 814.2929
    Cell Significance Index: -206.5400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 689.1896
    Cell Significance Index: -283.9100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 618.6722
    Cell Significance Index: -251.3400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 591.5200
    Cell Significance Index: -279.2700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 546.2443
    Cell Significance Index: -280.9800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 417.9221
    Cell Significance Index: -280.4400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 267.6427
    Cell Significance Index: -255.5300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 211.5485
    Cell Significance Index: -260.8300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 78.6761
    Cell Significance Index: -241.6500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 70.4806
    Cell Significance Index: -278.1200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 48.7666
    Cell Significance Index: -106.7300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 33.2828
    Cell Significance Index: -89.1600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 19.6193
    Cell Significance Index: 1030.0900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 12.8227
    Cell Significance Index: 343.0000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 11.2153
    Cell Significance Index: 329.3800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 10.7944
    Cell Significance Index: 199.5100
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 10.6889
    Cell Significance Index: 91.8500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 9.7783
    Cell Significance Index: 459.5700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 9.1424
    Cell Significance Index: 1078.1700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 9.1409
    Cell Significance Index: 240.3600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 7.8012
    Cell Significance Index: 271.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 7.3915
    Cell Significance Index: 4036.7000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 7.3324
    Cell Significance Index: 947.2900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 6.4681
    Cell Significance Index: 82.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 5.9812
    Cell Significance Index: 821.3900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 5.8238
    Cell Significance Index: 375.7300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 5.8097
    Cell Significance Index: 102.6700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 5.8029
    Cell Significance Index: 713.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 5.4783
    Cell Significance Index: 987.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 5.3442
    Cell Significance Index: 249.1700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 5.0570
    Cell Significance Index: 2235.8100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 4.9461
    Cell Significance Index: 103.5300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 4.8374
    Cell Significance Index: 111.7600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 4.8207
    Cell Significance Index: 617.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 4.5714
    Cell Significance Index: 238.1200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 4.2956
    Cell Significance Index: 48.8000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 4.1612
    Cell Significance Index: 310.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.6353
    Cell Significance Index: 98.9500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.6167
    Cell Significance Index: 96.5700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 3.4990
    Cell Significance Index: 26.9700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 3.4831
    Cell Significance Index: 344.5600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.8792
    Cell Significance Index: 203.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.7340
    Cell Significance Index: 542.5800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.2210
    Cell Significance Index: 24.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3585
    Cell Significance Index: 272.5200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.3504
    Cell Significance Index: 38.7100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 1.3150
    Cell Significance Index: 995.3700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.1974
    Cell Significance Index: 9.5600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8811
    Cell Significance Index: 167.6800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8555
    Cell Significance Index: 306.8700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.7571
    Cell Significance Index: 555.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5620
    Cell Significance Index: 95.9600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1460
    Cell Significance Index: 274.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1105
    Cell Significance Index: 5.7400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0768
    Cell Significance Index: 1.2900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0321
    Cell Significance Index: 49.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0113
    Cell Significance Index: -20.8600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0504
    Cell Significance Index: -5.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0768
    Cell Significance Index: -104.4900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0994
    Cell Significance Index: -73.6300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1814
    Cell Significance Index: -115.2100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2078
    Cell Significance Index: -12.4800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2392
    Cell Significance Index: -149.3800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2939
    Cell Significance Index: -133.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.3478
    Cell Significance Index: -196.1600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3609
    Cell Significance Index: -28.5800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.5412
    Cell Significance Index: -114.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.8334
    Cell Significance Index: -239.8000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.9163
    Cell Significance Index: -149.0300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.9574
    Cell Significance Index: -60.3400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.0331
    Cell Significance Index: -117.9300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.2412
    Cell Significance Index: -69.6500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.2503
    Cell Significance Index: -31.9400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.3565
    Cell Significance Index: -197.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.4096
    Cell Significance Index: -161.4900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.4487
    Cell Significance Index: -100.1900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -1.6171
    Cell Significance Index: -188.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.7645
    Cell Significance Index: -79.9800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.9353
    Cell Significance Index: -118.9500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -2.0155
    Cell Significance Index: -34.5400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -2.0692
    Cell Significance Index: -19.0600
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -2.1558
    Cell Significance Index: -44.9600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -2.2922
    Cell Significance Index: -64.0600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -2.3139
    Cell Significance Index: -74.1100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.4172
    Cell Significance Index: -251.6900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -2.4751
    Cell Significance Index: -189.9400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -2.5976
    Cell Significance Index: -16.1400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -2.7823
    Cell Significance Index: -16.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -2.9563
    Cell Significance Index: -198.7800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -3.0443
    Cell Significance Index: -36.2900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -3.4640
    Cell Significance Index: -86.5900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -3.4910
    Cell Significance Index: -60.1800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -3.5569
    Cell Significance Index: -77.0600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -3.6647
    Cell Significance Index: -50.0000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -3.6868
    Cell Significance Index: -98.7900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -4.0236
    Cell Significance Index: -60.2900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -4.4298
    Cell Significance Index: -271.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -4.7859
    Cell Significance Index: -168.1700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -5.2089
    Cell Significance Index: -153.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** GAPDH is a homodimeric enzyme consisting of two identical subunits, each consisting of a catalytic domain and a regulatory domain. The catalytic domain is responsible for the enzyme's metabolic activity, while the regulatory domain modulates the enzyme's activity in response to various cellular signals. GAPDH is highly unstable and has a short half-life, which necessitates its rapid turnover and recycling to maintain cellular homeostasis. **Pathways and Functions** GAPDH is involved in several key cellular pathways, including: 1. **Glycolysis**: GAPDH is a crucial enzyme in the glycolytic pathway, catalyzing the conversion of glyceraldehyde-3-phosphate to 1,3-bisphosphoglycerate. 2. **Energy Metabolism**: GAPDH plays a key role in energy metabolism, generating NADH and producing ATP through the electron transport chain. 3. **Immune Response**: GAPDH has been implicated in immune response, particularly in the production of cytokines and type I interferons. 4. **Cell Signaling**: GAPDH can interact with various signaling molecules, including proteins and lipids, to modulate cellular signaling pathways. 5. **Apoptosis**: GAPDH has been shown to regulate apoptosis by interacting with pro-apoptotic and anti-apoptotic proteins. **Clinical Significance** GAPDH has been implicated in various diseases, including: 1. **Cancer**: GAPDH has been found to be overexpressed in various types of cancer, including breast, lung, and colon cancer, suggesting its potential role as a prognostic marker. 2. **Neurodegenerative Diseases**: GAPDH has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, where it may contribute to neuronal dysfunction and death. 3. **Inflammatory Diseases**: GAPDH has been shown to play a role in inflammatory diseases, such as rheumatoid arthritis and atherosclerosis, where it may contribute to the production of pro-inflammatory cytokines. In conclusion, GAPDH is a multifunctional enzyme that plays a critical role in various cellular processes, including glycolysis, energy metabolism, and immune response. Its dysregulation has been implicated in various diseases, highlighting the importance of GAPDH in maintaining cellular homeostasis and overall health.

Genular Protein ID: 754703678

Symbol: G3P_HUMAN

Name: N/A

UniProtKB Accession Codes:

P04406 E7EUT4 P00354 Q53X65

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CPTAC 4 CPTC 1 CTD 1 ChEBI 17 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 DrugCentral 1 EC 1 EMBL 23 EMDB 8 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 39 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 MoonDB 1 MoonProt 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 20 PDBsum 20 PIR 1 PIRSF 1 PRIDE 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 2 RefSeq 4 Rhea 7 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6096136

Title: The glyceraldehyde 3 phosphate dehydrogenase gene family: structure of a human cDNA and of an X chromosome linked pseudogene; amazing complexity of the gene family in mouse.

PubMed ID: 6096136

DOI: 10.1002/j.1460-2075.1984.tb02185.x

PubMed ID: 6096821

Title: The complete sequence of a full length cDNA for human liver glyceraldehyde-3-phosphate dehydrogenase: evidence for multiple mRNA species.

PubMed ID: 6096821

DOI: 10.1093/nar/12.23.9179

PubMed ID: 2987855

Title: Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene.

PubMed ID: 2987855

DOI: 10.1093/nar/13.7.2485

PubMed ID: 3664468

Title: Enhanced expression of a glyceraldehyde-3-phosphate dehydrogenase gene in human lung cancers.

PubMed ID: 3664468

PubMed ID: 3027061

Title: Identification of the 37-kDa protein displaying a variable interaction with the erythroid cell membrane as glyceraldehyde-3-phosphate dehydrogenase.

PubMed ID: 3027061

DOI: 10.1016/s0021-9258(19)75833-5

PubMed ID: 3170585

Title: Isolation and complete sequence of a functional human glyceraldehyde-3-phosphate dehydrogenase gene.

PubMed ID: 3170585

DOI: 10.1016/s0021-9258(19)37593-3

PubMed ID: 1924305

Title: A human nuclear uracil DNA glycosylase is the 37-kDa subunit of glyceraldehyde-3-phosphate dehydrogenase.

PubMed ID: 1924305

DOI: 10.1073/pnas.88.19.8460

PubMed ID: 10944468

Title: cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs.

PubMed ID: 10944468

DOI: 10.1006/bbrc.2000.3282

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7030790

Title: The complete amino acid sequence of human muscle glyceraldehyde 3-phosphate dehydrogenase.

PubMed ID: 7030790

DOI: 10.1016/0014-5793(81)80587-x

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 7498159

Title: The major protein expression profile and two-dimensional protein database of human heart.

PubMed ID: 7498159

DOI: 10.1002/elps.11501601192

PubMed ID: 1193541

Title: The covalent structure of glyceraldehyde-phosphate dehydrogenase from human muscles. Isolation and amino acid sequences of peptides from tryptic digest.

PubMed ID: 1193541

PubMed ID: 11724794

Title: Glyceraldehyde-3-phosphate dehydrogenase is phosphorylated by protein kinase Ciota /lambda and plays a role in microtubule dynamics in the early secretory pathway.

PubMed ID: 11724794

DOI: 10.1074/jbc.m109744200

PubMed ID: 12829261

Title: Subcellular localization of human glyceraldehyde-3-phosphate dehydrogenase is independent of its glycolytic function.

PubMed ID: 12829261

DOI: 10.1016/s0304-4165(03)00117-x

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15479637

Title: Noncanonical function of glutamyl-prolyl-tRNA synthetase: gene-specific silencing of translation.

PubMed ID: 15479637

DOI: 10.1016/j.cell.2004.09.030

PubMed ID: 15628863

Title: Oxidative stress-responsive intracellular regulation specific for the angiostatic form of human tryptophanyl-tRNA synthetase.

PubMed ID: 15628863

DOI: 10.1021/bi048313k

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16501887

Title: The ubiquitin-specific protease USP25 interacts with three sarcomeric proteins.

PubMed ID: 16501887

DOI: 10.1007/s00018-005-5533-1

PubMed ID: 16815975

Title: HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets.

PubMed ID: 16815975

DOI: 10.1073/pnas.0600397103

PubMed ID: 18183946

Title: Strategy for comprehensive identification of post-translational modifications in cellular proteins, including low abundant modifications: application to glyceraldehyde-3-phosphate dehydrogenase.

PubMed ID: 18183946

DOI: 10.1021/pr700657y

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19001379

Title: FKBP36 is an inherent multifunctional glyceraldehyde-3-phosphate dehydrogenase inhibitor.

PubMed ID: 19001379

DOI: 10.1074/jbc.m709779200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20644585

Title: Haponin (eIF1AD) interacts with glyceraldehyde 3-phosphate dehydrogenase in the CHO-K1 cell line.

PubMed ID: 20644585

DOI: 10.1134/s1068162010030027

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21908771

Title: The first identification of lysine malonylation substrates and its regulatory enzyme.

PubMed ID: 21908771

DOI: 10.1074/mcp.m111.012658

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 22771119

Title: Protection of extraribosomal RPL13a by GAPDH and dysregulation by S-nitrosylation.

PubMed ID: 22771119

DOI: 10.1016/j.molcel.2012.06.006

PubMed ID: 23071094

Title: Heterotrimeric GAIT complex drives transcript-selective translation inhibition in murine macrophages.

PubMed ID: 23071094

DOI: 10.1128/mcb.01168-12

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23332158

Title: NleB, a bacterial effector with glycosyltransferase activity, targets GAPDH function to inhibit NF-kappaB activation.

PubMed ID: 23332158

DOI: 10.1016/j.chom.2012.11.010

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25417112

Title: Target-selective protein S-nitrosylation by sequence motif recognition.

PubMed ID: 25417112

DOI: 10.1016/j.cell.2014.09.032

PubMed ID: 25086035

Title: Oxidation of an exposed methionine instigates the aggregation of glyceraldehyde-3-phosphate dehydrogenase.

PubMed ID: 25086035

DOI: 10.1074/jbc.m114.570275

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27387501

Title: Citrobacter rodentium NleB protein inhibits tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) ubiquitination to reduce host type I interferon production.

PubMed ID: 27387501

DOI: 10.1074/jbc.m116.738278

PubMed ID: 28522607

Title: NleB/SseK effectors from Citrobacter rodentium, Escherichia coli, and Salmonella enterica display distinct differences in host substrate specificity.

PubMed ID: 28522607

DOI: 10.1074/jbc.m117.790675

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 957435

Title: Twinning in crystals of human skeletal muscle D-glyceraldehyde-3-phosphate dehydrogenase.

PubMed ID: 957435

DOI: 10.1016/0022-2836(76)90013-9

PubMed ID: 16239728

Title: Structural analysis of human liver glyceraldehyde-3-phosphate dehydrogenase.

PubMed ID: 16239728

DOI: 10.1107/s0907444905026740

PubMed ID: 16510976

Title: High-resolution structure of human D-glyceraldehyde-3-phosphate dehydrogenase.

PubMed ID: 16510976

DOI: 10.1107/s0907444905042289

Sequence Information:

  • Length: 335
  • Mass: 36053
  • Checksum: C9C135E8AE3E8744
  • Sequence:
    • MGKVKVGVNG FGRIGRLVTR AAFNSGKVDI VAINDPFIDL NYMVYMFQYD STHGKFHGTV 
KAENGKLVIN GNPITIFQER DPSKIKWGDA GAEYVVESTG VFTTMEKAGA HLQGGAKRVI 
ISAPSADAPM FVMGVNHEKY DNSLKIISNA SCTTNCLAPL AKVIHDNFGI VEGLMTTVHA 
ITATQKTVDG PSGKLWRDGR GALQNIIPAS TGAAKAVGKV IPELNGKLTG MAFRVPTANV 
SVVDLTCRLE KPAKYDDIKK VVKQASEGPL KGILGYTEHQ VVSSDFNSDT HSSTFDAGAG 
IALNDHFVKL ISWYDNEFGY SNRVVDLMAH MASKE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.